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| Study name | Short Description | Data Owner |
|---|---|---|
| Appearance/physical state/colour | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 14th Edition | Author: Lewis R.J. Sr. | Year: 2001 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Appearance/physical state/colour | Robust Study Summary -- Title: 1,4 Butandiol | Author: GESTIS - Substance Database | Year: 2008 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition 2009-2010 | Author: Lide D.R. (ed.) | Year: 2009 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Melting point/freezing point | Robust Study Summary -- Title: 1,4 Butandiol | Author: GESTIS - Substance Database | Year: 2008 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Melting point/freezing point | Robust Study Summary -- Title: Reg. Nr.: 1633445 | Author: Beilstein Information Systems | Year: 2007 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Boiling point | Robust Study Summary -- Title: Siedegleichgewicht | Author: BASF AG | Year: 1968 | Guideline: BASF standard method | Klimisch score: 2 - Reliable with restrictions. | - |
| Boiling point | Right to refer to study -- Title: Siedegleichgewicht | Author: BASF AG | Year: 1968 | Guideline: BASF standard method | Klimisch score: 2 - Reliable with restrictions. | - |
| Boiling point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition 2009-2010 | Author: Lide D.R. | Year: 2009 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Boiling point | Robust Study Summary -- Title: Reg. No.: 1633445 | Author: Beilstein Information Systems | Year: 2007 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Boiling point | Robust Study Summary -- Title: 1,4 Butandiol | Author: GESTIS - Substance Database | Year: 2008 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Density | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Lide D.R. | Year: 2005 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Density | Robust Study Summary -- Title: Reg. No.: 1633445 | Author: Beilstein Information Systems | Year: 2007 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Density | Robust Study Summary -- Title: 1,4 Butandiol | Author: GESTIS - Substance Database | Year: 2008 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Vapour pressure | Robust Study Summary -- Title: Physical and Thermodynamic Properties of Pure Chemicals Data Compilation | Author: Daubert T.E., R.P. Danner | Year: 1989 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Vapour pressure | Robust Study Summary -- Title: Handbook of Chemical Compound Data for Process Safety | Author: Yaws Carl L. | Year: 1997 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Vapour pressure | Robust Study Summary -- Title: 1,4 Butandiol | Author: BGIA GESTIS-Stoffdatenbank | Year: 2008 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Vapour pressure | Robust Study Summary -- Title: Reg. No.: 1633445 | Author: Beilstein Information Systems | Year: 2007 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Vapour pressure | Robust Study Summary -- Title: Stoffwertmessungen | Author: BASF AG (1969) Verfahrenstechnik II unpublished study No. 169.349.1 15 Nov 1969 | Year: 1969 | Guideline: BASF standard method | Klimisch score: 2 - Reliable with restrictions. | - |
| Vapour pressure | Right to refer to study -- Title: Stoffwertmessungen | Author: BASF AG (1969) Verfahrenstechnik II unpublished study No. 169.349.1 15 Nov 1969 | Year: 1969 | Guideline: BASF standard method | Klimisch score: 2 - Reliable with restrictions. | - |
| Partition coefficient | Robust Study Summary -- Title: log Pow | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions. | - |
| Partition coefficient | Right to refer to study -- Title: log Pow | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions. | - |
| Partition coefficient | Robust Study Summary -- Title: Exploring QSAR-HydrophobicElectronic and Steric ConstantsAmerican Chemical Society | Author: Hansch C. Leo A. D. Hoekman | Year: 1995 | Guideline: 107/117/122/123 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Water solubility | Robust Study Summary -- Title: Estimation of Water Solubility for 1,4-butanediol (CASRN: 110-63-4) using USEPA WSKOWWIN v. 1.41 (March 2010) | Author: ISP | Year: 2010 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Water solubility | Robust Study Summary -- Title: AQUASOL Database of Aqueous Solubility | Author: Yalkowsky SH, Dannenfelser RM | Year: 1992 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Water solubility | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Water solubility | Robust Study Summary -- Title: 14-Butanediol (CASRN: 110-63-4) | Author: NITE Japan | Year: 2009 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Water solubility | Robust Study Summary -- Title: 14-Butanediol | Author: BGIA GESTIS-Stoffdatenbank | Year: 2009 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Water solubility | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition 2009-2010 | Author: Lide D.R. | Year: 2009 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Flash point | Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF | Year: 1994 | Guideline: DIN 51758 | Klimisch score: 2 - Reliable with restrictions. | - |
| Flash point | Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF | Year: 1994 | Guideline: DIN 51758 | Klimisch score: 2 - Reliable with restrictions. | - |
| Flash point | Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF | Year: 1981 | Guideline: BASF Method | Klimisch score: 2 - Reliable with restrictions. | - |
| Flash point | Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF | Year: 1981 | Guideline: BASF Method | Klimisch score: 2 - Reliable with restrictions. | - |
| Flash point | Robust Study Summary -- Title: Fire Protection Guide to Hazardous Materials 13th ed. | Author: NFPA | Year: 2002 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Flash point | Robust Study Summary -- Title: 14-Butanediol | Author: GESTIS Substance Database | Year: 2008 | Guideline: DIN 51794 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Auto-ignition temperature | Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1993 | Guideline: DIN 51794 | Klimisch score: 2 - Reliable with restrictions. | - |
| Auto-ignition temperature | Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1993 | Guideline: DIN 51794 | Klimisch score: 2 - Reliable with restrictions. | - |
| Auto-ignition temperature | Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1994 | Guideline: DIN 51794 | Klimisch score: 2 - Reliable with restrictions. | - |
| Auto-ignition temperature | Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1994 | Guideline: DIN 51794 | Klimisch score: 2 - Reliable with restrictions. | - |
| Auto-ignition temperature | Robust Study Summary -- Title: Fire Protection Guide to Hazardous Materials. 13 ed | Author: NFPA | Year: 1985 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Auto-ignition temperature | Robust Study Summary -- Title: 14-Butanediol | Author: BGIA GESTIS-Stoffdatenbank | Year: 2008 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Stability: Dissociation constant | Robust Study Summary -- Title: Calculation of pKa value (dissociation constant) for 1,4-butanediol using SPARC Online v4.5 | Author: ISP | Year: 2009 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Stability: Dissociation constant | Robust Study Summary -- Title: Techniques of Chemistry 4th ed. vol II. Organic Solvents | Author: Riddick J.A. et al. | Year: 1985 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Stability: Dissociation constant | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Viscosity | Robust Study Summary -- Title: Kirk-Othmer Encyclopedia of Chemical Technology | Author: Hort EV and Taylor P | Year: 2001 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Viscosity | Robust Study Summary -- Title: Reg. No.: 1633445 | Author: Beilstein Information Systems | Year: 2007 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Additional physico-chemical information | Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG (1981) Sicherheitstechnische Kenndaten unpublished study TKM/SIK 81/1037 10 Nov 1981 | Year: 1981 | Guideline: BASF standard method | Klimisch score: 2 - Reliable with restrictions. | - |
| Additional physico-chemical information | Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG (1981) Sicherheitstechnische Kenndaten unpublished study TKM/SIK 81/1037 10 Nov 1981 | Year: 1981 | Guideline: BASF standard method | Klimisch score: 2 - Reliable with restrictions. | - |
| Additional physico-chemical information | Robust Study Summary -- Title: | Author: BGIA GESTIS-Stoffdatenbank 08 Nov 2006 | Year: 2006 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Hydrolysis | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation and Bioaccumulation Data of Existing Chemicals Based on the CSCL Japan | Author: METI | Year: 1992 | Guideline: 301 C | Klimisch score: 1 - Reliable without restriction. | Consortium |
| Biodegradation in water: screening tests | Robust Study Summary -- Title: Butane-14-diol: Standversuch | Author: BASF | Year: 1977 | Guideline: 302 B | Klimisch score: 2 - Reliable with restrictions. | - |
| Biodegradation in water: screening tests | Right to refer to study -- Title: Butane-14-diol: Standversuch | Author: BASF | Year: 1977 | Guideline: 302 B | Klimisch score: 2 - Reliable with restrictions. | - |
| Biodegradation in water: screening tests | Robust Study Summary -- Title: | Author: BASF | Year: 1990 | Guideline: DIN 38409 | Klimisch score: 2 - Reliable with restrictions. | - |
| Biodegradation in water: screening tests | Right to refer to study -- Title: | Author: BASF | Year: 1990 | Guideline: DIN 38409 | Klimisch score: 2 - Reliable with restrictions. | - |
| Biodegradation in water: screening tests | Robust Study Summary -- Title: 14-Butandiol: Standversuch | Author: BASF | Year: 1990 | Guideline: 302 B | Klimisch score: 2 - Reliable with restrictions. | - |
| Biodegradation in water: screening tests | Right to refer to study -- Title: 14-Butandiol: Standversuch | Author: BASF | Year: 1990 | Guideline: 302 B | Klimisch score: 2 - Reliable with restrictions. | - |
| Biodegradation in water: screening tests | Robust Study Summary -- Title: Determination of biological degradability of organic substances. | Author: Pitter P. | Year: 1976 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Biodegradation in water: screening tests | Robust Study Summary -- Title: Toxicity and biodegradation of products from polyester hydrolysis. | Author: Kim MN et al. | Year: 2001 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Estimation of Bioaccumulation Potential (Aquatic / Sediment) for 1,4-butanediol (CASRN: 110-63-4) using USEPA BCFBAFWIN v3.0 (October 2008) | Author: ISP | Year: 2009 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Adsorption/desorption | Robust Study Summary -- Title: Estimation of Adsorption / Desorption (Koc) for 1,4-butanediol using USEPA KOCWIN v2.0 (February 2009) | Author: ISP | Year: 2009 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Adsorption/desorption | Robust Study Summary -- Title: 1,4-butanediol (CASRN: 110-63-4) Soil Adsorbtion/Mobility | Author: NLM NIH | Year: 2009 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Short-term toxicity to fish | Robust Study Summary -- Title: 96 hour LC50 to Fathead minnow | Author: DuPont | Year: 1982 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions. | - |
| Short-term toxicity to fish | Right to refer to study -- Title: 96 hour LC50 to Fathead minnow | Author: DuPont | Year: 1982 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions. | - |
| Short-term toxicity to fish | Robust Study Summary -- Title: 14-butandiol:Report on the study of the acute toxicity (Leuciscus idus) | Author: BASF | Year: 1989 | Guideline: DIN 38412 | Klimisch score: 2 - Reliable with restrictions. | - |
| Short-term toxicity to fish | Right to refer to study -- Title: 14-butandiol:Report on the study of the acute toxicity (Leuciscus idus) | Author: BASF | Year: 1989 | Guideline: DIN 38412 | Klimisch score: 2 - Reliable with restrictions. | - |
| Short-term toxicity to fish | Robust Study Summary -- Title: Screening test | Author: BASF | Year: 1976 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | - |
| Short-term toxicity to fish | Right to refer to study -- Title: Screening test | Author: BASF | Year: 1976 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | - |
| Short-term toxicity to fish | Robust Study Summary -- Title: Information on Environmental Toxicity - Fish (Oryzias latipes) -Acute toxicity | Author: NITE Japan | Year: 1996 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Short-term toxicity to fish | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Long-term toxicity to fish | Robust Study Summary -- Title: Information on Environmental Toxicity - Fish (Oryzias latipes) - Prolonged toxicity | Author: NITE Japan | Year: 1996 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Long-term toxicity to fish | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Short-term toxicity to fish | Robust Study Summary -- Title: The toxicity of 1085 chemicals to fish Toxicity Report No. 2 | Author: Hollis E.H., R.E. Lennon | Year: 1954 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Bestimmung der Auswirkungen von BUTANDIOL 14- auf das Schwimmverhalten von Daphnia magna (nach EG-Richtlinie 92/69/EWG) | Author: Hüls AG | Year: 1995 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction. | Consortium |
| Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Bestimmung der Auswirkungen von BUTANDIOL 14- auf das Schwimmverhalten von Daphnia magna (nach EG-Richtlinie 92/69/EWG) | Author: Hüls AG | Year: 1995 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction. | Consortium |
| Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: 48 hour LC50 to Daphnia magna | Author: DuPont | Year: 1982 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions. | - |
| Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: 48 hour LC50 to Daphnia magna | Author: DuPont | Year: 1982 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions. | - |
| Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Determination of the acute toxicity of 14-butandiol to the waterflea Daphnia magna Straus | Author: BASF | Year: 1988 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | - |
| Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Determination of the acute toxicity of 14-butandiol to the waterflea Daphnia magna Straus | Author: BASF | Year: 1988 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | - |
| Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Information on Environmental Toxicity - Daphnia Magna -Acute immobilization | Author: NITE Japan | Year: 1996 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Information on Environmental Toxicity - Daphnia Magna -Reproduction | Author: NITE Japan | Year: 1996 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Prüfung auf Oekotoxizitaet: Hemmung der Algen-Zellvermehrung nach DIN 38412 L9. Department of Ecology | Author: BASF | Year: 1989 | Guideline: DIN 38412 | Klimisch score: 2 - Reliable with restrictions. | - |
| Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Prüfung auf Oekotoxizitaet: Hemmung der Algen-Zellvermehrung nach DIN 38412 L9. Department of Ecology | Author: BASF | Year: 1989 | Guideline: DIN 38412 | Klimisch score: 2 - Reliable with restrictions. | - |
| Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Information on Environmental Toxicity - Alga (Selenastrum capricornutum) - Growth inhibition | Author: NITE Japan | Year: 1996 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Toxicity to microorganisms | Robust Study Summary -- Title: Reproducibility of toxicity across mode of toxic action in the Tetrahymena population growth impairment assay. | Author: Seward JR, Sinks GD, Schultz TW | Year: 2001 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Toxicity to microorganisms | Robust Study Summary -- Title: Kurzzeitatmungshemmtest | Author: BASF | Year: 1990 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions. | - |
| Toxicity to microorganisms | Right to refer to study -- Title: Kurzzeitatmungshemmtest | Author: BASF | Year: 1990 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions. | - |
| Toxicity to terrestrial plants | Robust Study Summary -- Title: Toxicity and biodegradation of products from polyester hydrolysis. | Author: Kim MN et al. | Year: 2001 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Basic toxicokinetics | Robust Study Summary -- Title: NTP Study Summary Report on the Metabolism Disposition and Toxicity of 1,4-butanediol. | Author: NTP | Year: 1996 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Basic toxicokinetics | Robust Study Summary -- Title: Toxicology | Author: Clayton G. D. et.al editors | Year: 1994 | Guideline: | Klimisch score: No reliability assigned. Provided for information purposes only.. | Consortium |
| Acute toxicity: oral | Robust Study Summary -- Title: Prüfung der akuten oralen Toxizitaet von Butandiol-1.4 an der Ratte. | Author: BASF | Year: 1981 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | - |
| Acute toxicity: oral | Right to refer to study -- Title: Prüfung der akuten oralen Toxizitaet von Butandiol-1.4 an der Ratte. | Author: BASF | Year: 1981 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | - |
| Acute toxicity: oral | Robust Study Summary -- Title: Acute toxicity of 1,4-butanediol in laboratory animals | Author: Jedrychowski et al. | Year: 1990 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Acute toxicity: oral | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Acute toxicity: dermal | Robust Study Summary -- Title: Prüfung der akuten dermalen Toxizitaet von Butandiol-1.4 an der Ratte. | Author: BASF | Year: 1981 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | - |
| Acute toxicity: dermal | Right to refer to study -- Title: Prüfung der akuten dermalen Toxizitaet von Butandiol-1.4 an der Ratte. | Author: BASF | Year: 1981 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | - |
| Acute toxicity: dermal | Robust Study Summary -- Title: Acute toxicity of 1,4-butanediol in laboratory animals | Author: Jedrychowski et al. | Year: 1990 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | - |
| Acute toxicity: dermal | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Skin irritation / corrosion | Robust Study Summary -- Title: Acute toxicity of 1,4-butanediol in laboratory animals. | Author: Jedrychowski et al. | Year: 1990 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Eye irritation | Robust Study Summary -- Title: Acute toxicity of 1,4-butanediol in laboratory animals. | Author: Jedrychowski et al. | Year: 1990 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Skin sensitisation | Robust Study Summary -- Title: Acute toxicity of 1,4-butanediol in laboratory animals. | Author: Jedrychowski et al. | Year: 1990 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Repeated dose toxicity: oral | Robust Study Summary -- Title: NTP Technical Report on the Toxicology and Carcinogenesis Studies of Gamma-Butyrolactone (Cas No. 96-48-0) In F344/N Rats and B6C3Fl Mice (Gavage Studies) | Author: NTP | Year: 1992 | Guideline: | Klimisch score: 1 - Reliable without restriction. | Consortium |
| Repeated dose toxicity: oral | Robust Study Summary -- Title: NTP Technical Report on the Toxicology and Carcinogenesis Studies of Gamma-Butyrolactone (Cas No. 96-48-0) In F344/N Rats and B6C3Fl Mice (Gavage Studies) | Author: NTP | Year: 1992 | Guideline: | Klimisch score: 1 - Reliable without restriction. | Consortium |
| Repeated dose toxicity: oral | Robust Study Summary -- Title: Combined Repeat Dose and Reproductive / Developmental Toxicity Screening Test of 1,4-butanediol in Rats | Author: MHW | Year: 1999 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Repeated dose toxicity: oral | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Repeated dose toxicity: oral | Robust Study Summary -- Title: Subacute toxicity of 1,4-butanediol in rats. | Author: Jedrychowski R., Stetkiewicz J., Stetkiewicz I. | Year: 1990 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronic inhalation toxicity of 1,4-butanediol | Author: DuPont | Year: 1984 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions. | - |
| Repeated dose toxicity: inhalation | Right to refer to study -- Title: Subchronic inhalation toxicity of 1,4-butanediol | Author: DuPont | Year: 1984 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions. | - |
| Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Inhalation toxicology of 1,4-butanediol | Author: Kinney L.A., Burgess B.A., Stula E.F., Kennedy G.L. | Year: 1991 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| in vitro genetic toxicity | Robust Study Summary -- Title: Metaphase Chromosome Analysis of Chinese Hamster Lung (V79) Cells treated with 1,4-butanediol | Author: Hüls | Year: 1993 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction. | Consortium |
| in vitro genetic toxicity | Right to refer to study -- Title: Metaphase Chromosome Analysis of Chinese Hamster Lung (V79) Cells treated with 1,4-butanediol | Author: Hüls | Year: 1993 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction. | Consortium |
| in vitro genetic toxicity | Robust Study Summary -- Title: In vitro mammalian cell gene mutation assay (HPRT test) with 1,4-butanediol | Author: Hüls | Year: 1993 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction. | Consortium |
| in vitro genetic toxicity | Right to refer to study -- Title: In vitro mammalian cell gene mutation assay (HPRT test) with 1,4-butanediol | Author: Hüls | Year: 1993 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction. | Consortium |
| in vitro genetic toxicity | Robust Study Summary -- Title: Reverse Mutation Test of 1,4-butanediol on Bacteria | Author: MHW | Year: 1997 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| in vitro genetic toxicity | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| in vitro genetic toxicity | Robust Study Summary -- Title: In Vitro Chromosomal Aberration Test of 1,4-butanediol on Cultured Chinese Hamster Cells | Author: MHW | Year: 1997 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| in vitro genetic toxicity | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| in vitro genetic toxicity | Robust Study Summary -- Title: In-vitro microbial mutagenicity studies of 1,4-butanediol | Author: DuPont | Year: 1976 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | - |
| in vitro genetic toxicity | Right to refer to study -- Title: In-vitro microbial mutagenicity studies of 1,4-butanediol | Author: DuPont | Year: 1976 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | - |
| in vitro genetic toxicity | Robust Study Summary -- Title: Salmonella Mutagenicity Tests: lV. Results from the Testing of 311 Chemicals. | Author: Zeiger E., Anderson B., Haworth S., Lawlor T., Mortelsman K. | Year: 1992 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Carcinogenicity | Robust Study Summary -- Title: Toxicology and Carcinogenesis Studies of Gamma-Butyrolactone (CAS No. 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) | Author: NTP | Year: 1992 | Guideline: | Klimisch score: 1 - Reliable without restriction. | Consortium |
| Carcinogenicity | Robust Study Summary -- Title: Toxicology and Carcinogenesis Studies of Gamma-Butyrolactone (CAS No. 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) | Author: NTP | Year: 1992 | Guideline: | Klimisch score: 1 - Reliable without restriction. | Consortium |
| Toxicity to reproduction | Robust Study Summary -- Title: Combined Repeat Dose and Reproductive / Developmental Toxicity Screening Test of 1,4-butanediol in Rats | Author: MHW | Year: 1999 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Toxicity to reproduction | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity evaluation of 1,4-butanediol administered by gavage to Swiss mice on gestation days 6 through 15. | Author: NTP | Year: 1994 | Guideline: | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratogenicity Test of Gamma-Butyrolactone in the Sprague-Dawley Rat | Author: Kronevi T. et. al. | Year: 1988 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Combined Repeat Dose and Reproductive / Developmental Toxicity Screening Test of 1,4-butanediol in Rats | Author: MHW | Year: 1999 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions. | Consortium |
| Developmental toxicity/teratogenicity | Robust Study Summary -- Title: OECD SIDS | Author: OECD | Year: 2000 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions. | Consortium |