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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Physico-chemical Properties Testing on a Sample of 4,4'-MDI / DPG (EC Number: 701-040-8) | Author: Shajad Younis | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Physico-chemical Properties Testing on a Sample of 4,4'-MDI / DPG (EC Number: 701-040-8) | Author: Shajad Younis | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Physico-chemical Properties Testing on a Sample of 4,4'-MDI / DPG (EC Number: 701-040-8) | Author: Shajad Younis | Year: 2019 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Physico-chemical Properties Testing on a Sample of 4,4'-MDI / DPG (EC Number: 701-040-8) | Author: Shajad Younis | Year: 2019 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Physico-chemical Properties Testing on a Sample of 4,4'-MDI / DPG (EC Number: 701-040-8) | Author: Shajad Younis | Year: 2019 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Physico-chemical Properties Testing on a Sample of 4,4'-MDI / DPG (EC Number: 701-040-8) | Author: Shajad Younis | Year: 2019 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Physico-chemical Properties Testing on a Sample of 4,4'-MDI / DPG (EC Number: 701-040-8) | Author: Shajad Younis | Year: 2019 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Physico-chemical Properties Testing on a Sample of 4,4'-MDI / DPG (EC Number: 701-040-8) | Author: Shajad Younis | Year: 2019 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of Log Pow values of MDI and TDI. Finalised report | Author: Yakabe | Year: 1997 | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of Log Pow values of MDI and TDI. Finalised report | Author: Yakabe | Year: 1997 | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Physico-chemical Properties Testing on a Sample of 4,4'-MDI / DPG (EC Number: 701-040-8) | Author: Shajad Younis | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Physico-chemical Properties Testing on a Sample of 4,4'-MDI / DPG (EC Number: 701-040-8) | Author: Shajad Younis | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary Dermal Irritation Study in Rabbits with SUPRASEC@2444, SUPRASEC@2449-PPF1-10, and SUPRASEC@ 2449-PPF1-15 | Author: Vasquez RE | Year: 2011 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary Dermal Irritation Study in Rabbits with SUPRASEC@2444, SUPRASEC@2449-PPF1-10, and SUPRASEC@ 2449-PPF1-15 | Author: Vasquez RE | Year: 2011 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 405 | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 405 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2449 | Author: Mallory VT | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2449 | Author: Mallory VT | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial Reverse Mutation Assay | Author: Wagner VO and VanDyke MR | Year: 2009 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial Reverse Mutation Assay | Author: Wagner VO and VanDyke MR | Year: 2009 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J & Gollapudi B | Year: 2001 | Guideline: 474 | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J & Gollapudi B | Year: 2001 | Guideline: 474 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2449 | Author: Mallory VT | Year: 2009 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2449 | Author: Mallory VT | Year: 2009 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI): acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI): acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit. | Author: Wazeter F.X., Buller R.H., and Geil R. G. | Year: 1964 | Guideline: 402 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit. | Author: Wazeter F.X., Buller R.H., and Geil R. G. | Year: 1964 | Guideline: 402 | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic toxicity/carcinogenicity inhalation study of polymeric methylenediphenyl diisocyanate aerosol in rats. 3 vols | Author: Reuzel PGJ et al. | Year: 1990 | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Chronic toxicity/carcinogenicity inhalation study of polymeric methylenediphenyl diisocyanate aerosol in rats. 3 vols | Author: Reuzel PGJ et al. | Year: 1990 | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Prenatal toxicity of polymeric MDI in rats. Aerosol inhalation. 3 vols | Author: Gamer AO | Year: 1994 | Guideline: 414 | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Prenatal toxicity of polymeric MDI in rats. Aerosol inhalation. 3 vols | Author: Gamer AO | Year: 1994 | Guideline: 414 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M | Year: 2016 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M | Year: 2016 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Water Extractability of (4,4'-) MDI/DPG | Author: Neuland M | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Water Extractability of (4,4'-) MDI/DPG | Author: Neuland M | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of 4,4’-MDI/DPG/HMWP under homogenous reaction conditions | Author: Neuland M | Year: 2021 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of 4,4’-MDI/DPG/HMWP under homogenous reaction conditions | Author: Neuland M | Year: 2021 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Report: 4,4'-MDI/DPG, Determination of the Biodegradability in the Manometric Respiration Test | Author: Damman | Year: 2019 | Guideline: 301F | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Report: 4,4'-MDI/DPG, Determination of the Biodegradability in the Manometric Respiration Test | Author: Damman | Year: 2019 | Guideline: 301F | Adequacy: weight of evidence. | - |