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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Safety data sheet "Vestanat T 1890/100" Version 6.5/DE | Author: Evonik Degussa GmbH | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Safety data sheet "Vestanat T 1890/100" Version 6.5/DE | Author: Evonik Degussa GmbH | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of the melting point / boiling point of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2010 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of the melting point / boiling point of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2010 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of the glass transition temperature of Vestanat T 1890/100 | Author: Steinheuer A | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of the glass transition temperature of Vestanat T 1890/100 | Author: Steinheuer A | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Determination of the melting point / boiling point of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2010 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Determination of the melting point / boiling point of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2010 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Determination of the relative density of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2010 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Determination of the relative density of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2010 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Determination of the vapour pressure of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2010 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Determination of the vapour pressure of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2010 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Physikalisch-chemische Daten und Verbleib von Isophorondiisocyanat Homopolymer | Author: Evonik Degussa GmbH | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. Read-Across (CAS 67873-91-0 | EC 267-445-2 | 1,3,5-tris[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-1,3,5-triazinane-2,4,6-trione) |
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| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Physikalisch-chemische Daten und Verbleib von Isophorondiisocyanat Homopolymer | Author: Evonik Degussa GmbH | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. Read-Across (CAS 67873-91-0 | EC 267-445-2 | 1,3,5-tris[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyl]-1,3,5-triazinane-2,4,6-trione) |
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| Phys-Chem | Explosive properties | Robust Study Summary -- Title: Determination of the explosion properties of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2009 | Guideline: A.14 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Explosive properties | Right to refer to study -- Title: Determination of the explosion properties of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2009 | Guideline: A.14 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Determination of the flammability of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2009 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Determination of the flammability of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2009 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute dermal irritation/corrosion test (patch test) of Vestanat T 1890/100 in rabbits according to EC guideline B.4. and OECD guideline 404 | Author: LPT (Laboratory et al. | Year: 2005 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Acute dermal irritation/corrosion test (patch test) of Vestanat T 1890/100 in rabbits according to EC guideline B.4. and OECD guideline 404 | Author: LPT (Laboratory et al. | Year: 2005 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Acute eye irritation study of Desmodur Z 4470 MPA/X by instillation into the conjunctival sac of rabbits - according to EC guideline B.5. and OECD guideline 405 | Author: LPT (Laboratory et al. | Year: 2002 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Acute eye irritation study of Desmodur Z 4470 MPA/X by instillation into the conjunctival sac of rabbits - according to EC guideline B.5. and OECD guideline 405 | Author: LPT (Laboratory et al. | Year: 2002 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Desmodur Z 4470 MPA/X - local lymph node assay in mice (LLNA/IMDS) | Author: Vohr HW | Year: 2003 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Desmodur Z 4470 MPA/X - local lymph node assay in mice (LLNA/IMDS) | Author: Vohr HW | Year: 2003 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Assessment of contact hypersensitivity to Vestanat T 1890 SV in the albino guinea pig (maximisation-test) | Author: NOTOX B.V. | Year: 2004 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Assessment of contact hypersensitivity to Vestanat T 1890 SV in the albino guinea pig (maximisation-test) | Author: NOTOX B.V. | Year: 2004 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella typhimurium and Escherichia coli reverse mutation assay with Oligomerization product (isocyanurate type) of isophorone diisocyanate | Author: Harlan CCR | Year: 2009 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Salmonella typhimurium and Escherichia coli reverse mutation assay with Oligomerization product (isocyanurate type) of isophorone diisocyanate | Author: Harlan CCR | Year: 2009 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Chromosomal aberration test with IPDI Trimer in cultured Chinese hamster ovary (CHO) cells | Author: de Vogel N | Year: 2007 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Chromosomal aberration test with IPDI Trimer in cultured Chinese hamster ovary (CHO) cells | Author: de Vogel N | Year: 2007 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: In vitro gene mutation test in CHO cells (HPRT locus assay) with IPDI trimer | Author: Schulz M et al. | Year: 2007 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: In vitro gene mutation test in CHO cells (HPRT locus assay) with IPDI trimer | Author: Schulz M et al. | Year: 2007 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Akute Toxizitätsprüfung von IPDI-Addukt T 1890 nach oraler Applikation an der Ratte | Author: IBR Inter. Bio-Research | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Akute Toxizitätsprüfung von IPDI-Addukt T 1890 nach oraler Applikation an der Ratte | Author: IBR Inter. Bio-Research | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Vestanat T 1890/100 - study on acute inhalation toxicity in rats according to OECD 403 | Author: Bayer AG | Year: 1996 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Vestanat T 1890/100 - study on acute inhalation toxicity in rats according to OECD 403 | Author: Bayer AG | Year: 1996 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Analysis of bronchoalveolar-lavage following acute inhalation toxicity in rats (exposure 1 x 6 hours) | Author: Pauluhn J | Year: 2003 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Analysis of bronchoalveolar-lavage following acute inhalation toxicity in rats (exposure 1 x 6 hours) | Author: Pauluhn J | Year: 2003 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: IPDI Trimer - subacute 14-day inhalation study in Wistar rats - dust aerosol exposure | Author: Ma-Hock L et al. | Year: 2009 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: IPDI Trimer - subacute 14-day inhalation study in Wistar rats - dust aerosol exposure | Author: Ma-Hock L et al. | Year: 2009 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A combined reproduction neonatal development and neurotoxicity study with 16-hexamethylene diisocyanate (HDI) in the rat | Author: Astroff AB et al | Year: 2000 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. Read-Across (CAS 822-06-0 | EC 212-485-8 | 1,6-diisocyanatohexane) |
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| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A combined reproduction neonatal development and neurotoxicity study with 16-hexamethylene diisocyanate (HDI) in the rat | Author: Astroff AB et al | Year: 2000 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. Read-Across (CAS 822-06-0 | EC 212-485-8 | 1,6-diisocyanatohexane) |
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| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using 16-hexamethylene diisocyanate (HDI) in the Sprague-Dawley rat. | Author: Astroff AB | Year: 1999 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. Read-Across (CAS 822-06-0 | EC 212-485-8 | 1,6-diisocyanatohexane) |
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| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using 16-hexamethylene diisocyanate (HDI) in the Sprague-Dawley rat. | Author: Astroff AB | Year: 1999 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. Read-Across (CAS 822-06-0 | EC 212-485-8 | 1,6-diisocyanatohexane) |
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| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Reproduction/Developmental Toxicity Screening Test in rats | Author: Eiben R & Rosenbruch M | Year: 2004 | Guideline: 421 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. Read-Across (CAS 5124-30-1 | EC 225-863-2 | 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane) |
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| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Reproduction/Developmental Toxicity Screening Test in rats | Author: Eiben R & Rosenbruch M | Year: 2004 | Guideline: 421 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. Read-Across (CAS 5124-30-1 | EC 225-863-2 | 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane) |
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| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Vestanat T 1890/100 - Determination of the acute toxicity for the fish Cyprinus carpio | Author: Infracor GmbH | Year: 2000 | Guideline: EU C.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Vestanat T 1890/100 - Determination of the acute toxicity for the fish Cyprinus carpio | Author: Infracor GmbH | Year: 2000 | Guideline: EU C.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: DESMODUR Z 4470 MPA/X Acute Immobilisation Test (48 h) to Daphnia magna STRAUS | Author: Noack A | Year: 2002 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: DESMODUR Z 4470 MPA/X Acute Immobilisation Test (48 h) to Daphnia magna STRAUS | Author: Noack A | Year: 2002 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: DESMODUR Z 4470 MPA/X Alga Growth Inhibition Test with Scenedesmus subspicatus 72 h Limit-Test | Author: Scheerbaum D | Year: 2002 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: DESMODUR Z 4470 MPA/X Alga Growth Inhibition Test with Scenedesmus subspicatus 72 h Limit-Test | Author: Scheerbaum D | Year: 2002 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of the hydrolysis as a function of pH of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2010 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of the hydrolysis as a function of pH of Vestanat T 1890/100 | Author: AQura GmbH | Year: 2010 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: IPDI trimer - biodegradation | Author: Weyers A | Year: 2007 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: IPDI trimer - biodegradation | Author: Weyers A | Year: 2007 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of the hydrolysis of IPDI trimer, Bayer Industry Services GmbH & Co. | Author: Feldhues E | Year: 2007 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of the hydrolysis of IPDI trimer, Bayer Industry Services GmbH & Co. | Author: Feldhues E | Year: 2007 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Akute orale Toxizität - Prüfmuster: Desmodur VP KL 5-2426 | Author: Bayer AG | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Akute orale Toxizität - Prüfmuster: Desmodur VP KL 5-2426 | Author: Bayer AG | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute skin irritation test (patch test) of Desmodur Z 4470 MPA/X in rabbits | Author: LPT (Laboratory et al. | Year: 2002 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Acute skin irritation test (patch test) of Desmodur Z 4470 MPA/X in rabbits | Author: LPT (Laboratory et al. | Year: 2002 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Prüfung von IPDI-T 1890 im Augenreiztest am Kaninchen | Author: IBR Inter. Bio-Research | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Prüfung von IPDI-T 1890 im Augenreiztest am Kaninchen | Author: IBR Inter. Bio-Research | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs | Author: Zissu D, et al. | Year: 1998 | Guideline: EU B.6 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs | Author: Zissu D, et al. | Year: 1998 | Guideline: EU B.6 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Prüfung von "IPDI-T 1890" im epicutanen Sensibilisierungstest an der Meerschweinchenhaut (25 %ig in Sojabohnenöl) | Author: IBR Inter. Bio-Research | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Prüfung von "IPDI-T 1890" im epicutanen Sensibilisierungstest an der Meerschweinchenhaut (25 %ig in Sojabohnenöl) | Author: IBR Inter. Bio-Research | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Desmodur Z 4470 MPA/X - special study - Ames-test screening | Author: Herbold B | Year: 2002 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Desmodur Z 4470 MPA/X - special study - Ames-test screening | Author: Herbold B | Year: 2002 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |