You are here: Home> South Korea>K-REACH>CAS 616-45-5> CAS 616-45-5 | Data Package 100 - 1000 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: 2-Pyrrolidone (CAS 616-45-5) | Author: GESTIS Database on Hazardous Substances | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 12th. edition | Author: Lewis R.J. (Editor) | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Industrial Solvents Handbook 4th ed. | Author: Flick E.W. (ed.) | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: 2-Pyrrolidone (CAS 616-45-5) | Author: GESTIS Database on Hazardous Substances | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Stoffwerte Pyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Stoffwerte Pyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdrücke von Pyrrolidon-2 und 15 N-substituierten Pyrrolidon-Derivaten im Bereich unter 5 mbar | Author: BASF AG | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdrücke von Pyrrolidon-2 und 15 N-substituierten Pyrrolidon-Derivaten im Bereich unter 5 mbar | Author: BASF AG | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Techniques of Chemistry 4th ed. Volume II. Organic Solvents | Author: Riddick J.A., Bunger W.B., Sakano T.K. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: 2-Pyrrolidone (CAS 616-45-5) | Author: GESTIS Database on Hazardous Substances | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: US EPA . Estimation Programs Interface Suite™ for Microsoft® Windows v 4.11. United States Environmental Protection Agency Washington DC USA; WSKOWWIN™ Version 1.42 | Author: U.S. Environmental Protection Agency 1200 Pennsylvania Ave. N.W. (Mail Code 7406M) Washington DC 20460 | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Bestimmung des Verteilungskoeffizienten POW von Pyrrolidon in n-Octanol/Wasser bei Raumtemperatur (25 °C) | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Bestimmung des Verteilungskoeffizienten POW von Pyrrolidon in n-Octanol/Wasser bei Raumtemperatur (25 °C) | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: EPI Suite (v4.1): KOWWIN v1.68 Programm | Author: Estimation Programs Interface Suite for Microsoft Windows v4.11 | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: 2-Pyrrolidone | Author: HSDB (Hazardous Substances Database) | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: SPARC by Archemcalc | Author: ARChem | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Stoffwerte Pyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Stoffwerte Pyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: untitled | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: untitled | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: 2-pyrrolidone (CAS 616-45-5) | Author: GESTIS Database on Hazardous Substances | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Dangerous Properties of Industrial Materials. 5th ed. | Author: Sax N.I. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Kennzahlen explosionsfähiger Stoffe | Author: BASF AG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Kennzahlen explosionsfähiger Stoffe | Author: BASF AG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Kennzahlen explosionsfähiger Stoffe | Author: BASF AG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Kennzahlen explosionsfähiger Stoffe | Author: BASF AG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: 2-Pyrrolidone (CAS 616-45-5) | Author: GESTIS Database on Hazardous Substances | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Oxidising properties | Robust Study Summary -- Title: 2-Pyrrolidone | Author: HSDB (Hazardous Substances Database) | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary skin irritation /corrosion study with HC1161 in the rabbit (4-hour semi-occlusive application) | Author: Notox B.V. | Year: 2003 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary skin irritation /corrosion study with HC1161 in the rabbit (4-hour semi-occlusive application) | Author: Notox B.V. | Year: 2003 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Gewerbetoxikologische Grundprüfung Pyrrolidon Roh. | Author: BASF AG | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Gewerbetoxikologische Grundprüfung Pyrrolidon Roh. | Author: BASF AG | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: N-Ethyl-2-pyrrolidon - Murine Local Lymph Node Assay (LLNA). | Author: BASF AG | Year: 2005 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 2687-91-4 | EC 220-250-6 | 1-ethylpyrrolidin-2-one) |
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| Toxicological | Skin sensitisation | Right to refer to study -- Title: N-Ethyl-2-pyrrolidon - Murine Local Lymph Node Assay (LLNA). | Author: BASF AG | Year: 2005 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 2687-91-4 | EC 220-250-6 | 1-ethylpyrrolidin-2-one) |
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| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In Vitro Cytogenetic Investigations of 2-Pyrrolidon in Human Lymphocytes | Author: BASF AG | Year: 1987 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: In Vitro Cytogenetic Investigations of 2-Pyrrolidon in Human Lymphocytes | Author: BASF AG | Year: 1987 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity Test on 2-Pyrrolidone in the Ames- Salmonella/Microsome Reverse Mutation Assay | Author: Jagannath D.R.. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Mutagenicity Test on 2-Pyrrolidone in the Ames- Salmonella/Microsome Reverse Mutation Assay | Author: Jagannath D.R.. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: 2-Pyrrolidone - In Vitro Mammalian Cell Gene Mutation Test (CHO/HPRT Assay) | Author: Wells M. | Year: 2019 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: 2-Pyrrolidone - In Vitro Mammalian Cell Gene Mutation Test (CHO/HPRT Assay) | Author: Wells M. | Year: 2019 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: N-Ethyl-2-pyrrolidone in vitro gene mutation test in CHO cells (HPRT locus assay) | Author: BASF SE | Year: 2008 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 2687-91-4 | EC 220-250-6 | 1-ethylpyrrolidin-2-one) |
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| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: N-Ethyl-2-pyrrolidone in vitro gene mutation test in CHO cells (HPRT locus assay) | Author: BASF SE | Year: 2008 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 2687-91-4 | EC 220-250-6 | 1-ethylpyrrolidin-2-one) |
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| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Cytogenetic Study In Vivo of Pyrrolidon-2 in Mice; Micronucleus Test Single Intraperitoneal Administration | Author: BASF AG | Year: 1993 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Cytogenetic Study In Vivo of Pyrrolidon-2 in Mice; Micronucleus Test Single Intraperitoneal Administration | Author: BASF AG | Year: 1993 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: 2-Pyrrolidone: Acute oral toxicity (Limit test) in the rat | Author: Safe Pharm Laboratories | Year: 1999 | Guideline: 401 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: 2-Pyrrolidone: Acute oral toxicity (Limit test) in the rat | Author: Safe Pharm Laboratories | Year: 1999 | Guideline: 401 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Bericht über die Prüfung von Pyrrolidon auf etwaige teratogene Wirkung an der Ratte bei peroraler Applikation. | Author: BASF AG | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Bericht über die Prüfung von Pyrrolidon auf etwaige teratogene Wirkung an der Ratte bei peroraler Applikation. | Author: BASF AG | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Gewerbetoxikologische Grundprüfung Pyrrolidon Roh. | Author: BASF AG | Year: 1981 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Gewerbetoxikologische Grundprüfung Pyrrolidon Roh. | Author: BASF AG | Year: 1981 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Industrial hygiene orientating investigation | Author: BASF AG | Year: 1953 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Industrial hygiene orientating investigation | Author: BASF AG | Year: 1953 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: No information | Author: MB Research Laboratories Inc. | Year: 1992 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: No information | Author: MB Research Laboratories Inc. | Year: 1992 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Percutaneous absorption of co-administered N-methyl-2-[' 4C]pyrrolidone and 2-['4C]pyrrolidone in the rat | Author: Midgley I et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Detection of the in vivo conversion of 2-pyrrolidinone to γ-aminobutyric acid in mouse brain | Author: Callery PS et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism of putreseine to 5-hydroxy-2-pyrrolidone via 2- pyrrolidone | Author: Lundgren DW and Fales HM | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism of putreseine to 5-hydroxy-2-pyrrolidone via 2- pyrrolidone J. Biolog. Chem. 255 4481-4486 | Author: Lundgren DW and Fales HM | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: 2-Pyrrolidone and succinimide endogenously present in several mammalian species | Author: Bandle EF et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: 2-Pyrrolidinone - A cyclization product of γ-aminobutyric acid detected in mouse brain | Author: Callery PS et al. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: 2-pyrrolidone - Study for clarification of thymus findings in female Wistar rats; Administration in drinking water up to 13 weeks | Author: BASF AG | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: 2-pyrrolidone - Study for clarification of thymus findings in female Wistar rats; Administration in drinking water up to 13 weeks | Author: BASF AG | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Palatability study with 2-Pyrrolidone in Wistar rats. Administration via drinking water over 2 weeks | Author: BASF AG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Palatability study with 2-Pyrrolidone in Wistar rats. Administration via drinking water over 2 weeks | Author: BASF AG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A Drinking Water Extended One-Generation Reproductive Toxicity Study of 2-Pyrrolidone in Rats | Author: Coder P.S. | Year: 2020 | Guideline: 443 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A Drinking Water Extended One-Generation Reproductive Toxicity Study of 2-Pyrrolidone in Rats | Author: Coder P.S. | Year: 2020 | Guideline: 443 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A Drinking Water Dose-Range Finding Reproductive Toxicity Study of 2-Pyrrolidone in Rats | Author: McElroy P. B. | Year: 2019 | Guideline: 421 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A Drinking Water Dose-Range Finding Reproductive Toxicity Study of 2-Pyrrolidone in Rats | Author: McElroy P. B. | Year: 2019 | Guideline: 421 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute toxicity study on the zebra fish (Brachydanio rerio HAM. and BUCH.) | Author: BASF AG | Year: 1995 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Acute toxicity study on the zebra fish (Brachydanio rerio HAM. and BUCH.) | Author: BASF AG | Year: 1995 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Produktprüfung Fischtoxizitätstest | Author: BASF AG | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Produktprüfung Fischtoxizitätstest | Author: BASF AG | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Bestimmung der akuten Wirkung von Pyrrolidon dest. gegenüber dem Wasserfloh Daphnia magna Straus | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Bestimmung der akuten Wirkung von Pyrrolidon dest. gegenüber dem Wasserfloh Daphnia magna Straus | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Pyrrolidon dest.: Hemmung der Algen-Zellvermehrung nach DIN 38412 L9 | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Pyrrolidon dest.: Hemmung der Algen-Zellvermehrung nach DIN 38412 L9 | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga growth inhibition test (OECD 201 EEC ISO): BASF AG Algae test project No. 2/0701/88) | Author: ECT Oekotoxikologie GmbH | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga growth inhibition test (OECD 201 EEC ISO): BASF AG Algae test project No. 2/0701/88) | Author: ECT Oekotoxikologie GmbH | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Prüfbericht über einen Atmungshemmtest mit Belebtschlamm (Kurzzeitatmungshemmtest). | Author: BASF AG | Year: 1991 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Prüfbericht über einen Atmungshemmtest mit Belebtschlamm (Kurzzeitatmungshemmtest). | Author: BASF AG | Year: 1991 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Wachstumshemmtest in Anlehnung an Bringmann-Kühn | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Wachstumshemmtest in Anlehnung an Bringmann-Kühn | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: EPI Suite (v4.1): HYDROWIN v2.00 Programm | Author: Estimation Programs Interface Suite for Microsoft Windows v4.11 | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: 2nd VCI ringtest 1976/77 | Author: BASF AG | Year: 1977 | Guideline: 301D | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 872-50-4 | EC 212-828-1 | 1-methylpyrrolidin-2-one) |
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| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: 2nd VCI ringtest 1976/77 | Author: BASF AG | Year: 1977 | Guideline: 301D | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 872-50-4 | EC 212-828-1 | 1-methylpyrrolidin-2-one) |
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| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Pyrrolidon dest.: Standtest | Author: BASF AG | Year: 1977 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Pyrrolidon dest.: Standtest | Author: BASF AG | Year: 1977 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation and Bioaccumulation Data of Existing Chemicals | Author: CITI | Year: 1992 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Untitled | Author: BASF AG | Year: 1979 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 872-50-4 | EC 212-828-1 | 1-methylpyrrolidin-2-one) |
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| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Untitled | Author: BASF AG | Year: 1979 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 872-50-4 | EC 212-828-1 | 1-methylpyrrolidin-2-one) |
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| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: A Correlation Study of Biodegradability Determinations with Various Chemicals in Various Tests | Author: Gerike P and Fischer WK | Year: 1979 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 872-50-4 | EC 212-828-1 | 1-methylpyrrolidin-2-one) |
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| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Methodenkombination zur sukzessiven Prüfung und Bewertung der biologischen Abbaubarkeit synthetischer Substanzen z.B. organischer Komplexbildner über allgemein gültige Summenparameter (BSB, CO2, COD, TOC). | Author: Fischer WK, Gerike P, and Schmid R | Year: 1974 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 872-50-4 | EC 212-828-1 | 1-methylpyrrolidin-2-one) |
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| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Untitled | Author: BASF AG | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 872-50-4 | EC 212-828-1 | 1-methylpyrrolidin-2-one) |
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| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Untitled | Author: BASF AG | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 872-50-4 | EC 212-828-1 | 1-methylpyrrolidin-2-one) |
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| Environmental | Adsorption/desorption | Robust Study Summary -- Title: KOCWIN v2.00 (EpiSuite v4.11) | Author: US EPA | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |