You are here: Home> South Korea>K-REACH>CAS 141-63-9> CAS 141-63-9 | Data Package 100 - 1000 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Dodecamethylpentasiloxane (L5): acute dermal toxicity study in rats; | Author: Dow Corning Corporation | Year: 2009 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Dodecamethylpentasiloxane (L5): acute dermal toxicity study in rats; | Author: Dow Corning Corporation | Year: 2009 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Dodecamethylpentasiloxane (L5, CAS 141-63-9): A 96 hour flow-through acute toxicity test with the rainbow trout (Oncorhynchus mykiss); | Author: Wildlife International, Ltd. 8598 Commerce Drive, Easton, Maryland 21601, USA | Year: 2010 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Dodecamethylpentasiloxane (L5, CAS 141-63-9): A 96 hour flow-through acute toxicity test with the rainbow trout (Oncorhynchus mykiss); | Author: Wildlife International, Ltd. 8598 Commerce Drive, Easton, Maryland 21601, USA | Year: 2010 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: 28-day oral toxicity (gavage) study in the Sprague-Dawley rat with dodecamethylpentasiloxane (L5); | Author: Dow Corning Corporation | Year: 2010 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: 28-day oral toxicity (gavage) study in the Sprague-Dawley rat with dodecamethylpentasiloxane (L5); | Author: Dow Corning Corporation | Year: 2010 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Dodecamethylpentasiloxane (L5) (CAS Number 141-63-9) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry; | Author: Health and Environmental Sciences, Dow Corning Corporation, 2200 W. Salzburg Road, Auburn, MI 48611 | Year: 2009 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Dodecamethylpentasiloxane (L5) (CAS Number 141-63-9) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry; | Author: Health and Environmental Sciences, Dow Corning Corporation, 2200 W. Salzburg Road, Auburn, MI 48611 | Year: 2009 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Dodecamethylpentasiloxane (L5, CAS 141-63-9): A flow-through life-cycle toxicity test with the Cladoceran (Daphnia magna); | Author: Wildlife International Ltd. 8598 Commerce Drive, Easton, Maryland, 21601 USA | Year: 2010 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Dodecamethylpentasiloxane (L5, CAS 141-63-9): A flow-through life-cycle toxicity test with the Cladoceran (Daphnia magna); | Author: Wildlife International Ltd. 8598 Commerce Drive, Easton, Maryland, 21601 USA | Year: 2010 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute dermal irritation/corrosion study in rabbits with dodecamethylpentasiloxane (L5); | Author: Dow Corning Corporation, Health and Environmental Sciences | Year: 2009 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Acute dermal irritation/corrosion study in rabbits with dodecamethylpentasiloxane (L5); | Author: Dow Corning Corporation, Health and Environmental Sciences | Year: 2009 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: AQUEOUS SOLUBILITY OF PERMETHYLSILOXANES (SILICONES) ; | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Activated sludge respiration inhibition test with Decamethyltetrasiloxane | Author: NOTOX B.V., Hambakenwetering 7, 5231 DD 's-Hertogenbosch, The Netherlands | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Activated sludge respiration inhibition test with Decamethyltetrasiloxane | Author: NOTOX B.V., Hambakenwetering 7, 5231 DD 's-Hertogenbosch, The Netherlands | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Decamethyltetrasiloxane L4 : L5178Y TK +/- mouse lymphoma assay | Author: Harlan Laboratories Ltd, Shardlow Business Park, Shardlow, Derbyshire DE72 2GD, UK | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Decamethyltetrasiloxane L4 : L5178Y TK +/- mouse lymphoma assay | Author: Harlan Laboratories Ltd, Shardlow Business Park, Shardlow, Derbyshire DE72 2GD, UK | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In vitro mammalian chromosome aberration test in Chinese hamster V79 cells with dodecamethylpentasiloxane; | Author: BSL BIOSERVICE Scientific Laboratories GmbH, Behringstraẞe 6/8, 82152 Planegg, Germany | Year: 2014 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: In vitro mammalian chromosome aberration test in Chinese hamster V79 cells with dodecamethylpentasiloxane; | Author: BSL BIOSERVICE Scientific Laboratories GmbH, Behringstraẞe 6/8, 82152 Planegg, Germany | Year: 2014 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Eye Irritation of Dow Corning 200(R) Fluid, 1.5 cSt in the Rabbit; | Author: Dow Corning Corporation, Health & Environmental Sciences | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Eye Irritation of Dow Corning 200(R) Fluid, 1.5 cSt in the Rabbit; | Author: Dow Corning Corporation, Health & Environmental Sciences | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Combined repeated dose toxicity study with the reproductive/developmental toxicity screening test for decamethyltetrasiloxane (L4) in Sprague-Dawley rats via inhalation exposure. | Author: Health and Environmental Sciences, Dow Corning Corporation, 2200 West Salzburg Road, Auburn, MI 48611. | Year: 2007 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Combined repeated dose toxicity study with the reproductive/developmental toxicity screening test for decamethyltetrasiloxane (L4) in Sprague-Dawley rats via inhalation exposure. | Author: Health and Environmental Sciences, Dow Corning Corporation, 2200 West Salzburg Road, Auburn, MI 48611. | Year: 2007 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: An acute whole body inhalation toxicity of octamethyltrisiloxane in rats | Author: Dow Corning, Health&Environmental Sciences, 2200 W. Salzburg Road, Auburn, MI 48611 | Year: 2004 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: An acute whole body inhalation toxicity of octamethyltrisiloxane in rats | Author: Dow Corning, Health&Environmental Sciences, 2200 W. Salzburg Road, Auburn, MI 48611 | Year: 2004 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: OCTAMETHYLTRISILOXANE (L3; CAS NO. 107-51-7): READY BIODEGRADABILITY-CO2 IN SEALED VESSELS (Headspace Test) | Author: Wildlife International, Ltd. 8598 Commerce Drive Easton, Maryland 21601 | Year: 2009 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: OCTAMETHYLTRISILOXANE (L3; CAS NO. 107-51-7): READY BIODEGRADABILITY-CO2 IN SEALED VESSELS (Headspace Test) | Author: Wildlife International, Ltd. 8598 Commerce Drive Easton, Maryland 21601 | Year: 2009 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial reverse mutation assay with Decamethyltetrasiloxane (L4) | Author: BioReliance, 9630 Medical Center Drive, Rockville, MD 20850, USA | Year: 2005 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial reverse mutation assay with Decamethyltetrasiloxane (L4) | Author: BioReliance, 9630 Medical Center Drive, Rockville, MD 20850, USA | Year: 2005 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis of Decamethyltetrasiloxane (L4) | Author: Dow Corning Corporation Health and Environmental Sciences (HES) 2200 W. Salzburg Road Auburn, MI 48611 | Year: 2009 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Environmental | Hydrolysis | Right to refer to study -- Title: Hydrolysis of Decamethyltetrasiloxane (L4) | Author: Dow Corning Corporation Health and Environmental Sciences (HES) 2200 W. Salzburg Road Auburn, MI 48611 | Year: 2009 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Early life-stage toxicity test with rainbow trout (Oncorhynchus mykiss) following OECD #210 with Decamethyltetrasiloxane (L4) | Author: Smithers Viscient, 790 Main Street, Wareham, Massachussettss 02571-1037 | Year: 2013 | Guideline: 210 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: Early life-stage toxicity test with rainbow trout (Oncorhynchus mykiss) following OECD #210 with Decamethyltetrasiloxane (L4) | Author: Smithers Viscient, 790 Main Street, Wareham, Massachussettss 02571-1037 | Year: 2013 | Guideline: 210 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: 14C-Decamethyltetrasiloxane (14C-L4): Toxicity to the Freshwater Alga (Pseudokirchneriella subcapitata) under Closed Bottle Test Conditions. | Author: Dow Corning Corporation, 2200 W. Salzburg Road, Aubum., MI 48611, USA | Year: 2008 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: 14C-Decamethyltetrasiloxane (14C-L4): Toxicity to the Freshwater Alga (Pseudokirchneriella subcapitata) under Closed Bottle Test Conditions. | Author: Dow Corning Corporation, 2200 W. Salzburg Road, Aubum., MI 48611, USA | Year: 2008 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Wacker Silicone Fluid AK 1: Contact hypersensitivity in albino guinea pigs maximization test; | Author: RCC Ltd, Switzerland | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Wacker Silicone Fluid AK 1: Contact hypersensitivity in albino guinea pigs maximization test; | Author: RCC Ltd, Switzerland | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Closed-cup flash points and flammability properties of selected chemical compounds; | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis of Octamethyltrisiloxane (MDM) | Author: Dow Corning Corporation Health and Environmental Sciences (HES) 2200 W. Salzburg Road Auburn, MI 48611 | Year: 2007 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Environmental | Hydrolysis | Right to refer to study -- Title: Hydrolysis of Octamethyltrisiloxane (MDM) | Author: Dow Corning Corporation Health and Environmental Sciences (HES) 2200 W. Salzburg Road Auburn, MI 48611 | Year: 2007 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Temperature-Dependent Vapour Pressure of Selected Cyclic and Linear Polydimethylsiloxane Oligomers; | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals and Drugs; | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data; | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals and Drugs; | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data; | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals and Drugs; | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals and Drugs; | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data; | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data; | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Dodecamethylpentasiloxane (L5) (CAS Number 141-63-9) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Dodecamethylpentasiloxane (L5) (CAS Number 141-63-9) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: An acute oral toxicity study in rats with octamethyltrisiloxane | Author: Dow Corning, Health&Environmental Sciences, 2200 W. Salzburg Road, Auburn, MI 48611 | Year: 2004 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: An acute oral toxicity study in rats with octamethyltrisiloxane | Author: Dow Corning, Health&Environmental Sciences, 2200 W. Salzburg Road, Auburn, MI 48611 | Year: 2004 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: An acute whole body vapor inhalation toxicity study with Hexamethyldisiloxane in albino rats | Author: Dow Corning Corporation | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: An acute whole body vapor inhalation toxicity study with Hexamethyldisiloxane in albino rats | Author: Dow Corning Corporation | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Hexamethyldisiloxane F-221 | Author: Stauffer Chemical Company | Year: 1973 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Hexamethyldisiloxane F-221 | Author: Stauffer Chemical Company | Year: 1973 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A skin sensitization study of hexamethyldisiloxane in guinea pigs | Author: Dow Corning Corporation | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: A skin sensitization study of hexamethyldisiloxane in guinea pigs | Author: Dow Corning Corporation | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Combined repeated dose toxicity study with the reproductive/developmental toxicity screening test for decamethyltetrasiloxane (L4) in Sprague-Dawley rats via inhalation exposure | Author: Dow Corning Corporation | Year: 2007 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Combined repeated dose toxicity study with the reproductive/developmental toxicity screening test for decamethyltetrasiloxane (L4) in Sprague-Dawley rats via inhalation exposure | Author: Dow Corning Corporation | Year: 2007 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. Read-Across (CAS 141-62-8 | EC 205-491-7 | Decamethyltetrasiloxane) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial Reverse Mutation Assay with Octamethyltrisiloxane (L3; CAS No.107-51-7) | Author: BioReliance, 9630 Medical Center Drive, Rockville, MD 20850, USA | Year: 2008 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial Reverse Mutation Assay with Octamethyltrisiloxane (L3; CAS No.107-51-7) | Author: BioReliance, 9630 Medical Center Drive, Rockville, MD 20850, USA | Year: 2008 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial Reverse Mutation Test with LS-7130., Report no. 94-004-0207-E | Author: Hita Research Laboratories | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial Reverse Mutation Test with LS-7130., Report no. 94-004-0207-E | Author: Hita Research Laboratories | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity Evaluation of Hexamethyldisiloxane (Me3Si)2O | Author: Litton Bionetics | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |