You are here: Home> Turkey>TR-REACH>CAS 75-56-9> CAS 75-56-9 | Data Package > 1000 t/a (Affiliates of PO-PG Consortium Members)
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Low-Temperature Heat Capacity and Related Thermodynamic Functions of Propylene Oxide | Author: Oetting FL | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.4 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.4 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Propylene Oxide: Acute toxicity (Salmo Gairdneri Daphnia magna and Selenastrum capricornutum) and n-octanol/water partition coefficient | Author: Shell Research Ltd. | Year: 1986 | Guideline: A.5 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Propylene Oxide: Acute toxicity (Salmo Gairdneri Daphnia magna and Selenastrum capricornutum) and n-octanol/water partition coefficient | Author: Shell Research Ltd. | Year: 1986 | Guideline: A.5 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Medchem Project | Author: Hansch C and Leo AJ | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Quantitative Structure-Activity Relationship for the Acute Toxicity of Some Epoxy Compounds to the Guppy. | Author: Deneer JW et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.6 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.6 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.5 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Surface tension | Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.5 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Organic Solvents: Physical Properties and Methods of Purification Techniques of Chemistry" Volume 2 4th Edition | Author: Riddick JA Bunger WB Sakano TK | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 114 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 114 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: European Union Risk Assessment Report methyloxirane (propylene oxide) | Author: EU RAR | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: The inductive effect in ethylene oxide ring openings | Author: Nichols PL Jr and Ingham JD | Year: 1955 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Chemicals of current interest. Propylene oxide: health and environmental effects profile | Author: Meylan W et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Effect of pressure on the spontaneous and the base-catalyzed hydrolases of epoxides | Author: Koskikallio J and Whalley E | Year: 1959 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Investigation of selected potential environmental contaminants: Epoxides | Author: Bogyo DA et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Critical review of hydrolysis of organic compounds in water under environmental conditions | Author: Mabey W and Mill T | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Entropies of activation and mechanism for the acid-catalyzed hydrolysis of ethylene oxide and its derivatives | Author: Long FA; Pritchard JB and Stafford FE | Year: 1957 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: The reactions of certain epoxides in aqueous solutions | Author: Ross WCJ | Year: 1950 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Studies on the reaction of aromatic bases with epoxides and anucleophilic buffer for the acid-catalyzed hydrolysis of epoxides | Author: Pritchard JG and Siddiqui IA | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: The mechanism of epoxide reactions. V. The reactions of 12-epoxybutane 34-epoxybutylene 12-epoxy-3-chloropropane and 12-epoxy-3-methoxypropane with chloride ion in water under neutral and acidic conditions. | Author: Addy J.K. and Parker R.E. | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: The mechanism of epoxide reactions. VII. The reactions of 12-epoxybutane 34-epoxybutylene 12-epoxy-3-chloropropane and 12-epoxy-3-methoxypropane with chloride ion in water under neutral and acidic conditions. | Author: Addy J.K. and Parker R.E. | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Rate of addition of the nitrate ion to the ethylene oxide ring. | Author: Petty W.L. and Nichols P.L Jr. | Year: 1954 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation and bioaccumulation testing results on existing chemical substances. | Author: MITI (Ministry of International Trade and Industry) Japan | Year: 1988 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Propylene oxide: an assessment of ready biodegradability | Author: Shell Research Ltd. | Year: 1985 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Propylene oxide: an assessment of ready biodegradability | Author: Shell Research Ltd. | Year: 1985 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Effects of propylene oxide on selected species of fishes | Author: Crews RC | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Propylene oxide: acute toxicity (Salmo gairdneri Daphnia magna and Selenastrum capricornutum) and n-octanol/water partition coefficient | Author: Shell Research Ltd. | Year: 1986 | Guideline: EPA-660/3-75-009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Propylene oxide: acute toxicity (Salmo gairdneri Daphnia magna and Selenastrum capricornutum) and n-octanol/water partition coefficient | Author: Shell Research Ltd. | Year: 1986 | Guideline: EPA-660/3-75-009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Propylene oxide: acute toxicity (Salmo gairdneri Daphnia magna and Selenastrum capricornutum) and n-octanol/water partition coefficient | Author: Shell Research Ltd. | Year: 1986 | Guideline: EPA-660/3-75-009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Propylene oxide: acute toxicity (Salmo gairdneri Daphnia magna and Selenastrum capricornutum) and n-octanol/water partition coefficient | Author: Shell Research Ltd. | Year: 1986 | Guideline: EPA-660/3-75-009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Propylene oxide: acute toxicity (Salmo gairdneri Daphnia magna and Selenastrum capricornutum) and n-octanol/water partition coefficient | Author: Shell Research Ltd. | Year: 1986 | Guideline: EPA-660/3-75-009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Propylene oxide: acute toxicity (Salmo gairdneri Daphnia magna and Selenastrum capricornutum) and n-octanol/water partition coefficient | Author: Shell Research Ltd. | Year: 1986 | Guideline: EPA-660/3-75-009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Activated sludge respiration inhibition test Project Nr. 2972/0005 | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Activated sludge respiration inhibition test Project Nr. 2972/0005 | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Biodegradation and bioaccumulation testing results on existing chemical substances. | Author: MITI (Ministry of International Trade and Industry) Japan | Year: 1988 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Propylene oxide: an assessment of ready biodegradability | Author: Shell Research Ltd. | Year: 1985 | Guideline: 301D | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Propylene oxide: an assessment of ready biodegradability | Author: Shell Research Ltd. | Year: 1985 | Guideline: 301D | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Nasal NPSH Depletion and Propylene Oxide Uptake in the Upper Respiratory Tract of the Mouse | Author: John B. Morris and Lynn H. Pottenger | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Uptake of Inspired Propylene Oxide in the Upper Respiratory Tract of the F344 Rat | Author: John B. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: A collaborative exercise in acute oral toxicity testing | Author: Shell Research Ltd. | Year: 1968 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: A collaborative exercise in acute oral toxicity testing | Author: Shell Research Ltd. | Year: 1968 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Toxicity studies on propyle oxide: acute inhalation toxicity and 10 day repeated exposure study | Author: Shell Research Ltd. | Year: 1977 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Toxicity studies on propyle oxide: acute inhalation toxicity and 10 day repeated exposure study | Author: Shell Research Ltd. | Year: 1977 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Range finding toxicity data. (List VII). | Author: Smyth HF et al. | Year: 1969 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute dermal irritation in the rabbit | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Acute dermal irritation in the rabbit | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: propylene oxide: in vitro skin corrosion in the Episkin reconstituted human epidermis model | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 431 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: propylene oxide: in vitro skin corrosion in the Episkin reconstituted human epidermis model | Author: Harlan Laboratories Ltd. | Year: 2010 | Guideline: 431 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Propylene Oxide: Skin Sensitization Potential | Author: Dow Chemical Company | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Propylene Oxide: Skin Sensitization Potential | Author: Dow Chemical Company | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: NTP technical report on the toxicity and carcinogenicity of propylene oxide in F344/N rats and B6C3F1 mice (inhalation studies) | Author: National Toxicology Program | Year: 1985 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 Rats | Author: Lynch DW et al. | Year: 1984 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Nasal histopathology of propylene oxide (PO)-exposed mice and rats | Author: Harkema J | Year: 2006 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Sub-chronic (13-week) inhalation toxicity study of proylene oxide in rats | Author: TNO | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Sub-chronic (13-week) inhalation toxicity study of proylene oxide in rats | Author: TNO | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: chronic (28-month) inhalation toxicity/carcinogenicity study of 1 2-propylene oxide in rats | Author: TNO | Year: 1984 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: chronic (28-month) inhalation toxicity/carcinogenicity study of 1 2-propylene oxide in rats | Author: TNO | Year: 1984 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic inhalation toxicity and carcinogenicity study of propylene oxide in Wistar rats | Author: Kuper CF et al. | Year: 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: NTP technical report on the toxicity and carcinogenicity of propylene oxide in F344/N rats and B6C3F1 mice (inhalation studies) | Author: National Toxicology Program | Year: 1985 | Guideline: 451 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: NTP technical report on the toxicity and carcinogenicity of propylene oxide in F344/N rats and B6C3F1 mice (inhalation studies) | Author: National Toxicology Program | Year: 1985 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Is propylene oxide induced cell proliferation in rat nasal respiratory epithelium mediated by a severe depletion of water-soluble non-protein thiol? | Author: Khan MDH et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: NTP technical report on the toxicity and carcinogenicity of propylene oxide in F344/N rats and B6C3F1 mice (inhalation studies) | Author: National Toxicology Program | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Short-term mutation test with industrial chemicals: propylene oxide. | Author: Shell Research Ltd. | Year: 1976 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Short-term mutation test with industrial chemicals: propylene oxide. | Author: Shell Research Ltd. | Year: 1976 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Comparative mutagenicity of aliphatic epoxides in Salmonella | Author: Canter DA et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Short-term mutation test with industrial chemicals: propylene oxide. | Author: Shell Research Ltd. | Year: 1976 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Short-term mutation test with industrial chemicals: propylene oxide. | Author: Shell Research Ltd. | Year: 1976 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapours. | Author: McGregor D et al. | Year: 1991 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro III: results with 27 chemicals. | Author: Gulati DK et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenic activity of propylene oxide in bacterial and mammalian systems | Author: Bootman J; Lodge DC and Whalley HE | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: DNA Adducts Hemoglobin Adducts Abasic Sites and Cell Proliferation in Rats and Mice Exposed to Propylene Oxide by Inhalation. | Author: Swenberg JA et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Propylene oxide: Genotoxicity profile of a rodent nasal carcinogen | Author: Albertini RJ and Sweeney LM | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: The response of germ cell s to Ethylene oxide propylene oxide propylene imine and methyl methanesulfonate is a matter of cell stage-related DNArepair. | Author: Vogel EW and Nivard MJ | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Sister-chromatid exchanges and chromosome aberrations in lymphocytes from monkeys exposed to ethylene oxide and propylene oxide by inhalation. | Author: Lynch DW et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Genotoxic effects of inhaled ethylene oxide propylene oxide and butylene oxide on germ cells: sensitivity of genetic endpoints in relation to dose and repair status | Author: Vogel EW and Nivard MJ | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: NTP technical report on the toxicity and carcinogenicity of propylene oxide in F344/N rats and B6C3F1 mice (inhalation studies) | Author: National Toxicology Program | Year: 1985 | Guideline: 451 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: chronic (28-month) inhalation toxicity/carcinogenicity study of 1 2-propylene oxide in rats | Author: TNO | Year: 1984 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: chronic (28-month) inhalation toxicity/carcinogenicity study of 1 2-propylene oxide in rats | Author: TNO | Year: 1984 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Chronic inhalation toxicity and carcinogenicity of propylene oxide in Wistar rats | Author: Kuper CF et al. | Year: 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 Rats | Author: Lynch DW et al. | Year: 1984 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Carcinogenicity of ethylene oxide and 12-propylene oxide upon intragastric administration to rats. | Author: Dunkelberg H | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Derivation of inhalation toxicity reference values for propylene oxide using mode of action analysis: Example of a threshold carcinogen | Author: Sweeney LM et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Propylene oxide: two-generation inhalation reproduction study in Fischer 344 Rats | Author: Dow Chemical Company | Year: 1985 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Propylene oxide: two-generation inhalation reproduction study in Fischer 344 Rats | Author: Dow Chemical Company | Year: 1985 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Effect of propylene oxide on reproductive parameters in Fischer 344 rats | Author: Hayes WC et al. | Year: 1988 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Reproductive-toxicologic assessment of the epoxides ethylene oxide propylene oxide butylene oxide and styrene oxide | Author: Hardin BD et al. | Year: 1983 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Inhalation developmental toxicity study in rats | Author: International Research and Development Corporation | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Inhalation developmental toxicity study in rats | Author: International Research and Development Corporation | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Inhalation developmental toxicity study of propylene oxide in Fischer 344 rats | Author: Harris SB et al. | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Propylene oxide: Assessment of neurotoxic potential in male rats | Author: Dow Chemical Company | Year: 1985 | Guideline: 424 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Neurotoxicity | Right to refer to study -- Title: Propylene oxide: Assessment of neurotoxic potential in male rats | Author: Dow Chemical Company | Year: 1985 | Guideline: 424 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Hazardous air pollutants and breast cancer risk in California teachers: a cohort study | Author: Garcia et al | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: E. Delzell COMMENTS ON Garcia et al. Environmental Health 2015; 14:14. Hazardous air pollutants and breast cancer risk in California teachers: a cohort study | Author: Delzell E | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |