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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: n-OCTANOL/WATER PARTITION COEFFICIENT OF 2-METHYLPENTAMETHYLENEDIAMINE | Author: E. I. du Pont de Nemours & Company, Inc. Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1989 | Guideline: EPA 40 CFR 796.1550 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: n-OCTANOL/WATER PARTITION COEFFICIENT OF 2-METHYLPENTAMETHYLENEDIAMINE | Author: E. I. du Pont de Nemours & Company, Inc. Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1989 | Guideline: EPA 40 CFR 796.1550 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: MEASUREMENT OF WATER MISCIBILITY | Author: INVISTA APPLIED RESEARCH CENTRE | Year: 2012 | Guideline: ASTM D 1722-09 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: MEASUREMENT OF WATER MISCIBILITY | Author: INVISTA APPLIED RESEARCH CENTRE | Year: 2012 | Guideline: ASTM D 1722-09 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Determination of Physico-Chemical Properties | Author: NOTOX B.V. | Year: 2010 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: MEASUREMENT OF pKa | Author: INVISTA S.a r.l Orange Site | Year: 2012 | Guideline: 112 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Right to refer to study -- Title: MEASUREMENT OF pKa | Author: INVISTA S.a r.l Orange Site | Year: 2012 | Guideline: 112 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: MEASUREMENT OF VISCOSITY | Author: INVISTA APPLIED RESEARCH CENTRE | Year: 2012 | Guideline: 114 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: MEASUREMENT OF VISCOSITY | Author: INVISTA APPLIED RESEARCH CENTRE | Year: 2012 | Guideline: 114 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biochemical Degradability | Author: NATEC Institut | Year: 1997 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Biochemical Degradability | Author: NATEC Institut | Year: 1997 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Adsorption/Desorption of BHT amine on Four Soils and One Sediment | Author: Harlan Laboratories Ltd. | Year: 2013 | Guideline: 106 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: Adsorption/Desorption of BHT amine on Four Soils and One Sediment | Author: Harlan Laboratories Ltd. | Year: 2013 | Guideline: 106 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Static acute 96-h LC50 of 1,6-hexanediamine to the fathead minnow, Pimephales promelas | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1985 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Static acute 96-h LC50 of 1,6-hexanediamine to the fathead minnow, Pimephales promelas | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1985 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: MPMD: Daphnia magna Reproduction Test | Author: Covance Laboratories Limited | Year: 2021 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: MPMD: Daphnia magna Reproduction Test | Author: Covance Laboratories Limited | Year: 2021 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: MPMD: Algal Growth Inhibition Test | Author: Covance CRS Research Limited | Year: 2021 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: MPMD: Algal Growth Inhibition Test | Author: Covance CRS Research Limited | Year: 2021 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Hexamethylenediamine: A Study on the Respiration Inhibition of Activated Sludge | Author: ECT Oekotoxikologie GmbH | Year: 2015 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Hexamethylenediamine: A Study on the Respiration Inhibition of Activated Sludge | Author: ECT Oekotoxikologie GmbH | Year: 2015 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Robust Study Summary -- Title: Hexamethylenediamine: Reproduction toxicity to the earthworm Eisenia fetida in artificial soil | Author: ECT Oekotoxikologie GmbH | Year: 2017 | Guideline: 222 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 124-09-4 | EC 204-679-6 | Hexamethylene-diamine) |
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| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Right to refer to study -- Title: Hexamethylenediamine: Reproduction toxicity to the earthworm Eisenia fetida in artificial soil | Author: ECT Oekotoxikologie GmbH | Year: 2017 | Guideline: 222 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 124-09-4 | EC 204-679-6 | Hexamethylene-diamine) |
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| Eco-Tox | Toxicity to soil microorganisms | Robust Study Summary -- Title: Hexamethylenediamine: Effects on Soil Microorganisms - Nitrogen Transformation Test | Author: ECT Oekotoxikologie GmbH | Year: 2017 | Guideline: 216 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 124-09-4 | EC 204-679-6 | Hexamethylene-diamine) |
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| Eco-Tox | Toxicity to soil microorganisms | Right to refer to study -- Title: Hexamethylenediamine: Effects on Soil Microorganisms - Nitrogen Transformation Test | Author: ECT Oekotoxikologie GmbH | Year: 2017 | Guideline: 216 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 124-09-4 | EC 204-679-6 | Hexamethylene-diamine) |
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| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biological monitoring of isocyanates and related amines | Author: Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. Read-Across (CAS 124-09-4 | EC 204-679-6 | Hexamethylene-diamine) |
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| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Median lethal dose (LD50) in rats | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1984 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Median lethal dose (LD50) in rats | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1984 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Inhalation One-Hour Median Lethal Concentration (LC50) of DytekeA Amine in Rats by IMDG Protocol | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1988 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Inhalation One-Hour Median Lethal Concentration (LC50) of DytekeA Amine in Rats by IMDG Protocol | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1988 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: DytekOne-Hour LC50 Recalculation | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1994 | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: DytekOne-Hour LC50 Recalculation | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1994 | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Skin Corrosion Test in Rabbits for International Maritime organization Packaging Classification | Author: E.I. du Pont de Nemours and Company, Huskell Laboratory for Toxicology and Industrial Medicine | Year: 1986 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Skin Corrosion Test in Rabbits for International Maritime organization Packaging Classification | Author: E.I. du Pont de Nemours and Company, Huskell Laboratory for Toxicology and Industrial Medicine | Year: 1986 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: IN VITRO SKIN CORROSION TEST WITH DYTEK® A AMINE USING A HUMAN SKIN MODEL | Author: Charles River Laboratories Den Bosch BV | Year: 2016 | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: IN VITRO SKIN CORROSION TEST WITH DYTEK® A AMINE USING A HUMAN SKIN MODEL | Author: Charles River Laboratories Den Bosch BV | Year: 2016 | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Eye Irritation test in Rabbits | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Eye Irritation test in Rabbits | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Skin sensitisation test on guinea pigs | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Skin sensitisation test on guinea pigs | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Dermal Sensitisation Study with Dytek A Amine in Guinea Pigs | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Dermal Sensitisation Study with Dytek A Amine in Guinea Pigs | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: REPEATED DOSE ORAL TOXICITY: 28-DAY STUDY WITH DYTEK A AMINE FEEDING STUDY IN RATS | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1990 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: REPEATED DOSE ORAL TOXICITY: 28-DAY STUDY WITH DYTEK A AMINE FEEDING STUDY IN RATS | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1990 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: DYTEK A amine: Toxicity Study by Oral Gavage Administration to Han Wistar Rats for 13 Weeks | Author: Labcorp Early Development Laboratories | Year: 2022 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: DYTEK A amine: Toxicity Study by Oral Gavage Administration to Han Wistar Rats for 13 Weeks | Author: Labcorp Early Development Laboratories | Year: 2022 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Two-Week Inhalation Toxicity Study with Dytek A Amine in Rats | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Two-Week Inhalation Toxicity Study with Dytek A Amine in Rats | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Two-Week Inhalation Toxicity Study with 1,2-Diaminocyclohexane in Rats | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: Y. Read-Across (CAS 694-83-7 | EC 211-776-7 | Cyclohex-1,2-ylenediamine) |
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| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Two-Week Inhalation Toxicity Study with 1,2-Diaminocyclohexane in Rats | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: Y. Read-Across (CAS 694-83-7 | EC 211-776-7 | Cyclohex-1,2-ylenediamine) |
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| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: NTP Technical Report on Toxicity Studies of 1,6-Hexanediamine Dihydrochloride administered by drinking water and inhalation to F344/N rats and B6C3F1 Mice | Author: No data | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Inhalation Toxicity of 1,6-Hexanediamine Dihydrochloride in F344/N Rats and B6C3F1 Mice | Author: Hébert C.D. et al. | Year: 1993 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: Y. Read-Across (CAS 6055-52-3 | EC 227-977-8 | 1,6-Hexanediamine Dihydrochloride) |
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| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Inhalation Toxicity of 1,6-Hexanediamine Dihydrochloride in F344/N Rats and B6C3F1 Mice | Author: Hébert C.D. et al. | Year: 1993 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: Y. Read-Across (CAS 6055-52-3 | EC 227-977-8 | 1,6-Hexanediamine Dihydrochloride) |
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| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 13 week inhalation toxicity study of Hexamethylene diamine in the rat | Author: Bio/dynamics Inc. | Year: 1981 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. Read-Across (CAS 124-09-4 | EC 204-679-6 | Hexamethylene-diamine - HMD ) |
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| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 13 week inhalation toxicity study of Hexamethylene diamine in the rat | Author: Bio/dynamics Inc. | Year: 1981 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. Read-Across (CAS 124-09-4 | EC 204-679-6 | Hexamethylene-diamine - HMD ) |
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| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronic inhalation toxicity of hexamethylenediamine in rats. | Author: Bio/dynamics Inc | Year: 1987 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. Read-Across (CAS 124-09-4 | EC 204-679-6 | Hexamethylene-diamine - HMD ) |
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| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Subchronic inhalation toxicity of hexamethylenediamine in rats. | Author: Bio/dynamics Inc | Year: 1987 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. Read-Across (CAS 124-09-4 | EC 204-679-6 | Hexamethylene-diamine - HMD ) |
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| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In vitro evaluation of Dytek A for chromosome aberrations in human lymphocytes | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1990 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: In vitro evaluation of Dytek A for chromosome aberrations in human lymphocytes | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1990 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Gene mutation test at the TK-locus of L5178Y cells with Dytek A (MPMD) | Author: TNO Nutrition and Food Research, Department of Biomolecular Sciences | Year: 2003 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Gene mutation test at the TK-locus of L5178Y cells with Dytek A (MPMD) | Author: TNO Nutrition and Food Research, Department of Biomolecular Sciences | Year: 2003 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella/mammalian-microsome plate incorporation mutagenicity assay (Ames test) and Escherichia coli WP2uvrA reverse mutation assay on Dytek A | Author: Microbiological Associates, Inc. | Year: 1990 | Guideline: 471 | Klimisch score: 3 - Not reliable | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Salmonella/mammalian-microsome plate incorporation mutagenicity assay (Ames test) and Escherichia coli WP2uvrA reverse mutation assay on Dytek A | Author: Microbiological Associates, Inc. | Year: 1990 | Guideline: 471 | Klimisch score: 3 - Not reliable | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Two Generation Reproduction Study in Rats | Author: International research and Development Corporation | Year: 1985 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 124-09-4 | EC 204-679-6 | Hexamethylene-diamine - HMD ) |
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| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Two Generation Reproduction Study in Rats | Author: International research and Development Corporation | Year: 1985 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 124-09-4 | EC 204-679-6 | Hexamethylene-diamine - HMD ) |
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| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A two-generation reproduction study in rats receiving diets containing Hexamethylenediamine | Author: Short R.D., Johannsen F.R. and Schardein J.L. | Year: 1991 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 124-09-4 | EC 204-679-6 | Hexamethylene-diamine - HMD ) |
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| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A two-generation reproduction study in rats receiving diets containing Hexamethylenediamine | Author: Short R.D., Johannsen F.R. and Schardein J.L. | Year: 1991 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 124-09-4 | EC 204-679-6 | Hexamethylene-diamine - HMD ) |
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| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: DYTEK A amine: Preliminary Study for Effects on Embryo-Fetal Development in the Han Wistar Rat by Oral Gavage Administration | Author: Labcorp Early Development Laboratories Ltd. | Year: 2022 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: DYTEK A amine: Preliminary Study for Effects on Embryo-Fetal Development in the Han Wistar Rat by Oral Gavage Administration | Author: Labcorp Early Development Laboratories Ltd. | Year: 2022 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: DYTEK A amine: Preliminary Study for Effects on Embryo-Fetal Development in the New Zealand White Rabbit by Oral Gavage Administration | Author: Labcorp Early Development Laboratories | Year: 2022 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: DYTEK A amine: Preliminary Study for Effects on Embryo-Fetal Development in the New Zealand White Rabbit by Oral Gavage Administration | Author: Labcorp Early Development Laboratories | Year: 2022 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: DYTEK A amine: Study for Effects on Embryo-Fetal Development in the Han Wistar rat by Oral Gavage Administration | Author: Labcorp Early Development Laboratories Ltd. | Year: 2023 | Guideline: 414 | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: DYTEK A amine: Study for Effects on Embryo-Fetal Development in the Han Wistar rat by Oral Gavage Administration | Author: Labcorp Early Development Laboratories Ltd. | Year: 2023 | Guideline: 414 | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: DYTEK A amine: Study for Effects on Embryo-Fetal Development in the New Zealand White Rabbit by Oral Gavage Administration | Author: Labcorp Early Development Laboratories Ltd. | Year: 2023 | Guideline: 414 | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: DYTEK A amine: Study for Effects on Embryo-Fetal Development in the New Zealand White Rabbit by Oral Gavage Administration | Author: Labcorp Early Development Laboratories Ltd. | Year: 2023 | Guideline: 414 | GLP: Y. | - |