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| Study name | Short Description | Data Owner |
|---|---|---|
| Melting point/freezing point | Robust Study Summary - Title: Determination of the melting point of VESTANAT H12MDI; Author: Aqura GmbH; Year: 2010; Guideline: 102; Klimisch score: 1 | Consortium |
| Melting point/freezing point | Right to refer to study - Title: Determination of the melting point of VESTANAT H12MDI; Author: Aqura GmbH; Year: 2010; Guideline: 102; Klimisch score: 1 | - |
| Boiling point | Robust Study Summary - Title: Thermische Untersuchung zur Destillation von Desmodur W; Author: Bayer AG; Year: 1998; Guideline: 103; Klimisch score: 2 | Consortium |
| Boiling point | Right to refer to study - Title: Thermische Untersuchung zur Destillation von Desmodur W; Author: Bayer AG; Year: 1998; Guideline: 103; Klimisch score: 2 | Covestro Deutschland AG |
| Density | Robust Study Summary - Title: International Chemical Safety Cards (ICSC) ; Author: NIOSH; Year: 2005; Guideline: 109; Klimisch score: 2 | Consortium |
| Density | Right to refer to study - Title: International Chemical Safety Cards (ICSC) ; Author: NIOSH; Year: 2005; Guideline: 109; Klimisch score: 2 | Publication |
| Vapour pressure | Robust Study Summary - Title: Desmodur W, Abschlussbericht Dampfdruck. ; Author: Bayer AG; Year: 1994; Guideline: 104; Klimisch score: 2 | Consortium |
| Vapour pressure | Right to refer to study - Title: Desmodur W, Abschlussbericht Dampfdruck. ; Author: Bayer AG; Year: 1994; Guideline: 104; Klimisch score: 2 | Covestro Deutschland AG |
| Water solubility | Robust Study Summary - Title: waived | Consortium |
| Water solubility | Right to refer to study - Title: waived | public |
| Partition coefficient | Robust Study Summary - Title: QSAR Estimations for Cyclohexane, 1,1'methylenbis-4-isocyanato-, CAS:5124-30-1 (Desmodur W) ; Author: Currenta GmbH & Co. OHG; Year: 2009; Guideline: 107/117; Klimisch score: 2 | Consortium |
| Partition coefficient | Right to refer to study - Title: QSAR Estimations for Cyclohexane, 1,1'methylenbis-4-isocyanato-, CAS:5124-30-1 (Desmodur W) ; Author: Currenta GmbH & Co. OHG; Year: 2009; Guideline: 107/117; Klimisch score: 2 | Covestro Deutschland AG |
| Particle size distribution | Robust Study Summary - Title: waived | Consortium |
| Particle size distribution | Right to refer to study - Title: waived | |
| Acute toxicity: oral | Robust Study Summary - Title: Akute Toxizitõtspr³fung von "Dicyclohexylmethan-4, 4'-diisocyanat" (H12MDI) nach oraler Applikation an der Ratte; Author: Sterner W & Stiglic A; Year: 1976; Guideline: 420, 423, 425; Klimisch score: 2 | Consortium |
| Acute toxicity: oral | Right to refer to study - Title: Akute Toxizitõtspr³fung von "Dicyclohexylmethan-4, 4'-diisocyanat" (H12MDI) nach oraler Applikation an der Ratte; Author: Sterner W & Stiglic A; Year: 1976; Guideline: 420, 423, 425; Klimisch score: 2 | Evonik Resource Efficiency GmbH |
| Skin irritation / corrosion | Robust Study Summary - Title: Study for skin irritation/corrosion in rabbits; Author: Kroetlinger F; Year: 1994; Guideline: 404; Klimisch score: 1 | Consortium |
| Skin irritation / corrosion | Right to refer to study - Title: Study for skin irritation/corrosion in rabbits; Author: Kroetlinger F; Year: 1994; Guideline: 404; Klimisch score: 1 | Covestro Deutschland AG |
| Skin irritation / corrosion | Robust Study Summary - Title: Acute dermal irritation corrosive study in rabbits in Desmodur W; Author: Wakefiled A; Year: 1996; Guideline: 404; Klimisch score: 1 | Consortium |
| Skin irritation / corrosion | Right to refer to study - Title: Acute dermal irritation corrosive study in rabbits in Desmodur W; Author: Wakefiled A; Year: 1996; Guideline: 404; Klimisch score: 1 | - |
| Skin sensitisation | Robust Study Summary - Title: 4,4-Diisocyanato-dicyclohexylmethan (H-MDI), Pruefung auf sensibilisierende Wirkung an der Meerschweinchenhaut (Maximierungstest nach Magnusson/Klingman); Author: Schmidt WM ; Year: 1985; Guideline: 406, 429; Klimisch score: 2 | Consortium |
| Skin sensitisation | Right to refer to study - Title: 4,4-Diisocyanato-dicyclohexylmethan (H-MDI), Pruefung auf sensibilisierende Wirkung an der Meerschweinchenhaut (Maximierungstest nach Magnusson/Klingman); Author: Schmidt WM ; Year: 1985; Guideline: 406, 429; Klimisch score: 2 | Covestro Deutschland AG |
| Skin sensitisation | Robust Study Summary - Title: Dicyclohexylmethan-4,4'-diisocyanat - Prüfung auf sensibilisierende Eigenschaften am Meerschweinchen nach Magnusson und Kligman (OECD Richtlinien); Author: Sterner W & Chibanguza G; Year: 1983; Guideline: 406, 429; Klimisch score: 2 | Consortium |
| Skin sensitisation | Right to refer to study - Title: Dicyclohexylmethan-4,4'-diisocyanat - Pr³fung auf sensibilisierende Eigenschaften am Meerschweinchen nach Magnusson und Kligman (gemõ? OECD Richtlinien); Author: Sterner W & Chibanguza G; Year: 1983; Guideline: 406, 429; Klimisch score: 2 | Evonik Resource Efficiency GmbH |
| Genetic toxicity in vitro | Robust Study Summary - Title: Desmodur W Salmonella/Microsome Test Plate Incoporation and Preincubation Method; Author: Wirnitzer U; Year: 2005; Guideline: 471; Klimisch score: 1 | Consortium |
| Genetic toxicity in vitro | Right to refer to study - Title: Desmodur W Salmonella/Microsome Test Plate Incoporation and Preincubation Method; Author: Wirnitzer U; Year: 2005; Guideline: 471; Klimisch score: 1 | Covestro Deutschland AG |
| Short-term toxicity to fish | Robust Study Summary - Title: Investigation of the ecological properties of Desmodur W; Author: Bayer AG; Year: 2000; Guideline: 203; Klimisch score: 2 | Consortium |
| Short-term toxicity to fish | Right to refer to study - Title: Investigation of the ecological properties of Desmodur W; Author: Bayer AG; Year: 2000; Guideline: 203; Klimisch score: 2 | Covestro Deutschland AG |
| Short-term toxicity to aquatic invertebrates | Robust Study Summary - Title: Investigation of the ecological properties of Desmodur W; Author: Bayer AG; Year: 2000; Guideline: 202; Klimisch score: 2 | Consortium |
| Short-term toxicity to aquatic invertebrates | Right to refer to study - Title: Investigation of the ecological properties of Desmodur W; Author: Bayer AG; Year: 2000; Guideline: 202; Klimisch score: 2 | Covestro Deutschland AG |
| Biodegradation in water: screening tests | Robust Study Summary - Title: Determination on the ecological behaviour of Desmodur W.; Author: Bayer AG; Year: 1992; Guideline: 301C; Klimisch score: 2 | Consortium |
| Biodegradation in water: screening tests | Right to refer to study - Title: Determination on the ecological behaviour of Desmodur W.; Author: Bayer AG; Year: 1992; Guideline: 301C; Klimisch score: 2 | Covestro Deutschland AG |
| Biodegradation in water: screening tests | Robust Study Summary - Title: Investigation of the ecological properties of Desmodur W; Author: Bayer AG; Year: 2000; Guideline: 301C; Klimisch score: 1 | Consortium |
| Biodegradation in water: screening tests | Right to refer to study - Title: Investigation of the ecological properties of Desmodur W; Author: Bayer AG; Year: 2000; Guideline: 301C; Klimisch score: 1 | Covestro Deutschland AG |
| Flammability | Robust Study Summary - Title: waived | public |
| Flammability | Right to refer to study - Title: waived | public |
| Explosiveness | Robust Study Summary - Title: waived | public |
| Explosiveness | Right to refer to study - Title: waived | public |
| Oxidising properties | Robust Study Summary - Title: waived | public |
| Oxidising properties | Right to refer to study - Title: waived | public |
| Hydrolysis | Robust Study Summary - Title: Decrease of NCO-Content in Water. ; Author: Bayer AG ; Year: 1999; Guideline: 111; Klimisch score: 2 | Consortium |
| Hydrolysis | Right to refer to study - Title: Decrease of NCO-Content in Water. ; Author: Bayer AG ; Year: 1999; Guideline: 111; Klimisch score: 2 | Covestro Deutschland AG |
| Hydrolysis | Robust Study Summary - Title: Hydrolysis as a function of pH and temperature of Desmodur W. Results of preliminary test. ; Author: Bayer Industry Services GmbH & Co. OHG; Year: 2004; Guideline: 111; Klimisch score: 2 | Consortium |
| Hydrolysis | Right to refer to study - Title: Hydrolysis as a function of pH and temperature of Desmodur W. Results of preliminary test. ; Author: Bayer Industry Services GmbH & Co. OHG; Year: 2004; Guideline: 111; Klimisch score: 2 | Covestro Deutschland AG |
| Acute toxicity: dermal | Robust Study Summary - Title: Akute dermale Toxizitõt von Dicyclohexylmethan-4,4'-diisocyanat (HMDI) f³r Ratten; Author: Muermann P; Year: 1985; Guideline: 402; Klimisch score: 2 | Consortium |
| Acute toxicity: dermal | Right to refer to study - Title: Akute dermale Toxizitõt von Dicyclohexylmethan-4,4'-diisocyanat (HMDI) f³r Ratten; Author: Muermann P; Year: 1985; Guideline: 402; Klimisch score: 2 | Evonik Resource Efficiency GmbH |
| Acute toxicity: inhalation | Robust Study Summary - Title: 4-Hour Acute Inhalation Toxicity Study in Rats; Author: Bernstein D M & ThÚvenaz P & Mladenovic P; Year: 1987; Guideline: 403; Klimisch score: 1 | Consortium |
| Acute toxicity: inhalation | Right to refer to study - Title: 4-Hour Acute Inhalation Toxicity Study in Rats; Author: Bernstein D M & ThÚvenaz P & Mladenovic P; Year: 1987; Guideline: 403; Klimisch score: 1 | Evonik Resource Efficiency GmbH |
| Acute toxicity: inhalation | Robust Study Summary - Title: Desmodur W Untersuchungen zur akuten Inhalationstoxizitaet an der Ratte nach OECD-No. 403; Author: Pauluhn J; Year: 1995; Guideline: 403; Klimisch score: 1 | Consortium |
| Acute toxicity: inhalation | Right to refer to study - Title: Desmodur W Untersuchungen zur akuten Inhalationstoxizitaet an der Ratte nach OECD-No. 403; Author: Pauluhn J; Year: 1995; Guideline: 403; Klimisch score: 1 | Covestro Deutschland AG |
| Eye irritation | Robust Study Summary - Title: Bericht ueber die Pruefung von Dicyclohexylmethan-4,4-diisocyanat fluessig auf Schleimhautreizwirkung; Author: Schreiber G; Year: 1981; Guideline: 405; Klimisch score: 2 | Consortium |
| Eye irritation | Right to refer to study - Title: Bericht ueber die Pruefung von Dicyclohexylmethan-4,4-diisocyanat fluessig auf Schleimhautreizwirkung; Author: Schreiber G; Year: 1981; Guideline: 405; Klimisch score: 2 | Covestro Deutschland AG |
| Genetic toxicity in vitro | Robust Study Summary - Title: V79/HPRT-Test in vitro for the detection of induced forward mutations; Author: Herbold B; Year: 2007; Guideline: 476, 474, 475; Klimisch score: 1 | Consortium |
| Genetic toxicity in vitro | Right to refer to study - Title: V79/HPRT-Test in vitro for the detection of induced forward mutations; Author: Herbold B; Year: 2007; Guideline: 476, 474, 475; Klimisch score: 1 | - |
| Repeated dose toxicity: oral | Robust Study Summary - Title: waived | public |
| Repeated dose toxicity: oral | Right to refer to study - Title: waived | public |
| Repeated dose toxicity: inhalation | Robust Study Summary - Title: Subacute inhalation toxicity on rats; Author: Pauluhn J; Year: 2004; Guideline: 412; Klimisch score: 1 | Consortium |
| Repeated dose toxicity: inhalation | Right to refer to study - Title: Subacute inhalation toxicity on rats; Author: Pauluhn J; Year: 2004; Guideline: 412; Klimisch score: 1 | Covestro Deutschland AG |
| Toxicity to reproduction | Robust Study Summary - Title: Reproduction/Developmental Toxicity Screening Test in rats ; Author: Eiben R & Rosenbruch M; Year: 2004; Guideline: 421, 422; Klimisch score: 1 | Consortium |
| Toxicity to reproduction | Right to refer to study - Title: Reproduction/Developmental Toxicity Screening Test in rats ; Author: Eiben R & Rosenbruch M; Year: 2004; Guideline: 421, 422; Klimisch score: 1 | Covestro Deutschland AG |
| Genetic toxicity in vitro | Robust Study Summary - Title: Desmodur W, in vitro chromosome aberration test with chinese hamster V79 cells; Author: Herbold B; Year: 2004; Guideline: 473, 485; Klimisch score: 1 | Consortium |
| Genetic toxicity in vitro | Right to refer to study - Title: Desmodur W, in vitro chromosome aberration test with chinese hamster V79 cells; Author: Herbold B; Year: 2004; Guideline: 473, 485; Klimisch score: 1 | Covestro Deutschland AG |
| Toxicity to aquatic algae and cyanobacteria | Robust Study Summary - Title: Investigation of the ecological properties of Desmodur W; Author: Bayer AG; Year: 2000; Guideline: 201; Klimisch score: 2 | Consortium |
| Toxicity to aquatic algae and cyanobacteria | Right to refer to study - Title: Investigation of the ecological properties of Desmodur W; Author: Bayer AG; Year: 2000; Guideline: 201; Klimisch score: 2 | Covestro Deutschland AG |
| Dissociation constant | Robust Study Summary - Title: waived | public |
| Dissociation constant | Right to refer to study - Title: waived | public |
| Viscosity | Robust Study Summary - Title: Physicochemical properties of 4,4'-dicyclohexylmethane diisocyanate.; Author: Zhuravlev EZ, Selivanov VD, Mulyanov PV, Konstantinov II ; Year: 1975; Guideline: 114; Klimisch score: 2 | public |
| Viscosity | Right to refer to study - Title: Physicochemical properties of 4,4'-dicyclohexylmethane diisocyanate.; Author: Zhuravlev EZ, Selivanov VD, Mulyanov PV, Konstantinov II ; Year: 1975; Guideline: 114; Klimisch score: 2 | Publication |
| Genetic toxicity in vivo | Robust Study Summary - Guideline: 486 | public |
| Genetic toxicity in vivo | Right to refer to study - Guideline: 486 | public |
| Long-term toxicity to fish | Robust Study Summary - Title: waived | public |
| Long-term toxicity to fish | Right to refer to study - Title: waived | public |
| Long-term toxicity to aquatic invertebrates | Robust Study Summary - Title: waived | public |
| Long-term toxicity to aquatic invertebrates | Right to refer to study - Title: waived | public |
| Toxicity to terrestrial plants | Robust Study Summary - Title: waived | public |
| Toxicity to terrestrial plants | Right to refer to study - Title: waived | public |
| Toxicity to soil macroorganisms except arthropods | Robust Study Summary - Title: waived | public |
| Toxicity to soil macroorganisms except arthropods | Right to refer to study - Title: waived | public |
| Toxicity to microorganisms | Robust Study Summary - Title: Investigation of the ecological properties of Desmodur W; Author: Bayer AG; Year: 2000; Guideline: 209; Klimisch score: 1 | Consortium |
| Toxicity to microorganisms | Right to refer to study - Title: Investigation of the ecological properties of Desmodur W; Author: Bayer AG; Year: 2000; Guideline: 209; Klimisch score: 1 | Covestro Deutschland AG |
| Biodegradation in water and sediment: simulation tests | Robust Study Summary - Title: waived | public |
| Biodegradation in water and sediment: simulation tests | Right to refer to study - Title: waived | public |
| Adsorption / desorption | Robust Study Summary - Title: QSAR Estimations for Cyclohexane, 1,1'methylenbis-4-isocyanato-, CAS:5124-30-1 (Desmodur W) ; Author: Currenta GmbH & Co. OHG; Year: 2009; Guideline: 106; Klimisch score: 2 | Consortium |
| Adsorption / desorption | Right to refer to study - Title: QSAR Estimations for Cyclohexane, 1,1'methylenbis-4-isocyanato-, CAS:5124-30-1 (Desmodur W) ; Author: Currenta GmbH & Co. OHG; Year: 2009; Guideline: 106; Klimisch score: 2 | Covestro Deutschland AG |
| Repeated dose toxicity: oral | Robust Study Summary - Title: 90-Day Inhalation Study with a 4-week recovery period in Wistar rats; Author: Pauluhn J; Year: 2008; Guideline: 408, 409, 411, 413; Klimisch score: 1 | Consortium |
| Repeated dose toxicity: oral | Right to refer to study - Title: 90-Day Inhalation Study with a 4-week recovery period in Wistar rats; Author: Pauluhn J; Year: 2008; Guideline: 408, 409, 411, 413; Klimisch score: 1 | - |
| Carcinogenicity | Robust Study Summary - Guideline: 453 | public |
| Carcinogenicity | Right to refer to study - Guideline: 453 | public |
| Developmental toxicity/teratogenicity | Robust Study Summary - Title: Developmental toxicity study in rats after inhalation; Author: Langewische FW; Year: 2004; Guideline: 414; Klimisch score: 1 | Consortium |
| Developmental toxicity/teratogenicity | Right to refer to study - Title: Developmental toxicity study in rats after inhalation; Author: Langewische FW; Year: 2004; Guideline: 414; Klimisch score: 1 | Covestro Deutschland AG |
| Toxicity to terrestrial plants | Robust Study Summary - Title: waived | public |
| Toxicity to terrestrial plants | Right to refer to study - Title: waived | public |
| Toxicity to terrestrial arthropods | Robust Study Summary - Title: waived | public |
| Toxicity to terrestrial arthropods | Right to refer to study - Title: waived | public |
| soil simulation test (Aerobic and anaerobic transformation in soil) | Robust Study Summary - Title: waived | public |
| soil simulation test (Aerobic and anaerobic transformation in soil) | Right to refer to study - Title: waived | public |
| Bioaccumulation: aquatic / sediment | Robust Study Summary - Title: QSAR Estimations for Cyclohexane, 1,1'methylenbis-4-isocyanato-, CAS:5124-30-1 (Desmodur W) ; Author: Currenta GmbH & Co. OHG; Year: 2009; Guideline: 305; Klimisch score: 2 | Consortium |
| Bioaccumulation: aquatic / sediment | Right to refer to study - Title: QSAR Estimations for Cyclohexane, 1,1'methylenbis-4-isocyanato-, CAS:5124-30-1 (Desmodur W) ; Author: Currenta GmbH & Co. OHG; Year: 2009; Guideline: 305; Klimisch score: 2 | Covestro Deutschland AG |
| Bioaccumulation: aquatic / sediment | Robust Study Summary - Title: QSAR Estimations for Cyclohexanamine, 4,4'-methylenebis-, CAS:1761-71-3 ; Author: Currenta GmbH & Co. OHG; Year: 2009; Guideline: 305; Klimisch score: 2 | Consortium |
| Bioaccumulation: aquatic / sediment | Right to refer to study - Title: QSAR Estimations for Cyclohexanamine, 4,4'-methylenebis-, CAS:1761-71-3 ; Author: Currenta GmbH & Co. OHG; Year: 2009; Guideline: 305; Klimisch score: 2 | Covestro Deutschland AG |
| Adsorption / desorption | Robust Study Summary - Title: QSAR Estimations for Cyclohexanamine, 4,4'-methylenebis-, CAS:1761-71-3 ; Author: Currenta GmbH & Co. OHG; Year: 2009; Guideline: 106; Klimisch score: 2 | Consortium |
| Adsorption / desorption | Right to refer to study - Title: QSAR Estimations for Cyclohexanamine, 4,4'-methylenebis-, CAS:1761-71-3 ; Author: Currenta GmbH & Co. OHG; Year: 2009; Guideline: 106; Klimisch score: 2 | Covestro Deutschland AG |
| CSR | CSR | Consortium |