You are here: Home> Turkey>TR-REACH>CAS 26471-62-5> CAS 26471-62-5 | Data Package > 1000 t/a (Affiliates of TDI-TDA-DNT Consortium members and III)
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J. Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J. Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y | Year: 1997 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y | Year: 1997 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficient of isocyanate compounds by an HPLC method. | Author: Yakabe Y. et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Thermal stability identity of breakdown products | Robust Study Summary -- Title: No title | Author: BASF SE | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Thermal stability identity of breakdown products | Right to refer to study -- Title: No title | Author: BASF SE | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Surface tension | Waiver | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Phys/Chem. Testing on Lupranat T80A | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Phys/Chem. Testing on Lupranat T80A | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Desmodur T 80 version 1.9 | Author: Bayer MaterialScience AG | Year: 2008 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Desmodur T 80 version 1.9 | Author: Bayer MaterialScience AG | Year: 2008 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Robust Study Summary -- Title: Chemical behaviour of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test | Author: Seel K. Walber U. Herbold B. & Kopp R. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Explosive properties | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Explosive properties | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Oxidising properties | Waiver | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on Lupranat T80A | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on Lupranat T80A | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Waiver | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Stability: Dissociation constant | Waiver | - |
| Phys-Chem | Self-reactive substances | Waiver | - |
| Phys-Chem | Organic peroxide | Waiver | - |
| Phys-Chem | Metal Corrosion | Waiver | - |
| Phys-Chem | Gasses under pressure | Waiver | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toluylenediisocyanate (TDI): Assessment of primary irritating/corrosive effects on the rabbit skin (Untersuchungen zur primär reizenden/ätzenden Wirkung an der Kaninchenhaut) | Author: Suberg H. Löser E. & Kaliner G. | Year: 1984 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Toluylenediisocyanate (TDI): Assessment of primary irritating/corrosive effects on the rabbit skin (Untersuchungen zur primär reizenden/ätzenden Wirkung an der Kaninchenhaut) | Author: Suberg H. Löser E. & Kaliner G. | Year: 1984 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Skin changes by Isocyanates (Desmodur) | Author: Peschel H. | Year: 1970 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: A combined murine local lymph node and irritancy assay to predict sensitzation and irritancy potential of chemicals | Author: Woolhiser M.R. Hayes B.B. & Meade B.J. | Year: 1998 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X. Buller R.H. & Geil R.G. | Year: 1964 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X. Buller R.H. & Geil R.G. | Year: 1964 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Waiver | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI, MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Waiver | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Identification of chemical respiratory allergens dose-response relationships in the mouse IgE test | Author: Hilton J. Dearman R.J. Basketter D.A. & Kimber I. | Year: 1995 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs | Author: Zissu D. Binet S. & Limasset J-C | Year: 1998 | Guideline: EU B.6 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A combined murine local lymph node and irritancy assay to predict sensitzation and irritancy potential of chemicals | Author: Woolhiser MR Hayes BB & Meade BJ | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Dermal contact with TDI produces respiratory tract hypersensitivity in guinea pigs | Author: Karol M.H., Hauth B.A., Riley E.J. & Magreni C.M. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Contact sensitivity by diisocyanates: potencies and cross-reactivities | Author: Thorne PS Hillebrand JA Lewis GR & Karol MH | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Isocyanate dose-related dermal irritation and delayed contact hypersensitization in guinea pigs | Author: Davies R.A. Auletta C.S. Friedmann M.A. | Year: 1984 | Guideline: 406 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Isocyanate dose-related dermal irritation and delayed contact hypersensitization in guinea pigs | Author: Davies R.A. Auletta C.S. Friedmann M.A. | Year: 1984 | Guideline: 406 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin sensitisation | Waiver | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Assessment of respiratory hypersensitivity in guinea pigs sensitized to toluene diisocyanate: a comparison of sensitization protocols | Author: Pauluhn J. & Mohr U. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Sensitisation of guinea pigs by inhalation exposure to low molecular weight chemicals | Author: Botham P.A. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Concentration-dependent immunologic response to toluene diisocyanate (TDI) following inhalation exposure | Author: Karol M.H. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chemical behavior of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test | Author: Seel K. Walber U. Herbold B. & Kopp R. | Year: 1999 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Tolylene diisocyanate; CAS No. 26471-62-5; methyl-13-phenylene diisocyanate/toluene diisocyanate | Author: Ministry of Health Labour & Welfare Japan | Year: 2001 | Guideline: 473 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: [Toluene diisocyanate: chromosome aberration test results] | Author: JETOC | Year: 1996 | Guideline: 473 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Waiver | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Waiver | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Toluene di-isocyanate: an evaluation in the mouse micronucleus test | Author: MacKay J.M. | Year: 1992 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Toluene di-isocyanate: an evaluation in the mouse micronucleus test | Author: MacKay J.M. | Year: 1992 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenicity study for the detection of unscheduled DNA synthesis ex-vivo in hepatocytes and lung following a single exposure of TDI to rats by inhalation | Author: Benford D.J. & Riley R.A. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Mutagenicity study for the detection of unscheduled DNA synthesis ex-vivo in hepatocytes and lung following a single exposure of TDI to rats by inhalation | Author: Benford D.J. & Riley R.A. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Long-term toxicity and carcinogenicity studies with 2,4/2,6-TDI (80/20) in rats and mice | Author: Loeser E. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: The toxicity and carcinogenicity to rats of TDI vapour administered by inhalation for a period of 113 weeks | Author: Owen P. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: The toxicity and carcinogenicity to rats of TDI vapour administered by inhalation for a period of 113 weeks | Author: Owen P. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Long-term toxicity and carcinogenicity studies with 24/26-TDI (80/20) in rats and mice | Author: Loeser E. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: The toxicity and carcinogenicity of TDI vapour when administered to mice over a period of approximately 2 years | Author: Owen P.E. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: The toxicity and carcinogenicity of TDI vapour when administered to mice over a period of approximately 2 years | Author: Owen P.E. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evaluation of the genetic toxicity of methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) in humans | Author: Zeiger E. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Evaluation of the genetic toxicity of methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) in humans | Author: Zeiger E. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: The genetic toxicity of diisocyanates in humans and laboratory animals | Author: Zeiger E. & Woolhiser M. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: The genetic toxicity of diisocyanates in humans and laboratory animals | Author: Zeiger E. & Woolhiser M. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Tolylene diisocyanate; CAS No. 26471-62-5; methyl-1,3-phenylene diisocyanate/toluene diisocyanate | Author: Ministry of Health Labour & Welfare Japan | Year: 2001 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology and Carcinogenesis studies of commercial grade 2,4(80%)- and 2,6(20%)- toluene diisocyanate (CAS No. 26471-62-5) in F344/N rats and B6C3F1 mice (gavage studies) | Author: National Toxicology Program | Year: 1986 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology and Carcinogenesis studies of commercial grade 2,4(80%)- and 2,6(20%)- toluene diisocyanate (CAS No. 26471-62-5) in F344/N rats and B6C3F1 mice (gavage studies) | Author: National Toxicology Program | Year: 1986 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute toxicity studies (LD50) in male albino rats | Author: Wazeter F.X. Keller J.G. Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute toxicity studies (LD50) in male albino rats | Author: Wazeter F.X. Keller J.G. Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Toluene diisocyanate: acute inhalation toxicity in the rat | Author: Doe J.E. & Horspool G.M. | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Toluene diisocyanate: acute inhalation toxicity in the rat | Author: Doe J.E. & Horspool G.M. | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Toluene di-isocyanate: an evaluation in the mouse micronucleus test | Author: MacKay J.M. | Year: 1992 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Toluene di-isocyanate: an evaluation in the mouse micronucleus test | Author: MacKay J.M. | Year: 1992 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Akute Inhalationstoxizität von Diisocyanaten Polymeren Isocyanaten und Lacksystemen an Ratten | Author: Kimmerle G. | Year: 1976 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Akute Inhalationstoxizität von Diisocyanaten Polymeren Isocyanaten und Lacksystemen an Ratten | Author: Kimmerle G. | Year: 1976 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Sensory irritation study of Mondur TD-80 in Sprague-Dawley rats | Author: Shiotsuka R.N. | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Sensory irritation study of Mondur TD-80 in Sprague-Dawley rats | Author: Shiotsuka R.N. | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X. Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X. Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Disposition of 2,6-toluene diisocyanate in Fischer 344 rats. Project report no.7 (Revised). Pharmacokinetics of xenobiotics | Author: Jeffcoat A.R. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Urinary excretion of toluene diisocyanates in rats following dermal exposure | Author: Yeh H-J et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Disposition of 2,6-toluene diisocyanate in Fischer 344 rats. Project report no.7 (Revised). Pharmacokinetics of xenobiotics | Author: Jeffcoat A.R. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biological monitoring of isocyanates and related amines. III. Test chamber exposure of humans to toluene diisocyanate | Author: Skarping G. Brorson T. & Sango C. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetics of TDI after inhalation exposure of rats to labelled TDI | Author: Saclay | Year: 1977 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Pharmacokinetics of TDI after inhalation exposure of rats to labelled TDI | Author: Saclay | Year: 1977 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Disposition of 2,6-toluene diisocyanate in Fischer 344 rats. Project report no.7 (Revised). Pharmacokinetics of xenobiotics | Author: Jeffcoat A.R. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Detection of protein changes in serum of workers following inhalation exposure to toluene diisocyanate vapors | Author: Czuppon A.B. Marczynski B. & Baur X. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism and disposition of 14C-labeled toluene diisocyanate (TDI) following oral and inhalation exposure : preliminary studies | Author: Stoltz M. et al. | Year: 1987 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Metabolism and disposition of 14C-labeled toluene diisocyanate (TDI) following oral and inhalation exposure : preliminary studies | Author: Stoltz M. et al. | Year: 1987 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism and disposition of 14C-labeled toluene diisocyanate (TDI) following oral and inhalation exposure : preliminary studies | Author: Stoltz M. et al. | Year: 1987 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Metabolism and disposition of 14C-labeled toluene diisocyanate (TDI) following oral and inhalation exposure : preliminary studies | Author: Stoltz M. et al. | Year: 1987 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A study of the diffusion rate of TDI in rats contaminated via the respiratory system. Preliminary study | Author: Saclay | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: A study of the diffusion rate of TDI in rats contaminated via the respiratory system. Preliminary study | Author: Saclay | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biological monitoring of isocyanates and related amines. IV. 24- and 26-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 24- and 26-toluene diisocyanate | Author: Brorson T. Skarping G. & Sango C. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: 2,4-TDI and 2,6-TDI dermal tolerance pilot study in rats | Author: Gamer A.O. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: 2,4-TDI and 2,6-TDI dermal tolerance pilot study in rats | Author: Gamer A.O. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toluene diisocyanate C50533: subchronic rat study | Author: Gordon E.B. Nwagbarocha S. & Sheldon J.A. | Year: 1978 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toluene diisocyanate C50533: subchronic mouse study | Author: Gordon EB Nwagbarocha S & Sheldon JA | Year: 1978 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Twenty-eight-day repeat dose oral toxicity test of tolylene diisocyanate in rats | Author: Ministry of Health Labour & Welfare Japan | Year: 2001 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Repeated dose toxicity: oral | Waiver | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: The toxicity and carcinogenicity to rats of toluene diisocyanate vapour administered by inhalation for a period of 113 weeks | Author: Owen P.E. | Year: 1980 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: The toxicity and carcinogenicity to rats of toluene diisocyanate vapour administered by inhalation for a period of 113 weeks | Author: Owen P.E. | Year: 1980 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: The toxicity and carcinogenicity to rats of toluene diisocyanate vapour administered by inhalation for a period of 113 weeks. Addendum Report Volume 1 | Author: Owen P.E. | Year: 1984 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: The toxicity and carcinogenicity to rats of toluene diisocyanate vapour administered by inhalation for a period of 113 weeks. Addendum Report Volume 1 | Author: Owen P.E. | Year: 1984 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Long-term toxicity and carcinogenicity studies with 2,4/2,6-toluene diisocyanate (80/20) in rats and mice | Author: Loeser E. | Year: 1983 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 30-day repeated inhalation toxicity study of toluene diisocyanate (TDI) in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 30-day repeated inhalation toxicity study of toluene diisocyanate (TDI) in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Tolylene di-isocyanate three week inhalation toxicity in the rat | Author: Bennett I.P. et al. | Year: 1980 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Tolylene di-isocyanate three week inhalation toxicity in the rat | Author: Bennett I.P. et al. | Year: 1980 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: The toxicity and carcinogenicity of toluene diisocyanate vapour when administered to mice over a period of approximately two years. Volumes I and II | Author: Owen P.E. | Year: 1986 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: The toxicity and carcinogenicity of toluene diisocyanate vapour when administered to mice over a period of approximately two years. Volumes I and II | Author: Owen P.E. | Year: 1986 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Long-term toxicity and carcinogenicity studies with 2,4/2,6-toluene diisocyanate (80/20) in rats and mice | Author: Loeser E. | Year: 1983 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Histopathological observations in selected tissues of Syrian hamsters exposed by inhalation to vapors of TDI for 6 hours/day 5 days/week for 4 weeks | Author: Kociba R.J. Keyes D.G. & Wolfe E.L. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Histopathological observations in selected tissues of Syrian hamsters exposed by inhalation to vapors of TDI for 6 hours/day 5 days/week for 4 weeks | Author: Kociba R.J. Keyes D.G. & Wolfe E.L. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: dermal | Waiver | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity study of inhaled toluene diisocyanate vapor in CD (Sprague-Dawley) rats | Author: Tyl R.W. | Year: 1988 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Developmental toxicity study of inhaled toluene diisocyanate vapor in CD (Sprague-Dawley) rats | Author: Tyl R.W. | Year: 1988 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Waiver | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: The toxicity and carcinogenicity to rats of toluene diisocyanate vapour administered by inhalation for a period of 113 weeks | Author: Owen P.E. | Year: 1980 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: The toxicity and carcinogenicity to rats of toluene diisocyanate vapour administered by inhalation for a period of 113 weeks | Author: Owen P.E. | Year: 1980 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: The toxicity and carcinogenicity to rats of toluene diisocyanate vapour administered by inhalation for a period of 113 weeks. Addendum Report Volume 1 | Author: Owen P.E. | Year: 1984 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: The toxicity and carcinogenicity to rats of toluene diisocyanate vapour administered by inhalation for a period of 113 weeks. Addendum Report Volume 1 | Author: Owen P.E. | Year: 1984 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Long-term toxicity and carcinogenicity studies with 2,4/2,6-toluene diisocyanate (80/20) in rats and mice | Author: Loeser E. | Year: 1983 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: TDI inhalation study: tumour statistics review | Author: Müller K. | Year: 2008 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: TDI inhalation study: tumour statistics review | Author: Müller K. | Year: 2008 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: The toxicity and carcinogenicity of toluene diisocyanate vapour when administered to mice over a period of approximately two years. Volumes I and II | Author: Owen P.E. | Year: 1986 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: The toxicity and carcinogenicity of toluene diisocyanate vapour when administered to mice over a period of approximately two years. Volumes I and II | Author: Owen P.E. | Year: 1986 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Long-term toxicity and carcinogenicity studies with 2,4/2,6-toluene diisocyanate (80/20) in rats and mice | Author: Loeser E. | Year: 1983 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: TDI inhalation study: tumour statistics review | Author: Müller K | Year: 2008 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: TDI inhalation study: tumour statistics review | Author: Müller K | Year: 2008 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicology and Carcinogenesis studies of commercial grade 2,4(80%)- and 2,6(20%)- toluene diisocyanate (CAS No. 26471-62-5) in F344/N rats and B6C3F1 mice (gavage studies) | Author: National Toxicology Program | Year: 1986 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Risk evaluation of chronic exposure to toluene diisocyanate based on long-term animal studies | Author: Ader A.W., Carney I.F. & Loeser E. | Year: 1987 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: The carcinogenic activity of commercial grade toluene diisocyanate in rats and mice in relation to the metabolism of the 24- and 26-TDI isomers | Author: Dieter M.P. et al. | Year: 1990 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicology and Carcinogenesis studies of commercial grade 2,4(80%)- and 2,6(20%)- toluene diisocyanate (CAS No. 26471-62-5) in F344/N rats and B6C3F1 mice (gavage studies) | Author: National Toxicology Program | Year: 1986 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Risk evaluation of chronic exposure to toluene diisocyanate based on long-term animal studies | Author: Ader A.W., Carney I.F. & Loeser E. | Year: 1987 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: The carcinogenic activity of commercial grade toluene diisocyanate in rats and mice in relation to the metabolism of the 24- and 26-TDI isomers | Author: Dieter M.P. et al. | Year: 1990 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicity of TDI: evaluation with respect to cancer | Author: International Isocyanate Institute | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: Toxicity of TDI: evaluation with respect to cancer | Author: International Isocyanate Institute | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Toluene diisocyanate | Author: Greim H. | Year: 2003 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: An overview of the epidemiology on MDI and TDI | Author: Collins M | Year: 2009 | Adequacy: other information. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Mortality and cancer morbidity of production workers in the UK flexible polyurethane foam industry: updated findings 1958-98 | Author: Sorahan T. & Nichols L. | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Current diagnostic methods for diisocyanate induced occupational asthma | Author: Bernstein D.I. & Jolly A. | Year: 1999 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Issues in diisocyanate antibody testing | Author: Ott M.G. Jolly A.T. Burkert A.L. & Brown W.E. | Year: 2007 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Evaluation of antibody binding to diisocyanate protein conjugates in a general population | Author: Bernstein D.I. et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Diisocyanate asthma: clinical aspects and immunopathogenesis | Author: Redlich C.A. & Karol M.H. | Year: 2002 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates | Author: Baur X. | Year: 1995 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Frequency and trends of occupational asthma due to toluene diisocyanate: a critical review | Author: Diller W.F. | Year: 2002 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Assessment of the relationship between isocyanate exposure levels and occupational asthma | Author: Tarlo S.M. Liss G.M. Dias C. & Banks D.E. | Year: 1997 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Patch-test Reactions to Plastic and Glue Allergens | Author: Kanerva L. et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Sensory irritation of Mondur TD 80 in SD rats | Author: Shiotsuka R.N. | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: Sensory irritation of Mondur TD 80 in SD rats | Author: Shiotsuka R.N. | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Biomarkers in hydrolysed urine plasma and erythrocytes among workers exposed to thermal degradation products from toluene diisocyanate foam | Author: Lind P., Dalene M., Tinnerberg H. & Skarping G. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Exposure to 2,4- and 2,6-toluene diisocyanate (TDI) during production of flexible foam: determination of airborne TDI and urinary 2,4- and 2,6-toluenediamine (TDA) | Author: Kääriä K.et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Biological monitoring of exposure to toluene diisocyanate | Author: Sennbro C.J. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Biological monitoring of occupational exposure to toluene diisocyanate : measurement of toluenediamine in hydrolysed urine and plasma by gas chromatography-mass spectrometry | Author: Persson P. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Biological monitoring of isocyanates and related amines. III. Test chamber exposure of humans to toluene diisocyanate | Author: Skarping G. Brorson T. & Sango C. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Improvement in the GC-MS method for determining urinary toluene-diamine and its application to the biological monitoring of workers exposed to toluene-diisocyanate | Author: Sakai T. et al. | Year: 2005 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Toxicokinetics of 2,4- and 2,6-toluenediamine in hydrolysed urine and plasma after occupational exposure to 2,4- and 2,6-toluene diisocyanate | Author: Lind P. Dalene M. Skarping G. & Hagmar L. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Development validation and characterization of an analytical method for the quantification of hydrolysable urinary metabolites and plasma protein adducts of 2,4- and 2,6-toluene diisocyanate 1,5-naphthalene diisocyanate and 4,4'-MDI | Author: Sennbro C.J. et al. | Year: 2003 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Albumin adducts in plasma from workers exposed to toluene diisocyanate | Author: Lind P. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Air and biological monitoring of toluene diisocyanate in a flexible foam plant | Author: Tinnerberg H. Dalene M. & Skarping G. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Biological monitoring of occupational exposure to toluene diisocyanate | Author: Maitre A. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Detection of protein changes in serum of workers following inhalation exposure to toluene diisocyanate vapors | Author: Czuppon A.B. Marczynski B. & Baur X. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Upper reference limits for biomarkers of exposure to aromatic diisocyanates | Author: Sennbro C.J. Littorin M. Tinnerberg H. & Jonsson B.A. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Determination of occupational exposure to toluene diisocyanate by biological monitoring | Author: Rosenberg C. & Savolainen H. | Year: 1986 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Biological monitoring of isocyanates and related amines. IV. 2,4- and 2,6-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 2,4- and 2,6-toluene diisocyanate | Author: Brorson T. Skarping G. & Sango C. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: LC-MS determination of urinary toxicokinetics in workers exposed to toluenediisocyanate | Author: Sakai T. Morita Y. Kim Y. & Tao Y.X. | Year: 2002 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Biological action of TDI and MDI in water | Author: Rhône-Poulenc Chimie | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Biological action of TDI and MDI in water | Author: Rhône-Poulenc Chimie | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Biological action of TDI and MDI in water | Author: Rhône-Poulenc Chimie | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Biological action of TDI and MDI in water | Author: Rhône-Poulenc Chimie | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Biological action of TDI and MDI in water | Author: Rhone-Poulenc Chimie | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Biological action of TDI and MDI in water | Author: Rhone-Poulenc Chimie | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Aquatic life study Phase II Step 2: accumulation of TDI, MDI, TDA, and MDA in fish and their toxicity | Author: Fujiwara K. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Aquatic life study Phase II Step 2: accumulation of TDI, MDI, TDA, and MDA in fish and their toxicity | Author: Fujiwara K. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Aquatic life study Phase II Step 2. Accumulation of TDI, MDI, TDA, and MDA in fish and their toxicity | Author: Fujiwara K. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: Aquatic life study Phase II Step 2. Accumulation of TDI, MDI, TDA, and MDA in fish and their toxicity | Author: Fujiwara K. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to fish | Waiver | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Determination of the effect of TDI on the reproduction of Daphnia magna | Author: Cerbelaud E., Saugues M., Cellier P. & Argoud M. | Year: 1997 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Determination of the effect of TDI on the reproduction of Daphnia magna | Author: Cerbelaud E., Saugues M., Cellier P. & Argoud M. | Year: 1997 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic plants other than algae | Waiver | - |
| Eco-Tox | Sediment toxicity | Waiver | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Robust Study Summary -- Title: Determination of the LC50 (14 days) of TDI TDA MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N. Roza P. & Henzen L. | Year: 1992 | Guideline: 207 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Right to refer to study -- Title: Determination of the LC50 (14 days) of TDI TDA MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N. Roza P. & Henzen L. | Year: 1992 | Guideline: 207 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to terrestrial arthropods | Waiver | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N. Roza P. & Henzen L. | Year: 1992 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to terrestrial plants | Right to refer to study -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N. Roza P. & Henzen L. | Year: 1992 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N. Roza P. & Henzen L. | Year: 1992 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to terrestrial plants | Right to refer to study -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N. Roza P. & Henzen L. | Year: 1992 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil microorganisms | Waiver | - |
| Eco-Tox | Toxicity to birds | Waiver | - |
| Eco-Tox | Toxicity to other above-ground organisms | Waiver | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: The bioconcentration of 2,4-TDI in Cyprinus carpio: Test Number 50311 | Author: CERI | Year: 2003 | Guideline: 305E | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: The bioconcentration of 2,4-TDI in Cyprinus carpio: Test Number 50311 | Author: CERI | Year: 2003 | Guideline: 305E | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Biological effects and fate of Desmodur 44 V 20 (polymeric MDI) in artificial ponds by simulating an accidental pollution | Author: Heimbach F. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Biological effects and fate of Desmodur 44 V 20 (polymeric MDI) in artificial ponds by simulating an accidental pollution | Author: Heimbach F. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Estimated bioconcentration factor (BCF) values for MDI and TDI | Author: Tury B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Estimated bioconcentration factor (BCF) values for MDI and TDI | Author: Tury B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: terrestrial | Waiver | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Fate of methylenediphenyl diisocyanate and toluene diisocyanate in the aquatic environment | Author: Yakabe Y. et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Fate of TDI in water. Part 1 : 2,4-TDI (T-100) | Author: Kitano M. Ouchiyama N. & Shimogawa Y. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Fate of TDI in water. Part 1 : 2,4-TDI (T-100) | Author: Kitano M. Ouchiyama N. & Shimogawa Y. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Summary report for the study on the fate of TDI in water. FE-E-63 project parts I II and III | Author: CITI | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Summary report for the study on the fate of TDI in water. FE-E-63 project parts I II and III | Author: CITI | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: A study of the fate of TDI in water. Effect of interfacial area under static condition | Author: Yakabe Y. Mori E. & Tadokoro H | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: A study of the fate of TDI in water. Effect of interfacial area under static condition | Author: Yakabe Y. Mori E. & Tadokoro H | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Reaction of TDI with water and with wet sand | Author: Abele L. & Brochhagen F. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Reaction of TDI with water and with wet sand | Author: Abele L. & Brochhagen F. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Aquatic life study Phase II Step 1 : biodegradation of TDI and MDI in the model river and marine water | Author: Fujiwara K. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Aquatic life study Phase II Step 1 : biodegradation of TDI and MDI in the model river and marine water | Author: Fujiwara K. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Gas phase reaction of toluene diisocyanate with water vapor | Author: Holdren M.W. Spicer C.W. & Riggin R.M. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Leaching of isocyanates from soil | Author: von Blumencron H.O. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Leaching of isocyanates from soil | Author: von Blumencron H.O. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Waiver | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 302C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 302C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Waiver | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Leaching of isocyanates from soil | Author: von Blumencron H.O. | Year: 1978 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: Leaching of isocyanates from soil | Author: von Blumencron H.O. | Year: 1978 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Environmental | Adsorption/desorption | Waiver | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Fate of TDI part II: vapour phase studies | Author: Holdren M. Spicer C. & Riggin R. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: Fate of TDI part II: vapour phase studies | Author: Holdren M. Spicer C. & Riggin R. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: The reactions of OH radicals with TDI TDA and MDA under simulated atmospheric conditions | Author: Becker K.H. Bastian V. & Klein T. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Prediction of atmospheric half-lives for MDI TDI MDA and TDA using the AOPWIN™ model | Author: Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: Prediction of atmospheric half-lives for MDI TDI MDA and TDA using the AOPWIN™ model | Author: Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Microbial degradation of polyurethane foams in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Right to refer to study -- Title: Microbial degradation of polyurethane foams in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Microbial degradation of polyurethane foams and isocyanate based polyureas in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Microbial degradation of polyurethane foams in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Right to refer to study -- Title: Microbial degradation of polyurethane foams in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Microbial degradation of polyurethane foams and isocyanate based polyureas in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Microbial degradation of polyurethane foams in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Right to refer to study -- Title: Microbial degradation of polyurethane foams in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Microbial degradation of polyurethane foams and isocyanate based polyureas in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Waiver | - |
| Environmental | Mode of degradation in actual use | Robust Study Summary -- Title: Incident at the Port of Quebec. Decontamination of TDI | Author: Parron J.C. & Ramonet J. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Mode of degradation in actual use | Right to refer to study -- Title: Incident at the Port of Quebec. Decontamination of TDI | Author: Parron J.C. & Ramonet J. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |