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| Study name | Short Description | Data Owner |
|---|---|---|
| Toxicological | Eye irritation | Robust Study Summary -- Title: Primary eye irritancy study of Dow Corning 556 cosmetic grade fluid in rabbits | Author: Dow Corning Corporation | Year: 1997 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Primary eye irritancy study of Dow Corning 556 cosmetic grade fluid in rabbits | Author: Dow Corning Corporation | Year: 1997 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Inhalation Developmental Toxicity Study in Rats with octamethylcyclotetrasiloxane. | Author: International Research and Development Corporation; Dow Corning Corporation | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Inhalation Developmental Toxicity Study in Rats with octamethylcyclotetrasiloxane. | Author: International Research and Development Corporation; Dow Corning Corporation | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Inhalation Developmental Toxicity Study in New Zealand White Rabbits with octamethylcyclotetrasiloxane (D4). | Author: International Research and Development Corporation | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Inhalation Developmental Toxicity Study in New Zealand White Rabbits with octamethylcyclotetrasiloxane (D4). | Author: International Research and Development Corporation | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: 24-Month combined chronic toxicity and oncogenicity whole body vapor inhalation study of octamethylcyclotetrasiloxane (D4) in Fischer 344 Rats. | Author: Batelle | Year: 2004 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: 24-Month combined chronic toxicity and oncogenicity whole body vapor inhalation study of octamethylcyclotetrasiloxane (D4) in Fischer 344 Rats. | Author: Batelle | Year: 2004 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Determining the Biodegradability of Octamethylcyclotetrasiloxane Based on the Draft OECD 310 Sealed Vessel CO2 Evolution Biodegradation Test | Author: Springborn Smithers Laboratories | Year: 2005 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Determining the Biodegradability of Octamethylcyclotetrasiloxane Based on the Draft OECD 310 Sealed Vessel CO2 Evolution Biodegradation Test | Author: Springborn Smithers Laboratories | Year: 2005 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethylcyclotetrasiloxane (D4) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Kozerski G E | Year: 2007 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethylcyclotetrasiloxane (D4) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Kozerski G E | Year: 2007 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: (Octamethylcyclotetrasiloxane) - Chronic toxicity to daphnids (Daphnia magna) under flow-through conditions. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: (Octamethylcyclotetrasiloxane) - Chronic toxicity to daphnids (Daphnia magna) under flow-through conditions. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis of Octamethylcyclotetrasiloxane | Author: Dow Corning Corporation | Year: 2005 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Hydrolysis of Octamethylcyclotetrasiloxane | Author: Dow Corning Corporation | Year: 2005 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: 4-hour acute inhalation toxicity study with octamethylcyclotetrasiloxane in rats | Author: RCC | Year: 1994 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: 4-hour acute inhalation toxicity study with octamethylcyclotetrasiloxane in rats | Author: RCC | Year: 1994 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Soil-Water Distribution of Octamethylcyclotetrasiloxane (D4) Using a Batch Equilibrium Method | Author: Dow Corning Corporation | Year: 2007 | Guideline: 106 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: Soil-Water Distribution of Octamethylcyclotetrasiloxane (D4) Using a Batch Equilibrium Method | Author: Dow Corning Corporation | Year: 2007 | Guideline: 106 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Supplemental study. Bioconcentration and elimination of C14-residues by fathead minnows (Pimephales promelas) exposed to octamethylcyclotetrasiloxane. | Author: Dow Corning | Year: 1991 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Supplemental study. Bioconcentration and elimination of C14-residues by fathead minnows (Pimephales promelas) exposed to octamethylcyclotetrasiloxane. | Author: Dow Corning | Year: 1991 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism and disposition of [14C]-methylcyclosiloxanes in rats | Author: Domoradzki JY et al. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: 24-Month combined chronic toxicity and oncogenicity whole body vapor inhalation study of octamethylcyclotetrasiloxane (D4) in Fischer 344 Rats. | Author: Batelle | Year: 2004 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: 24-Month combined chronic toxicity and oncogenicity whole body vapor inhalation study of octamethylcyclotetrasiloxane (D4) in Fischer 344 Rats. | Author: Batelle | Year: 2004 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Octamethylcyclotetrasiloxan - Prüfung auf sensibilisierende Wirkung an der Meerschweinchenhaut (Maximisierungstest nach Magnusson & Kligman). | Author: Institut für Toxikologie der Bayer AG | Year: 1985 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Octamethylcyclotetrasiloxan - Prüfung auf sensibilisierende Wirkung an der Meerschweinchenhaut (Maximisierungstest nach Magnusson & Kligman). | Author: Institut für Toxikologie der Bayer AG | Year: 1985 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: (Octamethylcyclotetrasiloxane) - Acute toxicity to daphnids (Daphnia magna) during a 48-hour flow-through exposure. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: (Octamethylcyclotetrasiloxane) - Acute toxicity to daphnids (Daphnia magna) during a 48-hour flow-through exposure. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Sediment toxicity | Robust Study Summary -- Title: D4 - Sediment-Water Lumbriculus Toxicity Test using Spiked Natural Sediment, Following OECD Guideline 225 | Author: Springborn Smithers | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Sediment toxicity | Right to refer to study -- Title: D4 - Sediment-Water Lumbriculus Toxicity Test using Spiked Natural Sediment, Following OECD Guideline 225 | Author: Springborn Smithers | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: (Octamethylcyclotetrasiloxane) - Toxicity to the freshwater green alga Selenastrum capricornutum. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: (Octamethylcyclotetrasiloxane) - Toxicity to the freshwater green alga Selenastrum capricornutum. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A two generation inhalation reproductive toxicity and developmental neurotoxicity study of octamethylcyclotetrasiloxane (D4) in rats. | Author: WIL Research Laboratories, Inc | Year: 2001 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A two generation inhalation reproductive toxicity and developmental neurotoxicity study of octamethylcyclotetrasiloxane (D4) in rats. | Author: WIL Research Laboratories, Inc | Year: 2001 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Simultaneous Determination of Partition Coefficients for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane. | Author: Dow Corning Corporation | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Simultaneous Determination of Partition Coefficients for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane. | Author: Dow Corning Corporation | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: (Octamethylcyclotetrasiloxane) - Toxicity test with Rainbow trout (Oncorhynchus mykiss) embryos and larvae. | Author: Springborn Laboratories | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: (Octamethylcyclotetrasiloxane) - Toxicity test with Rainbow trout (Oncorhynchus mykiss) embryos and larvae. | Author: Springborn Laboratories | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: dermal | Robust Study Summary -- Title: Baysilone COM 10000 (D4): Subakute toxikologische untersuchungen an kaninchen (versuch mit kutaner applikation über 3 wochen) | Author: Bayer AG | Year: 1988 | Guideline: 410 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: dermal | Right to refer to study -- Title: Baysilone COM 10000 (D4): Subakute toxikologische untersuchungen an kaninchen (versuch mit kutaner applikation über 3 wochen) | Author: Bayer AG | Year: 1988 | Guideline: 410 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: (Octamethylcyclotetrasiloxane) - Acute toxicity to Rainbow trout (Oncorhynchus mykiss) during a 14-day flow-through exposure. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: (Octamethylcyclotetrasiloxane) - Acute toxicity to Rainbow trout (Oncorhynchus mykiss) during a 14-day flow-through exposure. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Octamethyltetrasiloxane (5 147 R.P.) + Hexamethyldisiloxane (5 148 R.P.) Toxicite et Tolerance Locale | Author: Laboratoires de Recherches de la Societe des Usines | Year: 1971 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Octamethyltetrasiloxane (5 147 R.P.) + Hexamethyldisiloxane (5 148 R.P.) Toxicite et Tolerance Locale | Author: Laboratoires de Recherches de la Societe des Usines | Year: 1971 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evaluation of D4 in the Rodent Dominant Lethal Test. | Author: Dow Corning Corporation | Year: 1982 | Guideline: 478 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Evaluation of D4 in the Rodent Dominant Lethal Test. | Author: Dow Corning Corporation | Year: 1982 | Guideline: 478 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Bone Marrow Chromosomal Aberrations Assay in Rats. | Author: BRRC | Year: 1994 | Guideline: 475 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenic Potential in the Salmonella/Microsome (Ames) Assay. | Author: BRRC | Year: 1993 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: The fate of cyclic methylsiloxanes in soils: 2. Rates of degradation and volatilization. | Author: Xu S and Chandra G | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethylcyclotetrasiloxane (D4) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Kozerski G E | Year: 2007 | Guideline: 123 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethylcyclotetrasiloxane (D4) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Kozerski G E | Year: 2007 | Guideline: 123 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Genotoxicity Studies on Selected Organosilicon Compounds: In Vitro Assays. | Author: Isquith et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: D4 (Octamethylcyclotetrasiloxane): In Vitro Chromosomal Aberrations Assay in Chinese Hamster Ovary Cells. | Author: BRRC | Year: 1993 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Aqueous Solubility of Permethoxysiloxanes (Silicones) | Author: Varaprath, S. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Octamethylcyclotetrasiloxan - Untersuchungen zur akuten cutanen Toxizität an männlichen und weiblichen Wistar Ratten. | Author: Bayer AG | Year: 1985 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Octamethylcyclotetrasiloxan - Untersuchungen zur akuten cutanen Toxizität an männlichen und weiblichen Wistar Ratten. | Author: Bayer AG | Year: 1985 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Octamethylcyclotetrasiloxan - akute orale Toxizität. | Author: Bayer AG | Year: 1979 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Octamethylcyclotetrasiloxan - akute orale Toxizität. | Author: Bayer AG | Year: 1979 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Process Safety Test Results and Interpretation for Octamethylcyclotetrasiloxane, 98% | Author: Mercier DD | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Process Safety Test Results and Interpretation for Octamethylcyclotetrasiloxane, 98% | Author: Mercier DD | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: QSAR Model Reporting Format (Version 1.2): Prediction of the viscosity of cyclic siloxanes from boiling point | Author: Peter Fisk Associates | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: QSAR Model Reporting Format (Version 1.2): Prediction of the viscosity of cyclic siloxanes from boiling point | Author: Peter Fisk Associates | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: The DIPPR Information and Data Evaluation Manager (DIADEM, ver. 2.7.0) for the Design Institute for Physical Properties. Design Institute for Physical Property Data|(DIPPR) | Author: American Institute of Chemical Engineers (AIChE) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The DIPPR Information and Data Evaluation Manager, DIADEM, ver. 2.7.0) for the Design Institute for Physical Properties. Design Institute for Physical Property Data (DIPPR), | Author: American Institute of Chemical Engineers (AIChE) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Physical Properties of Organosilicon Compounds. I.Hexamethycyclotrisiloxane and Octamethylcyclotetrasiloxane | Author: Osthoff, R.L., Grubb, W.J., Burkhard, C.A. | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Methylpolysiloxanes | Author: Patnode, W., Wilcock, D.F. | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |