You are here: Home> Turkey>TR-REACH>CAS 67-56-1> CAS 67-56-1 | Data Package > 1000 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Pocket Guide to Chemical Hazards | Author: NIOSH | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Methanol | Author: GESTIS Substance data base | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The Merck Index | Author: O'Neil M.J. (ed.) | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Methanol | Author: Bennetto C. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Merck Index | Author: O'Neil M.J. (ed.) | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Methanol | Author: Beilstein | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Methanol | Author: Beilstein | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Merck Index | Author: Merck & Co. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Merck Index | Author: O'Neil M.J. (ed.) | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Methanol | Author: Nasirzadeh K. et al | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Methanol | Author: Boublik T. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: Beyond acid rain. Do soluble oxidants and organic toxins interact with SO2 and NOx to increase ecosystem effects? | Author: Gaffney J.S. et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Industrial Solvents Handbook | Author: Flick E.W. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Methanol | Author: BGIA GESTIS | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Methanol | Author: Smith C. J. and Hansch C. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: No information | Author: Sangster J. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Ionisation constants of organic acids in aqueous solution | Author: Serjeant E. P. and Dempsey B. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Tech Info for Problem Spills: Methanol (Draft) | Author: Environment Canada | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Methanol | Author: Beilstein | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Sicherheitstechnische Kennzahlen | Author: BASF AG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Sicherheitstechnische Kennzahlen | Author: BASF AG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: The Merck Index | Author: O'Neil M.J. (ed.) | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Fire Protection Guide to Hazardous Materials | Author: National Fire Protection Association (NFPA) | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Sicherheitstechnische Kennzahlen | Author: BASF AG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Sicherheitstechnische Kennzahlen | Author: BASF AG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Short-term tests with methanol. | Author: BASF AG | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Short-term tests with methanol. | Author: BASF AG | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: OECD eye irritation tests on three alcohols in: Acute Toxicity Data. | Author: Jacobs G.A. | Year: 1990 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Short-term tests with methanol. | Author: BASF AG | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Short-term tests with methanol. | Author: BASF AG | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Bericht zur Pruefung auf sensibilisierende Wirkung am Meerschweinchen - Maximierungstest (Magnusson and Kligman). | Author: BASF AG | Year: 1979 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Bericht zur Pruefung auf sensibilisierende Wirkung am Meerschweinchen - Maximierungstest (Magnusson and Kligman). | Author: BASF AG | Year: 1979 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Bericht zur vergleichenden Pruefung auf sensibilisierende Wirkung am Meerschweinchen (Magnusson and Kligman) | Author: BASF AG | Year: 1979 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Bericht zur vergleichenden Pruefung auf sensibilisierende Wirkung am Meerschweinchen (Magnusson and Kligman) | Author: BASF AG | Year: 1979 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: A comparative study on ethanol and acetaldehyde as inducers of chromosome malsegregation in Aspergillus nidulans. | Author: Crebelli R. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: The results of microbial mutation test for forty-three industrial chemicals. | Author: Shimizu H. S et al. | Year: 1985 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity testing with TA97 and TA 102 of 30 DNA-damaging compounds negative with other Salmonella strains. | Author: DeFlora S. et al. | Year: 1984 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Genotoxicity Biotransformation and Interactions of marine pollutants as related to genetic and carcinogenic hazards. | Author: DeFlora S. et al. | Year: 1990 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Study of 106 organic and inorganic compounds in the Salmonella/microsome test. | Author: DeFlora S. | Year: 1981 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: The in vitro micronucleus assay for the detection of cytogenetic effects induced by mutagen-carcinogens: comparison with the in vitro sister-chromatid exchange assay. | Author: Lasne C. et al | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Toxicological Research of Methanol as a fuel for Power Station. Summary Report on Tests with Monkeys Rats and Mice. | Author: New Energy Development Organization | Year: 1987 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Genotoxic activity and potency of 135 compounds in the Ames reversion test and in a bacterial DNA-repair test. | Author: DeFlora S. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Effect of Methanol on the Frequency of Micronuclei in Erythrocytes of Normal and Folate-deficient Swiss Mice (final) with Cover Letter dated 062191. | Author: American Petroleum Institute | Year: 1991 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evidence that methanol inhalation does not induce chromosome damage in mice. | Author: Campell J.A. et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evidence that methanol inhalation does not induce chromosome damage in mice. | Author: Campell J.A. et al. | Year: 1991 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Methanol Exposure Does Not Lead to Accumulation of Oxidative DNA Damage in Bone Marrow and Spleen of Mice Rabbits or Primates. | Author: McCallum G.P. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenicity of cosmetics ingredients licensed by the European Community. | Author: Gocke E. et al. | Year: 1981 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Influence of dietary folic acid on the developmental toxicity of methanol and the frequency of chromosomal breakage in the CD-1 mouse. | Author: Fu S.S. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: The biochemistry of methanol poisoning II. Metabolic acidosis in the monkey. | Author: Cooper J.R. and Felig P. | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Studies on the visual toxicity of methanol. IX. The effect of ethanol on methanol poisoning in the rhesus monkey. | Author: Gilger A.P. et al. | Year: 1956 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Studies on the visual toxicity of methanol. X. Further observations on the ethanol therapy of acute methanol poisoning in monkeys. | Author: Gilger A.P. et al. | Year: 1959 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: The visual toxicity of methanol VI. The clinical aspects of experimental methanol poisoning treated with base. | Author: Potts A.M. | Year: 1955 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Studies on the visual toxicity of methanol VIII. Additional observations on methanol poisoning in the primate test object. | Author: Potts A.M. et al. | Year: 1955 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Bericht ueber die orientierende toxikologische Pruefung von 3 Methanolproben aus der DMT-Druckveresterung. | Author: BASF AG | Year: 1961 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Bericht ueber die orientierende toxikologische Pruefung von 3 Methanolproben aus der DMT-Druckveresterung. | Author: BASF AG | Year: 1961 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute methanol toxicity in minipigs. | Author: Dorman D.C. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Short-term tests with methanol. | Author: BASF AG | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Short-term tests with methanol. | Author: BASF AG | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Effects on inhaled methanol in pituitary and testicular hormones in chamber acclimated and non-acclimated rats. | Author: Cooper R.L. et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Bestimmung der akuten Inhalationstoxizität LC50 von Methanol bei 6 stündiger Exposition bei Sprague-Dawley-Ratten. | Author: BASF AG | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Bestimmung der akuten Inhalationstoxizität LC50 von Methanol bei 6 stündiger Exposition bei Sprague-Dawley-Ratten. | Author: BASF AG | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Methanol. | Author: von Burg R. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Toxicity of methyl alcohol (methanol) following skin absorption and inhalation. | Author: McCord C.P. | Year: 1931 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Bestimmung der akuten Inhalationstoxizität LC50 von Methanol bei 4stündiger Exposition bei Sprague-Dawley-Ratten. | Author: BASF AG | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Bestimmung der akuten Inhalationstoxizität LC50 von Methanol bei 4stündiger Exposition bei Sprague-Dawley-Ratten. | Author: BASF AG | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Acute toxicity of methanol in the folate-deficient acatalasemic mouse. | Author: Smith E.N. and Taylor R.T. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Methanol poisoning. V. Role of formate metabolism in the monkey. | Author: McMartin K.E. et al. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Experimental methanol toxicity in the primate: Analysis of metabolic acidosis. | Author: Clay K.L. et al. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Physiologically based pharmacokinetic model for methanol in rats monkeys and humans. | Author: Horton V.L. Higuchi M.A. and Rickert D.E. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Automotive Methanol Vapors and Human Health: An Evaluation of Existing Scientific Information and Issues for Future Research. | Author: HEI (Health Effects Institute) | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Recent developments in methanol toxicity. | Author: Medinsky M.A. and Dorman D.C. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A pharmacokinetic model of inhaled methanol in humans and comparison to methanol disposition in mice and rats. | Author: Perkins R.A. Ward K.W. Pollack G.M. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Maternal-fetal pharmacokinetics of methanol. | Author: Pollack G.M. and Brouwer K.L.R. | Year: 1996 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Comparative toxicokinetics of inhaled methanol in the female CD-1 mouse and Sprague-Dawley rat. | Author: Perkins R.A. et al. | Year: 1995 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Developmental Neurotoxicity of Methanol Exposure by Inhalation in Rats. | Author: Weiss B. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Toxicological Research of Methanol as a fuel for Power Station. Summary Report on Tests with Monkeys Rats and Mice. | Author: New Energy Development Organization | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Perinatal methanol exposure in the rat. I. Blood methanol concentration and neural cell adhesion molecules. | Author: Stern S. et al. | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Species differences in methanol and formic acid pharmacokinetics in mice rabbits and primates. | Author: Sweeting J.N. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Methanol teratogenicity in mutant mice with deficient catalase activity and transgenic mice expressing human catalase | Author: Siu M.T. Wiley M.J. Wells P.G. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Species and strain-dependent teratogenicity of methanol in rabbits and mice. | Author: Sweeting J.N. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Lack of a role for formaldehyde in methanol poisoning in the monkey. | Author: McMartin K. et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Altered methanol embryopathies in embryo culture with mutant catalase-deficient mice and transgenic mice expressing human catalase. | Author: Miller L. and Wells P.G. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Oxidative stress in developmental origins of disease: Teratogenesis Neurodevelopmental Deficits and Cancer. | Author: Wells P.G. et al. | Year: 2009 | Klimisch score: additional information | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Receptor- and reactive intermediate mechanisms of teratogenesis. | Author: Wells P.G. et al. | Year: 2009 | Klimisch score: additional information | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Reproductive and offspring developm. effects following maternal inhalation exposure to methanol in nonhuman primates. Part I: Methanol disposition and reprod. toxicity in adult females. Part II: Developm. effects in infants exposed prenatally to methanol. | Author: Burbacher T. et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Methanol toxicity and formate oxidation in NEUT2 mice. | Author: Cook R.J. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Reproductive and Offspring Developm. Effects following Maternal Inhalation Exposure to Methanol in Nonhuman Primates: Part I: Methanol Disposition and Reprod. Toxicity in Adult Females; Part II: Developm. Effects in Infants exposed prenatally to Methanol. | Author: Burbacher T. et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmocokinetics of inhaled [14C]methanol and methanol-derived [14C]formate in normal and folate-deficient cynomolgus monkeys. | Author: Dorman D.C. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetics of methanol and formate in female cynomolgus monkeys exposed to methanol vapours. | Author: Medinsky M.A. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Comparative toxicokinetics of methanol in the female mouse and rat. | Author: Ward K.W. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Maternal-fetal pharmacokinetics of methanol. | Author: Pollack G.M. and Brouwer K.L.R. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Biochemical changes in brain in methanol poisoning--an experimental study. | Author: Rao K.R. et al. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Methyl alcohol poisoning. II. Development of a model for ocular toxicity in methyl alcohol poisoning using the Rhesus monkey. | Author: Martin-Amat G. et al. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Methanol poisoning: Ocular toxicity produced by formate. | Author: Martin-Amat G. et al. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Methyl alcohol poisoning IV. Alterations of the morphological findings of the retina and optic nerve. | Author: Baumbach G.L. et al. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Methyl alcohol poisoning. | Author: Hayreh M.S. et al. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: No information | Author: Martin-Amat G. et al. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Methanol poisoning I. The role of formic acid in the development of metabolic acidosis in the monkey and the reversal by 4-methylpyrazol. | Author: McMartin K.E. et al. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Effects on methanol vapors on testis testosterone production and morphology in rats. | Author: Lee E. et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicological Research of Methanol as a fuel for Power Station. Summary Report on Tests with Monkeys Rats and Mice. | Author: New Energy Development Organization | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicological Research of Methanol as a fuel for Power Station. Summary Report on Tests with Monkeys Rats and Mice. | Author: New Energy Development Organization | Year: 1987 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Methanol Environmental Health Criteria 196 | Author: IPCS/WHO | Year: 1997 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Proposal for reference concentrations (RfC) for inhalation exposure to methanol. | Author: Vyskocil A. and Viau C. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Biochemical and cytological studies of rat lung after inhalation of methanol vapours. | Author: White L. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Long-term effects of methanol vapor at low concentration. | Author: Takeda K. and Katoh N. | Year: 1988 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronic inhalation toxicity of methanol. | Author: Andrews L.S. et al. | Year: 1987 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Circulating concentrations of testosterone luteinizing hormone and follicle stimulating hormone in male rats after inhalation of methanol. | Author: Cameron A.M. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Altered methanol embryopathies in embryo culture with mutant catalase-deficient mice and transgenic mice expressing human catalase. | Author: Miller L. and Wells P.G. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: The developmental toxicity of inhaled methanol in the CD-1 mouse with quantitative dose-response modeling for estimation of benchmark doses. | Author: Rogers J.M. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Methanol teratogenicity in mutant mice with deficient catalase activity and transgenic mice expressing human catalase | Author: Siu M.T. Wiley M.J. Wells P.G. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental Neurotoxicity of Methanol Exposure by Inhalation in Rats. | Author: Weiss B. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Methanol causes posteriorization of cervical vertebrae in mice. | Author: Connelly L.E. and Rogers J.M. | Year: 1997 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Species and strain-dependent teratogenicity of methanol in rabbits and mice. | Author: Sweeting J.N. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Pathogenesis of Methanol-Induced Craniofacial Defects in C57BL/6J mice. | Author: Degitz S.J. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Alcohols: Ethanol and Methanol | Author: Rogers J.M. and Daston G.P. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Confocal laser scanning microscopy of the pathogenesis of methanol-induced craniofacial defects in C57BL/6J mice. | Author: Rogers J.M. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Methanol causes the holoprosencephaly spectrum of malformations at lower dosages than ethanol in C57BL/6J mice . | Author: Rogers J.M. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Glutathione depletion modulates methanol formaldehyde and formate toxicity in cultured rat conceptuses | Author: Harris C. Dixon M. Hansen J.M. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Toxicological Research of Methanol as a fuel for Power Station. Summary Report on Tests with Monkeys Rats and Mice. | Author: New Energy Development Organization | Year: 1987 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Long-term effects of methanol vapor at low concentration. | Author: Takeda K. and Katoh N. | Year: 1988 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture. | Author: Degitz S.J. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: 14C methanol incorporation into DNA and proteins of organogenesis stage mouse embryos in vitro | Author: Huang Y.S. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: In Vitro Assessment of the Effect of Methanol and the Metabolite Formic Acid on Embryonic Development of the Rat. | Author: Brown-Woodman P. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Methanol Exposure Does Not Lead to Accumulation of Oxidative DNA Damage in Bone Marrow and Spleen of Mice Rabbits or Primates. | Author: McCallum G.P. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: The developmental toxicity of inhaled methanol in the CD-1 mouse with quantitative dose-response modeling for estimation of benchmark doses. | Author: Rogers J.M. et al. | Year: 1993 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Embryotoxicity of methanol in well-nourished and malnourished rats. | Author: DeCarvalho R.R. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Critical periods of sensitivity to the developmental toxicity of inhaled methanol in CD-1 mouse. | Author: Rogers J.M. and Mole M.L. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Prenatal developmental toxicity study in Himalayan rabbits. Oral administration (Gavage). | Author: BASF AG | Year: 2008 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Prenatal developmental toxicity study in Himalayan rabbits. Oral administration (Gavage). | Author: BASF AG | Year: 2008 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratological assessment of methanol and ethanol at high inhalation levels in rats. | Author: Nelson B.K. et al. | Year: 1985 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental Toxicity of Formate and Formic Acid in Whole Embryo Culture: A Comparative Study with Mouse and Rat Embryos. | Author: Andrews J.E. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: New Zealand white rabbit progeny exposed in utero to methanol are resistant to skeletal anomalies reported for rodents but exhibit a novel vertebral defect | Author: Sweeting J.N. and Wells P.G. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Methanol-induced neural tube defects in mice: pathogenesis during neurulation. | Author: Bolon B. Welsch F. Morgan K.T. | Year: 1994 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Metabolic mechanisms of methanol/formaldehyde in isolated rat hepatocytes: Carbonyl-metabolizing enzymes versus oxidative stress . | Author: MacAllister S.L. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Chronic maternal methanol inhalation in nonhuman primates (Macaca fascicularis): reproductive performance with birth outcome. | Author: Burbacher T.M. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Neonatal behavioral toxicity in rats following prental exposure to methanol. | Author: Infurna R. and Weiss B.: | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Influence of dietary folic acid on the developmental toxicity of methanol and the frequency of chromosomal breakage in the CD-1 mouse. | Author: Fu S.S. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Influence of dietary folic acid on the developmental toxicity of methanol and the frequency of chromosomal breakage in the CD-1 mouse. | Author: Fu S.S. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Folate deficiency alone does not produce neural tube defects in mice. | Author: Heid M.K. et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Plasma formate levels in methanol treated dams are not markedly influenced by dietary folate. | Author: Hong K.H. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity of methanol in whole embryo culture: a comparative study with mouse and rat embryos. | Author: Andrews J.E. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Role of formate in methanol-induced exencephaly in CD-1 mice. | Author: Dorman D.C. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratogenicity of methanol following a single oral dose in Long-Evans rats. | Author: Youssef A.F. et al. | Year: 1997 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Methanol teratogenicity in pregnant Long-Evans rats. | Author: Youssef A.F. et al. | Year: 1991 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratogenicity of methanol by oral route. | Author: Youssef A.F. | Year: 1991 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Critical periods of sensitivity to the developmental toxicity of inhaled methanol in CD-1 mouse. | Author: Rogers J.M. and Mole M.L. | Year: 1997 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicoloty of industrial alcohols: a summary of 13 alcohols administered by inhalation to rats. | Author: Nelson B.K. Brightwell W.S. Krieg E.F. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Assessment of Offspring Development and Behavior Following Gestational Exposure to Inhaled Methanol in the Rat. | Author: Stanton M.E. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Comment on Sweeting and Wells (2015) | Author: DeSesso J.M. Williams A.L. White T.E. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Effects of Methanol on Embryonic Mouse Palata in Serum-Free Organ Culture. | Author: Abbott B.D. Logsdon T.R. Wilke T.S. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Cell deaths in rat and mouse embryos exposed to methanol in whole embryo culture. | Author: Abbott B.D. Ebreon-McCoy M. Andrews J.E. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Phase-Specific Developmental Toxicity in Mice Following Maternal Methanol Inhalation. | Author: Bolon B. et al. | Year: 1993 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Perinatal methanol exposure in the rat II. Behavioral effects in neonates and adults. | Author: Stern S. et al. | Year: 1996 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Perinatal methanol exposure in the rat I. Blood methanol concentration and neural cell adhesion molecules. | Author: Stern S. et al. | Year: 1997 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental Neurotoxicity of Methanol Exposure by Inhalation in Rats. | Author: Weiss B. et al. | Year: 1996 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Evaluation of the efects of methanol during early pregnancy in the rat. | Author: Cummings A.M. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Methanol metabolism nd embryotoxicity in rat and mouse conceptuses: comparisons of alcohol dehydrogenase (ADH1) formaldehyde dehydrogenase (ADH3) and catalase. | Author: Harris C. Wang S.W. Lauchu J.J. Hnse J.M. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity of methanol in rodents. | Author: Dorman D.C. and Welsch F. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Role of formate in methanol-induced exencephaly in CD-1 mice. | Author: Dorman D.C. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Pharmocokinetics of inhaled [14C]methanol and methanol-derived [14C]formate in normal and folate-deficient cynomolgus monkeys. | Author: Dorman D.C. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Recent developments in methanol toxicity. | Author: Medinsky M.A. and Dorman D.C. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Influence of folic acid intake on the developmental toxicity of methanol in the CD-1 mouse. (Abstract) | Author: Sakanashi T.M. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Reproductive and offspring developm. effects following maternal inhalation exposure to methanol in nonhuman primates. Part I: Methanol disposition and reprod. toxicity in adult females. Part II: Developm. effects in infants exposed prenatally to methanol. | Author: Burbacher T. et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Methanol. | Author: National Toxicology Program | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Reproductive and offspring developm. effects following maternal inhalation exposure to methanol in nonhuman primates. Part I: Methanol disposition and reprod. toxicity in adult females. Part II: Developm. effects in infants exposed prenatally to methanol. | Author: Burbacher T. et al. | Year: 1999 | Guideline: 415 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Sperm count morphology and fluorescent body frequency in autopsy service workers exposed to formaldehyde. | Author: Ward J. B. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Toxicological Research of Methanol as a fuel for Power Station. Summary Report on Tests with Monkeys Rats and Mice. | Author: New Energy Development Organization | Year: 1987 | Guideline: 416 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Long-term effects of methanol vapor at low concentration. | Author: Takeda K. and Katoh N. | Year: 1988 | Guideline: 416 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicological Research of Methanol as a fuel for Power Station. Summary Report on Tests with Monkeys Rats and Mice. | Author: New Energy Development Organization | Year: 1987 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Long-term effects of methanol vapor at low concentration. | Author: Takeda K. and Katoh N. | Year: 1988 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Assessment of the cancer potential of methanol | Author: Cruzan G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Methanol Environmental Health Criteria 196 | Author: IPCS/WHO | Year: 1997 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Severe methanol intoxication. | Author: Erlanson P. et al. | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Investigation and control of occupational hazards associated with the use of spirit duplicators. | Author: Frederick L.J. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: An outbreak of acute methyl alcohol intoxication. | Author: Naraqi S. et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: An Undercovered Health Threat in Turkey: Transdermal Methanol Intoxication | Author: Ali Ulvi Uca et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Ocular manifestations and complications of acute methyl alcohol intoxication. | Author: Dethlefs R. and Naraqi S. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: A rare case of fatal materno-fetal methanol poisoning. Volatile congeners analysis as forensic evidence | Author: Jung et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Breath urine and blood measurements as biological exposure indices of short-term inhalation exposure to methanol. | Author: Batterman S.A. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: other routes | Robust Study Summary -- Title: Experimental methanol toxicity in the primate: Analysis of metabolic acidosis. | Author: Clay K.L. et al. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |