You are here: Home> Turkey>TR-REACH>CAS 4098-71-9> CAS 4098-71-9 | Data Package 100 - 1000 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Bayer isophorone diisocyanate exposure questionnaire (unpublished) | Author: Bayer MaterialScience AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Bayer isophorone diisocyanate exposure questionnaire (unpublished) | Author: Bayer MaterialScience AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Degussa Corp. isophorone diisocyanate exposure questionnaire (unpublished) | Author: Degussa North America | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Degussa Corp. isophorone diisocyanate exposure questionnaire (unpublished) | Author: Degussa North America | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Isophorone diisocyanate / Hawley's condensed chemical dictionary eleventh edition | Author: Sax NI and Lewis RJ sr (Eds.) | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Diisocyanate d'isophorone | Author: INRS (Institut national de recherche et de sécurité) Paris | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Fiche toxicologique No 166: diisocyanate d'isophorone | Author: Morel C et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Isophorondiamin Isophorondiisocyanat / Auer Technikum | Author: Auergesellschaft | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Isophorondiisocyanat Merkblatt 917 / Handbuch der gefährlichen Güter | Author: Hommel G | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: TLVs and BEIs Threshold Limit Values for Chemical Substances and Physical Agents Biological Exposure Indices - isophorone diisocyanate | Author: ACGIH (American Conference of Governmental Industrial Hygienists) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Diisocyanate d'isophorone | Author: INRS (Institut national de recherche et de sécurité) Paris | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Diisocyanate d'isophorone | Author: INRS (Institut national de recherche et de sécurité) Paris | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Fiche toxicologique No 166: diisocyanate d'isophorone | Author: Morel C et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Isophorondiamin Isophorondiisocyanat / Auer Technikum | Author: Auergesellschaft | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Isophorone / Isophorone diisocyanate | Author: Lewis RJ jr (Ed.) | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Isophorone diisocyanate / Hawley's condensed chemical dictionary eleventh edition | Author: Sax NI and Lewis RJ sr (Eds.) | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: TLVs and BEIs Threshold Limit Values for Chemical Substances and Physical Agents Biological Exposure Indices - isophorone diisocyanate | Author: ACGIH (American Conference of Governmental Industrial Hygienists) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Diisocyanate d'isophorone | Author: INRS (Institut national de recherche et de sécurité) Paris | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Fiche toxicologique No 166: diisocyanate d'isophorone | Author: Morel C et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Isophorondiamin Isophorondiisocyanat / Auer Technikum | Author: Auergesellschaft | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Isophorone / Isophorone diisocyanate | Author: Lewis RJ jr (Ed.) | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Isophorone diisocyanate / Hawley's condensed chemical dictionary eleventh edition | Author: Sax NI and Lewis RJ sr (Eds.) | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Isophorone diisocyanate: Physical constants / Handbook of chemistry and physics | Author: Lide DR (Ed.) | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: TLVs and BEIs Threshold Limit Values for Chemical Substances and Physical Agents Biological Exposure Indices - isophorone diisocyanate | Author: ACGIH (American Conference of Governmental Industrial Hygienists) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Bestimmung von physikalisch-chemischen Stoffdaten - Dampfdruck | Author: Bayer AG | Year: 1994 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Bestimmung von physikalisch-chemischen Stoffdaten - Dampfdruck | Author: Bayer AG | Year: 1994 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Diisocyanate d'isophorone | Author: INRS (Institut national de recherche et de sécurité) Paris | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Fiche toxicologique No 166: diisocyanate d'isophorone | Author: Morel C et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Isophorondiamin Isophorondiisocyanat / Auer Technikum | Author: Auergesellschaft | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Isophorondiisocyanat Merkblatt 917 / Handbuch der gefährlichen Güter | Author: Hommel G | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Isophorone diisocyanate / Hawley's condensed chemical dictionary eleventh edition | Author: Sax NI and Lewis RJ sr (Eds.) | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: TLVs and BEIs Threshold Limit Values for Chemical Substances and Physical Agents Biological Exposure Indices - isophorone diisocyanate | Author: ACGIH (American Conference of Governmental Industrial Hygienists) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Isophorone diisocyanate: unpublished calculations using standard methods / equations | Author: Degussa AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Isophorone diisocyanate: unpublished calculations using standard methods / equations | Author: Degussa AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Löslichkeits- und Abbauverhalten von Isophorondiisocyanat (IPDI) in Wasser | Author: Infracor GmbH | Year: 2000 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Löslichkeits- und Abbauverhalten von Isophorondiisocyanat (IPDI) in Wasser | Author: Infracor GmbH | Year: 2000 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Solubility in organic solvents/fat solubility | Robust Study Summary -- Title: Isophorone diisocyanate / Hawley's condensed chemical dictionary eleventh edition | Author: Sax NI and Lewis RJ sr (Eds.) | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Determination of the flash point of Vestanat IPDI | Author: AQura GmbH | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Determination of the flash point of Vestanat IPDI | Author: AQura GmbH | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Diisocyanate d'isophorone | Author: INRS (Institut national de recherche et de sécurité) Paris | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Fiche toxicologique No 166: diisocyanate d'isophorone | Author: Morel C et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Isophorondiamin Isophorondiisocyanat / Auer Technikum | Author: Auergesellschaft | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Isophorondiisocyanat Merkblatt 917 / Handbuch der gefährlichen Güter | Author: Hommel G | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Diisocyanate d'isophorone | Author: INRS (Institut national de recherche et de sécurité) Paris | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Fiche toxicologique No 166: diisocyanate d'isophorone | Author: Morel C et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Isophorondiamin Isophorondiisocyanat / Auer Technikum | Author: Auergesellschaft | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Isophorondiisocyanat Merkblatt 917 / Handbuch der gefährlichen Güter | Author: Hommel G | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Oxidation reduction potential | Robust Study Summary -- Title: Determination of the explosion properties of Vestanat IPDI | Author: AQura GmbH | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Oxidation reduction potential | Right to refer to study -- Title: Determination of the explosion properties of Vestanat IPDI | Author: AQura GmbH | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Oxidation reduction potential | Robust Study Summary -- Title: Diisocyanate d'isophorone | Author: INRS (Institut national de recherche et de sécurité) Paris | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Oxidation reduction potential | Robust Study Summary -- Title: Isophorondiamin Isophorondiisocyanat / Auer Technikum | Author: Auergesellschaft | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Determination of the viscosity of Vestanat IPDI | Author: Fieseler A | Year: 2012 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Determination of the viscosity of Vestanat IPDI | Author: Fieseler A | Year: 2012 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Isophorone diisocyanate: unpublished calculations using standard methods / equations | Author: Degussa AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Isophorone diisocyanate: unpublished calculations using standard methods / equations | Author: Degussa AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Vestamin IPD - Determination of the partition coefficient (log pow) shake flask method | Author: Hüls Infracor GmbH | Year: 1998 | Guideline: 107 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 2855-13-2 | EC 220-666-8 | 3-(aminomethyl)-3,5,5-trimethylcyclohexanamine) |
- |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Vestamin IPD - Determination of the partition coefficient (log pow) shake flask method | Author: Hüls Infracor GmbH | Year: 1998 | Guideline: 107 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 2855-13-2 | EC 220-666-8 | 3-(aminomethyl)-3,5,5-trimethylcyclohexanamine) |
- |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Decrease of NCO-content in water - Desmodur I | Author: Bayer AG | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Decrease of NCO-content in water - Desmodur I | Author: Bayer AG | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Löslichkeits- und Abbauverhalten von Isophorondiisocyanat (IPDI) in Wasser | Author: Infracor GmbH | Year: 2000 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Löslichkeits- und Abbauverhalten von Isophorondiisocyanat (IPDI) in Wasser | Author: Infracor GmbH | Year: 2000 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: "Investigation of the ecological properties of DESMODUR I Bakterientox. Algentox. Daphnientox. Fischtox. leichte biologische Abbaubarkeit" | Author: Bayer AG | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: "Investigation of the ecological properties of DESMODUR I Bakterientox. Algentox. Daphnientox. Fischtox. leichte biologische Abbaubarkeit" | Author: Bayer AG | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Bestimmung der biologischen Abbaubarkeit von Vestamin IPD im DOC-DIE Away test | Author: Hüls AG | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 2855-13-2 | EC 220-666-8 | 3-(aminomethyl)-3,5,5-trimethylcyclohexanamine) |
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| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Bestimmung der biologischen Abbaubarkeit von Vestamin IPD im DOC-DIE Away test | Author: Hüls AG | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 2855-13-2 | EC 220-666-8 | 3-(aminomethyl)-3,5,5-trimethylcyclohexanamine) |
- |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: Bestimmung der biologischen Abbaubarkeit von Vestamin IPD im Modifizierten Coupled Units-Test | Author: Hüls AG | Year: 1992 | Guideline: 303A | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 2855-13-2 | EC 220-666-8 | 3-(aminomethyl)-3,5,5-trimethylcyclohexanamine) |
- |
| Environmental | Biodegradation in water and sediment: simulation tests | Right to refer to study -- Title: Bestimmung der biologischen Abbaubarkeit von Vestamin IPD im Modifizierten Coupled Units-Test | Author: Hüls AG | Year: 1992 | Guideline: 303A | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 2855-13-2 | EC 220-666-8 | 3-(aminomethyl)-3,5,5-trimethylcyclohexanamine) |
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| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Isophorone diisocyanate: unpublished calculations using standard methods / equations | Author: Degussa AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Isophorone diisocyanate: unpublished calculations using standard methods / equations | Author: Degussa AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Unpublished calculation using standard methods / equations (Isophorone diamine) | Author: Degussa AG | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. Read-Across (CAS 2855-13-2 | EC 220-666-8 | 3-(aminomethyl)-3,5,5-trimethylcyclohexanamine) |
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| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Unpublished calculation using standard methods / equations (Isophorone diamine) | Author: Degussa AG | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. Read-Across (CAS 2855-13-2 | EC 220-666-8 | 3-(aminomethyl)-3,5,5-trimethylcyclohexanamine) |
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| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Isophorone diisocyanate: unpublished calculations using standard methods / equations | Author: Degussa AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: Isophorone diisocyanate: unpublished calculations using standard methods / equations | Author: Degussa AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: "Investigation of the ecological properties of DESMODUR I Bakterientox. Algentox. Daphnientox. Fischtox. leichte biologische Abbaubarkeit" | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: "Investigation of the ecological properties of DESMODUR I Bakterientox. Algentox. Daphnientox. Fischtox. leichte biologische Abbaubarkeit" | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Bestimmung der akuten Wirkungen von Vestanat IPDI gegenüber Fischen (nach EG 92/69 C 1) | Author: Hüls AG | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Bestimmung der akuten Wirkungen von Vestanat IPDI gegenüber Fischen (nach EG 92/69 C 1) | Author: Hüls AG | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: "Investigation of the ecological properties of DESMODUR I Bakterientox. Algentox. Daphnientox. Fischtox. leichte biologische Abbaubarkeit" | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: "Investigation of the ecological properties of DESMODUR I Bakterientox. Algentox. Daphnientox. Fischtox. leichte biologische Abbaubarkeit" | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Bestimmung der Auswirkungen von Vestanat IPDI auf das Schwimmverhalten von Daphnia magna | Author: Hüls AG | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Bestimmung der Auswirkungen von Vestanat IPDI auf das Schwimmverhalten von Daphnia magna | Author: Hüls AG | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Re-evaluation of effect concentrations to Daphnia magna for Desmodur I (CAS: 4098-71-9). | Author: Bayer Industry Services | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Re-evaluation of effect concentrations to Daphnia magna for Desmodur I (CAS: 4098-71-9). | Author: Bayer Industry Services | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Tests and desk studies carried out by MT-TNO during 1980-1981 for annex II of marpol 1973 | Author: Adema DMM | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Bestimmung der Auswirkungen von Vestamin IPD auf die Reproduktionsrate von Daphnia magna | Author: Hüls AG | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 2855-13-2 | EC 220-666-8 | 3-(aminomethyl)-3,5,5-trimethylcyclohexanamine) |
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| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Bestimmung der Auswirkungen von Vestamin IPD auf die Reproduktionsrate von Daphnia magna | Author: Hüls AG | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 2855-13-2 | EC 220-666-8 | 3-(aminomethyl)-3,5,5-trimethylcyclohexanamine) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: "Investigation of the ecological properties of DESMODUR I Bakterientox. Algentox. Daphnientox. Fischtox. leichte biologische Abbaubarkeit" | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: "Investigation of the ecological properties of DESMODUR I Bakterientox. Algentox. Daphnientox. Fischtox. leichte biologische Abbaubarkeit" | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: "Investigation of the ecological properties of DESMODUR I Bakterientox. Algentox. Daphnientox. Fischtox. leichte biologische Abbaubarkeit" | Author: Bayer AG | Year: 2000 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: "Investigation of the ecological properties of DESMODUR I Bakterientox. Algentox. Daphnientox. Fischtox. leichte biologische Abbaubarkeit" | Author: Bayer AG | Year: 2000 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Test chamber exposure of humans to 16-hexamethylene diisocyanate and isophorone diisocyanate | Author: Tinnerberg H et al. | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Akute Toxizitätsprüfung von "3-Isocyanatomethyl-3.5.5-trimethylcyclohexyl isocyanat" nach oraler Applikation an der Ratte | Author: IBR International Bio-Research | Year: 1976 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Akute Toxizitätsprüfung von "3-Isocyanatomethyl-3.5.5-trimethylcyclohexyl isocyanat" nach oraler Applikation an der Ratte | Author: IBR International Bio-Research | Year: 1976 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Bestimmung der akuten Toxizität (LD50) Substanz 3-Isocyanatomethyl-3,5,5-trimethylcyclohexylisocyanat (IPDI) | Author: Thyssen | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Bestimmung der akuten Toxizität (LD50) Substanz 3-Isocyanatomethyl-3,5,5-trimethylcyclohexylisocyanat (IPDI) | Author: Thyssen | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Isophorondiisocyanat - toxikologische Untersuchungen | Author: Kimmerle G | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Isophorondiisocyanat - toxikologische Untersuchungen | Author: Kimmerle G | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: 3-Isocyanatomethyl-3.5.5-trimethylcyclohexylisocyanat - 4-hour acute inhalation toxicity study in rats | Author: RCC Research & Consulting Company Ltd. | Year: 1988 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: 3-Isocyanatomethyl-3.5.5-trimethylcyclohexylisocyanat - 4-hour acute inhalation toxicity study in rats | Author: RCC Research & Consulting Company Ltd. | Year: 1988 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Analysis of bronchoalveolar-lavage following acute inhalation toxicity in rats (exposure: 1 x 6 hours) | Author: Pauluhn J | Year: 2004 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Analysis of bronchoalveolar-lavage following acute inhalation toxicity in rats (exposure: 1 x 6 hours) | Author: Pauluhn J | Year: 2004 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Isophorondiisocyanat - study on acute inhalation toxicity in rats according to OECD 403 | Author: Bayer AG | Year: 1995 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Isophorondiisocyanat - study on acute inhalation toxicity in rats according to OECD 403 | Author: Bayer AG | Year: 1995 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Laboratory report on cyclohexane 5-isocyanate-1-(isocyanatomethyl)-133-trimethyl | Author: EI du Pont de Nemours & Co | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Mouse sensory irritation | Author: EI du Pont de Nemours & Co | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Pulmonary irritant potency of polyisocyanate aerosols in rats: comparative assessment of irritant threshold concentrations by bronchoalveolar lavage | Author: Pauluhn J | Year: 2004 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Sensory irritation of isophorone diisocyanate (IPDI) to mice study number 82-341-01 | Author: Mobay Chemical Corporation | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Sensory irritation of isophorone diisocyanate (IPDI) to mice study number 82-341-01 | Author: Mobay Chemical Corporation | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Sensory irritation with isophorone diisocyanate (IPDI) in rats | Author: Mobay Chemical Corporation | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Sensory irritation with isophorone diisocyanate (IPDI) in rats | Author: Mobay Chemical Corporation | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Akute dermale Toxizität von Isophorondiisocyanat (IPDI) für Ratten | Author: Hüls AG | Year: 1985 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Akute dermale Toxizität von Isophorondiisocyanat (IPDI) für Ratten | Author: Hüls AG | Year: 1985 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Bericht über die Prüfung von Isophorondiisocyanat auf primäre Hautreizwirkung | Author: Fraunhofer ITA | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Bericht über die Prüfung von Isophorondiisocyanat auf primäre Hautreizwirkung | Author: Fraunhofer ITA | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Isophorondiisocyanat - study for skin irritation/corrosion in rabbits | Author: Bayer AG | Year: 1994 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Isophorondiisocyanat - study for skin irritation/corrosion in rabbits | Author: Bayer AG | Year: 1994 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Prüfung der akuten Hautreizwirkung von Isophorondiisocyanat (IPDI) | Author: Hüls AG | Year: 1984 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Prüfung der akuten Hautreizwirkung von Isophorondiisocyanat (IPDI) | Author: Hüls AG | Year: 1984 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: The evaluation of isophorone diisocyanate for primary skin irritation in rabbits | Author: Mobay Chemical Corporation | Year: 1987 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: The evaluation of isophorone diisocyanate for primary skin irritation in rabbits | Author: Mobay Chemical Corporation | Year: 1987 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Vestanat IPDI: In vitro membrane barrier test for skin corrosion | Author: Sinn S | Year: 2016. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Vestanat IPDI: In vitro membrane barrier test for skin corrosion | Author: Sinn S | Year: 2016. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Bericht über die Prüfung von Isophorondiisocyanat auf Schleimhautreizwirkung | Author: Fraunhofer ITA | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Bericht über die Prüfung von Isophorondiisocyanat auf Schleimhautreizwirkung | Author: Fraunhofer ITA | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Prüfung der akuten Augen- und Schleimhautreizwirkung von Isophorondiisocyanat (IPDI) | Author: Hüls AG | Year: 1984 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Prüfung der akuten Augen- und Schleimhautreizwirkung von Isophorondiisocyanat (IPDI) | Author: Hüls AG | Year: 1984 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: The evaluation of isophorone diisocyanate for mucous membrane irritation in rabbits | Author: Mobay Chemical Corporation | Year: 1987 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: The evaluation of isophorone diisocyanate for mucous membrane irritation in rabbits | Author: Mobay Chemical Corporation | Year: 1987 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: 3-Isocyanatomethyl-3.5.5-trimethylcyclohexylisocyanat - Prüfung auf sensibilisierende Eigenschaften am Meerschweinchen nach B. Magnusson und A.M. Kligman (gemäẞ OECD Richtlinien) | Author: IBR (International Bio-Research) Huels AG | Year: 1983 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: 3-Isocyanatomethyl-3.5.5-trimethylcyclohexylisocyanat - Prüfung auf sensibilisierende Eigenschaften am Meerschweinchen nach B. Magnusson und A.M. Kligman (gemäẞ OECD Richtlinien) | Author: IBR (International Bio-Research) Huels AG | Year: 1983 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A closed-patch repeated insult dermal sensitization study in guinea pigs with TDI MDI p-TMXDI IPDI m-TMXDI HMDI and m-TMI (modified Buehler method) | Author: American Cyanamid Co | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Characterization of murine immune responses to allergenic diisocyanates | Author: Dearman RJ, Spence LM, and Kimber I | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Contact hypersensitivity response to isophorone diisocyanate in mice | Author: Stern ML et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs | Author: Zissu D Binet S and Limasset JC | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Dermal sensitization study of compound number 11583B15 and isophorone diisocyanate | Author: Biosphere Research Center Inc | Year: 1981 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Diss. Akademie für ärztl. Fortbildung der DDR Berlin | Author: Fiss J | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Isophorondiisocyanat - Untersuchungen auf hautsensibilisierende Wirkung bei Meerschweinchen (Maximierungstest nach Magnusson und Kligman) | Author: Vohr HW | Year: 1993 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Isophorondiisocyanat - Untersuchungen auf hautsensibilisierende Wirkung bei Meerschweinchen (Maximierungstest nach Magnusson und Kligman) | Author: Vohr HW | Year: 1993 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Isophorondiisocyanat (IPDI) - Untersuchungen zur sensibilisierenden Wirkung an der Meerschweinchenhaut (modif. "Maximierungstest" mit nur intrakutaner Induktion) | Author: Schmidt WM; Bayer AG | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Isophorondiisocyanat (IPDI) - Untersuchungen zur sensibilisierenden Wirkung an der Meerschweinchenhaut (modif. "Maximierungstest" mit nur intrakutaner Induktion) | Author: Schmidt WM; Bayer AG | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: The TINA test | Author: Ziegler V and Süss E | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Contact and respiratory sensitizers can be identified by cytokine profils following inhalation exposure | Author: De Jong WH et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Cytokine mRNA profiles for isocyanates with known and unknown potential to induce respiratory sensitization | Author: Plitnick LM et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Inconsistencies between cytokine profiles antibody responses and respiratory hyperresponsiveness following dermal exposure to isocyanates | Author: Selgrade MJK et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: IPDI (Isophorondiisocyanat) evaluation of respiratory sensitization in guinea-pigs following intradermal induction Report No. 24967 | Author: Bayer AG | Year: 1996 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Respiratory sensitisation | Right to refer to study -- Title: IPDI (Isophorondiisocyanat) evaluation of respiratory sensitization in guinea-pigs following intradermal induction Report No. 24967 | Author: Bayer AG | Year: 1996 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Role of sensitization routes in the development of type I hypersensitivity to natural rubber latex in mice | Author: Woolhiser MR, Munson AE, Meade BJ | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Th2 cytokines in skin draining lymph nodes and serum IgE do not predict airway hypersensitivity to intranasal isocyanate exposure in mice | Author: Farraj AK et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: The respiratory Local Lymph Node Assay as a tool to study respiratory sensitizers | Author: Arts JHE et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Isophorondiisocyanate (IPDI) subacute inhalation toxicity on rats study no. T0071598 | Author: Bayer AG | Year: 2003 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Isophorondiisocyanate (IPDI) subacute inhalation toxicity on rats study no. T0071598 | Author: Bayer AG | Year: 2003 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Isophorone diisocyanate (IPDI) 90-day inhalation study with a 4-week recovery period in Wistar rats | Author: Pauluhn J | Year: 2008 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Isophorone diisocyanate (IPDI) 90-day inhalation study with a 4-week recovery period in Wistar rats | Author: Pauluhn J | Year: 2008 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Determination of the mutagenicity of isophorone diisocyanate (IPDI) in the Ames Salmonella/mammalian microsomes mutagenicity test complying with Directive 84/449/EEC B.14 | Author: Hüls AG | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Determination of the mutagenicity of isophorone diisocyanate (IPDI) in the Ames Salmonella/mammalian microsomes mutagenicity test complying with Directive 84/449/EEC B.14 | Author: Hüls AG | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenitätsuntersuchung von Isophorondiisocyanat mit Hilfe des Salmonella typhimurium/Mikrosomen-Mutagenitäts-Tests nach Ames. | Author: Hüls AG | Year: 1981 | Klimisch score: 4 - Not assignable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Mutagenitätsuntersuchung von Isophorondiisocyanat mit Hilfe des Salmonella typhimurium/Mikrosomen-Mutagenitäts-Tests nach Ames. | Author: Hüls AG | Year: 1981 | Klimisch score: 4 - Not assignable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella mutagenicity tests: II. results from the testing of 270 chemicals | Author: Mortelmans K et al. | Year: 1986 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: IPDI chromosome aberrations in Chinese hamster ovary cells in vitro | Author: RTC (Research Toxicology Centre) | Year: 2003 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: IPDI chromosome aberrations in Chinese hamster ovary cells in vitro | Author: RTC (Research Toxicology Centre) | Year: 2003 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: In vitro gene mutation test in CHO cells (HPRT locus assay) with isophorone diisocyanate | Author: Schulz M and Landsiedel R | Year: 2007 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: In vitro gene mutation test in CHO cells (HPRT locus assay) with isophorone diisocyanate | Author: Schulz M and Landsiedel R | Year: 2007 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Isophorondiisocyanat (IPDI) - developmental toxicity study in rats after inhalation | Author: Klaus AM | Year: 2004 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Isophorondiisocyanat (IPDI) - developmental toxicity study in rats after inhalation | Author: Klaus AM | Year: 2004 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |