You are here: Home> Turkey>TR-REACH>CAS 584-84-9> CAS 584-84-9 | Data Package 10 - 100 t/a (Affiliates of TDI-TDA-DNT Consortium members and III)
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Tolylene-2,4-diisocyanate: determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Determination of physical-chemical property data according to GLP. Vapour pressure. Test substance: Scuranate T 100 | Author: Bayer AG | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Determination of physical-chemical property data according to GLP. Vapour pressure. Test substance: Scuranate T 100 | Author: Bayer AG | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor pressure of 2,4-tolylene diisocyanate | Author: Frensdorff H.K. & Adams R.K. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Phys/Chem. Testing on Ongrunat 1100 | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Phys/Chem. Testing on Ongrunat 1100 | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J. Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J. Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y. et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Phys-Chem | Surface tension | Waiver | - |
| Phys-Chem | Auto-ignition temperature | Waiver | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Phys-Chem | Explosive properties | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Phys-Chem | Oxidising properties | Waiver | - |
| Phys-Chem | Flammability | Waiver | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on Ongrunat 1100 | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on Ongrunat 1100 | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Toluylen 2,4-diisocyanat Produktnummer 89870 Fa. Sigma-Aldrich Chemie. [Flammpunkt] | Author: Schupp T. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Toluylen 2,4-diisocyanat Produktnummer 89870 Fa. Sigma-Aldrich Chemie. [Flammpunkt] | Author: Schupp T. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Phys/Chem. Testing on Ongrunat 1100 | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Phys/Chem. Testing on Ongrunat 1100 | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toluylendiisocyanat (TDI): Untersuchungen zur primär reizenden/ätzenden Wirkung an der Kaninchenhaut | Author: Suberg H., Löser E. & Kaliner G. | Year: 1984 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Toluylendiisocyanat (TDI): Untersuchungen zur primär reizenden/ätzenden Wirkung an der Kaninchenhaut | Author: Suberg H., Löser E. & Kaliner G. | Year: 1984 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Irritating and allergizing power of two isocyanates; toluene diisocyanate (TDI), diphenylmethane diisocyanate (MDI) | Author: Duprat P., Gradiski D. & Marignac B. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Skin irritation / corrosion | Waiver | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Eye irritation | Right to refer to study -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Eye irritation | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Eye irritation | Waiver | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Concentration-dependent elicitation of dermal sensitization in guinea pigs treated with 2,4-TDI | Author: Koschier F.J. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Irritating and allergizing power of two isocyanates; toluene diisocyanate (TDI), diphenylmethane diisocyanate (MDI) | Author: Duprat P., Gradiski D. & Marignac B. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Contact sensitivity in mice induced by tolylene diisocyanate (TDI). | Author: Tanaka K. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Studies on TDI-induced delayed type hypersensitivity | Author: Tominaga M. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Waiver | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chemical behavior of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test | Author: Seel K. et al. | Year: 1999 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenic activity of toluene 2,4-diisocyanate in the Salmonella/microsome assay | Author: Barrows R.S. | Year: 1976 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Mutagenic activity of toluene 2,4-diisocyanate in the Salmonella/microsome assay | Author: Barrows R.S. | Year: 1976 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Waiver | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: [Toluene diisocyanate: chromosome aberration test results] | Author: JETOC | Year: 1996 | Guideline: 473 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Waiver | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Toluene di-isocyanate: an evaluation in the mouse micronucleus test | Author: MacKay J.M. | Year: 1992 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Toluene di-isocyanate: an evaluation in the mouse micronucleus test | Author: MacKay J.M. | Year: 1992 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology and Carcinogenesis studies of commercial grade 2,4(80%)- and 2,6(20%)- toluene diisocyanate (CAS No. 26471-62-5) in F344/N rats and B6C3F1 mice (gavage studies) | Author: National Toxicology Program | Year: 1986 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Tolylene diisocyanate; CAS No. 26471-62-5; methyl-13-phenylene diisocyanate/toluene diisocyanate | Author: Ministry of Health Labour & Welfare Japan | Year: 2001 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute toxicity studies (LD50) in male albino rats | Author: Wazeter F.X. et al. | Year: 1964 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute toxicity studies (LD50) in male albino rats | Author: Wazeter F.X. et al. | Year: 1964 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: [2,4-Toluene diisocyanate: toxicity studies] | Author: Chinese Center for Disease Control and Prevention, and National Institute of Occupational Health and Poison Control | Year: 2004 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Toluene diisocyanate: acute inhalation toxicity in the rat | Author: Doe J.E. & Horspool G.M. | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Toluene diisocyanate: acute inhalation toxicity in the rat | Author: Doe J.E. & Horspool G.M. | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Sensory irritation by toluene diisocyanate in single and repeated exposures | Author: Sangha G.K. & Alarie Y. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: [2,4-Toluene diisocyanate: toxicity studies] | Author: Chinese Center for Disease Control and Prevention, and National Institute of Occupational Health and Poison Control | Year: 2004 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
- |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: [2,4-Toluene diisocyanate: toxicity studies] | Author: Chinese Center for Disease Control and Prevention, and National Institute of Occupational Health and Poison Control | Year: 2004 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Route-dependent comparative metabolism of [14C]toluene 2,4-diisocyanate and [14C]toluene 2,4-diamine in Fischer 344 rats | Author: Timchalk C., Smith F.A. & Bartels M.J. | Year: 1994 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolic fate of 14C-toluene-2,4-diisocyanate in Fischer 344 rats | Author: Timchalk C., Smith F.A. & Bartels M.J. | Year: 1992 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Metabolic fate of 14C-toluene-2,4-diisocyanate in Fischer 344 rats | Author: Timchalk C., Smith F.A. & Bartels M.J. | Year: 1992 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Absorption and disposition of orally administered 2,4-toluene diisocyanate in the Fischer 344 rat. Project report no.2 | Author: Jeffcoat A.R. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The carcinogenic activity of commercial grade toluene diisocyanate in rats and mice in relation to the metabolism of the 2,4- and 2,6-TDI isomers | Author: Dieter M.P. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Identification of binding sites for diisocyanates in proteins: a study with model amino acids and dipeptides | Author: Mraz J. & Bouskova S. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Identification of binding sites for diisocyanates in proteins: a study with model amino acids and dipeptides | Author: Mraz J. & Bouskova S. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: 2,4-Toluenediisocyanate and hexamethylenediisocyanate adducts with blood proteins: assessment of reactivity of amino acid residues in vitro | Author: Mraz J. & Bouskova S. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Detection of urinary amine metabolites in toluene diisocyanate exposed rats | Author: Rosenberg C. & Savolainen H. | Year: 1985 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Distribution and reactivity of inhaled 14C-labeled toluene diisocyanate (TDI) in rats | Author: Kennedy A.L. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Comparative uptake and distribution of 14C labeled diisocyanates | Author: Brown W.E. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Comparative uptake and distribution of 14C-labeled diisocyanates | Author: Brown W.E. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Interactions of diisocyanates with N-acetyl-L-cysteine | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Interactions of diisocyanates with N-acetyl-L-cysteine | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Interactions of aromatic isocyanates with N-acetyl-L-cyteine(sic) under physiological conditions: formation of conjugates ureas and amines | Author: Mormann W. Vaquero R.L. & Seel K. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Uptake and distribution of 14C during and following inhalation exposure to radioactive toluene diisocyanate | Author: Kennedy A.L. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: [Determination and analysis of toluene diisocyanate metabolites in mice using gas chromatography-mass spectrometry] | Author: Ji Y.B. et al. | Year: 2007 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Identification and analysis of 2,4-toluenediisocyanate (2,4-TDI) adducts with globin and albumin. Part 2 | Author: Mraz J. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Identification and analysis of 2,4-toluenediisocyanate (2,4-TDI) adducts with globin and albumin. Part 2 | Author: Mraz J. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Identification of 2,4-toluenediisocyanate (2,4-TDI) adducts with globin and albumin | Author: Mraz J. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Twenty-eight-day repeat dose oral toxicity test of tolylene diisocyanate in rats | Author: Ministry of Health Labour & Welfare Japan | Year: 2001 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: Y. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Toxicological | Repeated dose toxicity: dermal | Waiver | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute toxicity of 12 industrial chemicals to freshwater and saltwater organisms | Author: Curtis MW, Copeland TL & Ward CH | Year: 1979 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. et al. | Year: 1997 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. et al. | Year: 1997 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. et al. | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. et al. | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. et al. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. et al. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Eco-Tox | Toxicity to aquatic plants other than algae | Waiver | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Aquatic life study Phase II Step 2: accumulation of TDI, MDI, TDA, and MDA in fish and their toxicity | Author: Fujiwara K. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Aquatic life study Phase II Step 2: accumulation of TDI, MDI, TDA, and MDA in fish and their toxicity | Author: Fujiwara K. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Environmental | Hydrolysis | Robust Study Summary -- Title: Fate of TDI in water. Part 1 : 2,4-TDI (T-100) | Author: Kitano M., Ouchiyama N. & Shimogawa Y. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Fate of TDI in water. Part 1 : 2,4-TDI (T-100) | Author: Kitano M., Ouchiyama N. & Shimogawa Y. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Summary report for the study on the fate of TDI in water. FE-E-63 project parts I II and III | Author: CITI | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Summary report for the study on the fate of TDI in water. FE-E-63 project parts I II and III | Author: CITI | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: A study of the fate of TDI in water. Effect of interfacial area under static condition | Author: Yakabe Y., Mori E. & Tadokoro H. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: A study of the fate of TDI in water. Effect of interfacial area under static condition | Author: Yakabe Y., Mori E. & Tadokoro H. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Fate of methylenediphenyl diisocyanate and toluene diisocyanate in the aquatic environment | Author: Yakabe Y. et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Environmental | Biodegradation in water: screening tests | Waiver | - |