You are here: Home> Turkey>TR-REACH>CAS 584-84-9> CAS 584-84-9 | Data Package 1 - 10 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Determination of physical-chemical property data according to GLP. Vapour pressure. Test substance: Scuranate T 100 | Author: Bayer AG | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Determination of physical-chemical property data according to GLP. Vapour pressure. Test substance: Scuranate T 100 | Author: Bayer AG | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor pressure of 2,4-tolylene diisocyanate | Author: Frensdorff H.K. & Adams R.K. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Phys/Chem. Testing on Ongrunat 1100 | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Phys/Chem. Testing on Ongrunat 1100 | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J. Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J. Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y. et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Phys-Chem | Surface tension | Waiver | - |
| Phys-Chem | Auto-ignition temperature | Waiver | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Phys-Chem | Explosive properties | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Phys-Chem | Oxidising properties | Waiver | - |
| Phys-Chem | Flammability | Waiver | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on Ongrunat 1100 | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on Ongrunat 1100 | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Toluylen 2,4-diisocyanat Produktnummer 89870 Fa. Sigma-Aldrich Chemie. [Flammpunkt] | Author: Schupp T. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Toluylen 2,4-diisocyanat Produktnummer 89870 Fa. Sigma-Aldrich Chemie. [Flammpunkt] | Author: Schupp T. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Phys/Chem. Testing on Ongrunat 1100 | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Phys/Chem. Testing on Ongrunat 1100 | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toluylendiisocyanat (TDI): Untersuchungen zur primär reizenden/ätzenden Wirkung an der Kaninchenhaut | Author: Suberg H., Löser E. & Kaliner G. | Year: 1984 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Toluylendiisocyanat (TDI): Untersuchungen zur primär reizenden/ätzenden Wirkung an der Kaninchenhaut | Author: Suberg H., Löser E. & Kaliner G. | Year: 1984 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Irritating and allergizing power of two isocyanates; toluene diisocyanate (TDI), diphenylmethane diisocyanate (MDI) | Author: Duprat P., Gradiski D. & Marignac B. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Skin irritation / corrosion | Waiver | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Eye irritation | Right to refer to study -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Eye irritation | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Eye irritation | Waiver | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Concentration-dependent elicitation of dermal sensitization in guinea pigs treated with 2,4-TDI | Author: Koschier F.J. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Irritating and allergizing power of two isocyanates; toluene diisocyanate (TDI), diphenylmethane diisocyanate (MDI) | Author: Duprat P., Gradiski D. & Marignac B. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Contact sensitivity in mice induced by tolylene diisocyanate (TDI). | Author: Tanaka K. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Studies on TDI-induced delayed type hypersensitivity | Author: Tominaga M. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Waiver | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chemical behavior of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test | Author: Seel K. et al. | Year: 1999 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenic activity of toluene 2,4-diisocyanate in the Salmonella/microsome assay | Author: Barrows R.S. | Year: 1976 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Mutagenic activity of toluene 2,4-diisocyanate in the Salmonella/microsome assay | Author: Barrows R.S. | Year: 1976 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology and Carcinogenesis studies of commercial grade 2,4(80%)- and 2,6(20%)- toluene diisocyanate (CAS No. 26471-62-5) in F344/N rats and B6C3F1 mice (gavage studies) | Author: National Toxicology Program | Year: 1986 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Tolylene diisocyanate; CAS No. 26471-62-5; methyl-13-phenylene diisocyanate/toluene diisocyanate | Author: Ministry of Health Labour & Welfare Japan | Year: 2001 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute toxicity studies (LD50) in male albino rats | Author: Wazeter F.X. et al. | Year: 1964 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute toxicity studies (LD50) in male albino rats | Author: Wazeter F.X. et al. | Year: 1964 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: [2,4-Toluene diisocyanate: toxicity studies] | Author: Chinese Center for Disease Control and Prevention, and National Institute of Occupational Health and Poison Control | Year: 2004 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. et al. | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. et al. | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. et al. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. et al. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Eco-Tox | Toxicity to aquatic plants other than algae | Waiver | - |
| Environmental | Biodegradation in water: screening tests | Waiver | - |