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CAS 13463-67-7 | Data Package 100 - 1000 t/a

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Includes:

Study name Short Description Data Owner
Appearance/physical state/colour Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Year: 2007 | Klimisch score: 2 - Reliable with restrictions. -
Melting point/freezing point Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Year: 2007 | Klimisch score: 2 - Reliable with restrictions. -
Melting point/freezing point Robust Study Summary -- Title: RÖMPP Online Version 3.1 - Titandioxid | Year: 2008 | Klimisch score: 2 - Reliable with restrictions. -
Melting point/freezing point Robust Study Summary -- Title: Titanium dioxide | Year: 2009 | Klimisch score: 2 - Reliable with restrictions. -
Boiling point Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Year: 2007 | Klimisch score: 2 - Reliable with restrictions. -
Boiling point Robust Study Summary -- Title: RÖMPP Online Version 3.1 - Titandioxid | Year: 2008 | Klimisch score: 2 - Reliable with restrictions. -
Boiling point Robust Study Summary -- Title: Titanium dioxide | Year: 2009 | Klimisch score: 2 - Reliable with restrictions. -
Density Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Year: 2007 | Klimisch score: 2 - Reliable with restrictions. -
Particle size distribution (Granulometry)/Fibre length and diameter distribution Robust Study Summary -- Title: Report Aeroxide P 25 | Author: PD. Dr. Ing habil M. Stintz | Year: 2010 | Klimisch score: 1 - Reliable without restriction. -
Particle size distribution (Granulometry)/Fibre length and diameter distribution Right to refer to study -- Title: Report Aeroxide P 25 | Author: PD. Dr. Ing habil M. Stintz | Year: 2010 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Robust Study Summary -- Title: Determination of the water solubility of TiO2-E171-B | Author: Klawonn T. | Year: 2016 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Right to refer to study -- Title: Determination of the water solubility of TiO2-E171-B | Author: Klawonn T. | Year: 2016 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-1 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-1 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-2 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-2 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-3 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-3 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Robust Study Summary -- Title: Titanium dioxide | Author: Anonymous | Year: 2009 | Klimisch score: 2 - Reliable with restrictions. -
Water solubility Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Anonymous | Year: 2007 | Klimisch score: 2 - Reliable with restrictions. -
Water solubility Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-1 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-1 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-2 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-2 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-3 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction. -
Water solubility Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-3 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction. -
Solubility in organic solvents/fat solubility Robust Study Summary -- Title: Titanium dioxide | Author: Anonymous | Year: 2009 | Klimisch score: 2 - Reliable with restrictions. -
Flammability Robust Study Summary -- Title: Current Intelligence Bulletin 63 - Occupational Exposure to Titanium Dioxide | Author: National Institute for Occupational Safety and Health (NIOSH) | Year: 2011 | Klimisch score: 2 - Reliable with restrictions. -
Flammability Robust Study Summary -- Title: Manufacture and general properties of titanium dioxide pigments | Author: Huntsman | Year: 1999 | Klimisch score: 2 - Reliable with restrictions. -
Flammability Robust Study Summary -- Title: Production of titanium tetrachloride (TiCl4) from titanium ores: A review | Author: Bordbar H. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions. -
Flammability Robust Study Summary -- Title: Titanium dioxide - rutile | Author: International Labour Organisation (ILO) | Year: 2002 | Klimisch score: 2 - Reliable with restrictions. -
Flammability Robust Study Summary -- Title: Inorganic Chemistry | Author: Holleman A. F. & Wiberg E. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions. -
Flammability Robust Study Summary -- Title: Chemie-Basiswissen der Chemie | Author: Mortimer C. & Müller U. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions. -
Particle size distribution (Granulometry)/Fibre length and diameter distribution Robust Study Summary -- Title: Titanium Dioxide NM-100 NM-101 NM-102 NM-103 NM-104 NM-105: Characterisation and Physico-Chemical Properties - JRC Repository: NM-Series of Representative Manufactured Nanomaterials | Author: Rasmussen et. al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions. -
Bioaccumulation: terrestrial Robust Study Summary -- Title: Metal transfer to plants grown on a dredged sediment: use of radioactive isotope 203Hg and titanium. | Author: Caille et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions. -
Bioaccumulation: terrestrial Robust Study Summary -- Title: Vertical transport and plant uptake of nanoparticles in a soil mesocosm experiment | Author: Gogos A. et al. | Year: 2016 | Klimisch score: 2 - Reliable with restrictions. -
Bioaccumulation: terrestrial Robust Study Summary -- Title: Assessing the impacts of sewage sludge amendment containing nano-TiO2 on tomato plants: A life cycle study | Author: Bakshi M. et al. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions. -
Short-term toxicity to fish Robust Study Summary -- Title: Subtle alterations in swimming speed distributions of rainbow trout exposed to titanium dioxide nanoparticles are associated with gill rather than brain injury | Author: Boyle D. et al. | Year: 2013 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions. -
Short-term toxicity to fish Robust Study Summary -- Title: Sub-lethal effects of titanium dioxide nanoparticles on the physiology and reproduction of zebrafish | Author: Ramsden C. S. et al. | Year: 2013 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions. -
Short-term toxicity to fish Robust Study Summary -- Title: Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): Gill injury oxidative stress and other physiological effects. | Author: Federici et al. | Year: 2007 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions. -
Long-term toxicity to fish Robust Study Summary -- Title: A critical evaluation of the fish early-life stage toxicity test for engineered nanomaterials: experimental modifications and recommendations | Author: Shaw et al. | Year: 2016 | Guideline: 210 | Klimisch score: 2 - Reliable with restrictions. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: NANoREG DR D 4.12 | Author: Mendoza G. & Cerrillo C. (Fundación Tekniker) | Year: 2016 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Assessing nanomaterial exposures in aquatic ecotoxicological testing: Framework and case studies based on dispersion and dissolution | Author: Kennedy et al. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Influence of pH and media composition on suspension stability of silver zinc oxide and titanium dioxide nanoparticles and immobilization of Daphnia magna under guideline testing conditions. | Author: Cupi D. et al. | Year: 2016 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions. -
Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Investigation of widely used nanomaterials (TiO2 Ag) and gold nanoparticles in standardised ecotoxicological tests | Author: Hund-Rinke K.; Klawonn T. | Year: 2013 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction. -
Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Investigation of two widely used nanomaterials (TiO2 Ag) for ecotoxicological long-term effects - adaption of test guidelines | Author: Schaefers C.; Weil M. | Year: 2013 | Guideline: 225 | Klimisch score: 2 - Reliable with restrictions. -
Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Alga growth inhibition test over 72 h under static conditions (OECD 201). Effect of titanium dioxide on the growth of Pseudokirchneriella subcapitata | Author: Schlich K. | Year: 2015 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction. -
Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Alga growth inhibition test over 72 h under static conditions (OECD 201). Effect of titanium dioxide on the growth of Pseudokirchneriella subcapitata | Author: Schlich K. | Year: 2015 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction. -
Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: How do stream organisms respond to and influence the concentration of titanium dioxide nanoparticles? A mesocosm study with algae and herbivores | Author: Kulacki K. J. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions. -
Toxicity to aquatic plants other than algae Robust Study Summary -- Title: Study report: Lemna sp. Growth Inhibition Test (OECD 221) with TiO2-uf-2: Effects on the growth of Lemna minor | Author: Schlich K. | Year: 2019 | Guideline: 221 | Klimisch score: 1 - Reliable without restriction. -
Toxicity to aquatic plants other than algae Right to refer to study -- Title: Study report: Lemna sp. Growth Inhibition Test (OECD 221) with TiO2-uf-2: Effects on the growth of Lemna minor | Author: Schlich K. | Year: 2019 | Guideline: 221 | Klimisch score: 1 - Reliable without restriction. -
Toxicity to microorganisms Robust Study Summary -- Title: Environmental hazard of selected TiO2 nanomaterials under consideration of relevant exposure scenarios | Author: Wyrwoll A.J. et al. | Year: 2014 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions. -
Toxicity to soil macro-organisms except anthropods Robust Study Summary -- Title: Environmental hazard of selected TiO2 nanomaterials under consideration of relevant exposure scenarios | Author: Wyrwoll A.J. et al. | Year: 2014 | Guideline: 207 | Klimisch score: 1 - Reliable without restriction. -
Toxicity to soil macro-organisms except anthropods Robust Study Summary -- Title: Regulatory ecotoxicity testing of nanomaterials - proposed modifications of OECD test guidelines based on laboratory experience with silver and titanium dioxide nanoparticles | Author: Hund-Rinke K. et al. | Year: 2016 | Guideline: 220 | Klimisch score: 2 - Reliable with restrictions. -
Toxicity to terrestrial plants Robust Study Summary -- Title: Testing of TiO2 nanoparticles on wheat and microorganisms in a soil microcosm | Author: Klingenfuss F. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions. -
Toxicity to terrestrial plants Robust Study Summary -- Title: Effects of titanium dioxide nanoparticles on soil microbial communities and wheat biomass | Author: Moll J. et al. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions. -
Toxicity to terrestrial plants Robust Study Summary -- Title: Investigation of widely used nanomaterials (TiO2 Ag) and gold nanoparticles in standardised ecotoxicological tests | Author: Hund-Rinke K.; Klawonn T. | Year: 2013 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions. -
Toxicity to terrestrial plants Robust Study Summary -- Title: Influence of application techniques on the ecotoxicological effects of nanomaterials in soil | Author: Hund-Rinke K. et al. | Year: 2012 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions. -
Basic toxicokinetics Robust Study Summary -- Title: Absorption distribution and excretion of four forms of titanium dioxide pigment in the rat | Author: Farrell T.P. & Magnuson B. | Year: 2017 | Guideline: 417. -
Basic toxicokinetics Robust Study Summary -- Title: Biopersistence of NiO and TiO2 nanoparticles following intratracheal instillation and inhalation | Author: Oyabu T. et al. | Year: 2017. -
Basic toxicokinetics Robust Study Summary -- Title: Comparison of pulmonary inflammatory responses following intratracheal instillation and inhalation of nanoparticles | Author: Morimoto Y.; Izumi H.; Yoshiura Y.; Tomonaga T.; Lee B.-W.; Okada T.; Oyabu T.; Myojo T.; Kawai K.; Yatera K.; Shimada M.; Kubo M.; Yamamoto K.; Kitajima S.; Kuroda E.; Horie M.; Kawaguchi K.; and Sasaki T. | Year: 2015. -
Basic toxicokinetics Robust Study Summary -- Title: Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats | Author: Geraets L. et al. | Year: 2014. -
Basic toxicokinetics Robust Study Summary -- Title: Effects of exposure routes on the bio-distribution and toxicity of titanium dioxide nanoparticles in mice | Author: Yao C. et al. | Year: 2016. -
Basic toxicokinetics Robust Study Summary -- Title: The pulmonary effects and clearance of intratracheally instilled Ni3S2 and TiO2 in mice. | Author: Finch G.L.; et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions. -
Basic toxicokinetics Robust Study Summary -- Title: Intratracheal instillation versus intratracheal inhalation of tracer particles for measuring lung clearance function. | Author: Oberdörster G.; et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions. -
Basic toxicokinetics Robust Study Summary -- Title: Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration | Author: Wang J.; et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions. -
Basic toxicokinetics Robust Study Summary -- Title: Tissue distribution and clearance of intravenously administered titanium dioxide (TiO2) nanoparticles | Author: Shinohara N. et al. | Year: 2014. -
Basic toxicokinetics Robust Study Summary -- Title: Quantitative biokinetics of titanium dioxide nanoparticles after intratracheal instillation in rats: Part 3 | Author: Kreyling W. G. et al. | Year: 2017. -
Basic toxicokinetics Robust Study Summary -- Title: Lung clearance of particles in two strains of rats. | Author: Ferin J. & Morehouse B. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions. -
Basic toxicokinetics Robust Study Summary -- Title: Titanium dioxide nanoparticle-biomolecule interactions influence oral absorption | Author: Jo M.-R. et al. | Year: 2016 | Klimisch score: 2 - Reliable with restrictions. -
Basic toxicokinetics Robust Study Summary -- Title: Dose-dependent clearance kinetics of intratracheally administered titanium dioxide nanoparticles in rat lung | Author: Shinohara N. et al. | Year: 2014. -
Basic toxicokinetics Robust Study Summary -- Title: A study of the uptake and biodistribution of nano-titanium dioxide using in vitro and in vivo models of oral intake | Author: MacNicoll A. et al. | Year: 2015. -
Basic toxicokinetics Robust Study Summary -- Title: Retention and tissue binding of titanium in the rat | Author: Edel J. et al. | Year: 1985. -
Basic toxicokinetics Robust Study Summary -- Title: Toxicokinetics of Solid Particles in Chronic Rat Studies Using Diesel Soot Carbon Black Toner Titanium Dioxide and Quartz. | Author: Muhle H.; et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions. -
Basic toxicokinetics Robust Study Summary -- Title: Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats: Part 2 | Author: Kreyling W. G. et al. | Year: 2017. -
Basic toxicokinetics Robust Study Summary -- Title: Biological effects and toxicity assessment of titanium dioxides: anatase and rutile | Author: Ferin J. and Oberdörster G. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions. -
Basic toxicokinetics Robust Study Summary -- Title: Papain-induced emphysema and the elimination of TiO2 particulates from the lungs | Author: Ferin J. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions. -
Basic toxicokinetics Robust Study Summary -- Title: Silica and titanium dioxide nanoparticles cause pregnancy complications in mice | Author: Yamashita K. et al. | Year: 2011. -
Basic toxicokinetics Robust Study Summary -- Title: Susceptibility of young and adult rats to the oral toxicity of titanium dioxide nanoparticles | Author: Wang Y. et al. | Year: 2013. -
Basic toxicokinetics Robust Study Summary -- Title: Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats: Part 1 | Author: Kreyling W. G. et al. | Year: 2017. -
Basic toxicokinetics Robust Study Summary -- Title: Biopersistence and translocation to extrapulmonary organs of titanium dioxide nanoparticles after subacute inhalation exposure to aerosol in adult and elderly rats | Author: Gaté L. et al. | Year: 2017. -
Basic toxicokinetics Robust Study Summary -- Title: Impacts after inhalation of nano- and fine-sized titanium dioxide particles: morphological changes transcolation within the rat lung and evaluation of particle deposition using the relative deposition index | Author: Eydner M. et al. | Year: 2012 | Guideline: 412. -
Basic toxicokinetics Robust Study Summary -- Title: Cell uptake and oral absorption of titanium dioxide nanoparticles | Author: Janer G. et al. | Year: 2014. -
Basic toxicokinetics Robust Study Summary -- Title: Pulmonary clearance and hilar lymph node content in rats after particle exposure | Author: Ferin J.& Fieldstein M. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions. -
Basic toxicokinetics Robust Study Summary -- Title: Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. | Author: Geiser M.; et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions. -
Dermal absorption Robust Study Summary -- Title: The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin. | Author: Gamer A.O.; et al. | Year: 2006 | Guideline: 428 | Klimisch score: 1 - Reliable without restriction. -
Dermal absorption Robust Study Summary -- Title: In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. | Author: Mavon A.; et al. | Year: 2007 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions. -
Dermal absorption Robust Study Summary -- Title: The human stratum corneum layer: An effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide. | Author: Pflücker F.; et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions. -
Dermal absorption Robust Study Summary -- Title: Penetration and visualization of titanium dioxide microparticles in human stratum corneum - effect od different formulations on the penetration of titanium dioxide. | Author: Gottbrath S.; Müller-Goymann C.C. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: oral Robust Study Summary -- Title: Acute oral toxicity (limit) test in rats | Author: Cuthbert J.A.; Jackson D. | Year: 1989 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: oral Right to refer to study -- Title: Acute oral toxicity (limit) test in rats | Author: Cuthbert J.A.; Jackson D. | Year: 1989 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: oral Robust Study Summary -- Title: H-27416: Acute oral toxicity study in rats - up and down procedure | Author: Finlay C. | Year: 2006 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction. -
Acute toxicity: oral Right to refer to study -- Title: H-27416: Acute oral toxicity study in rats - up and down procedure | Author: Finlay C. | Year: 2006 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction. -
Acute toxicity: oral Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction. -
Acute toxicity: oral Robust Study Summary -- Title: Approximate lethal dose (ALD) of H-20762 in rats | Author: Sarver J.W. | Year: 1994 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: oral Right to refer to study -- Title: Approximate lethal dose (ALD) of H-20762 in rats | Author: Sarver J.W. | Year: 1994 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: oral Robust Study Summary -- Title: Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. | Author: Wang J. et al. | Year: 2007 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: oral Robust Study Summary -- Title: Acute oral test | Author: Carroll K.S. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: oral Right to refer to study -- Title: Acute oral test | Author: Carroll K.S. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: oral Robust Study Summary -- Title: Treated TiO2: Acute oral toxicity (limit test) in the rat | Author: Sanders A. | Year: 1996 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: oral Right to refer to study -- Title: Treated TiO2: Acute oral toxicity (limit test) in the rat | Author: Sanders A. | Year: 1996 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: inhalation Robust Study Summary -- Title: Titanium dioxide powders NP 89/117 and NP 89/118 acute inhalation toxicity study in rats (limit test) | Author: McDonaldP.; Oshodi R.O. | Year: 1989 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: inhalation Right to refer to study -- Title: Titanium dioxide powders NP 89/117 and NP 89/118 acute inhalation toxicity study in rats (limit test) | Author: McDonaldP.; Oshodi R.O. | Year: 1989 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: inhalation Robust Study Summary -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: inhalation Right to refer to study -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: inhalation Robust Study Summary -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions. -
Acute toxicity: inhalation Right to refer to study -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Robust Study Summary -- Title: H-25763 H-25764 H-25765 and H-25766: Skin Iiritation test In rabbits | Author: Finlay C. | Year: 2003 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction. -
Skin irritation / corrosion Right to refer to study -- Title: H-25763 H-25764 H-25765 and H-25766: Skin Iiritation test In rabbits | Author: Finlay C. | Year: 2003 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction. -
Skin irritation / corrosion Robust Study Summary -- Title: Titanium dioxide M372/21/22: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Right to refer to study -- Title: Titanium dioxide M372/21/22: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Robust Study Summary -- Title: Titanium dioxide M372/21/23: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Right to refer to study -- Title: Titanium dioxide M372/21/23: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Robust Study Summary -- Title: Titanium dioxide M372/21/24: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Right to refer to study -- Title: Titanium dioxide M372/21/24: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Robust Study Summary -- Title: Titanium dioxide M372/21/25: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Right to refer to study -- Title: Titanium dioxide M372/21/25: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Robust Study Summary -- Title: Primary skin irritation study in rabbits | Author: Durando J. | Year: 2004 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Right to refer to study -- Title: Primary skin irritation study in rabbits | Author: Durando J. | Year: 2004 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Robust Study Summary -- Title: Skin irritaiton test in rabbits | Author: Edwards D.F. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Right to refer to study -- Title: Skin irritaiton test in rabbits | Author: Edwards D.F. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Robust Study Summary -- Title: Skin irritaiton test in rabbits | Author: Ferenz R.L. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Right to refer to study -- Title: Skin irritaiton test in rabbits | Author: Ferenz R.L. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Robust Study Summary -- Title: Titanium dioxide base slurry: acute dermal irritation/corrosion study in rabbits | Author: Filliben T.A. | Year: 1998 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Right to refer to study -- Title: Titanium dioxide base slurry: acute dermal irritation/corrosion study in rabbits | Author: Filliben T.A. | Year: 1998 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Robust Study Summary -- Title: Raw titanium dioxide: skin irritation study in the rabbit | Author: Lees D. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Right to refer to study -- Title: Raw titanium dioxide: skin irritation study in the rabbit | Author: Lees D. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Robust Study Summary -- Title: Treated TiO2: Acute dermal irritation test in the rabbit | Author: Sanders A | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Right to refer to study -- Title: Treated TiO2: Acute dermal irritation test in the rabbit | Author: Sanders A | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Robust Study Summary -- Title: Skin irritation Test with H-19566 in rabbits | Author: Sarver J.W. | Year: 1992 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Right to refer to study -- Title: Skin irritation Test with H-19566 in rabbits | Author: Sarver J.W. | Year: 1992 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions. -
Skin irritation / corrosion Robust Study Summary -- Title: H-27416: Acute dermal irritation study in rabbits | Author: Finlay C. | Year: 2006 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction. -
Skin irritation / corrosion Right to refer to study -- Title: H-27416: Acute dermal irritation study in rabbits | Author: Finlay C. | Year: 2006 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction. -
Skin irritation / corrosion Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction. -
Skin irritation / corrosion Right to refer to study -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction. -
Skin irritation / corrosion Robust Study Summary -- Title: Skin irritation test with H-20762 in rabbits | Author: Filliben T.A. | Year: 1994 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction. -
Skin irritation / corrosion Right to refer to study -- Title: Skin irritation test with H-20762 in rabbits | Author: Filliben T.A. | Year: 1994 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction. -
Skin irritation / corrosion Robust Study Summary -- Title: Assessment of the in vitro dermal irritation potential of cerium silver and titanium nanoparticles in a human skin equivalent model | Author: Miyani V.A. & Hughes M. F. | Year: 2017 | Guideline: 439 | Klimisch score: 2 - Reliable with restrictions. -
Eye irritation Robust Study Summary -- Title: H-27416: Acute eye irritation study in rabbits | Author: Finlay C. | Year: 2006 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction. -
Eye irritation Right to refer to study -- Title: H-27416: Acute eye irritation study in rabbits | Author: Finlay C. | Year: 2006 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction. -
Eye irritation Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction. -
Eye irritation Right to refer to study -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction. -
Eye irritation Robust Study Summary -- Title: Primary eye irritation study in rabbits | Author: Durando J. | Year: 2004 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions. -
Eye irritation Right to refer to study -- Title: Primary eye irritation study in rabbits | Author: Durando J. | Year: 2004 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions. -
Eye irritation Robust Study Summary -- Title: Treated TiO2: Acute eye irritation test in the rabbit | Author: Sanders A. | Year: 1996 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions. -
Eye irritation Right to refer to study -- Title: Treated TiO2: Acute eye irritation test in the rabbit | Author: Sanders A. | Year: 1996 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions. -
Skin sensitisation Robust Study Summary -- Title: H-27416: Local lymph node assay (LLNA) in mice | Author: Hoban D. | Year: 2006 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction. -
Skin sensitisation Right to refer to study -- Title: H-27416: Local lymph node assay (LLNA) in mice | Author: Hoban D. | Year: 2006 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction. -
Skin sensitisation Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction. -
Skin sensitisation Right to refer to study -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction. -
Skin sensitisation Robust Study Summary -- Title: Delayed contact hypersensitivity test (Buehler method) with H-20762 in Guinea pigs | Author: Moore G.E. | Year: 1994 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction. -
Skin sensitisation Right to refer to study -- Title: Delayed contact hypersensitivity test (Buehler method) with H-20762 in Guinea pigs | Author: Moore G.E. | Year: 1994 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction. -
Respiratory sensitisation Robust Study Summary -- Title: Inhalation exposure to nanosized and fine TiO2 particles inhibits features of allergic asthema in a murine model. | Author: Rossi E. M. et al. | Year: 2010. -
Respiratory sensitisation Robust Study Summary -- Title: Genetic variation influences immune response in sensitive rats following exposure to TiO2 nanoparticles | Author: Gustafsson A. et al. | Year: 2014. -
Repeated dose toxicity: oral Robust Study Summary -- Title: H-27201 and H-27203: Repeated-dose oral toxicity 28-day gavage study in rats | Author: Mayer T.W.; et al. | Year: 2006 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions. -
Repeated dose toxicity: oral Right to refer to study -- Title: H-27201 and H-27203: Repeated-dose oral toxicity 28-day gavage study in rats | Author: Mayer T.W.; et al. | Year: 2006 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions. -
Repeated dose toxicity: oral Robust Study Summary -- Title: Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles | Author: Warheit DB Brown SC Donner EM | Year: 2015 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions. -
Repeated dose toxicity: oral Robust Study Summary -- Title: Evaluation of immunologic and intestinal effects in rats administered an E171-containing diet a food grade titanium dioxide (TiO2) | Author: Blevins L.K. et al. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions. -
Repeated dose toxicity: inhalation Robust Study Summary -- Title: Inhalation of high concentrations of low toxicity dusts in rats results in impaired pulmonary clearance mechanisms and persistent inflammation | Author: Warheit D.B. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions. -
Repeated dose toxicity: inhalation Robust Study Summary -- Title: Subchronic inhalation toxicity study of ultrafine titanium dioxide in female B6C3F1 mice Fischer 344 rats and Syrian golden hamsters | Author: Everitt J.I. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions. -
Repeated dose toxicity: inhalation Robust Study Summary -- Title: Pulmonary responses of mice rats and hamsters to subchronic inhalation of ultrafine titanium dioxide particles | Author: Bermudez E. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions. -
Repeated dose toxicity: inhalation Robust Study Summary -- Title: Titanium dioxide: Inhalation toxicology and epidemiology | Author: Hext P.M. et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions. -
Repeated dose toxicity: other routes Robust Study Summary -- Title: Oxidative stress mediated cytotoxicity of TiO2 nano anatase in liver and kidney of Wistar rat. | Author: Meena R. & Paulraj R. | Year: 2012. -
Repeated dose toxicity: other routes Robust Study Summary -- Title: In vivo biocompatibility studies of nano TiO2 materials. | Author: Han W. et al. | Year: 2009. -
Repeated dose toxicity: other routes Robust Study Summary -- Title: An increase in mouse tumor growth by an in vivo immunomodulating effect of titanium dioxide nanoparticles. | Author: Moon E.-Y. et al. | Year: 2011. -
Repeated dose toxicity: other routes Robust Study Summary -- Title: High sensitivity of testicular function to titanium nanoparticles | Author: Miura N. et al. | Year: 2017. -
Repeated dose toxicity: other routes Robust Study Summary -- Title: Size- and shape-dependent effects of titanium dioxide nanoparticles on the permeabilization of the blood-brain barrier | Author: Liu X. et al. | Year: 2017. -
in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Treated TiO2: an evaluation of mutagenic potential using S. Typhimurium and E.Coli | Author: Callander R.D. | Year: 1996 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions. -
in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Treated TiO2: an evaluation of mutagenic potential using S. Typhimurium and E.Coli | Author: Callander R.D. | Year: 1996 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions. -
other mutagenicity information Robust Study Summary -- Title: Rec assay and mutagenicity studies on metal compounds | Author: Kanematsu N. Hara M. and Kada T. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions. -
in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Treated TiO2: L5178Y TK mouse lymphoma mutation assay | Author: Clay P. | Year: 1997 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions. -
in vitro gene mutation study in mammalian cells Right to refer to study -- Title: Treated TiO2: L5178Y TK mouse lymphoma mutation assay | Author: Clay P. | Year: 1997 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions. -
in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Evaluation of the micronucleus test in vitro using Chinese hamster cells: results of four chemicals weakly positive in the in vivo micronucleus test | Author: Miller B.M.; et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions. -
in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: Treated TiO2: In vitro cytogenetic assay in human lymphocytes | Author: Fox V. | Year: 1997 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions. -
in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: Treated TiO2: In vitro cytogenetic assay in human lymphocytes | Author: Fox V. | Year: 1997 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions. -
in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: H-29865: In vitro mammalian chromosome aberration test in chinese hamster ovary cells | Author: Glover K. P. | Year: 2011 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction. -
in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: H-29865: In vitro mammalian chromosome aberration test in chinese hamster ovary cells | Author: Glover K. P. | Year: 2011 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction. -
in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals | Author: Ivett J.L.; et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions. -
in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: H-27416: Bacterial reverse mutation test | Author: Ford L.S. | Year: 2006 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions. -
in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: H-27416: Bacterial reverse mutation test | Author: Ford L.S. | Year: 2006 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions. -
in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions. -
in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations. | Author: Landsiedel R. et al. | Year: 2010 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions. -
other mutagenicity information Robust Study Summary -- Title: Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations. | Author: Landsiedel R. et al. | Year: 2010 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions. -
in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Titanium dioxide nanoparticles exhibit genotoxicity and impair DNA repair activity in A549 cells. | Author: Jugan M.L. et al. | Year: 2012 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions. -
in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: H-27416: In vitro mammalian chromosome aberration test in Chinese hamster ovary cells | Author: Donner E.M. | Year: 2006 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction. -
in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: H-27416: In vitro mammalian chromosome aberration test in Chinese hamster ovary cells | Author: Donner E.M. | Year: 2006 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction. -
in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction. -
in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: Titanium dioxide T 805: induction of chromosome aberrations in cultured Chinese hamster ovary (CHO) cells | Author: Riley S. | Year: 1999 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction. -
in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: Titanium dioxide T 805: induction of chromosome aberrations in cultured Chinese hamster ovary (CHO) cells | Author: Riley S. | Year: 1999 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction. -
in vitro genetic toxicity Robust Study Summary -- Title: Towards a method for detecting the potential genotoxicity of nanomaterials: Deliverable 5: In vitro testing strategy for nanomaterials including database | Author: Norppa H. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions. -
in vitro genetic toxicity Robust Study Summary -- Title: Genotoxicity evaluation of nanosized titanium dioxide synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes | Author: Tavares AM Louro H Antunes S Quarré S Simar S De Temmerman PJ Verleysen E Mast J Jensen KA Norppa H Nesslany F Silva MJ | Year: 2014 | Klimisch score: 2 - Reliable with restrictions. -
in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Genotoxicity evaluation of nanosized titanium dioxide synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes | Author: Tavares AM Louro H Antunes S Quarré S Simar S De Temmerman PJ Verleysen E Mast J Jensen KA Norppa H Nesslany F Silva MJ | Year: 2014 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions. -
in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Towards a method for detecting the potential genotoxicity of nanomaterials: Deliverable 5: In vitro testing strategy for nanomaterials including database | Author: Norppa H. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions. -
in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: Genotoxicity evaluation of nanosized titanium dioxide synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes | Author: Tavares AM Louro H Antunes S Quarré S Simar S De Temmerman PJ Verleysen E Mast J Jensen KA Norppa H Nesslany F Silva MJ | Year: 2014 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions. -
in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: Towards a method for detecting the potential genotoxicity of nanomaterials: Deliverable 5: In vitro testing strategy for nanomaterials including database | Author: Norppa H. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions. -
Genetic toxicity in vivo Robust Study Summary -- Title: H-29865: mouse bone marrow micronucleus test | Author: Donner E. M. | Year: 2011 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction. -
Genetic toxicity in vivo Right to refer to study -- Title: H-29865: mouse bone marrow micronucleus test | Author: Donner E. M. | Year: 2011 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction. -
Genetic toxicity in vivo Robust Study Summary -- Title: Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations. | Author: Landsiedel R. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions. -
Genetic toxicity in vivo Robust Study Summary -- Title: Genotoxicity of TiO2 anatase nanoparticles in B6C3F1 male mice evaluated using Pig-α and flow cytometric micronucleus assays | Author: Sadiq R. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions. -
Genetic toxicity in vivo Robust Study Summary -- Title: Integrated approach to the in vivo genotoxic effects of a titanium dioxide nanomaterial using LacZ plasmid-based transgenic mice | Author: Louro H Tavares A Vital N Costa PM Alverca E Zwart E de Jong WH Fessard V Lavinha J Silva MJ | Year: 2014 | Guideline: 488 | Klimisch score: 2 - Reliable with restrictions. -
Genetic toxicity in vivo Robust Study Summary -- Title: Towards a method for detecting the potential genotoxicity of nanomaterials: Deliverable 6: Characterisation of manufactured nanomaterials for their clastogenic/aneugenic effects or DNA damage potentials and correlation analysis | Author: Fessard V. et al. | Year: 2013 | Guideline: 488 | Klimisch score: 2 - Reliable with restrictions. -
Genetic toxicity in vivo Robust Study Summary -- Title: Towards a method for detecting the potential genotoxicity of nanomaterials: Deliverable 6: Characterisation of manufactured nanomaterials for their clastogenic/aneugenic effects or DNA damage potentials and correlation analysis | Author: Fessard V. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions. -
Epidemiological data Robust Study Summary -- Title: Mortality among workers employed in the titanium dioxide production industry in Europe | Author: Boffetta P. et al. | Year: 2004. -
Epidemiological data Robust Study Summary -- Title: A cohort mortality study among titanium dioxide manufacturing workers in the United States | Author: Fryzek J.P. et al. | Year: 2003. -
Epidemiological data Robust Study Summary -- Title: Mortality among itanium dioxide workers at three DuPont plants | Author: Ellis E. D. et al. | Year: 2010. -
Epidemiological data Robust Study Summary -- Title: Mortality among titanium dioxide workers at three DuPont plants | Author: Ellis E.D. et al. | Year: 2009. -
Epidemiological data Right to refer to study -- Title: Mortality among titanium dioxide workers at three DuPont plants | Author: Ellis E.D. et al. | Year: 2009. -
Epidemiological data Robust Study Summary -- Title: Occupational exposure and mortality among workers at three titanium dioxide plants | Author: Ellis E. D. et al. | Year: 2013. -
Epidemiological data Robust Study Summary -- Title: Risk of lung cancer following exposure to carbon black titanium dioxide and talc: results from two case-control studies in Montreal | Author: Ramanakumar A.V.; et al. | Year: 2008. -
Epidemiological data Robust Study Summary -- Title: Epidemiologic study of workers exposed to titanium dioxide | Author: Chen J.L. & Fayerweather W.E. | Year: 1988. -
Epidemiological data Robust Study Summary -- Title: Exposure to titanium dioxide and risk of lung cancer in a population-based study from Montreal | Author: Boffetta P.; et al. | Year: 2001. -
Epidemiological data Robust Study Summary -- Title: Occupational Risk Factors for Bladder Cancer: Results from a Case-Control Study in Montreal Quebec Canada. | Author: Siemiatycki J. et al. | Year: 1994. -
Epidemiological data Robust Study Summary -- Title: Pulmonary Deposits of Titanium Dioxide in Man | Author: Elo R.; Määtä K.; Uksila E.; and Arstila A.U. | Year: 1972. -