You are here: Home> South Korea>K-REACH>CAS 107-46-0> CAS 107-46-0 | Data Package 1 - 10 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Boiling point | Robust Study Summary -- Title: DIPPR Information and Data Evaluation Manager (DIADEM, ver. 3.1.0) for the Design Institute for Physical|Properties. | Author: DIPPR | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Hexamethyldisiloxane: Chemical Thermodynamic Properties and Internal Rotation about the Siloxane Linkage | Author: Scott, D.N., Messerly, J.F., Todd, S.S., Guthrie, G.B., Hossenlopp, I.A., Moore, R.T., Osborn, A., Berg, W.T., McCullough, J.P. | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Hexamethyldisiloxan (M2), acute toxicity to rainbow trout in a flow-through test. | Author: Bayer AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Hexamethyldisiloxan (M2), acute toxicity to rainbow trout in a flow-through test. | Author: Bayer AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Handbook of Data on Organic Compounds. Volume I. 3rd ed. | Author: Lide D.R., Milne G.W.A. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Handbook of Data on Organic Compounds. | Author: Lide, D.R., G.W.A. Milne | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: DIPPR Information and Data Evaluation Manager ((DIADEM, ver. 3.1.0) for the Design Institute for Physical|Properties. | Author: DIPPR | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Hexamethyldisiloxane: Chemical|Thermodynamic Properties and Internal Rotation about the|Siloxane Linkage | Author: Scott, D.N., Messerly, J.F., Todd, S.S., Guthrie, G.B., Hossenlopp, I.A., Moore, R.T., Osborn, A., Berg, W.T., McCullough, J.P. | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to soil microorganisms | Robust Study Summary -- Title: Hexamethyldisiloxane (L2) - Determination of the Effects on Soil Microflora Activity Following OECD Guideline 216 | Author: Smithers Viscient | Year: 2016 | Guideline: 216 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil microorganisms | Right to refer to study -- Title: Hexamethyldisiloxane (L2) - Determination of the Effects on Soil Microflora Activity Following OECD Guideline 216 | Author: Smithers Viscient | Year: 2016 | Guideline: 216 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Internal Technical ReportAn Acute Skin Irritation Study of Dow Corning®|Hexamethyldisiloxane in Albino Rabbits. | Author: Dow Corning Corporation | Year: 1991 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Internal Technical ReportAn Acute Skin Irritation Study of Dow Corning®|Hexamethyldisiloxane in Albino Rabbits. | Author: Dow Corning Corporation | Year: 1991 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Information and Data Evaluation Manager (DIADEM, ver. 3.1.0) for the Design Institute for Physical|Properties. | Author: DIPPR | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: ECOSAR v.1.11 | Author: ECOSAR | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: ECOSAR v.1.11 | Author: ECOSAR | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Untersuchungen zur akuten oralen Toxizität|anmännlichen und weiblichen Wistar-Ratten. | Author: Bayer AG | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Untersuchungen zur akuten oralen Toxizität|anmännlichen und weiblichen Wistar-Ratten. | Author: Bayer AG | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute toxicologic evaluation of|hexamethyldisiloxane. | Author: Bomhard E et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute toxicologic evaluation of|hexamethyldisiloxane. | Author: Bomhard E et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation test of LS-7130 by microorganisms | Author: Kurume Research Laboratories | Year: 1994 | Guideline: 301C | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Biodegradation test of LS-7130 by microorganisms | Author: Kurume Research Laboratories | Year: 1994 | Guideline: 301C | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Brady, J.E. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Safety Data Sheet | Author: GE-Bayer Silicones | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Metal-Organics for Material & Polymer Technology Supplement to the Gelest General Catalogue: Silicon, Germanium & Tin Compounds, Metal Alkoxides, Diketoniates and Carboxylates , | Author: Barry Arkles, Editor | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Hydrolysis of Hexamethyldisiloxane (HMDS) | Author: Dow Corning Corporation | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Surface tension | Right to refer to study -- Title: Hydrolysis of Hexamethyldisiloxane (HMDS) | Author: Dow Corning Corporation | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: No information | Author: Dow Corning Corporation | Year: 1983 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: No information | Author: Dow Corning Corporation | Year: 1983 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella/Mikrosomen-Test zur Untersuchung auf punktmutagene Wirkung Hexamethyldisiloxan (M2) | Author: Bayer | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Salmonella/Mikrosomen-Test zur Untersuchung auf punktmutagene Wirkung Hexamethyldisiloxan (M2) | Author: Bayer | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mutagenicity Evaluation of Hexamethyldisiloxane (Me3Si)2O. Final report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Genetic Testing of Basic Methyl Silanes and Siloxanes. Private Communication | Author: Brusick, D. | Year: 1978 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith, A. et al. | Year: 1988 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mutagenicity Evaluation of Hexamethyldisiloxane (Me3Si)2O. Final report | Author: Litton Bionetics | Year: 1978 | Guideline: B.19 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith, A. et al. | Year: 1988 | Guideline: B.19 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mutagenicity Evaluation of Hexamethyldisiloxane (Me3Si)2O. Final report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Information and Data Evaluation Manager ((DIADEM, ver. 3.1.0) for the Design Institute for Physical|Properties. | Author: DIPPR | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data | Author: Haynes, W. M., Lide, D. R. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Temperature Dependence of Air/Water, 1-Octanol/Air, and 1-Octanol/Water Partitioning Coefficients of Hexamethyldisiloxane (L2) (CAS No. 107-46-0) | Author: Dow Corning Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Temperature Dependence of Air/Water, 1-Octanol/Air, and 1-Octanol/Water Partitioning Coefficients of Hexamethyldisiloxane (L2) (CAS No. 107-46-0) | Author: Dow Corning Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Temperature Dependence of Air/Water, 1-Octanol/Air, and 1-Octanol/Water Partitioning Coefficients of Hexamethyldisiloxane (L2) (CAS No. 107-46-0) | Author: Xu, S.; Kropscott, B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Temperature Dependence of Air/Water, 1-Octanol/Air, and 1-Octanol/Water Partitioning Coefficients of Hexamethyldisiloxane (L2) (CAS No. 107-46-0) | Author: Xu, S.; Kropscott, B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: 1-Octanol/Air Partitioning Coefficients of Hexamethyldisiloxane (L2), Octamethyltrisiloxane (L3) and Decamethyltetrasiloxane (L4) at Four Different Temperatures. | Author: Xu S | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: 1-Octanol/Air Partitioning Coefficients of Hexamethyldisiloxane (L2), Octamethyltrisiloxane (L3) and Decamethyltetrasiloxane (L4) at Four Different Temperatures. | Author: Xu S | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Bioaccumulation test of LS-7130 in Carp | Author: Matsunobu Y | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Bioaccumulation test of LS-7130 in Carp | Author: Matsunobu Y | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: An acute skin irritation|study (expanded range finding) with Dow Corning Q7-9179 | Author: Dow Corning Corporation | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: An acute skin irritation|study (expanded range finding) with Dow Corning Q7-9179 | Author: Dow Corning Corporation | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: No information | Author: Dow Corning Corporation | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: No information | Author: Dow Corning Corporation | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Silicone Fluid Y-4081:Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Silicone Fluid Y-4081:Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Hexamethyldisiloxane F-221. | Author: Stauffer Chemical Company | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Hexamethyldisiloxane F-221. | Author: Stauffer Chemical Company | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A skin sensitization study of hexamethyldisiloxane in guinea pigs | Author: Dow Corning Corporation | Year: 1992 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: A skin sensitization study of hexamethyldisiloxane in guinea pigs | Author: Dow Corning Corporation | Year: 1992 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Measurement of Thermophysical Pure Component Properties for a Fee Siloxanes Used as Working Fluids for Organic Rankine Cycles | Author: Abbas, R., Schedemann, A., Ihmels, C., Enders, S., Gmehling, J. | Year: 2011 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Flaningan, O.L. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Physical properties determination of Silanes. | Author: Kohn D Y | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Physical properties determination of Silanes. | Author: Kohn D Y | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Human repeated insult patch test with hexamethyldisiloxane | Author: TKL Research | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Human repeated insult patch test with hexamethyldisiloxane | Author: TKL Research | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow of hexamethyldisiloxane | Author: Peter Fisk Associates | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow of hexamethyldisiloxane | Author: Peter Fisk Associates | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: QSAR Model Reporting Format: KOWWIN v 1.68 (EPI Suite) for the calculation of the n-octanol-water partition coefficient (log Kow) of organosilicon compounds. Version 2. | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Model Reporting Format: KOWWIN v 1.68 (EPI Suite) for the calculation of the n-octanol-water partition coefficient (log Kow) of organosilicon compounds. Version 2. | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Aqueous Solubility of Permethoxysiloxanes (Silicones) | Author: Varaprath, S., Frye, C. L., Hamelink, J. | Year: 1996 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Waiver | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Waiver | - |
| Toxicological | Skin irritation / corrosion | Waiver | - |
| Phys-Chem | Surface tension | Waiver | - |