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CAS 1634-04-4 | Data Package > 1000 t/a

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Includes:

Study name Short Description Data Owner
Appearance/physical state/colour Robust Study Summary -- Title: Methyl Tert-Butyl Ether | Author: Scholz B et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Melting point/freezing point Robust Study Summary -- Title: Methyl tert-butyl ether | Author: Scholz B et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Melting point/freezing point Robust Study Summary -- Title: Physical and thermodynamic properties of pure chemicals | Author: Daubert TE; Danner RP | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Melting point/freezing point Robust Study Summary -- Title: Handbook of Environmental Fate and Exposure Data for Organic Chemicals. | Author: Howard PH | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Melting point/freezing point Robust Study Summary -- Title: Merck Index | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Boiling point Robust Study Summary -- Title: Methyl Tert-Butyl Ether | Author: Scholz B et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Boiling point Robust Study Summary -- Title: Handbook of Environmental Fate and Exposure Data for Organic Chemicals. | Author: Howard PH | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Boiling point Robust Study Summary -- Title: Physical and thermodynamic properties of pure chemicals | Author: Daubert TE; Danner RP | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Density Robust Study Summary -- Title: The Merck Index | Author: Budavari S (ed.) | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Vapour pressure Robust Study Summary -- Title: MTBE: determination of vapour pressure | Author: Harlan Laboratories Ltd. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Vapour pressure Right to refer to study -- Title: MTBE: determination of vapour pressure | Author: Harlan Laboratories Ltd. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Vapour pressure Robust Study Summary -- Title: Physical and thermodynamic properties of pure chemicals: | Author: Daubert TE; Danner RP | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Vapour pressure Robust Study Summary -- Title: Thermodynamic properties of organic oxygen compounds XLIII. Vapour pressures of some ethers. | Author: Ambrose D et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Vapour pressure Robust Study Summary -- Title: Air-Water Transfer of MTBE Its Degradation Products and Alternative Fuel Oxygenates: The Role of Temperature | Author: Arp HPH Schmidt TC | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Partition coefficient Robust Study Summary -- Title: Vertailungskoeffizient n-Oktanol-Wasser (Pow-Wert) fur "Altstoffe" | Author: Huels AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Partition coefficient Right to refer to study -- Title: Vertailungskoeffizient n-Oktanol-Wasser (Pow-Wert) fur "Altstoffe" | Author: Huels AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Partition coefficient Robust Study Summary -- Title: Methyl tertiary butyl ether: partition coefficient determination for the n-octanol/water system | Author: Bennett D. | Year: 1981 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Partition coefficient Right to refer to study -- Title: Methyl tertiary butyl ether: partition coefficient determination for the n-octanol/water system | Author: Bennett D. | Year: 1981 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Partition coefficient Robust Study Summary -- Title: n-Octanol/water partition coefficient (Kow) for Methyl Tertiary Butyl Ether (MTBE) at 25°C +/- 1°C. | Author: Montgomery CR | Year: 1994 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Partition coefficient Right to refer to study -- Title: n-Octanol/water partition coefficient (Kow) for Methyl Tertiary Butyl Ether (MTBE) at 25°C +/- 1°C. | Author: Montgomery CR | Year: 1994 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Water solubility Robust Study Summary -- Title: Mutual solubilities: water ketones water ethers and water gasoline alcohols | Author: Stephenson RM | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Water solubility Robust Study Summary -- Title: Methyl Tert-Butyl Ether | Author: Scholz B et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Water solubility Robust Study Summary -- Title: Study of fuel oxygenates solubility in aqueous media as a function of temperature and tert-butyl alcohol concentration | Author: Gonzalez-Olmos R Iglesias M | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Water solubility Robust Study Summary -- Title: Determination of the water-solubility of gasolines containing ethers | Author: Oil Product Research | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Water solubility Right to refer to study -- Title: Determination of the water-solubility of gasolines containing ethers | Author: Oil Product Research | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Surface tension Robust Study Summary -- Title: MTBE: determination of viscosity and surface tension. | Author: SafePharm Laboratories Ltd. | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Surface tension Right to refer to study -- Title: MTBE: determination of viscosity and surface tension. | Author: SafePharm Laboratories Ltd. | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Flash point Robust Study Summary -- Title: Methyl Tert-Butyl Ether | Author: Scholz B et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Flash point Robust Study Summary -- Title: Physical and thermodynamic properties of pure chemicals: | Author: Daubert TE; Danner RP | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Auto-ignition temperature Robust Study Summary -- Title: Methyl Tert-Butyl Ether | Author: Scholz B et al. | Year: 1990 | Guideline: A.15-16 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Viscosity Robust Study Summary -- Title: MTBE: determination of viscosity and surface tension. | Author: SafePharm Laboratories Ltd. | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Viscosity Right to refer to study -- Title: MTBE: determination of viscosity and surface tension. | Author: SafePharm Laboratories Ltd. | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Hydrolysis Robust Study Summary -- Title: Methyl Tertiary-Butyl Ether (MTBE): Abiotic Degradation: Hydrolysis as a Function of pH (Preliminary Test) | Author: Envigo CRS Limited Study Director | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Hydrolysis Right to refer to study -- Title: Methyl Tertiary-Butyl Ether (MTBE): Abiotic Degradation: Hydrolysis as a Function of pH (Preliminary Test) | Author: Envigo CRS Limited Study Director | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Hydrolysis Robust Study Summary -- Title: Hydrolysis of tert-butyl methyl ether (MTBE) in dilute aqueous acid | Author: O'Reilly KT et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in water: screening tests Robust Study Summary -- Title: Bestimmung der biologischen Abbaubarkeit von DRIVERON | Author: Hüls AG | Year: 1991 | Guideline: 301 D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Biodegradation in water: screening tests Right to refer to study -- Title: Bestimmung der biologischen Abbaubarkeit von DRIVERON | Author: Hüls AG | Year: 1991 | Guideline: 301 D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Biodegradation in water: screening tests Robust Study Summary -- Title: MTBE ready biodegradability (closed bottle test OECD 301D) | Author: RBM | Year: 1996 | Guideline: 301 D | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Biodegradation in water: screening tests Right to refer to study -- Title: MTBE ready biodegradability (closed bottle test OECD 301D) | Author: RBM | Year: 1996 | Guideline: 301 D | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Biodegradation in water: screening tests Robust Study Summary -- Title: Ready Biodegradability OECD 301 D 'Determination of BOD - Closed Bottle Test' Test substance: TAME (tert-amyl methyl ether) In comparison with: MTBE (Methyl tert-butyl ether) a ETBE (Ethyl tert-butyl ether) | Author: Slovnaft VÚRUP a.s. | Year: 2005 | Guideline: 301 D | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Biodegradation in water: screening tests Right to refer to study -- Title: Ready Biodegradability OECD 301 D 'Determination of BOD - Closed Bottle Test' Test substance: TAME (tert-amyl methyl ether) In comparison with: MTBE (Methyl tert-butyl ether) a ETBE (Ethyl tert-butyl ether) | Author: Slovnaft VÚRUP a.s. | Year: 2005 | Guideline: 301 D | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Biodegradation in water: screening tests Robust Study Summary -- Title: Aerobic degradation of ethyl-tert-butyl ether by a microbial consortium: selection and evaluation of biodegradation ability | Author: Kharoune M et al. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in water: screening tests Robust Study Summary -- Title: Aerobic Biodegradation of MTBE - Basic Fate and Biokinetics Evaluation | Author: Shell | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in water: screening tests Right to refer to study -- Title: Aerobic Biodegradation of MTBE - Basic Fate and Biokinetics Evaluation | Author: Shell | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in water: screening tests Robust Study Summary -- Title: Biodegradation of methyl t-butyl ether by pure bacterial cultures | Author: Mo K et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in water: screening tests Robust Study Summary -- Title: Biodegradation of the gasoline oxygenates methyl tert-butyl ether ethyl tert-butyl ether and tert-amyl methyl ether ether by propane oxidising bacteria | Author: Steffan RJ et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in water: screening tests Robust Study Summary -- Title: A Direct Comparison of U.S. Environmental Protection Agency's Method 30b and Batch Tests for Determining Activated Sludge Biodegradation Rate Constants for Volatile Organic Compounds | Author: Cano MN et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in water: screening tests Robust Study Summary -- Title: Isolation of a Bacterial Culture that Degrades Methyl t Butyl Ether | Author: Salanitro JP et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in water: screening tests Robust Study Summary -- Title: Biodegradability of methyl-t-butyl ether (MTBE) | Author: Shell | Year: 1981 | Guideline: 301 D | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in water: screening tests Right to refer to study -- Title: Biodegradability of methyl-t-butyl ether (MTBE) | Author: Shell | Year: 1981 | Guideline: 301 D | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in water: screening tests Robust Study Summary -- Title: Biodegradation kinetics of benzene methyl tert-butyl ether and toluene as a substrate under various substrate concentrations | Author: Lin C. Cheng Y | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in water and sediment: simulation tests Robust Study Summary -- Title: Anaerobic biodegradation of gasoline oxygenates: extrapolation of information to multiple sites and redox conditions | Author: Mormile MR ret al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Biodegradation in water and sediment: simulation tests Robust Study Summary -- Title: Anaerobic biodegradation of known and potential gasoline oxygenates in the terrestrial subsurface | Author: Suflita JM; Mormile MR | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Biodegradation in water and sediment: simulation tests Robust Study Summary -- Title: Aerobic mineralization of MTBE and tert-butyl alcohol by stream bed sediment microorganisms | Author: Bradley P et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Biodegradation in soil Robust Study Summary -- Title: ETBE as an additive in gasoline: advantages and disadvantages | Author: Yuan H | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Biodegradation in soil Robust Study Summary -- Title: Anaerobic biodegradation of gasoline oxygenates in soils | Author: Yeh CK; Novak JT | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in soil Robust Study Summary -- Title: The Aerobic Biodegradation of Tert-Butyl Methyl Ether and Tert- Butanol: an Initiatory Study | Author: Allard AS et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in soil Robust Study Summary -- Title: MTBE and Benzene Plume Behavior A Comparative Perspective | Author: Reisinger J et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Biodegradation in soil Robust Study Summary -- Title: Intrinsic biodegradation of MTBE and BTEX in a gasoline-contaminated aquifer | Author: Borden RC et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: Biodegradation and Bioconcentration of Alkyl Ethers | Author: Fujiwara Y et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Short-term toxicity to fish Robust Study Summary -- Title: Acute toxicities of organic chemicals to Fathead minnows (Pimephales promelas) | Author: Geiger DL et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Short-term toxicity to fish Robust Study Summary -- Title: Acute Toxicity of Methyl-Tertiary Butyl Ether (MTBE) to Aquatic Organisms | Author: BenKinney MT et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Short-term toxicity to fish Robust Study Summary -- Title: Structure-toxicity relationships for the fathead minnow Pimephales promelas: narcotic industrial chemicals | Author: Veith GD et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Short-term toxicity to fish Robust Study Summary -- Title: Acute Toxicity of Methyl-Tertiary Butyl Ether (MTBE) to Aquatic Organisms | Author: BenKinney MT et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Short-term toxicity to fish Robust Study Summary -- Title: Acute toxicity of MTBE (methyl tertiary butyl ether) to Fathead Minnow (Pimephales promelas) under flow-through test conditions. | Author: ENSR | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to fish Right to refer to study -- Title: Acute toxicity of MTBE (methyl tertiary butyl ether) to Fathead Minnow (Pimephales promelas) under flow-through test conditions. | Author: ENSR | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to fish Robust Study Summary -- Title: Acute toxicity of MTBE (methyl tertiary butyl ether) to the rainbow trout (Oncorhynchus mykiss) under flowthrough conditions | Author: ENSR | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to fish Right to refer to study -- Title: Acute toxicity of MTBE (methyl tertiary butyl ether) to the rainbow trout (Oncorhynchus mykiss) under flowthrough conditions | Author: ENSR | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to fish Robust Study Summary -- Title: Acute toxicity of methyl tertiary-butyl ether (MTBE) to bluegill sunfish (Lepomis macrochirus) under flow-through test conditions. | Author: ENSR | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to fish Robust Study Summary -- Title: Short-term sub-chronic toxicity of MTBE (methyl tertiary butyl ether) to the Fathead Minnow (Pimephales promelas) under static renewal test conditions. | Author: ENSR | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to fish Right to refer to study -- Title: Short-term sub-chronic toxicity of MTBE (methyl tertiary butyl ether) to the Fathead Minnow (Pimephales promelas) under static renewal test conditions. | Author: ENSR | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to fish Robust Study Summary -- Title: Acute lethal toxicity with Poecilia reticulata Test substance: MTBE (methyl tert-butyl ether) | Author: Slovnaft VÚRUP a.s. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Short-term toxicity to fish Right to refer to study -- Title: Acute lethal toxicity with Poecilia reticulata Test substance: MTBE (methyl tert-butyl ether) | Author: Slovnaft VÚRUP a.s. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Short-term toxicity to fish Robust Study Summary -- Title: MTBE - A 96-hour flow-through acute toxicity test with the threespine stickleback (Gasterosteus aculeatus): | Author: Wildlife International Ltd. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to fish Robust Study Summary -- Title: MTBE - A 96-hour flow-through acute toxicity test with the sheepshead minnow (Cyprinodon variegatus) | Author: Wildlife International Ltd. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Long-term toxicity to fish Robust Study Summary -- Title: Early-life stage toxicity of methyl tertiary-butyl ether (MTBE) to the fathead minnow (Pimephales promelas) under flow-through test conditions | Author: ENSR | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Long-term toxicity to fish Robust Study Summary -- Title: Methyl Tertiary-Butyl Ether (MTBE): Fish Sexual Development Test With The Zebrafish (Danio rerio) | Author: EAG Study Director | Year: 2018 | Guideline: 234 | Klimisch score: Score to be determined on study completion | Adequacy: supporting study. -
Long-term toxicity to fish Right to refer to study -- Title: Methyl Tertiary-Butyl Ether (MTBE): Fish Sexual Development Test With The Zebrafish (Danio rerio) | Author: EAG Study Director | Year: 2018 | Guideline: 234 | Klimisch score: Score to be determined on study completion | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: MTBE- A 48-hour flow-through acute toxicity test with the cladoceran (Daphnia magna) | Author: Wildlife International Ltd. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Toxicity of methyl tert-butyl ether to marine organisms: ambient water quality criteria calculation | Author: Rausina GA et al. | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute Toxicity of Methyl-Tertiary Butyl Ether (MTBE) to Aquatic Organisms | Author: BenKinney MT et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute Toxicity of Methyl Tertiary Butyl Ether to the Mysid Mysidopsis bahia | Author: T.R. Wilbury Laboratories Inc. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Bestimmung der Auswirkungen von MTB-Ether auf das Schwimmverhalten von Daphnia magna (nach EG 84/449 Nov. 1989) | Author: Hüls AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Bestimmung der Auswirkungen von MTB-Ether auf das Schwimmverhalten von Daphnia magna (nach EG 84/449 Nov. 1989) | Author: Hüls AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute Toxicity of MTBE (methyl tertiary-butyl ether) to Ceriodaphnia dubia under Static- Renewal Test Conditions. | Author: ENSR | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Acute Toxicity of MTBE (methyl tertiary-butyl ether) to Ceriodaphnia dubia under Static- Renewal Test Conditions. | Author: ENSR | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Toxicity of MTBE to Freshwater Organisms | Author: Werner I; Hinton DE | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute toxicity of Methyl tertiary-butyl ether (MTBE) to the snail (Physa gyrina) under flow-through test conditions | Author: ENSR | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute toxicity of methyl tertiary-butyl ether (MTBE) to the mayfly Hexagenia limbata under flowthrough test conditions | Author: ENSR | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute Toxicity of Methyl tertiary-Butyl Ether (MTBE) to the Dipteran Chironomus tentans under flow-through test conditions. | Author: ENSR | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute Toxicity of Methyl tertiary-Butyl Ether (MTBE) to the freshwater amphipod Hyalella azteca under flow-through test conditions. | Author: ENSR | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute Toxicity of Methyl-Tertiary Butyl Ether (MTBE) to Aquatic Organisms | Author: BenKinney MT Barbieri JF Gross JS; Naro PA | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute Toxicity of MTBE (methyl tertiary-butyl ether) to Daphnia magna under Static-Renewal Test Conditions | Author: ENSR | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Toxicity of MTBE to Freshwater Organisms | Author: Werner I; Hinton DE | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: MTBE - A 96-hour flow-through acute toxicity test with the blue crab (Callinectes sapidus) | Author: Wildlife International Ltd. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: MTBE - A 96-hour shell deposition test with the eastern oyster (Crassostrea virginica) | Author: Wildlife International Ltd. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute Toxicity of methyl tertiary-butyl ether (MTBE) to the marine amphipos Rhepoxynius abronius under static-renewal test conditions | Author: EVS | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: MTBE - A 96-hour flow-through acute toxicity test with the grass shrimp (Palaemonetes pugio) | Author: Wildlife International Ltd. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute immobilization test with Daphnia magna Test substance: MTBE (methyl tert-butyl ether) | Author: Slovnaft VÚRUP a.s. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Acute immobilization test with Daphnia magna Test substance: MTBE (methyl tert-butyl ether) | Author: Slovnaft VÚRUP a.s. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Methyl tertiary-butyl ether a flow-through life-cycle toxicity test with the cladoceran (Daphnia magna) | Author: Wildlife International Ltd. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: MTBE - A flow-through life-cycle toxicity test with the saltwater mysid (Mysidopsis bahia) | Author: Wildlife International Ltd. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Short-Term Chronic Toxicity of MTBE (methyl tertiary-butyl ether) to Ceriodaphnia dubia under Static Renewal Test Conditions. | Author: ENSR | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Long-term toxicity to aquatic invertebrates Right to refer to study -- Title: Short-Term Chronic Toxicity of MTBE (methyl tertiary-butyl ether) to Ceriodaphnia dubia under Static Renewal Test Conditions. | Author: ENSR | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Toxicity of methyl tertiary-butyl ether (MTBE) to Selenastrum capricornutum under static test conditions | Author: ENSR | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Acute Toxicity of Methyl-Tertiary Butyl Ether (MTBE) to Aquatic Organisms | Author: BenKinney MT Barbieri JF Gross JS; Naro PA | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Bestimmung der Auswirkungen von MTB-Ether (Driveron) auf das Wachstum von Scenedesmus subspicatus | Author: Hüls AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Bestimmung der Auswirkungen von MTB-Ether (Driveron) auf das Wachstum von Scenedesmus subspicatus | Author: Hüls AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Alga growth inhibition test Test substance: MTBE (methyl tert-butyl ether) | Author: Slovnaft VÚRUP a.s. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Alga growth inhibition test Test substance: MTBE (methyl tert-butyl ether) | Author: Slovnaft VÚRUP a.s. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicity to microorganisms Robust Study Summary -- Title: Bestimmung der Bakterientoxizität von Driveron nach Bringmann und Kühn | Author: Hüls AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicity to microorganisms Right to refer to study -- Title: Bestimmung der Bakterientoxizität von Driveron nach Bringmann und Kühn | Author: Hüls AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicity to microorganisms Robust Study Summary -- Title: Determination of the bacteriotoxicity in the test according to Bringmann and Kuhn | Author: Diefenbach R | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicity to microorganisms Right to refer to study -- Title: Determination of the bacteriotoxicity in the test according to Bringmann and Kuhn | Author: Diefenbach R | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicity to microorganisms Robust Study Summary -- Title: Bestimmung der Bakterientoxizität von DRIVERON im Sauerstoff-Konsumptions-Test (Huels Methode) | Author: Hüls AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicity to microorganisms Right to refer to study -- Title: Bestimmung der Bakterientoxizität von DRIVERON im Sauerstoff-Konsumptions-Test (Huels Methode) | Author: Hüls AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicity to soil macro-organisms except anthropods Robust Study Summary -- Title: Comparative and combined toxicities of toluene and methyl tert-butyl ether to an Asian earthworm Perionyx excavatus | Author: An Y J and Lee W M | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicity to soil macro-organisms except anthropods Robust Study Summary -- Title: Assessing soil ecotoxicity of methyl tert-butyl ether using earthworm bioassay; closed soil microcosm test for volatile organic compounds. | Author: An Y J | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicity to soil macro-organisms except anthropods Robust Study Summary -- Title: Combined toxicities of methyl tert-butyl ether and its metabolite tert-butyl alcohol on earthworms via different exposure routes | Author: Lee W-M et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicity to terrestrial arthropods Robust Study Summary -- Title: Toxicity of methyl Tert butyl ether to soil invertebrates (springtails: Folsomia candida Proisotoma minuta and Onychiurus folsomi) and lettuce (Lactuca sativa) | Author: Dodd M and Addison A J | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicity to terrestrial plants Robust Study Summary -- Title: Influence of methyl tert butyl ether (MTBE) on white corn (Zea mays L) Plant growth. | Author: Ismail Ma et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Basic toxicokinetics Robust Study Summary -- Title: Biotransformation of MTBE ETBE and TAME after inhalation or ingestion in rats and humans | Author: Dekant W et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Acute toxicity: oral Robust Study Summary -- Title: Acute oral toxicity study in rats treated with the test article MTBE. | Author: RBM | Year: 1996 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Acute toxicity: oral Right to refer to study -- Title: Acute oral toxicity study in rats treated with the test article MTBE. | Author: RBM | Year: 1996 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Acute toxicity: oral Robust Study Summary -- Title: Acute Toxicity Studies on X-801-25 | Author: Industrial Bio-test Laboratories Inc. | Year: 1969 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Acute toxicity: oral Robust Study Summary -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Acute toxicity: oral Right to refer to study -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Acute toxicity: inhalation Robust Study Summary -- Title: Acute Toxicity Studies on X-801-25 | Author: Industrial Bio-test Laboratories Inc. | Year: 1969 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Acute toxicity: inhalation Robust Study Summary -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Acute toxicity: inhalation Right to refer to study -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Acute toxicity: dermal Robust Study Summary -- Title: Acute dermal toxicity study in rats treated with the test article MTBE | Author: RBM | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Acute toxicity: dermal Right to refer to study -- Title: Acute dermal toxicity study in rats treated with the test article MTBE | Author: RBM | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Acute toxicity: dermal Robust Study Summary -- Title: Single Dose Dermal Toxicity Study in Rabbits Tert-Butyl Methyl Ether (TBME). | Author: Hazelton Laboratories | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Acute toxicity: dermal Right to refer to study -- Title: Single Dose Dermal Toxicity Study in Rabbits Tert-Butyl Methyl Ether (TBME). | Author: Hazelton Laboratories | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Acute toxicity: dermal Robust Study Summary -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Acute toxicity: dermal Right to refer to study -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Acute toxicity: dermal Robust Study Summary -- Title: Acute Toxicity Studies on X-801-25 | Author: Industrial Bio-test Laboratories Inc. | Year: 1969 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Acute toxicity: dermal Right to refer to study -- Title: Acute Toxicity Studies on X-801-25 | Author: Industrial Bio-test Laboratories Inc. | Year: 1969 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Skin irritation / corrosion Robust Study Summary -- Title: Prüfung der akuten Hautreizwirkung von Driveron (MTB) | Author: Hüls | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Skin irritation / corrosion Right to refer to study -- Title: Prüfung der akuten Hautreizwirkung von Driveron (MTB) | Author: Hüls | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Skin irritation / corrosion Robust Study Summary -- Title: Acute dermal irritation study in New Zealand White rabbits treated with test article MTBE. | Author: RBM | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Skin irritation / corrosion Right to refer to study -- Title: Acute dermal irritation study in New Zealand White rabbits treated with test article MTBE. | Author: RBM | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Skin irritation / corrosion Robust Study Summary -- Title: Acute dermal irritation study in New Zealand White rabbits treated with the test article MTBE. | Author: RBM | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Skin irritation / corrosion Right to refer to study -- Title: Acute dermal irritation study in New Zealand White rabbits treated with the test article MTBE. | Author: RBM | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Skin irritation / corrosion Robust Study Summary -- Title: No information | Author: Hazelton Laboratories America Inc. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Skin irritation / corrosion Right to refer to study -- Title: No information | Author: Hazelton Laboratories America Inc. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Skin irritation / corrosion Robust Study Summary -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Skin irritation / corrosion Right to refer to study -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Skin irritation / corrosion Robust Study Summary -- Title: Safety Tests on Methyl tert-butyl ether. | Author: Inveresk Research International | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Skin irritation / corrosion Right to refer to study -- Title: Safety Tests on Methyl tert-butyl ether. | Author: Inveresk Research International | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eye irritation Robust Study Summary -- Title: Prüfung der akuten Augen- und Schleimhautreizwirkung von DRIVERON (MTB) | Author: Hüls | Year: 1985 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eye irritation Right to refer to study -- Title: Prüfung der akuten Augen- und Schleimhautreizwirkung von DRIVERON (MTB) | Author: Hüls | Year: 1985 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eye irritation Robust Study Summary -- Title: Acute eye irritation study in New Zealand White rabbits treated with test article MTBE. | Author: RBM | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eye irritation Right to refer to study -- Title: Acute eye irritation study in New Zealand White rabbits treated with test article MTBE. | Author: RBM | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eye irritation Robust Study Summary -- Title: Acute eye irritation study in New Zealand White rabbits treated with the test article MTBE. | Author: RBM | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eye irritation Right to refer to study -- Title: Acute eye irritation study in New Zealand White rabbits treated with the test article MTBE. | Author: RBM | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eye irritation Robust Study Summary -- Title: Acute Eye Irritation Study in Rabbits Tert-butyl Methyl Ether (95%). | Author: Hazelton Laboratories America Inc. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eye irritation Right to refer to study -- Title: Acute Eye Irritation Study in Rabbits Tert-butyl Methyl Ether (95%). | Author: Hazelton Laboratories America Inc. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eye irritation Robust Study Summary -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eye irritation Right to refer to study -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eye irritation Robust Study Summary -- Title: Acute Toxicity Studies on X-801-25 | Author: Industrial Bio-test Laboratories Inc. | Year: 1969 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eye irritation Robust Study Summary -- Title: Safety Tests on Methyl tert-butyl ether. | Author: Inveresk Research International | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eye irritation Right to refer to study -- Title: Safety Tests on Methyl tert-butyl ether. | Author: Inveresk Research International | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Skin sensitisation Robust Study Summary -- Title: Guinea Pig Sensitization Study: TBME-99 | Author: Litton Bionetics Inc. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Skin sensitisation Right to refer to study -- Title: Guinea Pig Sensitization Study: TBME-99 | Author: Litton Bionetics Inc. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Skin sensitisation Robust Study Summary -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Skin sensitisation Right to refer to study -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Skin sensitisation Robust Study Summary -- Title: Safety Tests on Methyl tert-butyl ether. IRI proj no 412139 | Author: Inveresk Research International | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Skin sensitisation Right to refer to study -- Title: Safety Tests on Methyl tert-butyl ether. IRI proj no 412139 | Author: Inveresk Research International | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Repeated dose toxicity: oral Robust Study Summary -- Title: Methyl tertiary-butyl ether (MTBE): thirteen-week subchronic drinking water toxicity study in Wistar rats | Author: CIIT | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Repeated dose toxicity: oral Right to refer to study -- Title: Methyl tertiary-butyl ether (MTBE): thirteen-week subchronic drinking water toxicity study in Wistar rats | Author: CIIT | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Repeated dose toxicity: oral Robust Study Summary -- Title: Toxicity of methyl tertiary-butyl ether (MTBE) following exposure to Wistar Rats for 13 weeks or one year via drinking water | Author: Bermudez E Willson G Parkinson H Dodd D | Year: 2012 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Repeated dose toxicity: oral Robust Study Summary -- Title: Fourteen- and ninety-day oral toxicity studies of methyl tertiary-butyl ether in Sprague-Dawley rats. | Author: Robinson M Bruner RH; Olson GR . | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Repeated dose toxicity: oral Robust Study Summary -- Title: 28 day oral (gavage) toxicity study of methyl tert-butyl ether (MTBE) in rats. | Author: IITRI (IIT Research Laboratories) | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Repeated dose toxicity: oral Right to refer to study -- Title: 28 day oral (gavage) toxicity study of methyl tert-butyl ether (MTBE) in rats. | Author: IITRI (IIT Research Laboratories) | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Repeated dose toxicity: oral Robust Study Summary -- Title: Subchronic Oral Methyl Tertiary Butyl Ether (MTBE) Exposure in Male Sprague-Dawley Rats and Effects on Health of MTBE Exposed Workers. | Author: Zhou W; Ye S | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Repeated dose toxicity: oral Robust Study Summary -- Title: Alterations in Endocrine Responses in Male Sprague-Dawley Rats following Oral Administrationof Male tert-Butyl Ether | Author: Williams TM et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Repeated dose toxicity: oral Robust Study Summary -- Title: Toxicity of methyl tertiary-butyl ether (MTBE) following exposure to Wistar Rats for 13 weeks or one year via drinking water | Author: Bermudez E et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Repeated dose toxicity: oral Robust Study Summary -- Title: Effects of subchronic methyl tert-butyl ether exposure on male Sprague-Dawley rats | Author: Dong-mei L et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Repeated dose toxicity: inhalation Robust Study Summary -- Title: Methyl Tertiary Butyl Ether (MTBE): Repeated (13-week) Vapour Inhalation Study in Rats with Neurotoxicity Evaluation. | Author: Bushy Run Research Center | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Repeated dose toxicity: inhalation Right to refer to study -- Title: Methyl Tertiary Butyl Ether (MTBE): Repeated (13-week) Vapour Inhalation Study in Rats with Neurotoxicity Evaluation. | Author: Bushy Run Research Center | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Repeated dose toxicity: inhalation Robust Study Summary -- Title: Evaluation of 13-week inhalation toxicity study on methyl t-butyl ether (MTBE) in Fischer 344 rats. | Author: Lington AW et al. | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Repeated dose toxicity: inhalation Robust Study Summary -- Title: Neurotoxicological evaluation of methyl tertiary-butyl ether in rats. | Author: Daughtrey WC et al. | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Repeated dose toxicity: inhalation Robust Study Summary -- Title: Methyl Tertiary Butyl Ether: Twenty-Eight Day Vapor Inhalation Study in Rats and Mice. | Author: Bushy Run Research Center | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Repeated dose toxicity: inhalation Right to refer to study -- Title: Methyl Tertiary Butyl Ether: Twenty-Eight Day Vapor Inhalation Study in Rats and Mice. | Author: Bushy Run Research Center | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Repeated dose toxicity: inhalation Robust Study Summary -- Title: Methyl Tertiary Butyl Ether: Twenty-Eight Day Vapor Inhalation Study in Rats and Mice. | Author: Bushy Run Research Center | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Repeated dose toxicity: inhalation Right to refer to study -- Title: Methyl Tertiary Butyl Ether: Twenty-Eight Day Vapor Inhalation Study in Rats and Mice. | Author: Bushy Run Research Center | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Repeated dose toxicity: inhalation Robust Study Summary -- Title: Methyl Tertiary Butyl Ether (Driveron) Three Month Inhalation Toxicity in Rats. | Author: Inveresk Research International | Year: 1980 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Repeated dose toxicity: inhalation Right to refer to study -- Title: Methyl Tertiary Butyl Ether (Driveron) Three Month Inhalation Toxicity in Rats. | Author: Inveresk Research International | Year: 1980 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Repeated dose toxicity: inhalation Robust Study Summary -- Title: Methyl tert-butyl ether causes α2u-globulin nephropathy and enhanced renal cell proliferation in male Fischer-344 rats. | Author: Prescott-Mathews JS et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Repeated dose toxicity: inhalation Robust Study Summary -- Title: Health assessment of gasoline and fuel oxygenate vapors: Subchronic inhalation toxicity | Author: Clark C R et al | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Bestimmung der Mutagenität von DRIVERON im Salmonella/ Säuger-Mikrosomen-Mutagenitätstest nach Ames Mutagenitätstest nach Richtlinie 84/449/EWG B.14. | Author: Hüls | Year: 1991 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Bestimmung der Mutagenität von DRIVERON im Salmonella/ Säuger-Mikrosomen-Mutagenitätstest nach Ames Mutagenitätstest nach Richtlinie 84/449/EWG B.14. | Author: Hüls | Year: 1991 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
in vitro genetic toxicity Robust Study Summary -- Title: Reverse Mutation in Salmonella typhimurium. Test Substance: MTBE. pp. 50. | Author: Life Science Research | Year: 1989 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: MTBE Ames test | Author: RBM | Year: 1996 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: MTBE Ames test | Author: RBM | Year: 1996 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Gene Mutation in Chinese Hamster V79 Cells. Test Substance: MTBE. | Author: Life Science Research | Year: 1989 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Mutagenicity of Methyl Tertiary Butyl Ether. | Author: Zhou W et al. | Year: 2000 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: The mutagenicity testing of tertiary-butyl alcohol tertiary-butyl acetate and methyl tertiary-butyl ether in Salmonella typhimurium. | Author: McGregor DB et al. | Year: 2005 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Mutagenicity Evaluation of TBME-95 in the Ames Salmonella/Microsome Plate Test. | Author: Litton Bionetics Inc. | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Mutagenicity Evaluation of TBME-95 in the Ames Salmonella/Microsome Plate Test. | Author: Litton Bionetics Inc. | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Absence of mutagenicity of methyl-tertiary-butyl ether. | Author: Cinelli S et al. | Year: 1992 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Genotoxicity testing of methyl tertiary-butylether (MTBE) in the Salmonella microsuspension assay and mouse bone marrow micronucleus test. | Author: Kado NY et al. | Year: 1998 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Mutagenicity of Methyl Tertiary Butyl Ether. | Author: Zhou W et al. | Year: 2000 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Mutagenicity Evaluation of TBME-95 in the Ames Salmonella/Microsome Plate Test. | Author: Litton Bionetics Inc. | Year: 1978 | Guideline: 480 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Mutagenicity Evaluation of TBME-95 in the Ames Salmonella/Microsome Plate Test. | Author: Litton Bionetics Inc. | Year: 1978 | Guideline: 480 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro genetic toxicity Robust Study Summary -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Guideline: 480 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro genetic toxicity Right to refer to study -- Title: Methyl Tertiary Butyl Ether: Acute Toxicological Studies | Author: ARCO Chemical Company | Year: 1980 | Guideline: 480 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Effect of methyl tert-butyl ether in standard tests for mutagenicity and environmental toxicity. | Author: Vosahlikova M et al. | Year: 2006 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: In vitro metabolic study of TBME in the mouse lymphoma mutation test. | Author: Litton Bionetics Inc. | Year: 1979 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: In vitro metabolic study of TBME in the mouse lymphoma mutation test. | Author: Litton Bionetics Inc. | Year: 1979 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Identification of formaldehyde as the metabolite responsible for the mutagenicity of methyl tertiary-butyl ether in the activated mouse lymphoma assay. | Author: Mackerer CR et al. | Year: 1996 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Genetic toxicity in vivo Robust Study Summary -- Title: Unscheduled DNA Synthesis (UDS) in Primary Rat Hepatocytes (Autoradiographic Method). pp. 79. | Author: Life Science Research | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Absence of mutagenicity of methyl-tertiary-butyl ether. | Author: Cinelli S et al. | Year: 1992 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Mutagenicity of Methyl Tertiary Butyl Ether. | Author: Zhou W et al. | Year: 2000 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Mutagenicity Evaluation of TBME A995 (Tert-Butyl Methyl Ether) in an in-vitro Cytogenetic Assay Measuring Sister Chromatid Exchange and Chromosome Aberration Frequencies in Chinese Hamster Ovary (CHO) Cells. | Author: Litton Bionetics Inc. | Year: 1980 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
in vitro gene mutation study in mammalian cells Right to refer to study -- Title: Mutagenicity Evaluation of TBME A995 (Tert-Butyl Methyl Ether) in an in-vitro Cytogenetic Assay Measuring Sister Chromatid Exchange and Chromosome Aberration Frequencies in Chinese Hamster Ovary (CHO) Cells. | Author: Litton Bionetics Inc. | Year: 1980 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Genetic toxicity in vivo Robust Study Summary -- Title: Methyl tertiary butyl ether: In vivo-in vitro hepatocyte unscheduled DNA synthesis assay in mice | Author: Bushy Run Research Center | Year: 1994 | Guideline: 486 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Genetic toxicity in vivo Right to refer to study -- Title: Methyl tertiary butyl ether: In vivo-in vitro hepatocyte unscheduled DNA synthesis assay in mice | Author: Bushy Run Research Center | Year: 1994 | Guideline: 486 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Genetic toxicity in vivo Robust Study Summary -- Title: Assessment of the in vivo mutagenic potential of methyl tertiary-butyl ether. | Author: McKee RH et al. | Year: 1997 | Guideline: 486 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Genetic toxicity in vivo Robust Study Summary -- Title: Methyl Tertiary Butyl Ether: Bone Marrow Micronucleus Test in Mice | Author: Bushy Run Research Center | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Genetic toxicity in vivo Right to refer to study -- Title: Methyl Tertiary Butyl Ether: Bone Marrow Micronucleus Test in Mice | Author: Bushy Run Research Center | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Genetic toxicity in vivo Robust Study Summary -- Title: Methyl Tertiary Butyl Ether Repeated Exposure Vapor Inhalation Study in Rats: In-Vivo Cytogenetic Evaluation. | Author: Bushy Run Research Center | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Genetic toxicity in vivo Right to refer to study -- Title: Methyl Tertiary Butyl Ether Repeated Exposure Vapor Inhalation Study in Rats: In-Vivo Cytogenetic Evaluation. | Author: Bushy Run Research Center | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Genetic toxicity in vivo Robust Study Summary -- Title: Assessment of the in vivo mutagenic potential of methyl tertiary-butyl ether. | Author: McKee RH et al. | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Genetic toxicity in vivo Robust Study Summary -- Title: Mutagenicity Test on Methyl Tertiary Butyl Ether Drosphilia Melanogaster Sex-Linked Recessive Lethal Test. | Author: Hazelton Laboratories | Year: 1989 | Guideline: 461 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Genetic toxicity in vivo Right to refer to study -- Title: Mutagenicity Test on Methyl Tertiary Butyl Ether Drosphilia Melanogaster Sex-Linked Recessive Lethal Test. | Author: Hazelton Laboratories | Year: 1989 | Guideline: 461 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Genetic toxicity in vivo Robust Study Summary -- Title: Assessment of the in vivo mutagenic potential of methyl tertiary-butyl ether. | Author: McKee RH et al. | Year: 1997 | Guideline: 461 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Genetic toxicity in vivo Robust Study Summary -- Title: Genotoxicity testing of methyl tertiary-butyl ether (MTBE) in the Salmonella microsuspension assay and mouse bone marrow micronucleus test. | Author: Kado NY Kuzmicky PA Loarca-Pina G; Moiz Mumtaz M | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Genetic toxicity in vivo Robust Study Summary -- Title: Mutagenicity Evaluation of TBME 99% in the Rat Bone Marrow Cytogenetic Analysis. | Author: Litton Bionetics Inc | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Genetic toxicity in vivo Right to refer to study -- Title: Mutagenicity Evaluation of TBME 99% in the Rat Bone Marrow Cytogenetic Analysis. | Author: Litton Bionetics Inc | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Genetic toxicity in vivo Robust Study Summary -- Title: Health assessment of gasoline and fuel oxygenate vapors: Micronucleus and sister chromatid exchange evaluations | Author: Schreiner C A et al | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Genetic toxicity in vivo Robust Study Summary -- Title: In Vivo Mutation Assay of Methyl tert-butyl ether at the cII Locus in Big Blue® Transgenic Male F344 Rats Dosed via Whole Body Inhalation | Author: CRA; Ashland LLC Principal Investigator; BioReliance Corporation Study Director | Year: 2018 | Guideline: 488 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Genetic toxicity in vivo Right to refer to study -- Title: In Vivo Mutation Assay of Methyl tert-butyl ether at the cII Locus in Big Blue® Transgenic Male F344 Rats Dosed via Whole Body Inhalation | Author: CRA; Ashland LLC Principal Investigator; BioReliance Corporation Study Director | Year: 2018 | Guideline: 488 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Carcinogenicity Robust Study Summary -- Title: Methyl Tertiary Butyl Ether: Vapor Inhalation Oncogenicity Study in Fischer 344 rats. | Author: Bushy Run Research Center | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Carcinogenicity Right to refer to study -- Title: Methyl Tertiary Butyl Ether: Vapor Inhalation Oncogenicity Study in Fischer 344 rats. | Author: Bushy Run Research Center | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Carcinogenicity Robust Study Summary -- Title: Oncogenicity studies of inhaled methyl tertiary-butyl ether (MTBE) in CD-1 mice and F-344 rats. | Author: Bird MG et al. | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Carcinogenicity Robust Study Summary -- Title: Methyl Tertiary Butyl Ether: Vapor Inhalation Oncogenicity Study in CD-1 Mice | Author: Bushy Run Research Center | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Right to refer to study -- Title: Methyl Tertiary Butyl Ether: Vapor Inhalation Oncogenicity Study in CD-1 Mice | Author: Bushy Run Research Center | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Oncogenicity studies of inhaled methyl tertiary-butyl ether (MTBE) in CD-1 mice and F-344 rats. | Author: Bird MG et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Methyl tertiary butyl ether lacks tumor-promoting activity in N-nitrosodiethylamine-initiated B6C3F1 female mouse liver. | Author: Moser GJ et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Methyl tertiary butyl ether-induced endocrine alterations in mice are not mediated through the estrogen receptor | Author: Moser GJ et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Methyl tertiary butyl ether-induced endocrine alterations in mice are not mediated through the estrogen receptor | Author: Moser GJ et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents. | Author: Cruzan G et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Expert review of kidney histopathology in the 2-year carcinogenicity study of methyl tert butyl ether (MTBE) administered to Fischer 344 rats by vapor inhalation | Author: Hard GC | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Right to refer to study -- Title: Expert review of kidney histopathology in the 2-year carcinogenicity study of methyl tert butyl ether (MTBE) administered to Fischer 344 rats by vapor inhalation | Author: Hard GC | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Scientific consideratioons for evaluating cancer bioassays conducted by the Ramazzini Institute | Author: Gift JS et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Mycoplasma pulmonis and Lymphoma in Bioassays in Rats | Author: Schoeb TR et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Further comments on Mycoplasma pulmonis and lymphoma in bioassays of rats. | Author: Schoeb T R; McConnell E E | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Evaluation of evidence for infection as a mode of action for induction of rat lymphoma | Author: Caldwell J C; Jinot J; DeVoney D; Gift J S | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Confidence in Rodent Carcinogenesis Bioassays | Author: Ward JM Alden CL | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Effects of MTBE on the reported incidence of Leydig cell tumors in Sprague-Dawley rats: range of possible Poly-3 results. | Author: Goodman J E; Gaylor D; Beyer L A; Rhomber L R; Beck B D | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Applications of the Poly-K Statistical Test to Life-Time Cancer Bioassay Studies | Author: Gebregziabher M; Hoel D | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: Methyl tertiary-butyl ether (MTBE): Two year combined chronic toxicity/carcinogenicity drinking water study in Wistar rats | Author: Dodd DE Layko DK Bermudez E | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Carcinogenicity Robust Study Summary -- Title: CHRONIC CARCINOGENICITY STUDY OF GASOLINE VAPOR CONDENSATE (GVC) AND GVC CONTAINING METHYL TERTIARY-BUTYL ETHER IN F344 RATS | Author: Benson et al | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicity to reproduction Robust Study Summary -- Title: Two-generation reproductive toxicity study of inhaled methyl tertiary-butyl ether (MTBE) in CD (Sprague Dawley) rats | Author: Bushy Run Research Center | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicity to reproduction Right to refer to study -- Title: Two-generation reproductive toxicity study of inhaled methyl tertiary-butyl ether (MTBE) in CD (Sprague Dawley) rats | Author: Bushy Run Research Center | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicity to reproduction Robust Study Summary -- Title: Two-generation reproductive toxicity study of methyl tertiary-butyl ether (MTBE) in rats. | Author: Bevan C et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicity to reproduction Robust Study Summary -- Title: A Single Generation Inhalation Reproduction/Fertility Study in Rats with Methyl t-Butyl Ether (MTBE). | Author: Bio/Dynamics Inc. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicity to reproduction Robust Study Summary -- Title: Methyl tertiary butyl ether inhalation in rats - a single generation reproduction study. | Author: Biles RW Schroeder RE; Holdsworth CE | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicity to reproduction Robust Study Summary -- Title: Induction of testosterone biotransformation enzymes following oral administration of methyl tert-butyl ether to male Sprague-Dawley Rats. | Author: Williams TM et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicity to reproduction Robust Study Summary -- Title: Evaluation of toxicity of methyl tert-butyl ether (MTBE) on mouse spermatogenic cells in vitro | Author: DM Li XD Han | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicity to reproduction Robust Study Summary -- Title: Health assessment of gasoline and fuel oxygenate vapors: Reproductive toxicity assessment | Author: Gray T M et al | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental Toxicity Study of Inhaled Methyl Terttiary Butyl Ether in New Zealand White Rabbits. | Author: Bushy Run Research Center | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Developmental toxicity/teratogenicity Right to refer to study -- Title: Developmental Toxicity Study of Inhaled Methyl Terttiary Butyl Ether in New Zealand White Rabbits. | Author: Bushy Run Research Center | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental toxicity evaluation of methyl tertiary-butyl ether (MTBE) by inhalation in mice and rabbits. | Author: Bevan C et al. | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental Toxicity Study of Inhaled Methyl tert-Butyl Ether in CD-1 Mice. | Author: Bushy Run Research Center | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Developmental toxicity/teratogenicity Right to refer to study -- Title: Developmental Toxicity Study of Inhaled Methyl tert-Butyl Ether in CD-1 Mice. | Author: Bushy Run Research Center | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental toxicity evaluation of methyl tertiary-butyl ether (MTBE) by inhalation in mice and rabbits. | Author: Bevan C et al. | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Developmental toxicity/teratogenicity Robust Study Summary -- Title: Teratology evaluation of methyl tertiary butyl ether in rats and mice. | Author: Conaway CC et al. | Year: 1985 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Developmental toxicity/teratogenicity Robust Study Summary -- Title: Teratology evaluation of methyl tertiary butyl ether in rats and mice. | Author: Conaway CC et al. | Year: 1985 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Developmental toxicity/teratogenicity Robust Study Summary -- Title: Methyl tert-butyl ether is anti-angiogenic in both in vitro and in vivo mammalian model systems | Author: Kozlosky J et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Developmental toxicity/teratogenicity Robust Study Summary -- Title: Health assessment of gasoline and fuel oxygenate vapors: Developmental toxicity in rats | Author: Roberts L G et al | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Developmental toxicity/teratogenicity Robust Study Summary -- Title: Health assessment of gasoline and fuel oxygenate vapors: Developmental toxicity in mice | Author: Roberts L G et al | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -