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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of the melting point/melting range of 12-hydroxystearic acid | Author: Fieseler A | Year: 2010 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of the melting point/melting range of 12-hydroxystearic acid | Author: Fieseler A | Year: 2010 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Determination of the boiling point of 12-hydroxystearic acid | Author: Fieseler A | Year: 2010 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Determination of the boiling point of 12-hydroxystearic acid | Author: Fieseler A | Year: 2010 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Determination of the relative density of 12-hydroxy stearic acid | Author: Fieseler A | Year: 2010 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Determination of the relative density of 12-hydroxy stearic acid | Author: Fieseler A | Year: 2010 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Determination of the vapour pressure of oils vegetable deodorizer distillates by isothermogravimetry | Author: Brekelmans MJC | Year: 2010 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Determination of the vapour pressure of oils vegetable deodorizer distillates by isothermogravimetry | Author: Brekelmans MJC | Year: 2010 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the water solubility of 12-hydroxystearic acid | Author: Mollandin G | Year: 2010 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the water solubility of 12-hydroxystearic acid | Author: Mollandin G | Year: 2010 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of the partition coefficient (n-octanol/water) of 12-hydroxystearic acid by high pressure liquid chromatography (HPLC) | Author: Molladin G | Year: 2010 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of the partition coefficient (n-octanol/water) of 12-hydroxystearic acid by high pressure liquid chromatography (HPLC) | Author: Molladin G | Year: 2010 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Determination of the partition coefficient (n-octanol/water) of 12-hydroxystearic acid by high pressure liquid chromatography (HPLC) | Author: Molladin G | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Right to refer to study -- Title: Determination of the partition coefficient (n-octanol/water) of 12-hydroxystearic acid by high pressure liquid chromatography (HPLC) | Author: Molladin G | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: Expert statement on the explosive properties of 12-hydroxystearic acid | Author: Meinerling M | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Explosive properties | Right to refer to study -- Title: Expert statement on the explosive properties of 12-hydroxystearic acid | Author: Meinerling M | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Determination of the flammability of 12-hydroxystearic acid | Author: Fieseler A | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Determination of the flammability of 12-hydroxystearic acid | Author: Fieseler A | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Oxidising properties | Robust Study Summary -- Title: Expert statement on the oxidising properties of 12-hydroxystearic acid | Author: Meinerling M | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Oxidising properties | Right to refer to study -- Title: Expert statement on the oxidising properties of 12-hydroxystearic acid | Author: Meinerling M | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Determination of the relative self-ignition temperature of 12-hydroxystearic acid | Author: Fieseler A | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Determination of the relative self-ignition temperature of 12-hydroxystearic acid | Author: Fieseler A | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: 12-HSA In Vitro Skin Irritation Study using u Reconstructed Human Epidermis (RHE) Model (Episkin™/MTT Method) | Author: L. Bisini | Year: 2021 | Guideline: 439 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: 12-HSA In Vitro Skin Irritation Study using u Reconstructed Human Epidermis (RHE) Model (Episkin™/MTT Method) | Author: L. Bisini | Year: 2021 | Guideline: 439 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Evaluation of 12-HSA in the Bovine Corneal Opacity and Permeability (BCOP) Test Method following OECD Guideline 437 and EU Method B.47 | Author: Annika Himmelsbach | Year: 2022 | Guideline: 437 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Evaluation of 12-HSA in the Bovine Corneal Opacity and Permeability (BCOP) Test Method following OECD Guideline 437 and EU Method B.47 | Author: Annika Himmelsbach | Year: 2022 | Guideline: 437 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Skin sensitization test in Guinea pigs (maximization method of Magnusson and Kligman) | Author: Gerbeix C | Year: 2012 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Skin sensitization test in Guinea pigs (maximization method of Magnusson and Kligman) | Author: Gerbeix C | Year: 2012 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Skin sensitization test in Guinea pigs (maximization method of Magnusson and Kligman) | Author: Gerbeix C | Year: 2012 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Skin sensitization test in Guinea pigs (maximization method of Magnusson and Kligman) | Author: Gerbeix C | Year: 2012 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: 12-hydroxystearic acid: local lymph node assay in the mouse | Author: Sanders A | Year: 2012 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: 12-hydroxystearic acid: local lymph node assay in the mouse | Author: Sanders A | Year: 2012 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Amended final report on the safety assessessment of hydroxystearic acid (Reviewed by the Cosmetic Ingredient Review Expert Panel). | Author: Cosmetic Ingredient Review (CIR) Panel | Year: 1999 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Amended final report on the safety assessessment of hydroxystearic acid (Reviewed by the Cosmetic Ingredient Review Expert Panel) | Author: Cosmetic Ingredient Review (CIR) Panel | Year: 1999 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Amended final report on the safety assessessment of hydroxystearic acid (Reviewed by the Cosmetic Ingredient Review Expert Panel) | Author: Cosmetic Ingredient Review (CIR) Panel | Year: 1999 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: 12-HSA Acute Oral Toxicity Study In Rats (Acute Toxic Class Method) | Author: R. Caruso | Year: 2021 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: 12-HSA Acute Oral Toxicity Study In Rats (Acute Toxic Class Method) | Author: R. Caruso | Year: 2021 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Danish (Q)SAR Database | Author: Division of Diet Disease Prevention and Toxicology National Food Institute Technical University of Denmark | Year: 2017 | Guideline: QSAR | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Danish (Q)SAR Database | Author: Division of Diet Disease Prevention and Toxicology National Food Institute Technical University of Denmark | Year: 2017 | Guideline: QSAR | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Predicting passive intestinal absorption using a single parameter | Author: Sanghvi T, Ni N, Mayersohn M, Yalkowsky SH | Year: 2003 | Guideline: QSAR | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Predicting passive intestinal absorption using a single parameter | Author: Sanghvi T, Ni N, Mayersohn M, Yalkowsky SH | Year: 2003 | Guideline: QSAR | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A 'Rule of Unity' for Human Intestinal Absorption | Author: Yalkowsky SH, Johnson JL, Sanghvi T, Machatha SG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: 12-HSA 2 Week Preliminary Oral Toxicity Study In Rats For OECD 422 | Author: V. Liberati | Year: 2022 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: 12-HSA 2 Week Preliminary Oral Toxicity Study In Rats For OECD 422 | Author: V. Liberati | Year: 2022 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Amended final report on the safety assessessment of hydroxystearic acid (Reviewed by the Cosmetic Ingredient Review Expert Panel). | Author: Cosmetic Ingredient Review (CIR) Panel | Year: 1999 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: 12-Hydroxystearic Acid (CAS 106-14-9) Fish Acute Toxicity Test | Author: François Chastenet | Year: 2022 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: 12-Hydroxystearic Acid (CAS 106-14-9) Fish Acute Toxicity Test | Author: François Chastenet | Year: 2022 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute toxicity of 12-hydroxystearic acid to Daphnia magna in a static 48-hour immobilisation test | Author: Böttcher M and Wydra V | Year: 2010 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Acute toxicity of 12-hydroxystearic acid to Daphnia magna in a static 48-hour immobilisation test | Author: Böttcher M and Wydra V | Year: 2010 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Toxicity of 12-hydroxystearic acid to Pseudokirchneriella subcapitata in an algal growth inhibition test | Author: Böttcher M and Wydra V | Year: 2010 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Toxicity of 12-hydroxystearic acid to Pseudokirchneriella subcapitata in an algal growth inhibition test | Author: Böttcher M and Wydra V | Year: 2010 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: 12-Hydroxystearic Acid (CAS 106-14-9) Activated Sludge Respiration Inhibition Test | Author: François Chastenet | Year: 2022 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: 12-Hydroxystearic Acid (CAS 106-14-9) Activated Sludge Respiration Inhibition Test | Author: François Chastenet | Year: 2022 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: BCFBAF v3.00 (EPIWEB v 4.0) | Author: U.S. Environmental Protection Agency | Year: 2009 | Guideline: QSAR | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: BCFBAF v3.00 (EPIWEB v 4.0) | Author: U.S. Environmental Protection Agency | Year: 2009 | Guideline: QSAR | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: 12-HYDROXYSTEARIC ACID (CAS 106-14-9) READY BIODEGRADABILITY TEST | Author: François Chastenet | Year: 2022 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: 12-HYDROXYSTEARIC ACID (CAS 106-14-9) READY BIODEGRADABILITY TEST | Author: François Chastenet | Year: 2022 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: EAWAG-BBD PPS predictions on degradation products and EPISUITE properties for a screening PBT vPvB assessment | Author: Arkema | Year: 2023 | Guideline: QSAR | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: EAWAG-BBD PPS predictions on degradation products and EPISUITE properties for a screening PBT vPvB assessment | Author: Arkema | Year: 2023 | Guideline: QSAR | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation test - 12-Hydroxystearic acid | Author: NITE | Year: 1989 | Guideline: 301C | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: 12-hydroxystearic acid (CAS 106-14-9) estimation of the adsorption coefficient (Koc) on soil and on sewage sludge using high performance liquid chromatography (HPLC) | Author: François CHASTENET | Year: 2022 | Guideline: 121 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: 12-hydroxystearic acid (CAS 106-14-9) estimation of the adsorption coefficient (Koc) on soil and on sewage sludge using high performance liquid chromatography (HPLC) | Author: François CHASTENET | Year: 2022 | Guideline: 121 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: KOCWIN v2.00 (EPIWEB v 4.0) | Author: U.S. Environmental Protection Agency | Year: 2009 | Guideline: QSAR | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: KOCWIN v2.00 (EPIWEB v 4.0) | Author: U.S. Environmental Protection Agency | Year: 2009 | Guideline: QSAR | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |