You are here: Home> Turkey>TR-REACH>CAS 2627-95-4> CAS 2627-95-4 | Data Package 10 - 100 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Skin sensitization study of Dow Corning 2-0707 intermediate (platinum 4) using the guinea pig maximization test (GPTM) | Author: Dow Corning | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Skin sensitization study of Dow Corning 2-0707 intermediate (platinum 4) using the guinea pig maximization test (GPTM) | Author: Dow Corning | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: 1,1,3,3-tetramethyl-1,3-divinyldisiloxane: Determination of the Water Solubility Using a Slow Stirring Method | Author: Grubelnik A. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: 1,1,3,3-tetramethyl-1,3-divinyldisiloxane: Determination of the Water Solubility Using a Slow Stirring Method | Author: Grubelnik A. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Methylvinylpolysiloxanes | Author: Kantor S.W., Osthoff R.C., Hurd D.T. | Year: 1955 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: QSAR Model Reporting Format: Prediction of the boiling point of other organosilicon substances excluding chlorosilanes and trialkoxysilanes Version 3 | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: QSAR Model Reporting Format: Prediction of the boiling point of other organosilicon substances excluding chlorosilanes and trialkoxysilanes Version 3 | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the boiling point of 1,1,3,3-tetramethyl-1,3-divinyldisiloxane | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the boiling point of 1,1,3,3-tetramethyl-1,3-divinyldisiloxane | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Methylvinylpolysiloxanes | Author: Kantor S.W., Osthoff R.C., Hurd D.T. | Year: 1955 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Divinyltetramethyldisiloxane and polymers therefrom | Author: Cohen M. | Year: 1955 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Physchem data summary | Author: Wacker Chemie AG | Year: 2007 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Physchem data summary | Author: Wacker Chemie AG | Year: 2007 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Divinyltetramethyldisiloxane and polymers therefrom | Author: Cohen M. | Year: 1955 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Methylvinylpolysiloxanes | Author: Kantor S.W., Osthoff R.C., Hurd D.T. | Year: 1955 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: QSAR Model Reporting Format: Prediction of density based on structural contributions Version 3 | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Right to refer to study -- Title: QSAR Model Reporting Format: Prediction of density based on structural contributions Version 3 | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the density of 1,1,3,3-tetramethyl-1,3-divinyldisiloxane | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the density of 1,1,3,3-tetramethyl-1,3-divinyldisiloxane | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: 1,3-Diethenyl-1,1,3,3-tetramethyldisiloxane; CAS No. 2627-95-4 - Determination of the Vapor Pressure by the Static Procedure Following OECD Guideline 104 | Author: McLean S. | Year: 2012 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: 1,3-Diethenyl-1,1,3,3-tetramethyldisiloxane; CAS No. 2627-95-4 - Determination of the Vapor Pressure by the Static Procedure Following OECD Guideline 104 | Author: McLean S. | Year: 2012 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: 1,1,3,3-tetramethyl-1,3-divinyldisiloxane: Determination of the Water Solubility Using a Slow Stirring Method | Author: Grubelnik A. | Year: 2011 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: 1,1,3,3-tetramethyl-1,3-divinyldisiloxane: Determination of the Water Solubility Using a Slow Stirring Method | Author: Grubelnik A. | Year: 2011 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Estimation of the n-Octanol/Water Partition Coefficient of 1,3-divinyltetramethyldisiloxane (CAS No. 2627-95-4) by the High Performance Liquid Chromatography Method | Author: J. A. Miller | Year: 2011 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Estimation of the n-Octanol/Water Partition Coefficient of 1,3-divinyltetramethyldisiloxane (CAS No. 2627-95-4) by the High Performance Liquid Chromatography Method | Author: J. A. Miller | Year: 2011 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - III | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - III | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Bestimmung von Explosionsgrenzen | Author: Bienert | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Bestimmung von Explosionsgrenzen | Author: Bienert | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - III | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - III | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Determination of Physico-chemical Properties of SILOXAN VSI 2 (CAS No. 2627-95-4) | Author: Haas H. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Determination of Physico-chemical Properties of SILOXAN VSI 2 (CAS No. 2627-95-4) | Author: Haas H. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - III | Author: DCC | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - III | Author: DCC | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute eye and skin irritation studies of Dow Corning 4-2776 intermediate in albino rabbits | Author: Dow Corning Corporation | Year: 1987 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: An acute skin irritation|study (expanded range finding) with Dow Corning Q7-9179 | Author: Dow Corning Corporation | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: An acute skin irritation|study (expanded range finding) with Dow Corning Q7-9179 | Author: Dow Corning Corporation | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Dot skin corrosion study | Author: Toxikon | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Dot skin corrosion study | Author: Toxikon | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Hexamethyldisiloxane F-221. | Author: Stauffer Chemical Company | Year: 1973 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Eye irritation | Right to refer to study -- Title: Hexamethyldisiloxane F-221. | Author: Stauffer Chemical Company | Year: 1973 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Eye irritation | Robust Study Summary -- Title: Acute eye and skin irritation studies of Dow Corning 4-2776 intermediate in albino rabbits | Author: Dow Corning Corporation | Year: 1987 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Skin sensitization study of Dow Corning 2-0707n INT (Platinum 4) using the guinea pig maximization test (GPMT) | Author: Dow Corning Corporation | Year: 1998 | Guideline: 406 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Skin sensitization study of Dow Corning 2-0707n INT (Platinum 4) using the guinea pig maximization test (GPMT) | Author: Dow Corning Corporation | Year: 1998 | Guideline: 406 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Skin sensitization study of Dow Corning 2-0707 intermediate (platinum 4) using the guinea pig maximization test (GPTM) | Author: Dow Corning Corporation | Year: 1996 | Guideline: 406 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Skin sensitization study of Dow Corning 2-0707 intermediate (platinum 4) using the guinea pig maximization test (GPTM) | Author: Dow Corning Corporation | Year: 1996 | Guideline: 406 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella/mammalian microsome plate incorporation mutagenicity assay (Ames test) and Escherichia coli WP2 uvrA reverse mutation assay with a confirmatory assay of Dow Corning® 2-7952 Crosslinker | Author: Microbiological Associates | Year: 1992 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Salmonella/mammalian microsome plate incorporation mutagenicity assay (Ames test) and Escherichia coli WP2 uvrA reverse mutation assay with a confirmatory assay of Dow Corning® 2-7952 Crosslinker | Author: Microbiological Associates | Year: 1992 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: In vitro Mammalian Gene Mutation Assay (Thymidine Kinase Locus/TK+/-) in Mouse Lymphoma L5178Y Cells with 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane | Author: BSL BIOSERVICE | Year: 2012 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: In vitro Mammalian Gene Mutation Assay (Thymidine Kinase Locus/TK+/-) in Mouse Lymphoma L5178Y Cells with 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane | Author: BSL BIOSERVICE | Year: 2012 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: An acute oral gavage study in mice to determine the systemic availability of 1,3-Diethenyl-1,1,3,3-tetramethyldisiloxane (CAS No. 2627-95-4) | Author: DCC | Year: 2012 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: An acute oral toxicity study of Dow Corning 4-2776 intermediate | Author: Dow Corning Corporation | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: An acute oral toxicity study of Dow Corning 4-2776 intermediate | Author: Dow Corning Corporation | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: An acute whole body vapor inhalation toxicity study with Hexamethyldisiloxane in albino rats. | Author: Dow Corning Corporation | Year: 1997 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: An acute whole body vapor inhalation toxicity study with Hexamethyldisiloxane in albino rats. | Author: Dow Corning Corporation | Year: 1997 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A two-week repeated dose inhalation toxicity study of DOW CORNING 4-2776 Fluid in albino rats. | Author: Dow Corning Corporation | Year: 1993 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A two-week repeated dose inhalation toxicity study of DOW CORNING 4-2776 Fluid in albino rats. | Author: Dow Corning Corporation | Year: 1993 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Hexamethyldisiloxane (M2) Etude de toxicite aigue par voie percutanee chez le rat | Author: Institut Francais de Recherches et Essais Biologiques | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Hexamethyldisiloxane (M2) Etude de toxicite aigue par voie percutanee chez le rat | Author: Institut Francais de Recherches et Essais Biologiques | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Non-regulated study: Hexamethyldisiloxane: A limited disposition pharmacokinetic inhalation (nose only) study in female Fischer 344 rats at 5000 ppm. | Author: Dow Corning Corporation | Year: 2008 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Non-regulated study: Hexamethyldisiloxane: A limited disposition pharmacokinetic inhalation (nose only) study in female Fischer 344 rats at 5000 ppm. | Author: Dow Corning Corporation | Year: 2008 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Non-regulated study: Major metabolites of hexamethyldisiloxane (MM) in Fischer 344 rat urine. | Author: Dow Corning Corporation | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Non-regulated study: Major metabolites of hexamethyldisiloxane (MM) in Fischer 344 rat urine. | Author: Dow Corning Corporation | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Assessing the metabolism of|Hexamethyldisiloxane using gas uptake methods and PBPK modeling. | Author: Dobrev I.D. et al. | Year: 2002 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Study of hexamethyldisiloxane (HMDS) in the rat following a 14-day nose-only vapor inhalation exposure to HMDS followed by an exposure to 14C-HMDS on day 15, additionally studied is a single nose-only vapor inhalation exposure to 14C-HMDS | Author: Dow Corning Corporation | Year: 2006 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Study of hexamethyldisiloxane (HMDS) in the rat following a 14-day nose-only vapor inhalation exposure to HMDS followed by an exposure to 14C-HMDS on day 15, additionally studied is a single nose-only vapor inhalation exposure to 14C-HMDS | Author: Dow Corning Corporation | Year: 2006 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Dermal absorption | Robust Study Summary -- Title: Absorption of hexamethyldisiloxane (HMDS) using the flow-through diffusion cell system for in vitro dermal absorption in human skin. | Author: Dow Corning Corporation | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Dermal absorption | Right to refer to study -- Title: Absorption of hexamethyldisiloxane (HMDS) using the flow-through diffusion cell system for in vitro dermal absorption in human skin. | Author: Dow Corning Corporation | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: A Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with the Reproductive/Developmental Toxicity Screening Test of 1,3-Diethenyl-1,1,3,3-Tetramethyldisiloxane (CAS No. 2627-95-4) in Rats Including a 14-Day Recovery | Author: WIL Research Laboratories | Year: 2011 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: A Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with the Reproductive/Developmental Toxicity Screening Test of 1,3-Diethenyl-1,1,3,3-Tetramethyldisiloxane (CAS No. 2627-95-4) in Rats Including a 14-Day Recovery | Author: WIL Research Laboratories | Year: 2011 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: A 14-day oral (gavage) toxicity study of 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane (CAS No. 2627-95-4) in rats. | Author: WIL Research Laboratories | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: A 14-day oral (gavage) toxicity study of 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane (CAS No. 2627-95-4) in rats. | Author: WIL Research Laboratories | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A two-week repeated dose inhalation toxicity study of DOW CORNING 4-2776 Fluid in albino rats. | Author: Dow Corning Corporation | Year: 1993 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A two-week repeated dose inhalation toxicity study of DOW CORNING 4-2776 Fluid in albino rats. | Author: Dow Corning Corporation | Year: 1993 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with the Reproduction/Developmental Toxicity Screening Test of 1,3-Diethenyl-1,1,3,3-Tetramethyldisiloxane (CAS No. 2627-95-4) in Rats Including a 14-Day Recovery | Author: WIL Research Laboratories | Year: 2011 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: A Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with the Reproduction/Developmental Toxicity Screening Test of 1,3-Diethenyl-1,1,3,3-Tetramethyldisiloxane (CAS No. 2627-95-4) in Rats Including a 14-Day Recovery | Author: WIL Research Laboratories | Year: 2011 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with the Reproductive/Developmental Toxicity Screening Test of 1,3-Diethenyl-1,1,3,3-Tetramethyldisiloxane (CAS No. 2627-95-4) in Rats Including a 14-Day Recovery | Author: WIL Research Laboratories | Year: 2011 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with the Reproductive/Developmental Toxicity Screening Test of 1,3-Diethenyl-1,1,3,3-Tetramethyldisiloxane (CAS No. 2627-95-4) in Rats Including a 14-Day Recovery | Author: WIL Research Laboratories | Year: 2011 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Human repeated insult patch test with hexamethyldisiloxane | Author: TKL Research | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Toxicological | Sensitisation data (humans) | Right to refer to study -- Title: Human repeated insult patch test with hexamethyldisiloxane | Author: TKL Research | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane) |
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| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Tetramethyldivinyldisiloxane (CAS No. 2627-95-4): Acute Toxicity to the Rainbow Trout (Oncorhynchus mykiss) Under Flow-Through Test Conditions | Author: Dow Corning Corporation | Year: 2011 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Tetramethyldivinyldisiloxane (CAS No. 2627-95-4): Acute Toxicity to the Rainbow Trout (Oncorhynchus mykiss) Under Flow-Through Test Conditions | Author: Dow Corning Corporation | Year: 2011 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Tetramethyldivinyldisiloxane (CAS No.2627-95-4): Daphnia sp., 48-Hour Acute Immobilization Range-finding Test | Author: Harlan Laboratories | Year: 2013 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Tetramethyldivinyldisiloxane (CAS No.2627-95-4): Daphnia sp., 48-Hour Acute Immobilization Range-finding Test | Author: Harlan Laboratories | Year: 2013 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Tetramethyldivinyldisiloxane (CAS Number 2627-95-4): Toxicity to the Freshwater Alga (Pseudokirchneriella subcapitata) Under Closed Bottle Test Conditions | Author: Dow Corning Corporation | Year: 2011 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Tetramethyldivinyldisiloxane (CAS Number 2627-95-4): Toxicity to the Freshwater Alga (Pseudokirchneriella subcapitata) Under Closed Bottle Test Conditions | Author: Dow Corning Corporation | Year: 2011 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Activated sludge respiration inhibition test (carbon and ammonium oxidation) with Tetramethyldivinyldisiloxane | Author: Desmares-Koopmans Ing. M.J.E. | Year: 2012 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Activated sludge respiration inhibition test (carbon and ammonium oxidation) with Tetramethyldivinyldisiloxane | Author: Desmares-Koopmans Ing. M.J.E. | Year: 2012 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis of Hexamethyldisiloxane (HMDS) | Author: Dow Corning Corporation | Year: 2006 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane ) |
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| Environmental | Hydrolysis | Right to refer to study -- Title: Hydrolysis of Hexamethyldisiloxane (HMDS) | Author: Dow Corning Corporation | Year: 2006 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane ) |
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| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis of Octamethyltrisiloxane (MDM) | Author: Dow Corning Corporation | Year: 2007 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Environmental | Hydrolysis | Right to refer to study -- Title: Hydrolysis of Octamethyltrisiloxane (MDM) | Author: Dow Corning Corporation | Year: 2007 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane) |
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| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis of 1,3-Diethenyl-1,1,3,3-tetramethyldisilxoane (CAS Number 2627-95-4) | Author: Dow Corning Corporation | Year: 2012 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Hydrolysis of 1,3-Diethenyl-1,1,3,3-tetramethyldisilxoane (CAS Number 2627-95-4) | Author: Dow Corning Corporation | Year: 2012 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Examination of the biodegradability (closed bottle test) of Siloxan VSI2 - according to the EC Guideline L383 A: C.4-E and OECD guideline 301 D. | Author: Leuschner J. | Year: 2002 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Examination of the biodegradability (closed bottle test) of Siloxan VSI2 - according to the EC Guideline L383 A: C.4-E and OECD guideline 301 D. | Author: Leuschner J. | Year: 2002 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: QSAR Model Reporting Format: Prediction of the log Koc of organosilicon substances | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: QSAR Model Reporting Format: Prediction of the log Koc of organosilicon substances | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the log Koc of 1,1,3,3-tetramethyl-1,3-divinyldisiloxane | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Koc of 1,1,3,3-tetramethyl-1,3-divinyldisiloxane | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Estimation of the n-Octanol/Water Partition Coefficient of 1,3-divinyltetramethyldisiloxane (CAS No. 2627-95-4) by the High Performance Liquid Chromatography Method | Author: J. A. Miller | Year: 2011 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Estimation of the n-Octanol/Water Partition Coefficient of 1,3-divinyltetramethyldisiloxane (CAS No. 2627-95-4) by the High Performance Liquid Chromatography Method | Author: J. A. Miller | Year: 2011 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |