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| Study name | Short Description | Data Owner |
|---|---|---|
| Appearance/physical state/colour | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 89th ed. | Author: Lide et al (Ed) | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 89th ed. | Author: Lide et al (Ed) | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Boiling point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 89th ed. | Author: Lide et al (Ed) | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Density | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 89th ed. | Author: Lide et al (Ed) | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Vapour pressure | Robust Study Summary -- Title: Handbook of vapour pressures and heats of vapourisation of hydrocarbons and related compounds | Author: Zwolinski B.J and Wilhoit R.C | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Surface tension | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 89th ed. | Author: Lide et al (Ed) | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Water solubility | Robust Study Summary -- Title: Solubility in water of Paraffin Cycloparaffin Olefin Acetylene Cycloolefin and Aromatic Hydrocarbons | Author: McAuliffe C | Year: 1966 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Partition coefficient | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 89th ed. | Author: Lide et al (Ed) | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Viscosity | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 89th ed. | Author: Lide et al (Ed) | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Flammability | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 89th ed. | Author: Lide et al (Ed) | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | HCSC Consortium |
| Flash point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 89th ed. | Author: Lide et al (Ed) | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Auto-ignition temperature | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 89th ed. | Author: Lide et al (Ed) | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Skin irritation / corrosion | Robust Study Summary -- Title: Primary dermal irritation study in the rabbit | Author: Trimmer G.W. | Year: 1990 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | HCSC Consortium |
| Skin irritation / corrosion | Right to refer to study -- Title: Primary dermal irritation study in the rabbit | Author: Trimmer G.W. | Year: 1990 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | ExxonMobil |
| Skin sensitisation | Robust Study Summary -- Title: Dermal sensitization test in the guinea pig | Author: Trimmer G.W. | Year: 1991 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | HCSC Consortium |
| Skin sensitisation | Right to refer to study -- Title: Dermal sensitization test in the guinea pig | Author: Trimmer G.W. | Year: 1991 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | ExxonMobil |
| in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: In vitro microbiological mutagenicity studies of hydrocarbon propellants | Author: Kirwin C.J. et al. | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Acute toxicity: oral | Robust Study Summary -- Title: Acute oral toxicity study in rats. Cyclopentane. | Author: Pence D.H. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Acute toxicity: oral | Right to refer to study -- Title: Acute oral toxicity study in rats. Cyclopentane. | Author: Pence D.H. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | CP Chem |
| Acute toxicity: inhalation | Robust Study Summary -- Title: Relative acute neurotoxicity of solvents: Isoeffective air concentrations of 48 compounds evaluated in rats and mice | Author: Frantik E. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Basic toxicokinetics | Robust Study Summary -- Title: Metabolism of ethane and pentane to carbon dioxide by the rat | Author: Daugherty M.S. et al. | Year: 1988 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Basic toxicokinetics | Robust Study Summary -- Title: Uptake of 19 hydrocarbon vapors inhaled by F344 rats | Author: Dahl A.R. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicity evaluation of petroleum blending streams: Inhalation subchronic toxicity/neurotoxicity study of a light alkylate naphtha distillate in rats | Author: Schreiner C. | Year: 1998 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | HCSC Consortium |
| Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Inhalation developmental toxicity and reproduction studies with cyclohexane | Author: Kreckmann K. et al. | Year: 2000 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | HCSC Consortium |
| Toxicity to reproduction | Robust Study Summary -- Title: Assessment in rats of the reproductive toxicity of gasoline from a gasoline vapor recovery unit | Author: McKee R. H. et al. | Year: 2000 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | HCSC Consortium |
| Short-term toxicity to fish | Robust Study Summary -- Title: Aquatic Toxicity Predictions Obtained Using the Petrotox Model for Hydrocarbons | Author: Concawe 2009 Petrotox User's Guide; Version 3.04 updated April 16 2009 | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Short-term toxicity to fish | Right to refer to study -- Title: Aquatic Toxicity Predictions Obtained Using the Petrotox Model for Hydrocarbons | Author: Concawe 2009 Petrotox User's Guide; Version 3.04 updated April 16 2009 | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | CONCAWE |
| Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Aquatic toxicity of compounds that may be carried by ships (MARPOL 1973 Annex II). A progress report for 1986 | Author: Adema D.M.M and van den Bos Baker G.H | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | HCSC Consortium |
| Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Predictions of the Aquatic Toxicity of High- Production Volume Chemicals Part A and B. | Author: Bol J Verhaar et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | HCSC Consortium |
| Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Aquatic Toxicity Predictions Obtained Using the Petrotox Model for Hydrocarbons | Author: Concawe 2009 Petrotox User's Guide; Version 3.04 | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Aquatic Toxicity Predictions Obtained Using the Petrotox Model for Hydrocarbons | Author: Concawe 2009 Petrotox User's Guide; Version 3.04 | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | CONCAWE |
| Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Aquatic Toxicity Predictions Obtained Using the Petrotox Model for Hydrocarbons | Author: Concawe 2009 Petrotox User's Guide; Version 3.04 | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Aquatic Toxicity Predictions Obtained Using the Petrotox Model for Hydrocarbons | Author: Concawe 2009 Petrotox User's Guide; Version 3.04 | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | CONCAWE |
| Toxicity to microorganisms | Robust Study Summary -- Title: Aquatic Toxicity Predictions Obtained Using the Petrotox Model for Hydrocarbons | Author: Concawe 2009 Petrotox User's Guide; Version 3.04 | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Toxicity to microorganisms | Right to refer to study -- Title: Aquatic Toxicity Predictions Obtained Using the Petrotox Model for Hydrocarbons | Author: Concawe 2009 Petrotox User's Guide; Version 3.04 | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | CONCAWE |
| Long-term toxicity to fish | Robust Study Summary -- Title: Aquatic Toxicity Predictions Obtained Using the Petrotox Model for Hydrocarbons | Author: Concawe 2009 Petrotox User's Guide; Version 3.04 | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Long-term toxicity to fish | Right to refer to study -- Title: Aquatic Toxicity Predictions Obtained Using the Petrotox Model for Hydrocarbons | Author: Concawe 2009 Petrotox User's Guide; Version 3.04 | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | CONCAWE |
| Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Aquatic Toxicity Predictions Obtained Using the Petrotox Model for Hydrocarbons | Author: Concawe 2009 Petrotox User's Guide; Version 3.04 | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Aquatic Toxicity Predictions Obtained Using the Petrotox Model for Hydrocarbons | Author: Concawe 2009 Petrotox User's Guide; Version 3.04 | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | CONCAWE |
| Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Structure-toxicity relationships for industrial chemicals causing type (II)Narcosis Syndrome | Author: Veith GD and Broderius SJ. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Sediment toxicity | Robust Study Summary -- Title: Technical basis for establishing sediment quality criteria for nonionic organic chemicals using equilibrium partitioning | Author: Di Toro D.M. et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Sediment toxicity | Robust Study Summary -- Title: Refinement and validation of TLM-derived HC5 values. Independent review. | Author: McGrath JA et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Sediment toxicity | Robust Study Summary -- Title: Extension and validation of the target lipid model for deriving predicted no-effect concentrations for soils and sediments | Author: Redman AD et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Toxicity to soil macro-organisms except anthropods | Robust Study Summary -- Title: Refinement and validation of TLM-derived HC5 values. Independent review. | Author: McGrath JA et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Toxicity to soil macro-organisms except anthropods | Robust Study Summary -- Title: Extension and validation of the target lipid model for deriving predicted no-effect concentrations for soils and sediments | Author: Redman AD et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Toxicity to soil macro-organisms except anthropods | Robust Study Summary -- Title: Technical basis for establishing sediment quality criteria for nonionic organic chemicals using equilibrium partitioning | Author: Di Toro D.M. et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Toxicity to terrestrial plants | Robust Study Summary -- Title: Refinement and validation of TLM-derived HC5 values. Independent review. | Author: McGrath JA et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Toxicity to terrestrial plants | Robust Study Summary -- Title: Extension and validation of the target lipid model for deriving predicted no-effect concentrations for soils and sediments | Author: Redman AD et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Toxicity to terrestrial plants | Robust Study Summary -- Title: Technical basis for establishing sediment quality criteria for nonionic organic chemicals using equilibrium partitioning | Author: Di Toro D.M. et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Toxicity to terrestrial arthropods | Robust Study Summary -- Title: Extension and validation of the target lipid model for deriving predicted no-effect concentrations for soils and sediments | Author: Redman AD et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Toxicity to terrestrial arthropods | Robust Study Summary -- Title: Refinement and validation of TLM-derived HC5 values. Independent review. | Author: McGrath JA et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Toxicity to terrestrial arthropods | Robust Study Summary -- Title: Technical basis for establishing sediment quality criteria for nonionic organic chemicals using equilibrium partitioning | Author: Di Toro D.M. et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Hydrolysis | Robust Study Summary -- Title: Mechanism and Structure | Author: Gould E | Year: 1959 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | HCSC Consortium |
| Hydrolysis | Robust Study Summary -- Title: Chapter 7: Rate of Hydrolysis | Author: Harris J | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | HCSC Consortium |
| Hydrolysis | Robust Study Summary -- Title: Hydrolysis | Author: Neely W | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | HCSC Consortium |
| Biodegradation in water: screening tests | Robust Study Summary -- Title: Ready biodegradability: 'manometric respirometry test' | Author: ExxonMobil Chemical | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | HCSC Consortium |
| Biodegradation in water: screening tests | Right to refer to study -- Title: Ready biodegradability: 'manometric respirometry test' | Author: ExxonMobil Chemical | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | ExxonMobil |
| Adsorption/desorption | Robust Study Summary -- Title: QSARs for soil sorption. In: Overview of Structure-Activity Relationships for Environmental Endpoints. Hermens JLM (ed.) | Author: Sabljic A and Güsten H | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Phototransformation in air | Robust Study Summary -- Title: Kinetics and mechanisms of gas-phase reactions with the hydroxyl radical with organic compounds under atmospheric conditions | Author: Atkinson R | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Partition coefficient | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 89th ed. | Author: Lide et al (Ed) | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Hydrolysis | Robust Study Summary -- Title: Mechanism and Structure | Author: Gould E | Year: 1959 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | HCSC Consortium |
| Hydrolysis | Robust Study Summary -- Title: Hydrolysis | Author: Neely W | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | HCSC Consortium |
| Hydrolysis | Robust Study Summary -- Title: Chapter 7: Rate of Hydrolysis | Author: Harris J | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | HCSC Consortium |
| Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Evaluation of primary irritation potential in humans (single 24-hour application) | Author: Rue B. and Plaza M.E. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |
| Direct observations: clinical cases, poisoning incidents and other | Right to refer to study -- Title: Evaluation of primary irritation potential in humans (single 24-hour application) | Author: Rue B. and Plaza M.E. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | ExxonMobil |
| Neurotoxicity | Robust Study Summary -- Title: The relative anaesthetic activity of the butanes and pentanes | Author: Stoughton R. and Lamson P. | Year: 1936 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | HCSC Consortium |
| Neurotoxicity | Robust Study Summary -- Title: A comparative study on the neurotoxicity of n-pentane n-hexane and n-heptane in the rat | Author: Takeuchi Y. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | HCSC Consortium |