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CAS 111-44-4 | Data Package 10 - 100 t/a

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Study name Short Description Data Owner
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals Drugs and Biologicals (13th ed.) | Author: O'Neil M.J. (Ed.) | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Properties and Hazards of 108 selected substances - 1990 Edition | Author: Lucius J.E. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 76th Edition | Author: Lide D.R. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Handbook of environmental data on organic chemicals (2nd ed.) | Author: Verschueren K. (Ed.) | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Lacquer solvents in commercial use | Author: Doolittle A.K. | Year: 1935 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Boiling point Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Lide | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Lange's handbook of chemistry (15th ed.) | Author: Dean J.A. (Ed.) | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Phys-Chem | Density Robust Study Summary -- Title: The physical properties of some aliphatic compounds | Author: Mumford S.A. & Philips J.W.C. | Year: 1950 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Density Robust Study Summary -- Title: Lacquer solvents in commercial use | Author: Doolittle A.K. | Year: 1935 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Density Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Lide | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Handbook of Environmental Data on Organic Chemicals | Author: Verschueren K. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Lacquer solvents in commercial use | Author: Doolittle A.K. | Year: 1935 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Phys-Chem | Surface tension Robust Study Summary -- Title: The physical properties of some aliphatic compounds | Author: Mumford S.A. & Philips J.W.C. | Year: 1950 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Surface tension Robust Study Summary -- Title: Studies on Reactions Relating to Carbohydrates and Polysaccharides. LIV. The Surface Tension Constants of the Polyethylene Glycols and their Derivatives | Author: Gallaugher A.F. & Hibbert H. | Year: 1932 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Phys-Chem | Surface tension Right to refer to study -- Title: Studies on Reactions Relating to Carbohydrates and Polysaccharides. LIV. The Surface Tension Constants of the Polyethylene Glycols and their Derivatives | Author: Gallaugher A.F. & Hibbert H. | Year: 1932 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Solubility in water of one batch of 22-dichlorodiethyl ether (CAS No. 111-44-4) | Author: Jean-Baptise C. | Year: 2017 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Evaluation and prediction of Henry's law constants and aqueous solubilities for solvents and hydrocarbon fuel components. Vol. 1: technical discussion. | Author: Howe G.B.; Mullins M.E.; Rogers T.N. | Year: 1987 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Mutual solubilities: water-ketones water-ethers and water-gasolines-alcohols | Author: Stephenson R.M. | Year: 1992 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: An evaluation of using partition coefficient and water solubility to estimate bioconcentration factors for organic chemicals in fish | Author: Veith G.D. | Year: 1980 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Partition coefficients and their uses. | Author: Leo A; Hansch C & Elkins D | Year: 1971 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Aquatic fate process data for organic priority pollutants | Author: Mabey W.R. et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Phys-Chem | Flammability Robust Study Summary -- Title: DCEE Vapour Flammability Testing | Author: Andrew Jennings | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flammability Right to refer to study -- Title: DCEE Vapour Flammability Testing | Author: Andrew Jennings | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flash point Robust Study Summary -- Title: Flash point test on Bis(2-chloroethyl)ether | Author: B. Demangel | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Flash point Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals Drugs and Biologicals (13th ed.) | Author: O'Neil M.J. (Ed.) | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Flash point Robust Study Summary -- Title: Lacquer solvents in commercial use | Author: Doolittle A.K. | Year: 1935 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Phys-Chem | Flash point Right to refer to study -- Title: Lacquer solvents in commercial use | Author: Doolittle A.K. | Year: 1935 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Eye irritation Robust Study Summary -- Title: 22`- Dichlorodiethyl ether - In Vitro Eye Irritation Test in Isolated Chicken Eyes | Author: Orovecz B. | Year: 2016 | Guideline: 438 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Eye irritation Right to refer to study -- Title: 22`- Dichlorodiethyl ether - In Vitro Eye Irritation Test in Isolated Chicken Eyes | Author: Orovecz B. | Year: 2016 | Guideline: 438 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Skin Sensitisation Test: Local Lymph Node Assay with 22`-Dichlorodiethyl ether | Author: Váliczkó E. | Year: 2016 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Skin sensitisation Right to refer to study -- Title: Skin Sensitisation Test: Local Lymph Node Assay with 22`-Dichlorodiethyl ether | Author: Váliczkó E. | Year: 2016 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: 2,2'-Dichlorodiethyl ether: Bacterial Reverse Mutation Assay | Author: Hargitai J. | Year: 2016 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: 2,2'-Dichlorodiethyl ether: Bacterial Reverse Mutation Assay | Author: Hargitai J. | Year: 2016 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: In vitro micronucleus test in L5178Y TK mouse lymphoma cells for 2,2'-dichloroethyl ether | Author: Brient A. | Year: 2016 | Guideline: 487 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in mammalian cells Right to refer to study -- Title: In vitro micronucleus test in L5178Y TK mouse lymphoma cells for 2,2'-dichloroethyl ether | Author: Brient A. | Year: 2016 | Guideline: 487 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: In vitro Mammalian Cell Gene Mutation Test (Mouse Lymphoma Assay) for 2,2'-Dichlorodiethyl ether | Author: Hargitai J. | Year: 2017 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals | Author: Mortelmans K | Year: 1986 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Carcinogenic potency in rodents versus genotoxic potency in E. coli: a correlation analysis for bifunctional alkylating agents | Author: Quinto I. & Radman M. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Further experience with range finding test in the industrial toxicology laboratory | Author: Smyth H.F. Jr. & Carpenter C.P. | Year: 1948 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: The place of the range finding test in the industrial toxicology laboratory | Author: Smyth H.F. Jr. & Carpenter C.P. | Year: 1944 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Handbook of Toxicology Vol. 1 | Author: Spector W.S. (Ed.) | Year: 1956 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Oral Toxicity of DCEE (Dichloroethyl ether) in Rats and Mice | Author: Drake K.D. & Myer J.R. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Toxicometri parameters of industrial chemicals under single exposure | Author: Izmerov N.F.; Sanotsky I.V. & Sidorov K.K. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: The assay of acute vapor toxicity and the grading and interpretation of results on 96 chemical compounds. | Author: Carpenter CP; Smyth HF and Pozzani UC | Year: 1949 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Acute Response of Guinea Pigs to Vapors of Some New Commercial Organic Compounds:VII. Dichloroethyl Ether | Author: Schrenk H.H.; Patty F.A. & Yant W.P. | Year: 1933 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Methanol antifreeze and methanol poisoning | Author: Yant W.P.; Schrenk H.H. & Syaers R.R. | Year: 1931 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Acute response of Guinea pigs to vapors of some new commercial organic compounds: I. Ethylene dichloride | Author: Sayers R.R. et al. | Year: 1930 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Halogenated alkyl ethers | Author: Clayton G.D. & Clayton F.E. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Handbook of Toxicology Vol. 1 | Author: Spector W.S. (Ed.) | Year: 1956 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Toxicological profile for bis(2-chloroethyl) ether | Author: USEPA | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Metabolism of Bis(2-chloroethyl)ether and Bis(2-chloroisopropyl)ether in the Rat | Author: Lingg R.D. et al. | Year: 1982 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Thiodiglycolic Acid: A Major Metabolite of Bis(2-chloroethyl)ether | Author: Ling R.D. et al. | Year: 1979 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Evidence of chloroethylene oxide being the reactive metabolite of vinyl chloride towards DNA: comparative studies with 2,2'-dichlorodiethylether | Author: Gwinner L.M. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Identification of S-(carboxymethyl)-L-cysteine and thioglygollic acid urinary metabolites of 2,2'-bis(chloroethyl)-ether in the rat. | Author: Muller G. & Norpoth K. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Investigations on metabolism genotoxic effects and carcinogenicity of 2,2'-dichlorodiethylether | Author: Norpoth K. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: Combined Repeated Dose and Reproductive/Developmental Toxicity Screening Test of 2,2'-dichlorodiethylether by Oral Administration in Rats | Author: Anonymous | Year: 2007 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Combined Repeated Dose and Reproductive/Developmental Toxicity Screening Test of 2,2'-dichlorodiethylether by Oral Administration in Rats | Author: Anonymous | Year: 2007 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Acute Toxicity Test of Bis(2-chloroethyl) ether to Oryzias latipes | Author: Anonymous | Year: 1996 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute toxicity of priority pollutants to water flea (Daphnia magna) | Author: LeBlanc G.A. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Acute Immobilization Test of Bis(2-chloroethyl) ether to Daphnia magna | Author: Anonymous | Year: 1996 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Acute Immobilization Test of Bis(2-chloroethyl) ether to Daphnia magna | Author: Anonymous | Year: 1996 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Growth inhibition test with 22`-Dichlorodiethyl ether on Algae (Pseudokirchneriella subcapitata) | Author: Koós D. | Year: 2017 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Growth inhibition test with 22`-Dichlorodiethyl ether on Algae (Pseudokirchneriella subcapitata) | Author: Koós D. | Year: 2017 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: 2,2'-Dichlorodiethyl ether: Activated Sludge Respiration Inhibition Test (Carbon and Ammonium Oxidation) | Author: Sipos K. | Year: 2016 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Assessing microbial toxicity of 2-ethoxyethanol and BIS (2-chloroethyl) ether by a modified spread plate method | Author: Cho Y.-H.; Davis E.M. & Ramey G.D. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Inhibition of Anaerobic Digestion by Organic Priority Pollutants | Author: Johnson L.D. & Young J.C. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Toxicity of mixture of organic chemicals to microorganisms | Author: Nirmalakhandan N. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Toxicity of binary mixtures of organic chemicals to microorganisms | Author: Prakash J. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to microorganisms Right to refer to study -- Title: Toxicity of binary mixtures of organic chemicals to microorganisms | Author: Prakash J. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Environmental | Hydrolysis Robust Study Summary -- Title: Determination of Hydrolysis as a function of pH of 2,2'-Dichlorodiethyl ether (Preliminary test) | Author: Sárvári Z. | Year: 2017 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Environmental | Hydrolysis Robust Study Summary -- Title: Aquatic fate process data for organic priority pollutants | Author: Mabey W.R. et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Environmental | Hydrolysis Robust Study Summary -- Title: Die Hydrolyse halogenierter Äther und Thioäther in Dioxan-Wasser-Gemischen | Author: Böhme H. & Sell K. | Year: 1948 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Environmental | Hydrolysis Robust Study Summary -- Title: Degradation dans l'eau par hydrolyse et photolyse du bis-2 chloroethyl ether | Author: Milano J.C.; Bernat-Escallon C. & Vernet J.L. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Environmental | Hydrolysis Right to refer to study -- Title: Degradation dans l'eau par hydrolyse et photolyse du bis-2 chloroethyl ether | Author: Milano J.C.; Bernat-Escallon C. & Vernet J.L. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Ready Biodegradability of 2,2'-Dichlorodiethyl ether in a Closed Bottle Test | Author: Sipos K. | Year: 2017 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Biodegradability studies with organic priority pollutant compounds | Author: Tabak HH et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Environmental | Adsorption/desorption Robust Study Summary -- Title: Transport and fate of selected organic pollutants in a sandy soil | Author: Wilson JT et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -