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CAS 25686-28-6 | Data Package 10 - 100 t/a

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Includes:

Study name Short Description Data Owner
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Daniel Baker | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Appearance/physical state/colour Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Daniel Baker | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Daniel Baker | Year: 2009 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Melting point/freezing point Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Daniel Baker | Year: 2009 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Boiling point Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Density Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Density Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Vapor pressure of MDI Homopolymer | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Vapour pressure Right to refer to study -- Title: Vapor pressure of MDI Homopolymer | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Water solubility Robust Study Summary -- Title: No information | Author: Yakabe | Year: 1997 | Adequacy: key study. -
Phys-Chem | Water solubility Right to refer to study -- Title: No information | Author: Yakabe | Year: 1997 | Adequacy: key study. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y. et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Flammability Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Daniel Baker | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flammability Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Daniel Baker | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Primary Dermal Irritation Study in Rabbits with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Primary Dermal Irritation Study in Rabbits with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Eye irritation Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Eye irritation Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Skin sensitisation Right to refer to study -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Bacterial Reverse Mutation Assay | Author: Wagner V.O., VanDyke M.R. | Year: 2009 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Bacterial Reverse Mutation Assay | Author: Wagner V.O., VanDyke M.R. | Year: 2009 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Bone marrow micronucleus assay in Brown-Norway rats exposed to diphenyl-methane-4,4'-diisocyanate | Author: Pauluhn J. et al. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence.
Read-Across (CAS 101-68-8 | Diphenylmethane 4,4'-diisocyanate)
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Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI): acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence.
Read-Across (CAS 101-68-8 | Diphenylmethane 4,4'-diisocyanate)
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Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI): acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence.
Read-Across (CAS 101-68-8 | Diphenylmethane 4,4'-diisocyanate)
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Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit. | Author: Wazeter F. X. et al. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: dermal Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit. | Author: Wazeter F. X. et al. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Chronic inhalation toxicity and carcinogenicity study of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats | Author: Reuzel P.G.J. et al. | Year: 1994 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Prenatal toxicity of polymeric MDI in rats. Aerosol inhalation. 3 vols | Author: Gamer A.O. | Year: 1994 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | Developmental toxicity/teratogenicity Right to refer to study -- Title: Prenatal toxicity of polymeric MDI in rats. Aerosol inhalation. 3 vols | Author: Gamer A.O. | Year: 1994 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA | Author: Caspers N. et al. | Year: 1986 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA | Author: Caspers N. et al. | Year: 1986 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A. | Year: 2021 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A. | Year: 2021 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence.
Read-Across (CAS 101-68-8 | Diphenylmethane 4,4'-diisocyanate)
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Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence.
Read-Across (CAS 101-68-8 | Diphenylmethane 4,4'-diisocyanate)
-
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Report: 4,4'-MDI/DPG Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Guideline: 301F | Adequacy: weight of evidence. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Report: 4,4'-MDI/DPG Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Guideline: 301F | Adequacy: weight of evidence. -
Environmental | Hydrolysis Robust Study Summary -- Title: Water Extractability of 4,4'-MDI Homopolymer | Author: Neuland M. | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Environmental | Hydrolysis Right to refer to study -- Title: Water Extractability of 4,4'-MDI Homopolymer | Author: Neuland M. | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -