You are here: Home> Turkey>TR-REACH>CAS 5124-30-1> CAS 5124-30-1 | Data Package 100 - 1000 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: International Chemical Safety Cards (ICSC) | Author: NIOSH | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of the melting point of VESTANAT H12MDI | Author: Aqura GmbH | Year: 2010 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of the melting point of VESTANAT H12MDI | Author: Aqura GmbH | Year: 2010 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Polyurethanes | Author: Dieterich D and Uhlig K | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: International Chemical Safety Cards (ICSC) | Author: NIOSH | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Physicochemical properties of 4,4'-dicyclohexylmethane diisocyanate | Author: Zhuravlev EZ Selivanov VD Mulyanov PV Konstantinov II | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Thermische Untersuchung zur Destillation von Desmodur W | Author: Bayer AG | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Thermische Untersuchung zur Destillation von Desmodur W | Author: Bayer AG | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: No information | Author: Beilstein | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: International Chemical Safety Cards (ICSC) | Author: NIOSH | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Physicochemical properties of 4,4'-dicyclohexylmethane diisocyanate | Author: Zhuravlev EZ Selivanov VD Mulyanov PV Konstantinov II | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Desmodur W Abschluẞbericht Dampfdruck. | Author: Bayer AG | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Desmodur W Abschluẞbericht Dampfdruck. | Author: Bayer AG | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: International Chemical Safety Cards (ICSC) | Author: NIOSH | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Physicochemical properties of 4,4'-dicyclohexylmethane diisocyanate | Author: Zhuravlev EZ Selivanov VD Mulyanov PV Konstantinov II | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Henry''s law constant | Robust Study Summary -- Title: QSAR Estimations for Cyclohexane 1,1'methylenbis-4-isocyanato- CAS:5124-30-1 (Desmodur W) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Henry''s law constant | Right to refer to study -- Title: QSAR Estimations for Cyclohexane 1,1'methylenbis-4-isocyanato- CAS:5124-30-1 (Desmodur W) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: QSAR Estimations for Cyclohexane 1,1'methylenbis-4-isocyanato- CAS:5124-30-1 (Desmodur W) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Estimations for Cyclohexane 1,1'methylenbis-4-isocyanato- CAS:5124-30-1 (Desmodur W) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Physicochemical properties of 4,4'-dicyclohexylmethane diisocyanate. | Author: Zhuravlev EZ Selivanov VD Mulyanov PV Konstantinov II | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Robust Study Summary -- Title: Decrease of NCO-Content in Water. | Author: Bayer AG | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Right to refer to study -- Title: Decrease of NCO-Content in Water. | Author: Bayer AG | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Robust Study Summary -- Title: Lehrbuch der organischen Chemie. | Author: Beyer H. Walter W. Franke W. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Desmodur W Flammpunkt. | Author: Bayer AG | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Desmodur W Flammpunkt. | Author: Bayer AG | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Flash point and ignition point of certain organic isocyanates | Author: Zhuravlev E.Z. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute Dermal Irritation/Corrosivity Study in Rabbits in Desmodur W | Author: Wakefiled A | Year: 1996 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Acute Dermal Irritation/Corrosivity Study in Rabbits in Desmodur W | Author: Wakefiled A | Year: 1996 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Study for skin irritation/corrosion in rabbits | Author: Kroetlinger F | Year: 1994 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Study for skin irritation/corrosion in rabbits | Author: Kroetlinger F | Year: 1994 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Prüfung der akuten Hautreizwirkung von Dicyclohexylmethan-4,4'-diisocyanat (HMDI) | Author: Muermann P | Year: 1985 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Prüfung der akuten Hautreizwirkung von Dicyclohexylmethan-4,4'-diisocyanat (HMDI) | Author: Muermann P | Year: 1985 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Pruefung der akuten Augen- und Schleimhautreizwirkung von Dicyclohexylmethan-4,4'-diisocyanat (HMDI) | Author: Muermann P | Year: 1985 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Pruefung der akuten Augen- und Schleimhautreizwirkung von Dicyclohexylmethan-4,4'-diisocyanat (HMDI) | Author: Muermann P | Year: 1985 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Bericht ueber die Pruefung von Dicyclohexylmethan-4,4'-diisocyanat fluessig auf Schleimhautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Bericht ueber die Pruefung von Dicyclohexylmethan-4,4'-diisocyanat fluessig auf Schleimhautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Bericht ueber die Pruefung von Dicyclohexylmethan-4,4'-diisocyanat fest auf Schleimhautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Characterization of Murine Immune Responses to Allergenic Diisocyanates Variable Effects of Chemical Allergens on serum IgE Concentration in Mice. Preliminary Evaluation of a Novel Approach to the Indentification of Respiratory Sensitizers | Author: Dearman RJ et al. | Year: 1992 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Dicyclohexylmethan-4,4'-diisocyanat Pruefung auf sensibilisierende Eigenschaften am Meerschweinchen nach Magnusson und Kligman (gemäẞ OECD Richtlinien) | Author: Sterner W & Chibanguza G | Year: 1983 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Dicyclohexylmethan-4,4'-diisocyanat Pruefung auf sensibilisierende Eigenschaften am Meerschweinchen nach Magnusson und Kligman (gemäẞ OECD Richtlinien) | Author: Sterner W & Chibanguza G | Year: 1983 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: 4,4'-Diisocyanato-dicyclohexylmethan (H-MDI) Pruefung auf sensibilisierende Wirkung an der Meerschweinchenhaut (Maximierungstest nach Magnusson/Klingman) | Author: Schmidt WM | Year: 1985 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: 4,4'-Diisocyanato-dicyclohexylmethan (H-MDI) Pruefung auf sensibilisierende Wirkung an der Meerschweinchenhaut (Maximierungstest nach Magnusson/Klingman) | Author: Schmidt WM | Year: 1985 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: 4,4'-Diisocyanato-dicyclohexylmethan (H-MDI) Untersuchungen zur sensibilisierenden Wirkung an der Meerschweinchenhaut (modif. "Maximierungstest" mit nur intrakutaner Induktion) | Author: Schmidt WM | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: 4,4'-Diisocyanato-dicyclohexylmethan (H-MDI) Untersuchungen zur sensibilisierenden Wirkung an der Meerschweinchenhaut (modif. "Maximierungstest" mit nur intrakutaner Induktion) | Author: Schmidt WM | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs | Author: Zissu D et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A closed-patch repeated insult dermal sensitization study in guinea pigs with toluene diisocyanate and others | Author: Auletta CS | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Experimental delayed hypersensitvity following inhalation of dicyclohexylmethane-4,4'-diisocyanate: a concentration-response relationship Experimental delayed hypersensitvity following inhalation of dicyclohexylmethane-4,4'-diisocyanate: a concentration-response relationship | Author: Stadler JC & Karol MH | Year: 1984 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Experimental delayed hypersensitvity following inhalation of dicyclohexylmethane-4,4'-diisocyanate: a concentration-response relationship Experimental delayed hypersensitvity following inhalation of dicyclohexylmethane-4,4'-diisocyanate: a concentration-response relationship | Author: Stadler JC & Karol MH | Year: 1984 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Desmodur W Pilot study for lung sensitization in Guinea-pigs following intradermal induction | Author: Pauluhn J | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Respiratory sensitisation | Right to refer to study -- Title: Desmodur W Pilot study for lung sensitization in Guinea-pigs following intradermal induction | Author: Pauluhn J | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Th2 Cytokines in Skin Draining Lymph Nodes and Serum IgE Do Not Predict Airway Hypersensitivity to Intranasal Isocyanate Exposure in Mice Inconsistencies between Cytokine Profiles Antibody Responses and Respiratory Hyperresponsiveness following Dermal Exposure to Isocyanates Pulmonary Hyperresponsiveness following dermal exposure to certain diisocyanates | Author: Farraj AK et al. | Year: 2007 2006 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Right to refer to study -- Title: Th2 Cytokines in Skin Draining Lymph Nodes and Serum IgE Do Not Predict Airway Hypersensitivity to Intranasal Isocyanate Exposure in Mice Inconsistencies between Cytokine Profiles Antibody Responses and Respiratory Hyperresponsiveness following Dermal Exposure to Isocyanates Pulmonary Hyperresponsiveness following dermal exposure to certain diisocyanates | Author: Farraj AK et al. | Year: 2007 2006 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Cytokine mRNA profiles for isocyanates with known and unknown potential to induce respiratory sensitization Cytokine profiling for chemical sinsitizers using the Ribonuclease Protection Assay: Determination of Cytokines generated by Isocyanates | Author: Plitnick LM et al. | Year: 2005 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Right to refer to study -- Title: Cytokine mRNA profiles for isocyanates with known and unknown potential to induce respiratory sensitization Cytokine profiling for chemical sinsitizers using the Ribonuclease Protection Assay: Determination of Cytokines generated by Isocyanates | Author: Plitnick LM et al. | Year: 2005 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Characterization of Murine Immune Responses to Allergenic Diisocyanates Variable Effects of Chemical Allergens on serum IgE Concentration in Mice. Preliminary Evaluation of a Novel Approach to the Indentification of Respiratory Sensitizers | Year: 1992 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Right to refer to study -- Title: Characterization of Murine Immune Responses to Allergenic Diisocyanates Variable Effects of Chemical Allergens on serum IgE Concentration in Mice. Preliminary Evaluation of a Novel Approach to the Indentification of Respiratory Sensitizers | Year: 1992 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Desmodur W Salmonella/Microsome Test Plate Incoporation and Preincubation Method | Author: Wirnitzer U | Year: 2005 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Desmodur W Salmonella/Microsome Test Plate Incoporation and Preincubation Method | Author: Wirnitzer U | Year: 2005 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: 4,4'-Methylenedicyclohexyl diisocyanate (tested as Desmodur W) V79/HPRT-Test in vitro for the detection of induced forward mutations | Author: Herbold B | Year: 2007 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: 4,4'-Methylenedicyclohexyl diisocyanate (tested as Desmodur W) V79/HPRT-Test in vitro for the detection of induced forward mutations | Author: Herbold B | Year: 2007 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Desmodur W In vitro chromosome aberration test with chinese hamster V79 cells | Author: Herbold B | Year: 2004 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Desmodur W In vitro chromosome aberration test with chinese hamster V79 cells | Author: Herbold B | Year: 2004 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Akute Toxizitätsprüfung von "Dicyclohexylmethan-4,4'-diisocyanat" (H12MDI) nach oraler Applikation an der Ratte | Author: Sterner W & Stiglic A | Year: 1976 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Akute Toxizitätsprüfung von "Dicyclohexylmethan-4,4'-diisocyanat" (H12MDI) nach oraler Applikation an der Ratte | Author: Sterner W & Stiglic A | Year: 1976 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicological investigation of: 4,4'-diisocyanato dicyclohexyl methane | Author: Younger FM | Year: 1966 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Desmodur W Untersuchungen zur akuten Inhalationstoxizitaet an der Ratte nach OECD-No. 403 | Author: Pauluhn J | Year: 1995 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Desmodur W Untersuchungen zur akuten Inhalationstoxizitaet an der Ratte nach OECD-No. 403 | Author: Pauluhn J | Year: 1995 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: 4-Hour Acute Inhalation Toxicity Study in Rats | Author: Bernstein DM et al. | Year: 1987 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: 4-Hour Acute Inhalation Toxicity Study in Rats | Author: Bernstein DM et al. | Year: 1987 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Acute inhalation study with dicyclohexylmethane 4,4'-diisocyanate (Desmodur W) in rats | Author: Sangha GK | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Acute inhalation study with dicyclohexylmethane 4,4'-diisocyanate (Desmodur W) in rats | Author: Sangha GK | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Akute dermale Toxizität von Dicyclohexylmethan-4,4'-diisocyanat (HMDI) für Ratten | Author: Muermann P | Year: 1985 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Akute dermale Toxizität von Dicyclohexylmethan-4,4'-diisocyanat (HMDI) für Ratten | Author: Muermann P | Year: 1985 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toxicological investigation of: 4,4'-diisocyanato dicyclohexyl methane | Author: Younger FM | Year: 1966 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: 4,4'-Methylenedicyclohexyl diisocyanate (CAS-Nr. 5124-30-1); Information/Assumptions regarding toxicokinetics | Author: Karthaus | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: 4,4'-Methylenedicyclohexyl diisocyanate (CAS-Nr. 5124-30-1); Information/Assumptions regarding toxicokinetics | Author: Karthaus | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: 4,4'-Methylenedicyclohexyl Diisocyanate 90-Day Inhalation Study with a 4-week recovery period in Wistar rats | Author: Pauluhn J | Year: 2008 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: 4,4'-Methylenedicyclohexyl Diisocyanate 90-Day Inhalation Study with a 4-week recovery period in Wistar rats | Author: Pauluhn J | Year: 2008 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Dicyclohexylmethane-4,4'-diisocyanate (Desmodur W) Subacute inhalation toxicity on rats (Exposure 5 x 6 hour/day for 4-weeks) | Author: Pauluhn J | Year: 2004 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Dicyclohexylmethane-4,4'-diisocyanate (Desmodur W) Subacute inhalation toxicity on rats (Exposure 5 x 6 hour/day for 4-weeks) | Author: Pauluhn J | Year: 2004 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Desmodur W Reproduction/Developmental Toxicity Screening Test in rats according OECD 421 (Nose-only Inhalation of dicyclohexylmethane-4,4'-diisocyanate over 7 x 6 hours per week) | Author: Eiben R & Rosenbruch M | Year: 2004 | Guideline: 421 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Desmodur W Reproduction/Developmental Toxicity Screening Test in rats according OECD 421 (Nose-only Inhalation of dicyclohexylmethane-4,4'-diisocyanate over 7 x 6 hours per week) | Author: Eiben R & Rosenbruch M | Year: 2004 | Guideline: 421 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Desmodur W Developmental Toxicity Study in Rats after Inhalation | Author: Langewische FW | Year: 2004 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Desmodur W Developmental Toxicity Study in Rats after Inhalation | Author: Langewische FW | Year: 2004 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Desmodur W Reproduction/Developmental Toxicity Screening Test in Rats according to OECD 421 (Nose-only Inhalation of dicyclohexylmethane -4,4'-diisocyanate over 7 x 6 hours per week) | Author: Eiben R & Rosenbruch M | Year: 2004 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Desmodur W Reproduction/Developmental Toxicity Screening Test in Rats according to OECD 421 (Nose-only Inhalation of dicyclohexylmethane -4,4'-diisocyanate over 7 x 6 hours per week) | Author: Eiben R & Rosenbruch M | Year: 2004 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Desmodur W Reproduction/Developmental Toxicity Screening Test in Rats according to OECD 421 (Nose-only Inhalation of dicyclohexylmethane -4,4'-diisocyanate over 7 x 6 hours per week) | Author: Eiben R & Rosenbruch M | Year: 2004 | Guideline: 421 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Desmodur W Reproduction/Developmental Toxicity Screening Test in Rats according to OECD 421 (Nose-only Inhalation of dicyclohexylmethane -4,4'-diisocyanate over 7 x 6 hours per week) | Author: Eiben R & Rosenbruch M | Year: 2004 | Guideline: 421 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Investigation of the ecological properties of Desmodur W | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Investigation of the ecological properties of Desmodur W | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Investigation of the ecological properties of Desmodur W | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Investigation of the ecological properties of Desmodur W | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Investigation of the ecological properties of Desmodur W | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Investigation of the ecological properties of Desmodur W | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Investigation of the ecological properties of Desmodur W | Author: Bayer AG | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Investigation of the ecological properties of Desmodur W | Author: Bayer AG | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: QSAR Estimations for Cyclohexane 1,1'methylenbis-4-isocyanato- CAS:5124-30-1 (Desmodur W) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: QSAR Estimations for Cyclohexane 1,1'methylenbis-4-isocyanato- CAS:5124-30-1 (Desmodur W) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: QSAR Estimations for Cyclohexanamine 4,4'-methylenebis- CAS:1761-71-3 | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 1761-71-3 | EC 217-168-8 | 4,4'-methylenedicyclohexanamine) |
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| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: QSAR Estimations for Cyclohexanamine 4,4'-methylenebis- CAS:1761-71-3 | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 1761-71-3 | EC 217-168-8 | 4,4'-methylenedicyclohexanamine) |
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| Environmental | Hydrolysis | Robust Study Summary -- Title: Decrease of NCO-Content in Water. | Author: Bayer AG | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Decrease of NCO-Content in Water. | Author: Bayer AG | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis as a function of pH and temperature of Desmodur W. Results of preliminary test. | Author: Bayer Industry Services GmbH & Co. OHG | Year: 2004 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Hydrolysis as a function of pH and temperature of Desmodur W. Results of preliminary test. | Author: Bayer Industry Services GmbH & Co. OHG | Year: 2004 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Investigation of the ecological properties of Desmodur W | Author: Bayer AG | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Investigation of the ecological properties of Desmodur W | Author: Bayer AG | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Determination on the ecological behaviour of Desmodur W. | Author: Bayer AG | Year: 1992 | Guideline: 301F | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Determination on the ecological behaviour of Desmodur W. | Author: Bayer AG | Year: 1992 | Guideline: 301F | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: QSAR Estimations for Cyclohexane 1,1'methylenbis-4-isocyanato- CAS:5124-30-1 (Desmodur W) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: QSAR Estimations for Cyclohexane 1,1'methylenbis-4-isocyanato- CAS:5124-30-1 (Desmodur W) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: QSAR Estimations for Cyclohexanamine 4,4'-methylenebis- CAS:1761-71-3 | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 1761-71-3 | EC 217-168-8 | 4,4'-methylenedicyclohexanamine) |
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| Environmental | Adsorption/desorption | Right to refer to study -- Title: QSAR Estimations for Cyclohexanamine 4,4'-methylenebis- CAS:1761-71-3 | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 1761-71-3 | EC 217-168-8 | 4,4'-methylenedicyclohexanamine) |
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| Environmental | Phototransformation in air | Robust Study Summary -- Title: QSAR Estimations for Cyclohexane 1,1'methylenbis-4-isocyanato- CAS:5124-30-1 (Desmodur W) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: QSAR Estimations for Cyclohexane 1,1'methylenbis-4-isocyanato- CAS:5124-30-1 (Desmodur W) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: QSAR Estimations for Cyclohexanamine 4,4'-methylenebis- CAS:1761-71-3 | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 1761-71-3 | EC 217-168-8 | 4,4'-methylenedicyclohexanamine) |
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| Environmental | Phototransformation in air | Right to refer to study -- Title: QSAR Estimations for Cyclohexanamine 4,4'-methylenebis- CAS:1761-71-3 | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 1761-71-3 | EC 217-168-8 | 4,4'-methylenedicyclohexanamine) |
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