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CAS 141-62-8 | Data Package 10 - 100 t/a

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Includes:

Study name Short Description Data Owner
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: 14C-Decamethyltetrasiloxane (14C-L4): Toxicity to the Freshwater Alga (Pseudokirchneriella subcapitata) under Closed Bottle Test Conditions. | Author: Dow Corning Corporation | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: 14C-Decamethyltetrasiloxane (14C-L4): Toxicity to the Freshwater Alga (Pseudokirchneriella subcapitata) under Closed Bottle Test Conditions. | Author: Dow Corning Corporation | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Combined repeated dose toxicity study with the reproductive/developmental toxicity screening test for decamethyltetrasiloxane (L4) in Sprague-Dawley rats via inhalation exposure. | Author: Health and Environmental Sciences Dow Corning Corporation | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Toxicity to reproduction Right to refer to study -- Title: Combined repeated dose toxicity study with the reproductive/developmental toxicity screening test for decamethyltetrasiloxane (L4) in Sprague-Dawley rats via inhalation exposure. | Author: Health and Environmental Sciences Dow Corning Corporation | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Acute dermal irritation/corrosion study in rabbits with decamethyltetrasiloxane (L4) | Author: Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Acute dermal irritation/corrosion study in rabbits with decamethyltetrasiloxane (L4) | Author: Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Decamethyltetrasiloxane (14C-L4): Acute Toxicity to the Rainbow Trout (Oncorhynchus mykiss) Under Flow-Through Test Conditions | Author: Dow Corning Corporation | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Decamethyltetrasiloxane (14C-L4): Acute Toxicity to the Rainbow Trout (Oncorhynchus mykiss) Under Flow-Through Test Conditions | Author: Dow Corning Corporation | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: 28-Day oral (gavage) toxicity study in the Sprague-Dawley rat with decamethyltetrasiloxane (L4) | Author: No author | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Repeated dose toxicity: oral Right to refer to study -- Title: 28-Day oral (gavage) toxicity study in the Sprague-Dawley rat with decamethyltetrasiloxane (L4) | Author: No author | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Eye irritation Robust Study Summary -- Title: Eye Irritation of Dow Corning 200® Fluid, 1.5 cSt in the Rabbit | Author: Dow Corning Corporation | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Eye irritation Right to refer to study -- Title: Eye Irritation of Dow Corning 200® Fluid, 1.5 cSt in the Rabbit | Author: Dow Corning Corporation | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Decamethyltetrasiloxane (L4): Acute Dermal Toxicity Study in Rats | Author: Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Acute toxicity: dermal Right to refer to study -- Title: Decamethyltetrasiloxane (L4): Acute Dermal Toxicity Study in Rats | Author: Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Decamethyltetrasiloxane (L4) (CAS Number 141-62-8) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Health and Environmental Sciences Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Partition coefficient Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Decamethyltetrasiloxane (L4) (CAS Number 141-62-8) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Health and Environmental Sciences Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Decamethyltetrasiloxane (L4, CAS No. 141-62-8). A Flow-Through Life Cycle Toxicity Test With The Cladoceran (Daphnia magna). | Author: Health and Environmental Sciences (HES) Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Long-term toxicity to aquatic invertebrates Right to refer to study -- Title: Decamethyltetrasiloxane (L4, CAS No. 141-62-8). A Flow-Through Life Cycle Toxicity Test With The Cladoceran (Daphnia magna). | Author: Health and Environmental Sciences (HES) Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Hydrolysis Robust Study Summary -- Title: Hydrolysis of Decamethyltetrasiloxane (L4) | Author: Dow Corning Corporation Health and Environmental Sciences (HES) | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Hydrolysis Right to refer to study -- Title: Hydrolysis of Decamethyltetrasiloxane (L4) | Author: Dow Corning Corporation Health and Environmental Sciences (HES) | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Decamethyltetrasiloxane L4 : L5178Y TK +/- mouse lymphoma assay | Author: Harlan Laboratories Ltd | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | in vitro gene mutation study in mammalian cells Right to refer to study -- Title: Decamethyltetrasiloxane L4 : L5178Y TK +/- mouse lymphoma assay | Author: Harlan Laboratories Ltd | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Bacterial reverse mutation assay with Decamethyltetrasiloxane (L4) | Author: BioReliance | Year: 2005 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Bacterial reverse mutation assay with Decamethyltetrasiloxane (L4) | Author: BioReliance | Year: 2005 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Evaluation of decamethyltetrasiloxane with the Rat Uterotrophic Assay using ovariectomized adult Sprague Dawley rats | Author: Health and Environmental Sciences Dow Corning Corporation | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Evaluation of decamethyltetrasiloxane with the Rat Uterotrophic Assay using ovariectomized adult Sprague Dawley rats | Author: Health and Environmental Sciences Dow Corning Corporation | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Measurement of Thermophysical Pure Component Properties for a Fee Siloxanes Used as Working Fluids for Organic Rankine Cycles | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Short Communication - AQUEOUS SOLUBILITY OF PERMETHYLSILOXANES (SILICONES) | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: An acute oral toxicity study in rats with octamethyltrisiloxane | Author: Dow Corning Corporation | Year: 2004 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: An acute oral toxicity study in rats with octamethyltrisiloxane | Author: Dow Corning Corporation | Year: 2004 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Wacker Silicone Fluid AK 1: Contact hypersensitivity in albino guinea pigs maximization test | Author: RCC Ltd | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin sensitisation Right to refer to study -- Title: Wacker Silicone Fluid AK 1: Contact hypersensitivity in albino guinea pigs maximization test | Author: RCC Ltd | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: OCTAMETHYLTRISILOXANE (L3, CAS NO. 107-51-7): READY BIODEGRADABILITY-CO2 IN SEALED VESSELS (Headspace Test) | Author: Wildlife International Ltd. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 107-51-7)
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Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: OCTAMETHYLTRISILOXANE (L3, CAS NO. 107-51-7): READY BIODEGRADABILITY-CO2 IN SEALED VESSELS (Headspace Test) | Author: Wildlife International Ltd. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 107-51-7)
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Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: In vitro Mammalian Chromosome Aberration Test with L3 (Octamethyltrisiloxane, CAS No.107-51-7) | Author: BioReliance | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 107-51-7)
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Toxicological | in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: In vitro Mammalian Chromosome Aberration Test with L3 (Octamethyltrisiloxane, CAS No.107-51-7) | Author: BioReliance | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 107-51-7)
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Phys-Chem | Partition coefficient Robust Study Summary -- Title: Temperature Dependence of Air/Water 1-Octanol/Air 1-Octanol/Water Partitioning Coefficients of Decamethyltetrasiloxane (L4) | Author: Health and Environmental Sciences Dow Corning Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Partition coefficient Right to refer to study -- Title: Temperature Dependence of Air/Water 1-Octanol/Air 1-Octanol/Water Partitioning Coefficients of Decamethyltetrasiloxane (L4) | Author: Health and Environmental Sciences Dow Corning Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Evaluation of decamethyltetrasiloxane with the rat uterotrophic assay using ovariectomised adult Sprague-Dawley rats. | Author: Dow Corning Corporation | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: inhalation Right to refer to study -- Title: Evaluation of decamethyltetrasiloxane with the rat uterotrophic assay using ovariectomised adult Sprague-Dawley rats. | Author: Dow Corning Corporation | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Flash point Robust Study Summary -- Title: Closed-cup flash points and flammability properties of selected chemical compounds | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Flash point Robust Study Summary -- Title: Flashpoint and Other Physical Property Data Collected for Reach Reconsile Project | Author: Dow Corning Corporation | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Flash point Right to refer to study -- Title: Flashpoint and Other Physical Property Data Collected for Reach Reconsile Project | Author: Dow Corning Corporation | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Environmental | Hydrolysis Robust Study Summary -- Title: Hydrolysis of Octamethyltrisiloxane (MDM) | Author: Dow Corning Corporation Health and Environmental Sciences (HES) | Year: 2007 | Klimisch score: 1 (reliable without restriction) | Adequacy: supporting study. -
Environmental | Hydrolysis Right to refer to study -- Title: Hydrolysis of Octamethyltrisiloxane (MDM) | Author: Dow Corning Corporation Health and Environmental Sciences (HES) | Year: 2007 | Klimisch score: 1 (reliable without restriction) | Adequacy: supporting study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals and Drugs | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Boiling point Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Density Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals and Drugs | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Density Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals and Drugs | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals and Drugs | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -