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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Hazardous Substances Data Bank | Author: National Library of Medicine | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Encyclopedia of Chemical Technology (3rd ed. Vol. 13) | Author: Kirk-Othmer | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: The Merck Index Fourteenth Edition | Author: Merck Index | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Handbook of environmental data on organic chemicals (3rd ed.) | Author: Verschueren K. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Handbook of Data on Organic Compounds 3rd Edition Vol. I | Author: Lide DR Milne GWA (Ed.) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: SRC PhysProp-database | Author: Syracuse Research Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Hazardous Substances Databank | Author: National Library of Medicine | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Encyclopedia of Chemical Technology (3rd ed. Vol. 13) | Author: Kirk-Othmer | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The Merck Index Fourteenth Edition | Author: Merck Index | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Handbook of environmental data on organic chemicals (3rd ed.) | Author: Verschueren K. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: SAX Dangerous Properties of Industrial Materials (8th ed.) | Author: Lewis JR | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: PhysProp database | Author: Syracuse Research Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Encyclopedia of Chemical Technology (3rd ed. Vol. 13) | Author: Kirk-Othmer | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Hazardous Substances Data Bank | Author: National Library of Medicine | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Merck Index Fourteenth Edition | Author: Merck Index | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Handbook of Data on Organic Compounds 3rd Edition Vol. I | Author: Lide DR Milne GWA (Ed.) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: SAX Dangerous Properties of Industrial Materials (8th ed.) | Author: Lewis JR | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Encyclopedia of Chemical Technology (3rd ed. Vol 13) | Author: Kirk-Othmer | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Merck Index Fourteenth Edition | Author: Merck Index | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: SAX Dangerous Properties of Industrial Materials (8th ed.) | Author: Lewis JR | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Hazardous Substances Data Bank | Author: National Library of Medicine | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: PhysProp-database | Author: Syracuse Research Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Hazardous Substances Data Bank | Author: National Library of Medicine | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: SAX Dangerous Properties of Industrial Materials (8th ed.) | Author: Lewis JR | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Handbook of environmental data on organic chemicals (3rd ed.) | Author: Verschueren K. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Estimation Program Interface (EPI) Suite Version 4.00 | Author: Episuite | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Estimation Program Interface (EPI) Suite Version 4.00 | Author: Fraunhofer | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Estimating octanol-air partition coefficients with octanol-water partition coefficients and Henry's law constants. | Author: Meylan W.M., Howard P.H. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Oxidation and reduction of hydroquinone and quinone from the standpoint of electromotive-force measurement | Author: Granger F.S. & Nelson J.M. | Year: 1921 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Hazardous Substances Data Bank | Author: National Library of Medicine | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: PhysProp-database | Author: Syracuse Research Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Encyclopedia of Chemical Technology (3rd ed. Vol 13) | Author: Kirk-Othmer | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: The Merck Index Fourteenth Edition | Author: Merck Index | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Handbook of environmental data on organic chemicals (3rd ed.) | Author: Verschueren K. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Exploring QSAR. Hydrophobic Electronic and Steric Constants. ACS Professional Reference Book | Author: Hansch C. Leo A. & Hoekman D. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Calculation of Hydroquinone properties via EPISUITE 4.00 | Author: Fraunhofer | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: IUPAC Chemical Data Series No 23 Ionisation constants of organic acids in aqueous solution | Author: Serjeant E.P. & Dempsey B. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Encyclopedia of Chemical Technology (3rd ed. Vol 13) | Author: Kirk-Othmer | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Robust Study Summary -- Title: REACH Project: Granulometric characterization of Hydroquinone. | Author: Rhodia | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Right to refer to study -- Title: REACH Project: Granulometric characterization of Hydroquinone. | Author: Rhodia | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Solubility in organic solvents/fat solubility | Robust Study Summary -- Title: Encyclopedia of Chemical Technology (3rd ed. Vol 13) | Author: Kirk-Othmer | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Flammability of solids on Hydroquinone CAS: 123-31-9 | Author: RHODIA | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Flammability of solids on Hydroquinone CAS: 123-31-9 | Author: RHODIA | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Encyclopedia of Chemical Technology (3rd ed. Vol 13) | Author: Kirk-Othmer | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Hazardous Substances Data Bank | Author: National Insitutes of Health | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: SAX Dangerous Properties of Industrial Materials (8th ed.) | Author: Lewis JR | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Encyclopedia of Chemical Technology (3rd ed. Vol 13) | Author: Kirk-Othmer | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Hazardous Substances Data Bank | Author: National Institutes of Health | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: SAX Dangerous Properties of Industrial Materials (8th ed.) | Author: Lewis JR | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Hydroquinone: Acute and subchronic toxicity studies with emphasis on neurobehavioral and nephrotoxic effects. | Author: Topping D.C. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Hydroquinone: Acute and subchronic toxicity studies with emphasis on neurobehavioral and nephrotoxic effects. | Author: Topping D.C. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Hydroquinone. Acute dermal toxicity study in the rat. (Amended final report) | Author: Sheppard K.P. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Hydroquinone. Acute dermal toxicity study in the rat. (Amended final report) | Author: Sheppard K.P. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Phenol (4 030 R.P.), hydroquinone (4 373 R.P.) et pyrocatechine (30 488 R.P.). Toxicite aigue chez le rat par voie percutanee de ces produits on solution aqueuses (in French). | Author: Julou L. Pasquet J. Mazuret M. | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Phenol (4 030 R.P.), hydroquinone (4 373 R.P.) et pyrocatechine (30 488 R.P.). Toxicite aigue chez le rat par voie percutanee de ces produits on solution aqueuses (in French). | Author: Julou L. Pasquet J. Mazuret M. | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Assessment of the skin sentisation potential of topical medicaments using the local lymph node assay: an interlaboratory evaluation | Author: Kimber I. et al. | Year: 1998 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: The impact of vehicle on assessment of relative skin sensitization potency of 1,4-dihydroquinone in the local lymph node assay. | Author: Lea L.J. et al. | Year: 1999 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A comparison of three guinea-pig sensitization procedures for the detection of 19 reported human contact sensitizers. | Author: Goodwin B.F.J., Crevel R.W.R., and Johnson A.W. | Year: 1981 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Experimental study on cross-reactivity of α-arbutin toward p-phenylenediamine and hydroquinone in guinea pigs | Author: To-o K. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Concomitant sensitization to hydroquinone and P-methoxyphenol in the guinea-pig; inhibitors in acrylic monomers. | Author: van der Walle H.B., Delbressine L.P.C., and Seutter E. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Investigation of the prohapten concept. | Author: Basketter D.A. Goodwin B.F.J. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Comparison of the Local Lymph Node Assay with the Guinea-Pig Maximization Test for the Detection of a Range of Contact Allergens. | Author: Basketter D.A. Goodwin B.F.J. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: The local lymph node assay: Developments and applications. | Author: Kimber I. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A comparison of three guinea-pig sensitization procedures for the detection of 19 reported human contact sensitizers. | Author: Goodwin B.F.J., Crevel R.W.R., and Johnson A.W. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella mutagenicity test results for 250 chemicals. | Author: Haworth S. et al. | Year: 1983 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Toxicology and carcinogenesis studies of hydroquinone (CAS No. 123-31-9) in F344/N rats and B6C3F1 mice (gavage studies). | Author: NTP | Year: 1989 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial mutagenicity test on Salmonella typhimurium according to B.N. Ames's technique with liver and kidney S9 fraction. Screening assay performed in micromethod using 4 strains, TA1537, TA98, TA100, and TA102 without repetition with the compound HQ. | Author: Watzinger M. | Year: 2007 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial mutagenicity test on Salmonella typhimurium according to B.N. Ames's technique with liver and kidney S9 fraction. Screening assay performed in micromethod using 4 strains, TA1537, TA98, TA100, and TA102 without repetition with the compound HQ. | Author: Watzinger M. | Year: 2007 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Lack of clastogenic effects in cultured human lymphocytes treated with hydroquinone. | Author: Roza L., de Vogel N., and van Delft J.H.M. | Year: 2003 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro genetic toxicity | Right to refer to study -- Title: Lack of clastogenic effects in cultured human lymphocytes treated with hydroquinone. | Author: Roza L., de Vogel N., and van Delft J.H.M. | Year: 2003 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Chromosomal aberration test with hydroquinone in cultured human lymphocytes. | Author: de Vogel N. | Year: 2000 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Chromosomal aberration test with hydroquinone in cultured human lymphocytes. | Author: de Vogel N. | Year: 2000 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. | Author: Galloway S.M. et al. | Year: 1987 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Responses of the L1578Y tk+/tk- mouse lymphoma cell forward mutation assay. II. 18 coded chemicals. | Author: McGregor D.B. et al. | Year: 1988 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Toxicology and carcinogenesis studies of hydroquinone (CAS No. 123-31-9) in F344/N rats and B6C3F1 mice (gavage studies). | Author: NTP | Year: 1989 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Mechanisms of induction of chromosomal aberrations by hydroquinone in V79 cells. | Author: do Ceu Silva M. et al. | Year: 2003 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Sister chromatid exchange induction in human lymphocytes exposed to benzene and its metabolites in vitro. | Author: Erexson G.L., Wilmer J.L., and Kligerman A.D. | Year: 1985 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. | Author: Galloway S.M. et al. | Year: 1987 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Increase of sister chromatid exchanges and perturbations of cell division kinetics in human lymphocytes by benzene metabolites. | Author: Morimoto K. Wolff S. | Year: 1980 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: GSTM1, GSTT1 and GSTP1 genotypes and the genotoxicity of hydroquinone in human lymphocytes. | Author: do Ceu Silva M. et al. | Year: 2004 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Role of oxygen radicals in the chromosomal loss and breakage induced by quinone-forming compounds hydroquinone and tert-butylhydroquinone. | Author: Dobo K.L. Eastmond D.A. | Year: 1994 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Lack of induction of micronuclei in human peripheral blood lymphocytes treated with hydroquinone. | Author: Doepker C.L. et al. | Year: 2000 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Characterisation of micronuclei induced in human lymphocytes by benzene metabolites. | Author: Yager J.W. et al. | Year: 1990 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Antimutagenicity study with hydroquinone in a chromosomal aberration test with cultured human lymphocytes. | Author: Van Delft J.H.M., and de Vogel N. | Year: 1997 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Antimutagenicity study with hydroquinone in a chromosomal aberration test with cultured human lymphocytes. | Author: Van Delft J.H.M., and de Vogel N. | Year: 1997 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In vitro micronucleus test on mouse lymphoma cells (L5178Y) without metabolic activation and with metabolic activation by liver and kidney S9 fraction. Screening assay performed in micromethod with the compound hydroquinone. | Author: Watzinger M. | Year: 2007 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: In vitro micronucleus test on mouse lymphoma cells (L5178Y) without metabolic activation and with metabolic activation by liver and kidney S9 fraction. Screening assay performed in micromethod with the compound hydroquinone. | Author: Watzinger M. | Year: 2007 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: A method for in vitro culture of rat zymbal gland: Use in mechanistic studies of benzene carcinogenesis in combination with 32P-postlabeling. | Author: Reddy M.V. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: DNA adduction by phenol hydroquinone or benzoquinone in vitro but not in vivo: nuclease P1-enhanced 32P-postlabeling of adducts as labeled nucleoside biphosphates, dinucleotides and nucleosides monophosphates. | Author: Reddy M.V. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Detection of DNA adducts in HL-60 cells treated with hydroquinone and p-benzoquinone by 32P-post labelling. | Author: Levay G., Pongracz K., and Bodel W.J. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Peroxidase activation of hydroquinone results in the formation of DNA adducts in HL-60 cells mouse bone marrow macrophages and human bone marrow. | Author: Levay G., Ross D., and Bodell W.J. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo. | Author: Kolachana P. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Hydroquinone: Rat Alkaline Comet Assay | Author: Beevers Carol | Year: 2016 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Hydroquinone: Rat Alkaline Comet Assay | Author: Beevers Carol | Year: 2016 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evaluation of in vivo mutagenicity of hydroquinone in Muta™ mice | Author: Matsumoto M. et al. | Year: 2014 | Guideline: 488 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Hydroquinone: A dominant lethal assay in male rats. | Author: Krasavage W.J. | Year: 1984 | Guideline: 478 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Hydroquinone: A dominant lethal assay in male rats. | Author: Krasavage W.J. | Year: 1984 | Guideline: 478 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Comparison of single and multiple treatment regimens in the mouse bone marrow micronucleus assay for hydroquinone (HQ) and cyclophosphamide (CP). | Author: Adler I.D., and Kliesch U. | Year: 1990 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mouse micronucleus tests with known and suspect spindle poisons: results from two laboratories. | Author: Adler I.D. et al. | Year: 1991 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Benzene and the genotoxicity of its metabolites. II. The effect of the route of administration on the micronuclei and bone marrow depression in mouse bone marrow cells | Author: Ciranni R. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Quantitative and qualitative studies of micronucleus induction in mouse erythrocytes using flow cytometry .I. Measurement of micronucleus induction in peripheral blood polychromatic erythrocytes by chemicals with known and suspected genotoxicity | Author: Grawé J., Nüsse M., and Adler I-D | Year: 1997 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Clastogenic effects of hydroquinone: induction of chromosomal aberrations in mouse germ cells. | Author: Ciranni R. Adler I.D. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Measurement of nuclear DNA modification by 32P-postlabeling in the kidneys of male and female Fischer 344 rats after multiple gavage doses of hydroquinone. | Author: English J.C. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Lack of oxidative DNA damage by hydroquinone in the kidneys of rats after oral administration. (Draft) | Author: English J.C., Deisinger P.J., and Reddy M.V. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Lack of oxidative DNA damage by hydroquinone in the kidneys of rats after oral administration. (Draft) | Author: English J.C., Deisinger P.J., and Reddy M.V. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Lack of oxidative DNA damage by hydroquinone in the kidneys of rats after oral administration. | Author: Reddy M.V. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: DNA adduction by phenol hydroquinone or benzoquinone in vitro but not in vivo: nuclease P1-enhanced 32P-postlabeling of adducts as labeled nucleoside biphosphates, dinucleotides, and nucleosides monophosphates. | Author: Reddy M.V. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo. | Author: Kolachana P. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Clastogenic effects of known and suspect spindle poisons studied by chromosome analysis in mouse bone marrow cells. | Author: Xu W, and Adler ID | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Origin of aneuploidy in relation to disturbances of cell-cycle progression. II: Cytogenetic analysis of various parameters in mouse bone marrow cells after colchicine or hydroquinone treatment. | Author: Pacchierotti F. et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Hydroquinone: Acute and subchronic toxicity studies with emphasis on neurobehavioral and nephrotoxic effects. | Author: Topping D.C. et al. | Year: 2007 | Guideline: 401 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Hydroquinone. Acute oral toxicity study in the rat. (Final report) | Author: Sheppard K.P. | Year: 2002 | Guideline: 401 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Hydroquinone. Acute oral toxicity study in the rat. (Final report) | Author: Sheppard K.P. | Year: 2002 | Guideline: 401 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Experimental studies on the toxicity of lithographic developer solution. | Author: Saito T., Takeichi S. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: The benzenediols: catechol resorcinol and hydroquinone: a review of the industrial toxicology and current industrial exposure limits. | Author: Flickinger C.W. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Hydroquinone: Acute and subchronic toxicity studies with emphasis on neurobehavioral and nephrotoxic effects. | Author: Topping D.C. et al. | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Hydroquinone. Acute dermal toxicity study in the rat. (Amended final report) | Author: Sheppard K.P. | Year: 2001 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Hydroquinone. Acute dermal toxicity study in the rat. (Amended final report) | Author: Sheppard K.P. | Year: 2001 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Phenol (4 030 R.P.) hydroquinone (4 373 R.P.) et pyrocatechine (30 488 R.P.). Toxicite aigue chez le rat par voie percutanee de ces produits on solution aqueuses (in French). | Author: Julou L., Pasquet J., and Mazuret M. | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Phenol (4 030 R.P.) hydroquinone (4 373 R.P.) et pyrocatechine (30 488 R.P.). Toxicite aigue chez le rat par voie percutanee de ces produits on solution aqueuses (in French). | Author: Julou L., Pasquet J., and Mazuret M. | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism and disposition of hydroquinone in Fischer 344 rats after oral or dermal administration. | Author: English J.C., and Deisinger P.J. | Year: 2005 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Metabolism and disposition of hydroquinone in Fischer 344 rats after oral or dermal administration. | Author: English J.C., and Deisinger P.J. | Year: 2005 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Toxicokinetics studies with hydroquinone in male and female Fischer 344 rats. | Author: English J.C. et al. | Year: 1988 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Toxicokinetics studies with hydroquinone in male and female Fischer 344 rats. | Author: English J.C. et al. | Year: 1988 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Toxicokinetics studies with hydroquinone (HQ) in Fischer 344 rats. | Author: English J.C. et al. | Year: 1991 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Development of a physiologically based pharmacokinetic model for hydroquinone. | Author: Corley R.A. et al. | Year: 2000 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Development of a physiologically based pharmacokinetic model for hydroquinone. | Author: Corley R.A. et al. | Year: 2000 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Identification of multi-S-substituted conjugates of hydroquinone by HPLC-coulometric electrode array analysis and mass spectroscopy. | Author: Hill B.A. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A physiologically based pharmacokinetic model for hydroquinone. | Author: Corley R.A., English J.C., and Morgott D.A. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Development of a physiologically based pharmacokinetic model for hydroquinone. | Author: Corley R.A. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Development of a physiologically based pharmacokinetic model for hydroquinone. | Author: Corley R.A. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Tissue-to-plasma partition coefficients (PCS) for hydroquinone (HQ) in male Fischer and Sprague-Dawley rats. | Author: Hill T.S., Morgott D.A.,and English J.C. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The plasma protein binding of hydroquinone (HQ) in rats and humans. | Author: Fiorica L.A. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolic Rate Constants for Hydroquinone in F344 Rat and Human Liver Isolated Hepatocytes: Application to a PBPK Model. | Author: Poet T.S. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Comparison of the rates of interconversion of (L-Cystein-S-yl)-hydroquinone and (N-acetyl-L-cystein-S-yl)-hydroquinone in male and female Fischer 344 rat male Sprague-Dawley rat male B6C3F1 mouse and human kidneys. | Author: Barber E.D., English J.C. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Comparison of the rates of interconversion of (L-Cystein-S-yl)-hydroquinone and (N-acetyl-L-cystein-S-yl)-hydroquinone in male and female Fischer 344 rat male Sprague-Dawley rat male B6C3F1 mouse and human kidneys. | Author: Barber E.D., English J.C. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Hydroquinone PBPK model refinement and application to dermal exposure | Author: Poet T.S. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients | Author: Gajewska M.A. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Covalent protein adducts of hydroquinone in tissues from rats: identification and quantitation of sulfhydryl-bound forms. | Author: Boatman R.J. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Covalent protein adducts of hydroquinone in tissues from rats: quantitation of sulfhydryl-bound forms following single gavage or intraperitoneal administration or repetitive gavage administration. | Author: Boatman R.J. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Quantification of covalent protein adducts of hydroquinone in the blood and kidneys of rats. | Author: Boatman R.J. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Human exposure to naturally occurring hydroquinone. | Author: Deisinger P.J. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Human exposure to naturally occurring hydroquinone. | Author: Deisinger P.J., Hill T.S., and English J.C. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Bioavailability and metabolism of Hydroquinone after intratracheal instillation in male rats. | Author: Deisinger P.J. and English J.C. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism as a determinant of species susceptibility to 2,3,5- (triglutathion-S-yl)hydroquinone-mediated nephrotoxicity. The role of N- acetylation and N-deacetylation. | Author: Lau S.S., Kleiner H.E., and Monks T.J. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolic fate and disposition of [14C]hydroquinone given orally to Sprague-Dawley rats. | Author: Di Vincenzo et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Fate and disposition of [U-14C]hydroquinone in rats. | Author: Di Vincenzo et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Fate and disposition of [U-14C]hydroquinone in rats. | Author: Di Vincenzo et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The metabolic fate of [U-14C] hydroquinone administered by gavage to male Fischer 344 rats. | Author: Lockhart H.B., Fox J.A., Di Vincenzo G.D. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: The metabolic fate of [U-14C] hydroquinone administered by gavage to male Fischer 344 rats. | Author: Lockhart H.B., Fox J.A., Di Vincenzo G.D. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The metabolic fate of [U-14C] hydroquinone administered by gavage to female Fischer 344 rats. | Author: Lockhart H.B. Fox J.A. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: The metabolic fate of [U-14C] hydroquinone administered by gavage to female Fischer 344 rats. | Author: Lockhart H.B. Fox J.A. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Blood elimination kinetics of [U-14C]hydroquinone administered by intragastric intubation intratracheal instillation or intravenous injection to male Fischer 344 rats. | Author: Fox J.A., English J.C., and Lockhart Jr. J.B. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Blood elimination kinetics of [U-14C]hydroquinone administered by intragastric intubation intratracheal instillation or intravenous injection to male Fischer 344 rats. | Author: Fox J.A., English J.C., and Lockhart Jr. J.B. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Detection of hydroquinone in a poisoning case. | Author: Saito T. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: In vitro conjugation of benzene metabolites by human liver: potential influence of interindividual variability on benzene toxicity. | Author: Seaton M.J., Schlosser P.M., and Medinsky M.A. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetic interaction between benzene metabolites phenol and hydroquinone in B6C3F1 mice | Author: Legathe A., Hoener B.A., and Tozer T.N. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Metabolism and disposition of hydroquinone in Fischer 344 rats after oral or dermal administration. | Author: English J.C. Deisinger P.J. | Year: 2005 | Guideline: 427 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toxicity and carcinogenicity of hydroquinone in F344/N rats and B6C3F1 mice. | Author: Kari F.W. et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toxicology and carcinogenesis studies of hydroquinone (CAS No. 123-31-9) in F344/N rats and B6C3F1 mice (gavage studies). | Author: NTP | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Subchronic oral toxicity study of hydroquinone in rats utilizing a functional observational battery and neuropathology to detect neurotoxicity. | Author: Topping D.C. | Year: 1988 | Guideline: 424 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Subchronic oral toxicity study of hydroquinone in rats utilizing a functional observational battery and neuropathology to detect neurotoxicity. | Author: Topping D.C. | Year: 1988 | Guideline: 424 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Hydroquinone: Acute and subchronic toxicity studies with emphasis on neurobehavioral and nephrotoxic effects. | Author: Topping D.C. et al. | Year: 2007 | Guideline: 424 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Subchronic functional observation battery (FOB) and neuropathology studies on hydroquinone. | Author: Topping D. et al. | Year: 1991 | Guideline: 424 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toxicology and carcinogenesis studies of hydroquinone (CAS No. 123-31-9) in F344/N rats and B6C3F1 mice (gavage studies). | Author: NTP | Year: 1989 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Relationship of hydroquinone-associated rat renal tumors with spontaneous chronic progressive nephropathy. | Author: Hard G.C. et al. | Year: 1997 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toxicity and carcinogenicity of hydroquinone in F344/N rats and B6C3F1 mice. | Author: Kari F.W. et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toxicology and carcinogenesis studies of hydroquinone (CAS No. 123-31-9) in F344/N rats and B6C3F1 mice (gavage studies). | Author: NTP | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: dermal | Robust Study Summary -- Title: Lack of nephrotoxicity and renal cell proliferation following subchronic dermal application of a hydroquinone cream. | Author: David R.M. et al. | Year: 1998 | Guideline: 411 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: dermal | Robust Study Summary -- Title: Toxicology and carcinogenesis studies of hydroquinone (CAS No. 123-31-9) in F344/N rats and B6C3F1 mice (gavage studies). | Author: NTP | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A study of developmental toxicity of hydroquinone in the rabbit | Author: Murphy S.J. et al. | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A range-finding study to evaluate the toxicity of hydroquinone in the pregnant rabbit. | Author: Schroeder R.E. | Year: 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: A range-finding study to evaluate the toxicity of hydroquinone in the pregnant rabbit. | Author: Schroeder R.E. | Year: 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A developmental toxicity study in rabbits with hydroquinone. | Author: Schroeder R.E. | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: A developmental toxicity study in rabbits with hydroquinone. | Author: Schroeder R.E. | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Hydroquinone: A developmental toxicity study in rats | Author: Krasavage W.J. et al. | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Hydroquinone: A developmental toxicity study in rats | Author: Krasavage W.J. | Year: 1985 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Hydroquinone: A developmental toxicity study in rats | Author: Krasavage W.J. | Year: 1985 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Hydroquinone: A dominant lethal assay in male rats. | Author: Krasavage W.J. | Year: 1984 | Guideline: 478 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Hydroquinone: A dominant lethal assay in male rats. | Author: Krasavage W.J. | Year: 1984 | Guideline: 478 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A two-generation reproduction study with hydroquinone in rats. | Author: Blacker A.M. et al. | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A two-generation reproduction study in rats with hydroquinone. | Author: Schroeder R.E. | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A two-generation reproduction study in rats with hydroquinone. | Author: Schroeder R.E. | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicity and carcinogenicity of hydroquinone in F344/N rats and B6C3F1 mice. | Author: Kari F.W. et al. | Year: 1992 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicology and carcinogenesis studies of hydroquinone (CAS No. 123-31-9) in F344/N rats and B6C3F1 mice (gavage studies). | Author: NTP | Year: 1989 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Relationship of hydroquinone-associated rat renal tumors with spontaneous chronic progressive nephropathy. | Author: Hard G.C. et al. | Year: 1997 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Induction of renal cell tumors in rats and mice and enhancement of hepatocellular tumor development in mice after long-term hydroquinone treatment. | Author: Shibata M.A. et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Analysis of studies related to tumorigenicity induced by hydroquinone. | Author: Whysner J. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Hydroquinone: An evaluation of the human risks from its carcinogenic and mutagenic properties. | Author: McGregor D. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic antioxydants. | Author: Kurata Y. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Modification of hepato- and renal carcinogenesis by catechol and its isomers in rats pretreated with N-Ethyl-N-Hydroethylnitrosamine. | Author: Okasaki S. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis. | Author: Hasegawa R. Ito N. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Inhibition by dietary hydroquinone of acetylaminofluorene induction of initiation of rat liver carcinogenesis. | Author: Williams G.M. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: The role of GSH depletion and toxicity in hydroquinone-induced development of enzyme-altered foci. | Author: Stenius U. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Comparison of the effects of 13 phenolic compounds in induction of proliferative lesions of the forestomach and increase in the labelling indices of the glandular stomach and urinary bladder epithelium of Syrian golden hamsters. | Author: Hirose M. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Promotion by dihydroxybenzene derivatives of N-methyl-N'-nitro-N-nitrosoguanidine-induced F344 rat forestomach and glandular stomach carcinogenesis. | Author: Hirose M. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Effects of catechol and its analogs on pancreatic carcinogenesis initiated by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters. | Author: Maruyama H. et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Early proliferative responses of forestomach and glandular stomach of rats treated with five different phenolic antioxydants. | Author: Shibata M.A. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Cocarcinogenic and tumor-promoting agents in tobacco carcinogenesis. | Author: van Duuren B.L. Goldschmidt B.M. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Corneal and conjunctival pigmentation among workers engaged in manufacture of hydroquinone. | Author: Anderson B. | Year: 1947 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Quinone vapors and their harmful effects. I. Corneal and conjunctival injury. | Author: Sterner J.H., Oglesby F.L., and Anderson B. | Year: 1947 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Quinone vapors and their harmful effects. II. Plant exposures associated with eye injuries. | Author: Oglesby F.L., Sterner J.H., & Anderson B. | Year: 1947 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Hydroquinone. | Author: Grant W.M. Schuman J.S. (Eds.) | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Corneal changes from quinone-hydroquinone exposure. | Author: Anderson B. Oglesby F. | Year: 1958 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Measurement of median lethal dose as a rapid indication of contaminant toxicity to fish. | Author: Hodson P.V., Dixon D.G., and Kaiser K.L.E. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia acute immobilization test (Daphnia magna) by hydroquinone. | Author: IDEA Consultants Inc. | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Cyst-based ecotoxicological tests using Anostracans: Comparison of two species of Streptocephalus. | Author: Crisinel A. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Results of the harmful effects of selected water pollutants (anilines phenols aliphatic compounds) to Daphnia magna. | Author: Kühn R. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Befunde der Schadwirkung wassergefährdender Stoffe gegen Daphnia magna. | Author: Bringmann G. Kühn R. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Algal growth inhibition test (Pseudokirchneriella subcapitata) by hydroquinone. | Author: IDEA Consultants Inc. | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Monitoring the toxicity of phenolic chemicals to activated sludge using a novel optical scanning respirometer. | Author: Chan C.M. et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Comparison of the toxicity thresholds of water pollutants to bacteria algae and protozoa in the cell multiplication inhibition test. | Author: Bringmann G. Kühn R. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Testing for substances their toxicity threshold: Model organisms Microcystis (Diplocystis) aeruginosa and Scendesmus quadricauda. | Author: Bringmann G. Kühn R. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: FISH EARLY-LIFE STAGE TOXICITY TEST WITH HYDROQUINONE (FLOW-THROUGH) | Author: M.H.J. Migchielsen Bachelor | Year: 2016 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: FISH EARLY-LIFE STAGE TOXICITY TEST WITH HYDROQUINONE (FLOW-THROUGH) | Author: M.H.J. Migchielsen Bachelor | Year: 2016 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia reproduction (Daphnia magna) test by hydroquinone | Author: IDEA Consultants Inc. | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Calculation of Hydroquinone properties via EPISUITE 4.00 | Author: Fraunhofer | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to terrestrial arthropods | Robust Study Summary -- Title: Hydroquinone: Effect on Soil Microbial Nitrogen Transformations | Author: Collins C. | Year: 2015 | Guideline: 216 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to terrestrial arthropods | Right to refer to study -- Title: Hydroquinone: Effect on Soil Microbial Nitrogen Transformations | Author: Collins C. | Year: 2015 | Guideline: 216 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation and bioaccumulation - Data of existing chemicals based on the CSCL Japan. | Author: MITI | Year: 1992 | Guideline: 301C | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: A correlation study of biodegradability determinations with various chemicals in various tests | Author: Gerike P. & Fischer W.K. | Year: 1979 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Methanogenic degradation of four phenolic compounds | Author: Young L.Y. & Rivera M.D. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Methanogenic degradation of hydroquinone in an anaerobic fixed-bed reactor | Author: Szewzyk U. & Schink B. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: The biodegradation of hydroquinone | Author: Harbison K.G. & Belly R.T. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Adsorption coefficient for soils and sediment. In: Handbook of Chemical Property Estimation Methods. Lyman WJ Reehl WF & Rosenblatt DH (eds.) | Author: Lyman W.J. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Schutz vor weiteren anthropogenen Organika-Eintraegen. In: Handbuch des Bodenschutzes. Bodenoekologie und -belastung. Vorbeugende und abwehrende Schutzmassnahmen. Blume HP (ed.) | Author: Litz N. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Calculation of Hydroquinone properties via EPISUITE 4.00 | Author: Fraunhofer | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Schutz vor weiteren anthropogenen Organika-Eintraegen. In: Handbuch des Bodenschutzes. Bodenoekologie und -belastung. Vorbeugende und abwehrende Schutzmassnahmen. Blume HP (ed.) | Author: Litz N. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: The biodegradation of hydroquinone | Author: Harbison K.G. & Belly R.T. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: A correlation study of biodegradability determinations with various chemicals in various tests | Author: Gerike P. & Fischer W.K. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: The transformation of various coke industry products in Chernozem soil. In: Decomposition of toxic and nontoxic organic compounds in soil. Overcash MR (ed.) | Author: Medvedev V.A. & Davidov V.D. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |