You are here: Home> South Korea>K-REACH>CAS 556-67-2> CAS 556-67-2 | Data Package 100 - 1000 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Toxicological | Eye irritation | Robust Study Summary -- Title: Primary eye irritancy study of Dow Corning 556 cosmetic grade fluid in rabbits | Author: Dow Corning Corporation | Year: 1997 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Primary eye irritancy study of Dow Corning 556 cosmetic grade fluid in rabbits | Author: Dow Corning Corporation | Year: 1997 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Determining the Biodegradability of Octamethylcyclotetrasiloxane Based on the Draft OECD 310 Sealed Vessel CO2 Evolution Biodegradation Test | Author: Springborn Smithers Laboratories | Year: 2005 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Determining the Biodegradability of Octamethylcyclotetrasiloxane Based on the Draft OECD 310 Sealed Vessel CO2 Evolution Biodegradation Test | Author: Springborn Smithers Laboratories | Year: 2005 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethylcyclotetrasiloxane (D4) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Kozerski G E | Year: 2007 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethylcyclotetrasiloxane (D4) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Kozerski G E | Year: 2007 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis of Octamethylcyclotetrasiloxane | Author: Dow Corning Corporation | Year: 2005 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Hydrolysis of Octamethylcyclotetrasiloxane | Author: Dow Corning Corporation | Year: 2005 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: 4-hour acute inhalation toxicity study with octamethylcyclotetrasiloxane in rats | Author: RCC | Year: 1994 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: 4-hour acute inhalation toxicity study with octamethylcyclotetrasiloxane in rats | Author: RCC | Year: 1994 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism and disposition of [14C]-methylcyclosiloxanes in rats | Author: Domoradzki JY, et al. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: 24-Month combined chronic toxicity and oncogenicity whole body vapor inhalation study of octamethylcyclotetrasiloxane (D4) in Fischer 344 Rats. | Author: Batelle | Year: 2004 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: 24-Month combined chronic toxicity and oncogenicity whole body vapor inhalation study of octamethylcyclotetrasiloxane (D4) in Fischer 344 Rats. | Author: Batelle | Year: 2004 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Octamethylcyclotetrasiloxan - Prüfung auf sensibilisierende Wirkung an der Meerschweinchenhaut (Maximisierungstest nach Magnusson & Kligman). | Author: Institut für Toxikologie der Bayer AG | Year: 1985 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Octamethylcyclotetrasiloxan - Prüfung auf sensibilisierende Wirkung an der Meerschweinchenhaut (Maximisierungstest nach Magnusson & Kligman). | Author: Institut für Toxikologie der Bayer AG | Year: 1985 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: (Octamethylcyclotetrasiloxane) - Acute toxicity to daphnids (Daphnia magna) during a 48-hour flow-through exposure. Effects of octamethylcyclotetrasiloxane (OMCTS) on freshwater and marine organisms; Sousa, J.V. et al; publication; 1995 | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: (Octamethylcyclotetrasiloxane) - Acute toxicity to daphnids (Daphnia magna) during a 48-hour flow-through exposure. Effects of octamethylcyclotetrasiloxane (OMCTS) on freshwater and marine organisms; Sousa, J.V. et al; publication; 1995 | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: (Octamethylcyclotetrasiloxane) - Toxicity to the freshwater green alga Selenastrum capricornutum. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: (Octamethylcyclotetrasiloxane) - Toxicity to the freshwater green alga Selenastrum capricornutum. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A two generation inhalation reproductive toxicity and developmental neurotoxicity study of octamethylcyclotetrasiloxane (D4) in rats. A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation. ; Siddiqui WH et al.; publication; 2007; A Two-Generation Inhalation Reproductive Toxicity and Developmental Neurotoxicity Study of Octamethylcyclotetrasiloxane (D4) in Rats - Amendment to Report Number 2001-10000-50855; Radovasky A; Dow Coming Corporation ; other:; 2009; 2009-03-13; 2009-10000-60443 | Author: WIL Research Laboratories, Inc | Year: 2001 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A two generation inhalation reproductive toxicity and developmental neurotoxicity study of octamethylcyclotetrasiloxane (D4) in rats. A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation. ; Siddiqui WH et al.; publication; 2007; A Two-Generation Inhalation Reproductive Toxicity and Developmental Neurotoxicity Study of Octamethylcyclotetrasiloxane (D4) in Rats - Amendment to Report Number 2001-10000-50855; Radovasky A; Dow Coming Corporation ; other:; 2009; 2009-03-13; 2009-10000-60443 | Author: WIL Research Laboratories, Inc | Year: 2001 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Simultaneous Determination of Partition Coefficients for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane. | Author: Dow Corning Corporation | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Simultaneous Determination of Partition Coefficients for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane. | Author: Dow Corning Corporation | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: (Octamethylcyclotetrasiloxane) - Toxicity test with Rainbow trout (Oncorhynchus mykiss) embryos and larvae. Effects of octamethylcyclotetrasiloxane (OMCTS) on freshwater and marine organisms; Sousa, J.V. et al; publication; 1995 | Author: Springborn Laboratories | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: (Octamethylcyclotetrasiloxane) - Toxicity test with Rainbow trout (Oncorhynchus mykiss) embryos and larvae. Effects of octamethylcyclotetrasiloxane (OMCTS) on freshwater and marine organisms; Sousa, J.V. et al; publication; 1995 | Author: Springborn Laboratories | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: (Octamethylcyclotetrasiloxane) - Acute toxicity to Rainbow trout (Oncorhynchus mykiss) during a 14-day flow-through exposure. Effects of octamethylcyclotetrasiloxane (OMCTS) on freshwater and marine organisms; Sousa, J.V. et al; publication; 1995 | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: (Octamethylcyclotetrasiloxane) - Acute toxicity to Rainbow trout (Oncorhynchus mykiss) during a 14-day flow-through exposure. Effects of octamethylcyclotetrasiloxane (OMCTS) on freshwater and marine organisms; Sousa, J.V. et al; publication; 1995 | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Octamethyltetrasiloxane (5 147 R.P.) + Hexamethyldisiloxane (5 148 R.P.) Toxicite et Tolerance Locale | Author: Laboratoires de Recherches de la Societe des Usines | Year: 1971 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Octamethyltetrasiloxane (5 147 R.P.) + Hexamethyldisiloxane (5 148 R.P.) Toxicite et Tolerance Locale | Author: Laboratoires de Recherches de la Societe des Usines | Year: 1971 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Bone Marrow Chromosomal Aberrations Assay in Rats; No information ; | Author: BRRC; Vergnes et al. | Year: 1994; 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenic Potential in the Salmonella/Microsome (Ames) Assay. | Author: BRRC | Year: 1993 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Genotoxicity Studies on Selected Organosilicon Compounds: In Vitro Assays. | Author: Isquith et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: D4 (Octamethylcyclotetrasiloxane): In Vitro Chromosomal Aberrations Assay in Chinese Hamster Ovary Cells. | Author: BRRC | Year: 1993 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Aqueous Solubility of Permethoxysiloxanes (Silicones) | Author: Varaprath, S. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Octamethylcyclotetrasiloxan - Untersuchungen zur akuten cutanen Toxizität an männlichen und weiblichen Wistar Ratten. | Author: Bayer AG | Year: 1985 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Octamethylcyclotetrasiloxan - Untersuchungen zur akuten cutanen Toxizität an männlichen und weiblichen Wistar Ratten. | Author: Bayer AG | Year: 1985 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Process Safety Test Results and Interpretation for Octamethylcyclotetrasiloxane, 98% | Author: Mercier DD | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Process Safety Test Results and Interpretation for Octamethylcyclotetrasiloxane, 98% | Author: Mercier DD | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: QSAR Model Reporting Format (Version 1.2): Prediction of the viscosity of cyclic siloxanes from boiling point; QSAR Prediction Reporting Format (QPRF) for the viscosity of octamethylcyclotetrasiloxane; Peter Fisk Associates; Reconsile; other:; 2013; 2013-07-04 | Author: Peter Fisk Associates | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: QSAR Model Reporting Format (Version 1.2): Prediction of the viscosity of cyclic siloxanes from boiling point; QSAR Prediction Reporting Format (QPRF) for the viscosity of octamethylcyclotetrasiloxane; Peter Fisk Associates; Reconsile; other:; 2013; 2013-07-04 | Author: Peter Fisk Associates | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: The DIPPR Information and Data Evaluation Manager (DIADEM, ver. 2.7.0) for the Design Institute for Physical Properties. Design Institute for Physical Property Data (DIPPR) | Author: American Institute of Chemical Engineers (AIChE) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The DIPPR Information and Data Evaluation Manager (DIADEM, ver. 2.7.0) for the Design Institute for Physical Properties. Design Institute for Physical Property Data (DIPPR) | Author: American Institute of Chemical Engineers (AIChE) | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Physical Properties of Organosilicon Compounds. I.Hexamethycyclotrisiloxane and Octamethylcyclotetrasiloxane. The DIPPR Information and Data Evaluation Manager (DIADEM, ver. 2.7.0) for the Design Institute for Physical Properties. Design Institute for Physical Property Data|(DIPPR), ; American Institute of Chemical Engineers (AIChE); publication; 2004 | Author: Osthoff, R.L.; Grubb, W.J. and Burkhard, C.A. | Year: 1953 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Methylpolysiloxanes. The DIPPR Information and Data Evaluation Manager (DIADEM, ver. 2.7.0) for the Design Institute for Physical Properties. Design Institute for Physical Property Data (DIPPR); American Institute of Chemical Engineers (AIChE); publication; 2004 | Author: Patnode, W.; Wilcock, D.F. | Year: 1946 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Silanol - A novel class of antimicrobial agent; | Author: Kim Y; Farrah S and Baney R; | Year: 2006 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Bayer AG Safety Data Sheet | Author: Bayer AG; Momentive | Year: 1998 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Analytical solutions report; Silicones Environmental, Health and Safety Council; 03-039; | Author: Morgan D, Grosse R; | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Analytical solutions report; Silicones Environmental, Health and Safety Council; 03-039; | Author: Morgan D, Grosse R; | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Process Safety Test Results and Interpretation for Octamethylcyclotetrasiloxane, 98%; R/4675/0204/DM; Chilworth Technology, Inc, Monmouth Junction, NJ 08852 | Author: Mercier DD; | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Process Safety Test Results and Interpretation for Octamethylcyclotetrasiloxane, 98%; R/4675/0204/DM; Chilworth Technology, Inc, Monmouth Junction, NJ 08852 | Author: Mercier DD; | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Safety Data Sheet GE Bayer; | Author: Bayer | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: No information; 1995-I0000-40045 | Author: Dow Corning Corporation | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: No information; 1995-I0000-40045 | Author: Dow Corning Corporation | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: Anaerobic transformation of octmethylcyclotetrasiloxane (14C-D4) in aquatic sediment systems ; 11101-108; Health and Environmental Sciences | Author: Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Right to refer to study -- Title: Anaerobic transformation of octmethylcyclotetrasiloxane (14C-D4) in aquatic sediment systems ; 11101-108; Health and Environmental Sciences | Author: Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 28-day repeated dose inhalation study of octamethylcyclotetrasiloxane (D4) in multiple species. I-0005-2512 | Author: Dow Corning Corporation, Toxicology Department | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 28-day repeated dose inhalation study of octamethylcyclotetrasiloxane (D4) in multiple species. I-0005-2512 | Author: Dow Corning Corporation, Toxicology Department | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: Aerobic transformation of octamethylcyclotetrasiloxane (14C-D4) in aquatic sediment systems; 10885-108; Health and Environmental Sciences | Author: Dow Corning Corporation | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Right to refer to study -- Title: Aerobic transformation of octamethylcyclotetrasiloxane (14C-D4) in aquatic sediment systems; 10885-108; Health and Environmental Sciences | Author: Dow Corning Corporation | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |