You are here: Home> South Korea>K-REACH>CAS 141-63-9> CAS 141-63-9 | Data Package 1 - 10 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Dodecamethylpentasiloxane (L5, CAS 141-63-9): A 96 hour flow-through acute toxicity test with the rainbow trout (Oncorhynchus mykiss); | Author: Wildlife International, Ltd. 8598 Commerce Drive, Easton, Maryland 21601, USA | Year: 2010 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Dodecamethylpentasiloxane (L5, CAS 141-63-9): A 96 hour flow-through acute toxicity test with the rainbow trout (Oncorhynchus mykiss); | Author: Wildlife International, Ltd. 8598 Commerce Drive, Easton, Maryland 21601, USA | Year: 2010 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Dodecamethylpentasiloxane (L5) (CAS Number 141-63-9) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry; | Author: Health and Environmental Sciences, Dow Corning Corporation, 2200 W. Salzburg Road, Auburn, MI 48611 | Year: 2009 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Dodecamethylpentasiloxane (L5) (CAS Number 141-63-9) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry; | Author: Health and Environmental Sciences, Dow Corning Corporation, 2200 W. Salzburg Road, Auburn, MI 48611 | Year: 2009 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Dodecamethylpentasiloxane (L5, CAS 141-63-9): A flow-through life-cycle toxicity test with the Cladoceran (Daphnia magna); | Author: Wildlife International Ltd. 8598 Commerce Drive, Easton, Maryland, 21601 USA | Year: 2010 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Dodecamethylpentasiloxane (L5, CAS 141-63-9): A flow-through life-cycle toxicity test with the Cladoceran (Daphnia magna); | Author: Wildlife International Ltd. 8598 Commerce Drive, Easton, Maryland, 21601 USA | Year: 2010 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute dermal irritation/corrosion study in rabbits with dodecamethylpentasiloxane (L5); | Author: Dow Corning Corporation, Health and Environmental Sciences | Year: 2009 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Acute dermal irritation/corrosion study in rabbits with dodecamethylpentasiloxane (L5); | Author: Dow Corning Corporation, Health and Environmental Sciences | Year: 2009 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: AQUEOUS SOLUBILITY OF PERMETHYLSILOXANES (SILICONES) ; | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: OCTAMETHYLTRISILOXANE (L3; CAS NO. 107-51-7): READY BIODEGRADABILITY-CO2 IN SEALED VESSELS (Headspace Test) | Author: Wildlife International, Ltd. 8598 Commerce Drive Easton, Maryland 21601 | Year: 2009 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: OCTAMETHYLTRISILOXANE (L3; CAS NO. 107-51-7): READY BIODEGRADABILITY-CO2 IN SEALED VESSELS (Headspace Test) | Author: Wildlife International, Ltd. 8598 Commerce Drive Easton, Maryland 21601 | Year: 2009 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial reverse mutation assay with Decamethyltetrasiloxane (L4) | Author: BioReliance, 9630 Medical Center Drive, Rockville, MD 20850, USA | Year: 2005 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial reverse mutation assay with Decamethyltetrasiloxane (L4) | Author: BioReliance, 9630 Medical Center Drive, Rockville, MD 20850, USA | Year: 2005 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Wacker Silicone Fluid AK 1: Contact hypersensitivity in albino guinea pigs maximization test; | Author: RCC Ltd, Switzerland | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Wacker Silicone Fluid AK 1: Contact hypersensitivity in albino guinea pigs maximization test; | Author: RCC Ltd, Switzerland | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Temperature-Dependent Vapour Pressure of Selected Cyclic and Linear Polydimethylsiloxane Oligomers; | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals and Drugs; | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data; | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals and Drugs; | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data; | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals and Drugs; | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals and Drugs; | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data; | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data; | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Dodecamethylpentasiloxane (L5) (CAS Number 141-63-9) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Dodecamethylpentasiloxane (L5) (CAS Number 141-63-9) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: An acute oral toxicity study in rats with octamethyltrisiloxane | Author: Dow Corning, Health&Environmental Sciences, 2200 W. Salzburg Road, Auburn, MI 48611 | Year: 2004 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: An acute oral toxicity study in rats with octamethyltrisiloxane | Author: Dow Corning, Health&Environmental Sciences, 2200 W. Salzburg Road, Auburn, MI 48611 | Year: 2004 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A skin sensitization study of hexamethyldisiloxane in guinea pigs | Author: Dow Corning Corporation | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: A skin sensitization study of hexamethyldisiloxane in guinea pigs | Author: Dow Corning Corporation | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial Reverse Mutation Assay with Octamethyltrisiloxane (L3; CAS No.107-51-7) | Author: BioReliance, 9630 Medical Center Drive, Rockville, MD 20850, USA | Year: 2008 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial Reverse Mutation Assay with Octamethyltrisiloxane (L3; CAS No.107-51-7) | Author: BioReliance, 9630 Medical Center Drive, Rockville, MD 20850, USA | Year: 2008 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial Reverse Mutation Test with LS-7130., Report no. 94-004-0207-E | Author: Hita Research Laboratories | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial Reverse Mutation Test with LS-7130., Report no. 94-004-0207-E | Author: Hita Research Laboratories | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |