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| Study name | Short Description | Data Owner |
|---|---|---|
| Chemical Safety Report | Chemical Safety Report | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: 1-Vinyl-2-pyrrolidone | Author: GESTIS-Substance Database | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics, 90th Edition 2009-2010 | Author: Lide D.R. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruck von Vinylpyrrolidon | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruck von Vinylpyrrolidon | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Stoffwerte Pyrrolidon und Vinylpyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Stoffwerte Pyrrolidon und Vinylpyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruck von Vinylpyrrolidon | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruck von Vinylpyrrolidon | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Bestimmung des Verteilungskoeffizienten P(OW) von Vinylpyrrolidon in i-Octanol/Wasser beiRaumtemperatur (25 °C). | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Bestimmung des Verteilungskoeffizienten P(OW) von Vinylpyrrolidon in i-Octanol/Wasser beiRaumtemperatur (25 °C). | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: 1-Vinyl-2-pyrrolidone | Author: GESTIS Database | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Stoffwerte Pyrrolidon und Vinylpyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Stoffwerte Pyrrolidon und Vinylpyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Mechanistic studies of the acid hyrolysis of N-Vinyl-2-Pyrrolidone at pH <2.5. | Author: Hawi et. al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Über ein dimeres N-Vinylpyrrolidon und das 1,1-Bis-(1'-pyrrolidonyl)-äthan (on a dimer N-vinylpyrroldone and the 1,1-bis-(1'-pyrrolidonly)-ethane) | Author: Breitenbach J.W. et al. | Year: 1956 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: N-Vinyl-2-Pyrrolidone: Abiotic Degradation - Hydrolysis as a Function of Ph, VP | Author: (Dr. L. Sonnenschein) BASF SE | Year: 2013 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: N-Vinyl-2-Pyrrolidone: Abiotic Degradation - Hydrolysis as a Function of Ph, VP | Author: (Dr. L. Sonnenschein) BASF SE | Year: 2013 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Testing of the biologic degradability of 1-vinyl-2-pyrrolidone via the determination of the decrease of the dissolved oragnic carbon (DOC) in the DOC-Die-Away-Test | Author: BASF AG | Year: 1995 | Guideline: 301 A | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Testing of the biologic degradability of 1-vinyl-2-pyrrolidone via the determination of the decrease of the dissolved oragnic carbon (DOC) in the DOC-Die-Away-Test | Author: BASF AG | Year: 1995 | Guideline: 301 A | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: No information / BASF AG / other; Test protocol "Standversuch" / BASF AG / other; Testing of the physico-chemical elimination of vinyl pyrrolidone via the Zahn-Wellens-Test / BASF AG /study report | Author: BASF AG | Year: 1979 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: No information / BASF AG / other; Test protocol "Standversuch" / BASF AG / other; Testing of the physico-chemical elimination of vinyl pyrrolidone via the Zahn-Wellens-Test / BASF AG /study report | Author: BASF AG | Year: 1979 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Ecological testing of substances/sewage: vinyl pyrrolidone | Author: BASF AG | Year: 1979 | Guideline: ISO 5815 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Ecological testing of substances/sewage: vinyl pyrrolidone | Author: BASF AG | Year: 1979 | Guideline: ISO 5815 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Report on the study of the acute toxicity of vinyl pyrrolidone on rainbow trout | Author: BASF AG | Year: 1987 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Report on the study of the acute toxicity of vinyl pyrrolidone on rainbow trout | Author: BASF AG | Year: 1987 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Report on acute effect of vinyl pyrrolidone to Daphnia according to OECD 202 | Author: BASF AG | Year: 1990 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Report on acute effect of vinyl pyrrolidone to Daphnia according to OECD 202 | Author: BASF AG | Year: 1990 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Report on algae growth inhibition by vinyl pyrrolidone according to OECD 201 and DIN 38412, part 9 (draft) | Author: BASF AG | Year: 1989 | Guideline: 201 (before Mar. 2006) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Report on algae growth inhibition by vinyl pyrrolidone according to OECD 201 and DIN 38412, part 9 (draft) | Author: BASF AG | Year: 1989 | Guideline: 201 (before Mar. 2006) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Report on the growth inhibition test according to Bringmann-Kuehn | Author: BASF AG | Year: 1988 | Guideline: DIN 38412-8 (before Nov. 1992) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Report on the growth inhibition test according to Bringmann-Kuehn | Author: BASF AG | Year: 1988 | Guideline: DIN 38412-8 (before Nov. 1992) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Test protocol for the respiration inhibition test of vinyl pyrrolidone | Author: BASF AG | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Test protocol for the respiration inhibition test of vinyl pyrrolidone | Author: BASF AG | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Guideline: 401 (before 2002) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Guideline: 401 (before 2002) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: European Union Risk Assessment Report: 1-vinyl-2-pyrrolidone, CAS: 88-12-0, 2nd Priority List, Volume 39 | Author: European Commission | Year: 2003 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Bericht ueber die orientierende biologische Pruefung von a-Pyrrolidon und N-Vinyl-Pyrrolidon | Author: BASF AG | Year: 1953 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Bericht ueber die orientierende biologische Pruefung von a-Pyrrolidon und N-Vinyl-Pyrrolidon | Author: BASF AG | Year: 1953 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- GLP: . | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Bericht ueber die Bestimmung der akuten Inhalationstoxizitaet LC50 von Vinylpyrrolidori bei 4-stuendiger Exposition an Sprague-Dawley-Ratten | Author: BASF AG | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Bericht ueber die Bestimmung der akuten Inhalationstoxizitaet LC50 von Vinylpyrrolidori bei 4-stuendiger Exposition an Sprague-Dawley-Ratten | Author: BASF AG | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Bericht über die Pruefung der akuten dermalen Toxizitaet von Vinylpyrrolidon dest. (mit 10 ppm Kerobit BPD stabilisiert) an der Rueckenhaut weisser Kaninchen | Author: BASF AG | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Bericht über die Pruefung der akuten dermalen Toxizitaet von Vinylpyrrolidon dest. (mit 10 ppm Kerobit BPD stabilisiert) an der Rueckenhaut weisser Kaninchen | Author: BASF AG | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: ACUTE PERCUTANEOUS TOXICITY TO RATS OF n-VINYL PYRROLIDONE | Author: Kynoch S.R., Lloyd G.K. and Andrews C.D. | Year: 1978 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary skin and eye irritation tests with N-Vinylpyrrolidone in albino rabbits | Author: BASF AG | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary skin and eye irritation tests with N-Vinylpyrrolidone in albino rabbits | Author: BASF AG | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Primary skin and eye irritation tests with N-Vinylpyrrolidone in albino rabbits | Author: BASF AG | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Primary skin and eye irritation tests with N-Vinylpyrrolidone in albino rabbits | Author: BASF AG | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Vinylpyrrolidone - Buehler Test in guinea pigs | Author: Polloth and Hellwig | Year: 1996 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Vinylpyrrolidone - Buehler Test in guinea pigs | Author: Polloth and Hellwig | Year: 1996 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Report on the study of the inhalation toxicity of N-vinylpyrrolidone (extra pure) as vapor on female C 57 Black mice after 2 or 5.exposures or combination exposure (English translation of the original German report). | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Report on the study of the inhalation toxicity of N-vinylpyrrolidone (extra pure) as vapor on female C 57 Black mice after 2 or 5.exposures or combination exposure (English translation of the original German report). | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Supplementary Report on the study of the inhalation toxicity of N-vinylpyrrolidone (extra pure) as vapor on male Fischer 344 rats after 2 or 5 exposures or combination exposure (English translation of the original German report). | Author: BASF AG | Year: 1989 | Guideline: 413 (before Oct. 2017) | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Supplementary Report on the study of the inhalation toxicity of N-vinylpyrrolidone (extra pure) as vapor on male Fischer 344 rats after 2 or 5 exposures or combination exposure (English translation of the original German report). | Author: BASF AG | Year: 1989 | Guideline: 413 (before Oct. 2017) | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Report on the study of the inhalation toxicity of N-vinylpyrrolidone (extra pure ) as vapor on Fischer 344 rats (7-week test) (English translation of the original German report). | Author: BASF AG | Year: 1989 | Guideline: 413 (before Oct. 2017) | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Report on the study of the inhalation toxicity of N-vinylpyrrolidone (extra pure ) as vapor on Fischer 344 rats (7-week test) (English translation of the original German report). | Author: BASF AG | Year: 1989 | Guideline: 413 (before Oct. 2017) | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Report on the study of the inhalation toxicity of N-vinylpyrrolidone (extra pure) as vapor on C57 Black mice (7-week test) (English translation of the original German report). | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Report on the study of the inhalation toxicity of N-vinylpyrrolidone (extra pure) as vapor on C57 Black mice (7-week test) (English translation of the original German report). | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: N-Vinyl-2-pyrrolidone: Subacute 28-day inhalation study in Wistar rats; vapor exposure | Author: BASF SE | Year: 2011 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: N-Vinyl-2-pyrrolidone: Subacute 28-day inhalation study in Wistar rats; vapor exposure | Author: BASF SE | Year: 2011 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Ames test for vinylpyrrolidon | Author: BASF AG | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Ames test for vinylpyrrolidon | Author: BASF AG | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In Vitro Cytogenetic Investigations of N-vinylpyrrolidone-2 in Human Lymphocytes | Author: BASF | Year: 1987 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: In Vitro Cytogenetic Investigations of N-vinylpyrrolidone-2 in Human Lymphocytes | Author: BASF | Year: 1987 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Ames Metabolic Activation Test to Assess the Potential Mutagenic Effect of N-Vinyl Pyrrolidone | Author: HRC | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Ames Metabolic Activation Test to Assess the Potential Mutagenic Effect of N-Vinyl Pyrrolidone | Author: HRC | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Evaluation of V-pyrol (N-vinyl-2-pyrrolidone) in the In Vitro Transformation of BALB/3T3 Cells Assay | Author: GAF | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Evaluation of V-pyrol (N-vinyl-2-pyrrolidone) in the In Vitro Transformation of BALB/3T3 Cells Assay | Author: GAF | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Cytogenetic study in vivo of N-Vinylpyrrolidone-2 (NVP) in mice | Author: BASF AG | Year: 1993 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Cytogenetic study in vivo of N-Vinylpyrrolidone-2 (NVP) in mice | Author: BASF AG | Year: 1993 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: N-Vinyl-pyrrolidone: association of 14C-labelled chemical with rat liver DNA, Report, IRI Proj. No.732496 | Author: BASF AG | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: N-Vinyl-pyrrolidone: association of 14C-labelled chemical with rat liver DNA, Report, IRI Proj. No.732496 | Author: BASF AG | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: N-Vinyl Pyrrolidone - Prenatal developmental inhalation toxicity study in Wistar rats vapor exposure | Author: BASF AG | Year: 2001 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: N-Vinyl Pyrrolidone - Prenatal developmental inhalation toxicity study in Wistar rats vapor exposure | Author: BASF AG | Year: 2001 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |