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| Study name | Short Description | Data Owner |
|---|---|---|
| Carcinogenicity | Right to refer to study - Title: Toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CAS No. 75-09-2) in F344/N rats and B6C3F1 mice (inhalation studies); Author: NTP; Year: 1986; Klimisch score: 2 (reliable with restrictions) | - |
| Carcinogenicity | Robust Study Summary - Title: Toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CAS No. 75-09-2) in F344/N rats and B6C3F1 mice (inhalation studies); Author: NTP; Year: 1986; Klimisch score: 2 (reliable with restrictions) | - |
| Carcinogenicity | Right to refer to study - Title: Toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CAS No. 75-09-2) in F344/N rats and B6C3F1 mice (inhalation studies); Author: NTP; Year: 1986; Klimisch score: 2 (reliable with restrictions) | - |
| Carcinogenicity | Robust Study Summary - Title: Toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CAS No. 75-09-2) in F344/N rats and B6C3F1 mice (inhalation studies); Author: NTP; Year: 1986; Klimisch score: 2 (reliable with restrictions) | - |
| Biodegradation in water and sediment: simulation tests | Right to refer to study - Title: Introductory study of the biodegradation of the chlorinated methane, ethane, and ethene compounds. Progress Report ; Author: Wood PR, Parsons FZ, DeMarco J, Harween HJ, Lang RF, Ruiz MC ; Year: 1980; Klimisch score: 2 (reliable with restrictions) | - |
| Biodegradation in water and sediment: simulation tests | Robust Study Summary - Title: Introductory study of the biodegradation of the chlorinated methane, ethane, and ethene compounds. Progress Report ; Author: Wood PR, Parsons FZ, DeMarco J, Harween HJ, Lang RF, Ruiz MC ; Year: 1980; Klimisch score: 2 (reliable with restrictions) | - |
| Biodegradation in soil | Right to refer to study - Title: The biodegradation of methylene chloride in soils; Author: Davis JW, Madsen SS; Year: 1991; Klimisch score: 2 (reliable with restrictions) | - |
| Biodegradation in soil | Robust Study Summary - Title: The biodegradation of methylene chloride in soils; Author: Davis JW, Madsen SS; Year: 1991; Klimisch score: 2 (reliable with restrictions) | - |
| Bioaccumulation: aquatic / sediment | Right to refer to study - Title: Bio-accumulation study on dichloromethane; Author: Chemicals Inspection and Testing Institute, Japan ; Year: 1986; Klimisch score: 2 (reliable with restrictions) | - |
| Bioaccumulation: aquatic / sediment | Robust Study Summary - Title: Bio-accumulation study on dichloromethane; Author: Chemicals Inspection and Testing Institute, Japan ; Year: 1986; Klimisch score: 2 (reliable with restrictions) | - |
| Distribution modelling | Right to refer to study - Title: EPISUITE Level III fugacity model, US Environmental Protection Agency; Author: USEPA; Year: 2008; Klimisch score: 2 (reliable with restrictions) | - |
| Distribution modelling | Robust Study Summary - Title: EPISUITE Level III fugacity model, US Environmental Protection Agency; Author: USEPA; Year: 2008; Klimisch score: 2 (reliable with restrictions) | - |
| Repeated dose toxicity: oral | Right to refer to study - Title: A two-year drinking-water study of dichloromethane in rodents I. Rats; Author: Serota DG, Thakur AK, Ulland BM, Kirschman JC, Brown NM, Coots RG, Morgareidge K; Year: 1986; Klimisch score: 2 (reliable with restrictions) | - |
| Repeated dose toxicity: oral | Robust Study Summary - Title: A two-year drinking-water study of dichloromethane in rodents I. Rats; Author: Serota DG, Thakur AK, Ulland BM, Kirschman JC, Brown NM, Coots RG, Morgareidge K; Year: 1986; Klimisch score: 2 (reliable with restrictions) | - |
| Repeated dose toxicity: inhalation | Right to refer to study - Title: Methylene chloride: A 2-year inhalation toxicity and oncogenicity study in rats. ; Author: Nitschke KD, Burek JD, Bell TJ, Kociba RJ, Rampy LW, McKenna MJ; Year: 1988; Klimisch score: 1 (reliable without restriction) | - |
| Repeated dose toxicity: inhalation | Robust Study Summary - Title: Methylene chloride: A 2-year inhalation toxicity and oncogenicity study in rats. ; Author: Nitschke KD, Burek JD, Bell TJ, Kociba RJ, Rampy LW, McKenna MJ; Year: 1988; Klimisch score: 1 (reliable without restriction) | - |
| Developmental toxicity / teratogenicity | Right to refer to study - Title: Absence of dichloromethane teratogenicity with inhalation exposure in rats; Author: Hardin BD, Manson JM; Year: 1980; Klimisch score: 2 (reliable with restrictions) | - |
| Developmental toxicity / teratogenicity | Robust Study Summary - Title: Absence of dichloromethane teratogenicity with inhalation exposure in rats; Author: Hardin BD, Manson JM; Year: 1980; Klimisch score: 2 (reliable with restrictions) | - |
| Developmental toxicity / teratogenicity | Right to refer to study - Title: The effect of maternally inhaled trichloroethylene, perchloroethylene, methylene chloroform, methylene chloride on embryonal and fetal development in mice and rats; Author: Dow Chemical Company; Year: 1974; Klimisch score: 2 (reliable with restrictions) | - |
| Developmental toxicity / teratogenicity | Robust Study Summary - Title: The effect of maternally inhaled trichloroethylene, perchloroethylene, methylene chloroform, methylene chloride on embryonal and fetal development in mice and rats; Author: Dow Chemical Company; Year: 1974; Klimisch score: 2 (reliable with restrictions) | - |
| Melting point/freezing point | Right to refer to study - Title: CRC Handbook of chemistry and physics; Author: Lide DR; Year: 1994; Klimisch score: 2 (reliable with restrictions) | - |
| Melting point/freezing point | Robust Study Summary - Title: CRC Handbook of chemistry and physics; Author: Lide DR; Year: 1994; Klimisch score: 2 (reliable with restrictions) | - |
| Boiling point | Right to refer to study - Title: CRC handbook of chemistry and physics; Author: Lide DR ; Year: 1994; Klimisch score: 2 (reliable with restrictions) | - |
| Boiling point | Robust Study Summary - Title: CRC handbook of chemistry and physics; Author: Lide DR ; Year: 1994; Klimisch score: 2 (reliable with restrictions) | - |
| Density | Right to refer to study - Author: Weast RC, Astle MJ, Beyer WH; Year: 1988; Klimisch score: 2 (reliable with restrictions) | - |
| Density | Robust Study Summary - Author: Weast RC, Astle MJ, Beyer WH; Year: 1988; Klimisch score: 2 (reliable with restrictions) | - |
| Vapour pressure | Right to refer to study - Title: Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals; Author: Mackay D, Shiu WY, Ma KC; Year: 1993; Klimisch score: 2 (reliable with restrictions) | - |
| Vapour pressure | Robust Study Summary - Title: Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals; Author: Mackay D, Shiu WY, Ma KC; Year: 1993; Klimisch score: 2 (reliable with restrictions) | - |
| Partition coefficient | Right to refer to study - Title: Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals; Author: Mackay D, Shiu WY, Ma KC; Year: 1993; Klimisch score: 2 (reliable with restrictions) | - |
| Partition coefficient | Robust Study Summary - Title: Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals; Author: Mackay D, Shiu WY, Ma KC; Year: 1993; Klimisch score: 2 (reliable with restrictions) | - |
| Partition coefficient | Right to refer to study - Title: Estimation of log Kow for dichloromethane (CAS 75?09?2 ) using EPISUITE 4.0; Author: Zvinavashe E; Year: 2012; Klimisch score: 2 (reliable with restrictions) | - |
| Partition coefficient | Robust Study Summary - Title: Estimation of log Kow for dichloromethane (CAS 75?09?2 ) using EPISUITE 4.0; Author: Zvinavashe E; Year: 2012; Klimisch score: 2 (reliable with restrictions) | - |
| Water solubility | Right to refer to study - Title: Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals; Author: Mackay D, Shiu WY, Ma KC; Year: 1993; Klimisch score: 2 (reliable with restrictions) | - |
| Water solubility | Robust Study Summary - Title: Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals; Author: Mackay D, Shiu WY, Ma KC; Year: 1993; Klimisch score: 2 (reliable with restrictions) | - |
| Biodegradation in water: screening tests | Right to refer to study - Title: Biodegradability of dichloromethane (CAS 75-09-2) in the closed bottle test (OECD TG 301D); Author: Ginkel van CG; Year: 2012; Klimisch score: 1 (reliable without restriction) | - |
| Biodegradation in water: screening tests | Robust Study Summary - Title: Biodegradability of dichloromethane (CAS 75-09-2) in the closed bottle test (OECD TG 301D); Author: Ginkel van CG; Year: 2012; Klimisch score: 1 (reliable without restriction) | - |
| Short-term toxicity to fish | Right to refer to study - Title: Toxicity of perchloroethane, and methylene chloride to fathead minnows; Author: Alexander HC, McCarty WM, Bartlett EA; Year: 1978; Klimisch score: 2 (reliable with restrictions) | - |
| Short-term toxicity to fish | Robust Study Summary - Title: Toxicity of perchloroethane, and methylene chloride to fathead minnows; Author: Alexander HC, McCarty WM, Bartlett EA; Year: 1978; Klimisch score: 2 (reliable with restrictions) | - |
| Short-term toxicity to aquatic invertebrates | Right to refer to study - Title: Toxicity of methylene chloride to daphnids; Author: McCarty WM; Year: 1979; Klimisch score: 2 (reliable with restrictions) | - |
| Short-term toxicity to aquatic invertebrates | Robust Study Summary - Title: Toxicity of methylene chloride to daphnids; Author: McCarty WM; Year: 1979; Klimisch score: 2 (reliable with restrictions) | - |
| Short-term toxicity to aquatic invertebrates | Right to refer to study - Title: Acute Toxicity of Cadmium, Copper, Zinc, Ammonia, 3,3Æ-Dichlorobenzidine, 2,6-Dichloro-4-Nitroaniline, Methylene Chloride and 2,4,6- Trichlorophenol to Juvenile Grass Shrimp and Kilifish; Author: Burton DT, Fisher DJ; Year: 1990; Klimisch score: 2 (reliable with restrictions) | - |
| Short-term toxicity to aquatic invertebrates | Robust Study Summary - Title: Acute Toxicity of Cadmium, Copper, Zinc, Ammonia, 3,3Æ-Dichlorobenzidine, 2,6-Dichloro-4-Nitroaniline, Methylene Chloride and 2,4,6- Trichlorophenol to Juvenile Grass Shrimp and Kilifish; Author: Burton DT, Fisher DJ; Year: 1990; Klimisch score: 2 (reliable with restrictions) | - |
| Acute toxicity: oral | Right to refer to study - Title: Acute oral toxicity study with dichloromethane in rats. ; Author: Janssen PJM, Pot TE; Year: 1988; Klimisch score: 1 (reliable without restriction) | - |
| Acute toxicity: oral | Robust Study Summary - Title: Acute oral toxicity study with dichloromethane in rats. ; Author: Janssen PJM, Pot TE; Year: 1988; Klimisch score: 1 (reliable without restriction) | - |
| Skin irritation / corrosion | Right to refer to study - Title: Investigation of a possibility to reduce the use of rabbits in skin irritation tests; experiments with dichloromethane, trichloroethylene, tetrachloroethylene and 1,1,1-trichloroethane ; Author: Beek van L; Year: 1990; Klimisch score: 2 (reliable with restrictions) | - |
| Skin irritation / corrosion | Robust Study Summary - Title: Investigation of a possibility to reduce the use of rabbits in skin irritation tests; experiments with dichloromethane, trichloroethylene, tetrachloroethylene and 1,1,1-trichloroethane ; Author: Beek van L; Year: 1990; Klimisch score: 2 (reliable with restrictions) | - |
| Skin sensitisation | Right to refer to study - Title: Assessment of contact hypersensitivity to Dichloromethane in the mouse (Local Lymph Node Assay); Author: Huygevoort AHBM; Year: 2010; Klimisch score: 1 (reliable without restriction) | - |
| Skin sensitisation | Robust Study Summary - Title: Assessment of contact hypersensitivity to Dichloromethane in the mouse (Local Lymph Node Assay); Author: Huygevoort AHBM; Year: 2010; Klimisch score: 1 (reliable without restriction) | - |
| Flash point | Right to refer to study - Author: Nabert K, Sch÷n G ; Year: 1963; Klimisch score: 2 (reliable with restrictions) | - |
| Flash point | Robust Study Summary - Author: Nabert K, Sch÷n G ; Year: 1963; Klimisch score: 2 (reliable with restrictions) | - |
| Auto flammability | Right to refer to study - Author: Nabert K, Sch÷n G; Year: 1963; Klimisch score: 2 (reliable with restrictions) | - |
| Auto flammability | Robust Study Summary - Author: Nabert K, Sch÷n G; Year: 1963; Klimisch score: 2 (reliable with restrictions) | - |
| Hydrolysis | Right to refer to study - Title: Evaporation rates of methyl chloride, chloroform, 1,1,1-trichloroethane, trichloroethylene, tetrachloroethylene, and other chlorinated compounds in dilute aqueous solutions; Author: Dilling WL, Tefertiller NB, & Kallos GJ; Year: 1975; Klimisch score: 2 (reliable with restrictions) | - |
| Hydrolysis | Robust Study Summary - Title: Evaporation rates of methyl chloride, chloroform, 1,1,1-trichloroethane, trichloroethylene, tetrachloroethylene, and other chlorinated compounds in dilute aqueous solutions; Author: Dilling WL, Tefertiller NB, & Kallos GJ; Year: 1975; Klimisch score: 2 (reliable with restrictions) | - |
| Acute toxicity: inhalation | Right to refer to study - Title: The toxicity and narcotic action of mono-chloromono- bromo-methane with special reference to inorganic and volatile bromide in blood, urine and brain.; Author: Svirbely JL, Highman B, Alford WF, et al.; Year: 1947; Klimisch score: 2 (reliable with restrictions) | - |
| Acute toxicity: inhalation | Robust Study Summary - Title: The toxicity and narcotic action of mono-chloromono- bromo-methane with special reference to inorganic and volatile bromide in blood, urine and brain.; Author: Svirbely JL, Highman B, Alford WF, et al.; Year: 1947; Klimisch score: 2 (reliable with restrictions) | - |
| Acute toxicity: dermal | Right to refer to study - Title: Acute dermal toxicity study with dichloromethane in rats; Author: Janssen PJM, Pot TE ; Year: 1988; Klimisch score: 1 (reliable without restriction) | - |
| Acute toxicity: dermal | Robust Study Summary - Title: Acute dermal toxicity study with dichloromethane in rats; Author: Janssen PJM, Pot TE ; Year: 1988; Klimisch score: 1 (reliable without restriction) | - |
| Eye irritation | Right to refer to study - Title: Ophthalmic toxicology of dichloromethane; Author: Ballantyne B, Gazzard MF, Swanson DW; Year: 1976; Klimisch score: 2 (reliable with restrictions) | - |
| Eye irritation | Robust Study Summary - Title: Ophthalmic toxicology of dichloromethane; Author: Ballantyne B, Gazzard MF, Swanson DW; Year: 1976; Klimisch score: 2 (reliable with restrictions) | - |
| Genetic toxicity in vitro | Right to refer to study - Title: Induction of chromosome damage by methylene chloride in CHO cells; Author: Thilagar AK, Kumaroo PV; Year: 1983; Klimisch score: 2 (reliable with restrictions) | - |
| Genetic toxicity in vitro | Robust Study Summary - Title: Induction of chromosome damage by methylene chloride in CHO cells; Author: Thilagar AK, Kumaroo PV; Year: 1983; Klimisch score: 2 (reliable with restrictions) | - |
| Toxicity to reproduction | Right to refer to study - Title: Methylene Chloride: Two generation inhalation reproduction study in fischer 344 rats; Author: Dow Chemical Company; Year: 1985; Klimisch score: 2 (reliable with restrictions) | - |
| Toxicity to reproduction | Robust Study Summary - Title: Methylene Chloride: Two generation inhalation reproduction study in fischer 344 rats; Author: Dow Chemical Company; Year: 1985; Klimisch score: 2 (reliable with restrictions) | - |
| Genetic toxicity in vitro | Right to refer to study - Title: Mutagenicity of cosmetic ingredients licensed by the European Communities; Author: Gocke E, King M-T, Eckhardt K, Wild D ; Year: 1981; Klimisch score: 2 (reliable with restrictions) | - |
| Genetic toxicity in vitro | Robust Study Summary - Title: Mutagenicity of cosmetic ingredients licensed by the European Communities; Author: Gocke E, King M-T, Eckhardt K, Wild D ; Year: 1981; Klimisch score: 2 (reliable with restrictions) | - |
| Viscosity | Right to refer to study - Title: Excess molar volumes and excess viscosities of 2-propanol + methylacetate + dichloromethane at 298.15 K; Author: Acevedo IL, Postigo MA, Katz M; Year: 1988; Klimisch score: 2 (reliable with restrictions) | - |
| Viscosity | Robust Study Summary - Title: Excess molar volumes and excess viscosities of 2-propanol + methylacetate + dichloromethane at 298.15 K; Author: Acevedo IL, Postigo MA, Katz M; Year: 1988; Klimisch score: 2 (reliable with restrictions) | - |
| Long-term toxicity to fish | Right to refer to study - Title: Toxicity of Methylene Chloride to Life Stages of the Fathead Minnow; Author: Dill DC, Murphy PG, Mayes MA ; Year: 1987; Klimisch score: 2 (reliable with restrictions) | - |
| Long-term toxicity to fish | Robust Study Summary - Title: Toxicity of Methylene Chloride to Life Stages of the Fathead Minnow; Author: Dill DC, Murphy PG, Mayes MA ; Year: 1987; Klimisch score: 2 (reliable with restrictions) | - |
| Toxicity to microorganisms | Right to refer to study - Title: Toxicity assessment of common xenobiotic compounds on municipal activated sludge: comparison between respirometry and Microtoxs; Author: Ricco G, Tomei MC, Ramadori R, Laer R; Year: 2004; Klimisch score: 2 (reliable with restrictions) | - |
| Toxicity to microorganisms | Robust Study Summary - Title: Toxicity assessment of common xenobiotic compounds on municipal activated sludge: comparison between respirometry and Microtoxs; Author: Ricco G, Tomei MC, Ramadori R, Laer R; Year: 2004; Klimisch score: 2 (reliable with restrictions) | - |
| Toxicity to soil microorganisms | Right to refer to study - Title: Effect of trichloroethylene, tetrachloroethylene and dichloromethane on enzymatic activities in soil.; Author: Kanazawa S, Filip Z; Year: 1986; Klimisch score: 2 (reliable with restrictions) | - |
| Toxicity to soil microorganisms | Robust Study Summary - Title: Effect of trichloroethylene, tetrachloroethylene and dichloromethane on enzymatic activities in soil.; Author: Kanazawa S, Filip Z; Year: 1986; Klimisch score: 2 (reliable with restrictions) | - |
| Genetic toxicity in vivo | Right to refer to study - Title: Methylene chloride (dichloromethane): An evaluation in the mouse micronucleus test; Author: Sheldon T, Richardson CR, Hamilton K, Randall V, Hart D, Hollis K; Year: 1986; Klimisch score: 1 (reliable without restriction) | - |
| Genetic toxicity in vivo | Robust Study Summary - Title: Methylene chloride (dichloromethane): An evaluation in the mouse micronucleus test; Author: Sheldon T, Richardson CR, Hamilton K, Randall V, Hart D, Hollis K; Year: 1986; Klimisch score: 1 (reliable without restriction) | - |