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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (89th Ed) | Author: Lide DR | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: The Condensed Chemical Dictionary (10th Ed) | Author: Hawley G | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals Drugs and Biologicals (14th Edition) | Author: O'Neil MJ | Year: 2006 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals Drugs and Biologicals (14th Edition) | Author: O'Neil MJ | Year: 2006 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals Drugs and Biologicals (14th Edition) | Author: O'Neil MJ | Year: 2006 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: The Condensed Chemical Dictionary (10th Ed) | Author: Hawley G | Year: 1981 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the Water Solubility of 4-methylpentan-2-one | Author: Mollandin G | Year: 2010 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the Water Solubility of 4-methylpentan-2-one | Author: Mollandin G | Year: 2010 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Methyl Isobutyl Ketone: Determination of the n-Octanol/Water Partition Coefficient Using a Reverse-Phase HPLC Method | Author: Eadsforth CV | Year: 1983 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Methyl Isobutyl Ketone: Determination of the n-Octanol/Water Partition Coefficient Using a Reverse-Phase HPLC Method | Author: Eadsforth CV | Year: 1983 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: I-Lab Service: ACD/LogP v8.02 for MIBK | Author: Anonymous | Year: 2009 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Lange's Handbook of Chemistry (15th Ed) | Author: Dean JA | Year: 1991 | Guideline: 114 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Guideline: 114 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals Drugs and Biologicals (14th Edition) | Author: O'Neil MJ | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Guideline: A.15-16 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: The Condensed Chemical Dictionary (10th Ed) | Author: Hawley G | Year: 1981 | Guideline: A.15-16 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: METHYL ISO BUTYL KETONE : SKIN IRRITATION IN THE RABBIT | Author: Gardner JR | Year: 1996 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: METHYL ISO BUTYL KETONE : SKIN IRRITATION IN THE RABBIT | Author: Gardner JR | Year: 1996 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: METHYL ISO BUTYL KETONE : EYE IRRITATION IN THE RABBIT | Author: Gardner JR | Year: 1996 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: METHYL ISO BUTYL KETONE : EYE IRRITATION IN THE RABBIT | Author: Gardner JR | Year: 1996 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Methyl isobutyl ketone EEC study BCO-P assay no. 30 | Author: Giroux J | Year: 1992 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Interlaboratory assessment of the bovine corneal opacity and permeability (BCOP) assay | Author: Gautheron P et al. | Year: 1994 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Technical report no. 48. Eye irritation : reference chemical data bank | Author: ECETOC | Year: 1992 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Eye irritation: Reference chemicals data bank | Author: Bagley DM et al. | Year: 1992 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Prüfung auf hautsensibilisierende Wirkung am Meerschweinchen von Methylisobutylketon | Author: Mürmann P | Year: 1989 | Guideline: 406, 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Prüfung auf hautsensibilisierende Wirkung am Meerschweinchen von Methylisobutylketon | Author: Mürmann P | Year: 1989 | Guideline: 406, 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Toxicity Studies with chemical solvents: short-term in vitro tests for genotoxic activity with methyl isobutyl ketone | Author: Thorpe E | Year: 1982 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Toxicity Studies with chemical solvents: short-term in vitro tests for genotoxic activity with methyl isobutyl ketone | Author: Thorpe E | Year: 1982 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: The genetic toxicology of some hydrocarbon and oxygenated solvents | Author: Brooks TM; Meyer AL; and Hutson DH | Year: 1988 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity studies on ketone solvents: methyl ethyl ketone, methyl isobutyl ketone, and isophorone | Author: O'Donoghue JL et al. | Year: 1988 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity studies on ketone solvents: methyl ethyl ketone, methyl isobutyl ketone, and isophorone | Author: O'Donoghue JL et al. | Year: 1988 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Toxicity Studies with chemical solvents: short-term in vitro tests for genotoxic activity with methyl isobutyl ketone | Author: Thorpe E | Year: 1982 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Toxicity Studies with chemical solvents: short-term in vitro tests for genotoxic activity with methyl isobutyl ketone | Author: Thorpe E | Year: 1982 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: The genetic toxicology of some hydrocarbon and oxygenated solvents | Author: Brooks TM; Meyer AL; and Hutson DH | Year: 1988 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity studies on ketone solvents: methyl ethyl ketone, methyl isobutyl ketone, and isophorone | Author: O'Donoghue JL et al. | Year: 1988 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Toxicity Studies with chemical solvents: short-term in vitro tests for genotoxic activity with methyl isobutyl ketone | Author: Thorpe E | Year: 1982 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Toxicity Studies with chemical solvents: short-term in vitro tests for genotoxic activity with methyl isobutyl ketone | Author: Thorpe E | Year: 1982 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: The genetic toxicology of some hydrocarbon and oxygenated solvents | Author: Brooks TM; Meyer AL; and Hutson DH | Year: 1988 | Guideline: 480 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: RANGE-FINDING TOXICITY DATA: LIST IV | Author: Smyth HF; Carpenter CP; Weil CS | Year: 1951 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: RANGE-FINDING TOXICITY DATA: LIST IV | Author: Smyth HF; Carpenter CP; Weil CS | Year: 1951 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: METHYL ISO BUTYL KETONE : ACUTE DERMAL TOXICITY IN THE RAT | Author: Gardner JR | Year: 1996 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: METHYL ISO BUTYL KETONE : ACUTE DERMAL TOXICITY IN THE RAT | Author: Gardner JR | Year: 1996 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Diacetone Alcohol./Methyl isobutyl ketone: Pilot Pharmacokinetic Investigation in Sprague- Dawley Rats following single inhalation exposure | Author: Tóth B | Year: 2016 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Diacetone Alcohol./Methyl isobutyl ketone: Pilot Pharmacokinetic Investigation in Sprague- Dawley Rats following single inhalation exposure | Author: Tóth B | Year: 2016 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: DETERMINATION OF THE CONCENTRATIONS OF DAA MIBK AND MIBC IN RAT PLASMA BY GC-MS IN SUPPORT OF A PILOT PHARMACOKINETICS STUDY NO. 15/200-303P | Author: Fabreguettes G | Year: 2016 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: DETERMINATION OF THE CONCENTRATIONS OF DAA MIBK AND MIBC IN RAT PLASMA BY GC-MS IN SUPPORT OF A PILOT PHARMACOKINETICS STUDY NO. 15/200-303P | Author: Fabreguettes G | Year: 2016 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Tissue concentrations of methyl isobutyl ketone methyl nbutyl ketone and their metabolites after oral and inhalation exposure | Author: Duguay AB; Plaa GL | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Plasma concentrations in methyl isobutyl ketone-potentiated experimental cholestasis after inhalation or oral administration | Author: Duguay AB; Plaa GL | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolic fate of methyl n-butyl ketone methyl isobutyl ketone and their metabolites in mice | Author: Granvil CP; Aharkawi M; Plaa GL | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Mechanism of Transport and Distribution of Organic Solvents in Blood | Author: Lam C; Galen TL; Boyd JF; Pierson DL | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Characterization of the Metabolites of Methyl n-Butyl Ketone Methyl iso-Butyl Ketone and Methyl Ethyl Ketone in Guinea Pig and their Clearance | Author: DiVincenzo GD; Kaplan CJ; Dedinas J | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Comparative metabolism of methyl isobutyl carbinol and methyl isobutyl ketone in male rats | Author: Gingell R; Régnier JF; Wilson DM; Guillaumat PO; Appelqvist T | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The metabolism of methyl isobutyl ketone and its biological monitoring: Part 1. Qualitative and quantitative studies of methyl isobutyl ketone exhaled from the lungs and excreted in the urine and the metabolites in the urine of rats injected with MIBK | Author: Hirota N | Year: 1991 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Continuous exposure of animals to methyl isobutyl ketone | Author: Vernot EH; MacEwen JD; Harris ES | Year: 1971 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Pathological lesions caused by methylisobutylketone | Author: MacKenzie WF | Year: 1971 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure | Author: Stout MD et al. | Year: 2008 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Inhalation two-generation reproductive toxicity study of methyl isobutyl ketone in rats | Author: Nemec MD; Pitt JA; Topping DC; Gingell R; Pavkov KL et al. | Year: 2004 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute Toxicity of 4-methylpentan-2-one to Zebrafish (Danio rerio) in a 96-hour Static Limit-Test in Closed Vessel Design | Author: Kuhl R & Deierling T | Year: 2010 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Acute Toxicity of 4-methylpentan-2-one to Zebrafish (Danio rerio) in a 96-hour Static Limit-Test in Closed Vessel Design | Author: Kuhl R & Deierling T | Year: 2010 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute Toxicity of 4-methylpentan-2-one to Daphnia magna in a Static 48-hour Immobilisation Limit-Test in Closed Vessel Design | Author: Kuhl R & Wydra V | Year: 2009 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Acute Toxicity of 4-methylpentan-2-one to Daphnia magna in a Static 48-hour Immobilisation Limit-Test in Closed Vessel Design | Author: Kuhl R & Wydra V | Year: 2009 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Bakterien (Pseudomonas putida) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann G; Kühn R | Year: 1977 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Schadstoffeinwirkungen von Umweltchemikalien im Daphnien-Reproduktionstest als Grundlage zur Bewertung der Umweltgefährlichkeit in aquatischen Systemen | Author: Kühn R.; Pattard M.; Pernak K. | Year: 1988 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation and Bioaccumulation Data of Existing Chemicals Based on the CSCL Japan | Author: Chemicals Inspection & Testing Institute Japan | Year: 1992 | Guideline: 301 C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Ready Biodegradability of Methylisobutylcetone in a Manometric Respirometry Test | Author: Feil N | Year: 2009 | Guideline: 301 F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Ready Biodegradability of Methylisobutylcetone in a Manometric Respirometry Test | Author: Feil N | Year: 2009 | Guideline: 301 F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Non hydrophobic equation | Author: Guidance on information requirements and chemical safety assessment (IR & CSA),Chapter 16 "Environmental exposure estimate" | Year: 2010 | Guideline: 106 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |