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| Study name | Short Description | Data Owner |
|---|---|---|
| Chemical Safety Report | Chemical Safety Report | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: The Merck Index - An Encyclopedia of Chemicals Drugs and Biologicals. | Author: Budavari S. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: METHYL CHLORIDE CASRN: 74-87-3 | Author: Hazardous Substances Data Bank | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. | Author: Daubert T.E., Danner R.P. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Lide D.R. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Henry's Law Constant | Robust Study Summary -- Title: Chloromethane | Author: US EPA | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Henry's Law Constant | Right to refer to study -- Title: Chloromethane | Author: US EPA | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Henry's Law Constant | Robust Study Summary -- Title: MEASUREMENT OF HENRY'S LAW CONSTANT FOR C1 AND C2 CHLORINATED HYDROCARBONS | Author: Gossett J.M. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Henry's Law Constant | Robust Study Summary -- Title: SRC Henrywin programme v3.20 | Author: US EPA | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Henry's Law Constant | Right to refer to study -- Title: SRC Henrywin programme v3.20 | Author: US EPA | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: CHRIS - Hazardous Chemical Data. Volume II. | Author: U.S. Coast Guard Department of Transportation. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: METHYL CHLORIDE CASRN: 74-87-3 | Author: Hazardous Substances Data Bank | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Halogenated hydrocarbons: solubility-miscibility with water. | Author: Horvath A.L. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: METHYL CHLORIDE CASRN: 74-87-3 | Author: Hazardous Substances Data Bank | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Exploring QSAR - Hydrophobic Electronic and Steric Constants. | Author: Hansch C. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Chloromethane | Author: US EPA | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Chloromethane | Author: US EPA | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Sicherheitstechnische Kennzahlen brennbarer Gase und Dämpfe | Author: Nabert K., Schön G. | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Fire Protection Guide to Hazardous Materials. 12 ed. | Author: Quincy M.A. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: METHYL CHLORIDE CASRN: 74-87-3 | Author: Hazardous Substances Data Bank | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Fire Protection Guide to Hazardous Materials. 12 ed. | Author: Quincy M.A. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: METHYL CHLORIDE CASRN: 74-87-3 | Author: Hazardous Substances Data Bank | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Sicherheitstechnische Kennzahlen brennbarer Gase und Dämpfe | Author: Nabert K., Schön G. | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chlormethyl=Chlormethan Test for mutagenicity in bacteria strains in the absence and presence of a liver preparation | Author: Gericke D. | Year: 1977 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Chlormethyl=Chlormethan Test for mutagenicity in bacteria strains in the absence and presence of a liver preparation | Author: Gericke D. | Year: 1977 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenic Activity of Chemicals identified in Drinking Water | Author: Simmon V.F. et al. | Year: 1977 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenic Activity of Chemicals identified in Drinking Water | Author: Simmon V.F. et al. | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Methyl chloride CASRN: 74-87-3 Salmonalla study summary | Author: John Bucher | Year: 1991 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Assessment of the genotoxic effects of methyl chloride in human lymphoblasts | Author: Fostel J. et al. | Year: 1985 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Assessment of the genotoxic effects of methyl chloride in human lymphoblasts | Author: Fostel J. et al. | Year: 1985 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Reproductive effects of inhaled methyl chloride in the male Fischer 344 rat. I. Mating performance and dominant lethal assay | Author: Working P.K. et al. | Year: 1985 | Guideline: 478 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 478 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Guideline: 478 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Guideline: 478 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Role of epididymal inflammation in the induction of dominant lethal mutations in Fischer 344 rat sperm by methyl chloride | Author: Chellman G.J. et al. | Year: 1986 | Guideline: 478 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: The use of multiple endpoints to define the mechanism of action of reproductive toxicants and germ cell mutagens | Author: Working P.K., Chellman G.J. | Year: 1989 | Guideline: 478 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Unscheduled DNA synthesis in rat tracheal epithelial cells hepatocytes and spermatocytes following exposure to methyl chloride in vitro and in vivo | Author: Working P.K. et al. | Year: 1986 | Guideline: 486 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 486 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Guideline: 486 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Guideline: 486 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Association of inhaled [14C]methyl chloride with macromolecules from various rat tissues | Author: Kornbrust D.J. et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Methyl Chloride: Acute Inhalation Toxicity (Nose only) study in the rat | Author: Griffiths D.R., Watson P. | Year: 2009 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Methyl Chloride: Acute Inhalation Toxicity (Nose only) study in the rat | Author: Griffiths D.R., Watson P. | Year: 2009 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Inhibition of the acute toxicity of methyl chloride in male B6C3F1 mice by glutathione depletion | Author: Chellman G.J. et al. | Year: 1986 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism of Methyl Chloride to Formate in Rats | Author: Kornbrust D.J., Bus J.S. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The role of Glutathione and Cytochrome P-450 in the metabolism of methyl chloride | Author: Kornbrust D.J., Bus J.S. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetics and Metabolism of Inhaled Methyl Chloride in the Rat and Dog | Author: Landry T.D. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Final report on a chronic inhalation toxicology study in rats and mice exposed to methyl chloride. | Author: Chemical Industry Institute of Toxicology | Year: 1981 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Final report on a chronic inhalation toxicology study in rats and mice exposed to methyl chloride. | Author: Chemical Industry Institute of Toxicology | Year: 1981 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicology data assessment report. Executive summary. (Summary of audit report prepared for the CIIT by Experimental Pathology Laboratories CIIT Docket) | Author: Chemical Industry Institute of Toxicology | Year: 1983 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Toxicology data assessment report. Executive summary. (Summary of audit report prepared for the CIIT by Experimental Pathology Laboratories CIIT Docket) | Author: Chemical Industry Institute of Toxicology | Year: 1983 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Final report on a chronic inhalation toxicology study in rats and mice exposed to methyl chloride | Author: Chemical Industry Institute of Toxicology | Year: 1981 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Final report on a chronic inhalation toxicology study in rats and mice exposed to methyl chloride | Author: Chemical Industry Institute of Toxicology | Year: 1981 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicology data assessment report. Executive summary. (Summary of audit report prepared for the CIIT by Experimental Pathology Laboratories CIIT Docket) | Author: Chemical Industry Institute of Toxicology | Year: 1983 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Toxicology data assessment report. Executive summary. (Summary of audit report prepared for the CIIT by Experimental Pathology Laboratories CIIT Docket) | Author: Chemical Industry Institute of Toxicology | Year: 1983 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A ninety day inhalation toxicology study in F-344 albino rats and B6C3F1 mice exposed to atmospheric methyl chloride gas | Author: Chemical Industry Institute of Toxicology | Year: 1979 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A ninety day inhalation toxicology study in F-344 albino rats and B6C3F1 mice exposed to atmospheric methyl chloride gas | Author: Chemical Industry Institute of Toxicology | Year: 1979 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Methyl chloride a 90-day inhalation toxicity study in rats, mice and beagle dogs | Author: McKenna M.J. et al. | Year: 1981 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Methyl chloride a 90-day inhalation toxicity study in rats, mice and beagle dogs | Author: McKenna M.J. et al. | Year: 1981 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A prenatal development study in New Zealand White rabbits with Methyl Chloride by inhalation | Author: Theuns-van Vliet J.G. | Year: 2016 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: A prenatal development study in New Zealand White rabbits with Methyl Chloride by inhalation | Author: Theuns-van Vliet J.G. | Year: 2016 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Structural teratogenicity evaluation of methyl chloride in rats and mice after inhalation exposure | Author: Wolkowski-Tyl R. et al. | Year: 1983 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Structural teratogenicity evaluation of methyl chloride in rats and mice after inhalation exposure | Author: Wolkowski-Tyl R. et al. | Year: 1983 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Evaluation of heart malformations in B6C3F1 mouse fetuses induced by in utero exposure to methyl chloride | Author: Wolkowski-Tyl R. et al. | Year: 1983 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Reproduction in Fischer-344 rats exposed to methyl chloride by inhalation for two generations | Author: Hamm T.E. et al. | Year: 1985 | Guideline: 416 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 416 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Guideline: 416 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Guideline: 416 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Reproductive effects of inhaled methyl chloride in the male Fischer 344 rat. II. Spermatogonial toxicity and sperm quality | Author: Working P.K. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: The use of multiple endpoints to define the mechanism of action of reproductive toxicants and germ cell mutagens | Author: Working P.K., Chellman G.J. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Methyl chloride toxicity | Author: Working P.K., Bus J.S. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Final report on a chronic inhalation toxicology study in rats and mice exposed to methyl chloride. | Author: Chemical Industry Institute of Toxicology | Year: 1981 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: Final report on a chronic inhalation toxicology study in rats and mice exposed to methyl chloride. | Author: Chemical Industry Institute of Toxicology | Year: 1981 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicology data assessment report. Executive summary. (Summary of audit report prepared for the CIIT by Experimental Pathology Laboratories CIIT Docket) | Author: Chemical Industry Institute of Toxicology | Year: 1983 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: Toxicology data assessment report. Executive summary. (Summary of audit report prepared for the CIIT by Experimental Pathology Laboratories CIIT Docket) | Author: Chemical Industry Institute of Toxicology | Year: 1983 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Final report on a chronic inhalation toxicology study in rats and mice exposed to methyl chloride. | Author: Chemical Industry Institute of Toxicology | Year: 1981 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: Final report on a chronic inhalation toxicology study in rats and mice exposed to methyl chloride. | Author: Chemical Industry Institute of Toxicology | Year: 1981 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicology data assessment report. Executive summary. (Summary of audit report prepared for the CIIT by Experimental Pathology Laboratories CIIT Docket) | Author: Chemical Industry Institute of Toxicology | Year: 1983 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: Toxicology data assessment report. Executive summary. (Summary of audit report prepared for the CIIT by Experimental Pathology Laboratories CIIT Docket) | Author: Chemical Industry Institute of Toxicology | Year: 1983 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Neurotoxicity of methyl chloride in continuously versus intermittently exposed female C57BL/6 mice | Author: Landry T.D. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Inhibition of the acute toxicity of methyl chloride in male B6C3F1 mice by glutathione depletion | Author: Chellman G.J. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Methyl Chloride | Author: Löf A. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Toxicological review of methyl chloride (CAS No. 74-87-3) | Author: Greenberg M., Riddle J. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: EPI Suite was developed by EPA's Office of Pollution Prevention and Toxics and Syracuse Research Corporation. | Author: US EPA | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute Toxicity to Water Fleas (Daphnia magna) Under Static Renewal Conditions in a Closed System. | Author: Springborn Smithers Laboratories Inc | Year: 2002 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Acute Toxicity to Water Fleas (Daphnia magna) Under Static Renewal Conditions in a Closed System. | Author: Springborn Smithers Laboratories Inc | Year: 2002 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: EPI Suite was developed by EPA's Office of Pollution Prevention and Toxics and Syracuse Research Corporation. | Author: US EPA | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: EPI Suite was developed by EPA's Office of Pollution Prevention and Toxics and Syracuse Research Corporation. | Author: US EPA | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Critical review of hydrolysis of organic compounds in water under environmental conditions | Author: Mabey W., Mill T. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: BIODEGRADABILITY OF CHLOROMETHANE (CAS No 74-87-3 EC No 200-817-4) IN THE CLOSED BOTTLE TEST (OECD TG 301D) | Author: van Ginkel C.G. | Year: 2013 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: BIODEGRADABILITY OF CHLOROMETHANE (CAS No 74-87-3 EC No 200-817-4) IN THE CLOSED BOTTLE TEST (OECD TG 301D) | Author: van Ginkel C.G. | Year: 2013 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Chloromethane metabolism by Methylobacterium sp Strain CM4 | Author: Vannelli T. et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: SRC BIOWIN calculation | Author: Knoell Consult | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: SRC BIOWIN calculation | Author: Knoell Consult | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: STPWIN™ environmental model | Author: U.S. Environmental Protection Agency | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation of chloromethane by Pseudomonas aeruginosa strain NB 1 under nitrate-reducing and aerobic conditions | Author: Freedman D.L. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Methyl choride; natural occuring toxicant and C-1 growth substrate | Author: Hartmans S. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Production and Consumption of Methyl Halides in a Freshwater Lake | Author: Huang W. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Methyl chloride utilising bacteria are ubiquitous in the natural environment | Author: McAnulla C. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Degradation of methyl bromide and methyl chloride in soil microcosms use of stable C isotope fractionation and stable isotope probing to identify reaction and responsible microorganisms. | Author: Miller L.G. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: A mathematical model of biodegradability screening tests as an aid to interpretation of observed results | Author: Painter H.A., King E.F. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. R-A to readily biodegradable substances |
- |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biological degradation of methyl chloride in coastal seawater | Author: Tokarczyk R. et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: SRC KOCWIN calculation | Author: Knoell Consult | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: SRC KOCWIN calculation | Author: Knoell Consult | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Chloromethane | Author: US EPA | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: Chloromethane | Author: US EPA | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Chloromethane CAS: 74-87-3 | Author: OECD SIDS | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Kinetics and mechanisms of the gas-phase reactions of the hydroxyl radical with organic compounds | Author: Atkinson | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Chloromethane | Author: US EPA | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: Chloromethane | Author: US EPA | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |