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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Handbook of Chemistry and Physics 74th Ed. | Author: CRC | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Handbook of Data on Organic Compounds 2nd. Ed. | Author: CRC | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Handbook of Chemistry and Physics 74th Ed. | Author: CRC | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Chemical Safety Data Booklet Properties and Essential Information for Handling and Use of CHLOROSILANES | Author: Silicones Health Council | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Chemical Safety Data Booklet Properties and Essential Information for Handling and Use of CHLOROSILANES | Author: Silicones Health Council | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: PHYSICAL PROPERTIES DETERMINATION of SILANES | Author: CHILWORTH TECHNOLOGY INC. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: PHYSICAL PROPERTIES DETERMINATION of SILANES | Author: CHILWORTH TECHNOLOGY INC. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Chemical Safety Data Booklet Properties and Essential Information for Handling and Use of CHLOROSILANES | Author: Silicones Health Council | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Chemical Safety Data Booklet Properties and Essential Information for Handling and Use of CHLOROSILANES | Author: Silicones Health Council | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Trimethylchlosilan: Prüfung auf primär reizende/ätzende wirkung an der kaninchenhaut | Author: Suberg H | Year: 1985 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Trimethylchlosilan: Prüfung auf primär reizende/ätzende wirkung an der kaninchenhaut | Author: Suberg H | Year: 1985 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Organochlorosilane A-161 Acute Toxicity and Primary Irritancy Studies | Author: Myers RC | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Organochlorosilane A-161 Acute Toxicity and Primary Irritancy Studies | Author: Myers RC | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity Evaluation of Trimethylchlorisilane Me3SiCl - Final Report. Industrial Health Foundation Inc. | Author: Litton Bionetics | Year: 1978 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Silane M3 Study of the Mutagenic Potential in Strains of Salmonella typhimurium (Ames Test) and Eschericia coli | Author: Dr Muller. W | Year: 1987 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Silane M3 Study of the Mutagenic Potential in Strains of Salmonella typhimurium (Ames Test) and Eschericia coli | Author: Dr Muller. W | Year: 1987 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Mutagenicity Evaluation of Trimethylchlorisilane Me3SiCl - Final Report. Industrial Health Foundation Inc. | Author: Litton Bionetics | Year: 1978 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Organochlorosilane A-161 Acute Toxicity and Primary Irritancy Studies | Author: BRRC | Year: 1982 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Organochlorosilane A-161 Acute Toxicity and Primary Irritancy Studies | Author: BRRC | Year: 1982 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: An acute whole-body inhalation toxicity study of trimethylchlorosilane in Fischer 344 rats | Author: Jean PA | Year: 1999 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: An acute whole-body inhalation toxicity study of trimethylchlorosilane in Fischer 344 rats | Author: Jean PA | Year: 1999 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Organochlorosilane A-161 Acute Toxicity and Primary Irritancy Studies | Author: Myers RC | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Organochlorosilane A-161 Acute Toxicity and Primary Irritancy Studies | Author: Myers RC | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A WHOLE-BODY INHALATION REPEATED DOSE TOXICITY STUDY WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST OF TRIMETHYLSILANOL IN RATS | Author: Fleeman T.L. | Year: 2008 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A WHOLE-BODY INHALATION REPEATED DOSE TOXICITY STUDY WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST OF TRIMETHYLSILANOL IN RATS | Author: Fleeman T.L. | Year: 2008 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A two-week repeated dose inhalation toxicity study of hydrogen chloride and selected chlorosilanes in albino rats. | Author: Crofoot SD et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A two-week repeated dose inhalation toxicity study of hydrogen chloride and selected chlorosilanes in albino rats. | Author: Crofoot SD et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A WHOLE-BODY INHALATION REPEATED DOSE TOXICITY STUDY WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST OF TRIMETHYLSILANOL IN RATS | Author: Fleeman T.L. | Year: 2008 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 1066-40-6 | EC 213-914-1 | Trimethylsilanol) |
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| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A WHOLE-BODY INHALATION REPEATED DOSE TOXICITY STUDY WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST OF TRIMETHYLSILANOL IN RATS | Author: Fleeman T.L. | Year: 2008 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 1066-40-6 | EC 213-914-1 | Trimethylsilanol) |
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| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Trimethylsilanol: A 96-Hour Static-Renewal Acute Toxicity Test with the Rainbow Trout (Oncorhynchus mykiss). | Author: Wildlife International Ltd. | Year: 2004 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 1066-40-6 | EC 213-914-1 | Trimethylsilanol) |
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| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Trimethylsilanol: A 96-Hour Static-Renewal Acute Toxicity Test with the Rainbow Trout (Oncorhynchus mykiss). | Author: Wildlife International Ltd. | Year: 2004 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 1066-40-6 | EC 213-914-1 | Trimethylsilanol) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Trimethylsilanol: A 48-Hour Static-Renewal Acute Toxicity Test with the Cladoceran (Daphnia magna). | Author: Wildlife International Ltd. | Year: 2004 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 1066-40-6 | EC 213-914-1 | Trimethylsilanol) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Trimethylsilanol: A 48-Hour Static-Renewal Acute Toxicity Test with the Cladoceran (Daphnia magna). | Author: Wildlife International Ltd. | Year: 2004 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 1066-40-6 | EC 213-914-1 | Trimethylsilanol) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Trimethylsilanol: A 96-Hour Toxicity Test with the Freshwater Alga (Selenastrum capricornutum). | Author: Wildlife International Ltd. | Year: 2004 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 1066-40-6 | EC 213-914-1 | Trimethylsilanol) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Trimethylsilanol: A 96-Hour Toxicity Test with the Freshwater Alga (Selenastrum capricornutum). | Author: Wildlife International Ltd. | Year: 2004 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 1066-40-6 | EC 213-914-1 | Trimethylsilanol) |
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| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis Screening Studies of HPV Chlorosilanes | Author: Miller J. et al. | Year: 2001 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Hydrolysis Screening Studies of HPV Chlorosilanes | Author: Miller J. et al. | Year: 2001 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Assessment of Ready Biodegradability; CO2 in Sealed Vessels (CO2 Headspace Test) | Author: Safepharm Laboratories Limited | Year: 2008 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 1066-40-6 | EC 213-914-1 | Trimethylsilanol) |
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| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Assessment of Ready Biodegradability; CO2 in Sealed Vessels (CO2 Headspace Test) | Author: Safepharm Laboratories Limited | Year: 2008 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 1066-40-6 | EC 213-914-1 | Trimethylsilanol) |
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