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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften (BGIA) 09 Jan 2010 | Author: BGIA | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: The Merck Index | Author: O'Neill M.J. (ed.) | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary | Author: Lewis R. J. Sr. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition 2009-2010 | Author: Lide D.R. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: IPCS | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: GESTIS - Substance database of 'Berufsgenossenschaftlichen Instituts für Arbeitsschutz' (BGIA). 09 Jan 2010 | Author: BGIA | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Beilstein Data: Copyright© Beilstein Institut zur Foerderung der Chemischen Wissenschaften licensed to Beilstein GmbH and MDL Information Systems GmbH 05 Mar 2007 | Author: Beilstein | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Solvents | Author: Stoye D. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Merck Index - An Encyclopedia of Chemicals Drugs and Biologicals. Whitehouse Station NJ: Merck and Co. Inc. p. 262. (cited in HSDB 28 November 2009) | Author: Budavari S. (ed.). | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: No information | Author: IPCS | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Solvents | Author: Stoye D. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Beilstein Data: Copyright© 1988-2006 Beilstein Institut zur Foerderung der Chemischen Wissenschaften licensed to Beilstein GmbH and MDL Information Systems GmbH 05 Mar 2007 | Author: Beilstein | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition 2009-2010 | Author: Lide D.R. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: GESTIS - Substance database of 'Berufsgenossenschaftlichen Instituts für Arbeitsschutz' (BGIA) | Author: BGIA | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruck Butyrolacton | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruck Butyrolacton | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Stoffwerte γ-Butyrolacton | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Stoffwerte γ-Butyrolacton | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Beilstein Data: Copyright © 1988-2006, Beilstein Institut zur Foerderung der Chemischen Wissenschaften licensed to Beilstein GmbH and MDL Information Systems GmbH 05 Mar 2007 | Author: Beilstein | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Solvents | Author: Stoye D. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: IPCS | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Budavari S. (ed.). | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition 2009-2010 | Author: Lide D.R. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: GESTIS - Substance database of 'Berufsgenossenschaftlichen Instituts für Arbeitsschutz' (BGIA) 09 Jan 2010 | Author: BGIA | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. | Author: Daubert T.E. R.P. Danner. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruck Butyrolacton | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruck Butyrolacton | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Solvents | Author: Stoye D. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition 2009-2010 | Author: Lide D.R. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Handbook of Chemical Compound Data for Process Safety p. 35 as cited in HSDB 09 Jan 2010 | Author: Yaws C.L. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: GESTIS - Substance database of 'Berufsgenossenschaftlichen Instituts für Arbeitsschutz' (BGIA) as cited 09 Jan 2020 | Author: BGIA | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: No information | Author: IPCS | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Bestimmung des Verteilungskoeffizienten POW von γ-Butyrolacton in n-Octanol/Wasser | Author: BASF AG | Year: 1987 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Bestimmung des Verteilungskoeffizienten POW von γ-Butyrolacton in n-Octanol/Wasser | Author: BASF AG | Year: 1987 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Exploring QSAR - Hydrophobic Electronic and Steric Constants. | Author: Hansch C. Leo A. D. Hoekman. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Estimation of Octanol-Water Partition Coefficient by EPA KOWWIN v1.67a (Sept 2008) | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Estimation of Octanol-Water Partition Coefficient by EPA KOWWIN v1.67a (Sept 2008) | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Bestimmung der Wasserlöslichkeit | Author: BASF AG | Year: 1987 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Bestimmung der Wasserlöslichkeit | Author: BASF AG | Year: 1987 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Butyrolactone (CASRN: 96-48-0) | Author: O'Neal M.J. (ed.) | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Karteibogen | Author: BASF AG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Karteibogen | Author: BASF AG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Solvents | Author: Stoye D. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Butyrolactone (CASRN: 96-48-0) | Author: O'Neal N.D. (ed.). | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: No information | Author: IPCS | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: GESTIS - Substance database of 'Berufsgenossenschaftlichen Instituts für Arbeitsschutz' (BGIA) 08 Jan 2010 | Author: BGIA | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: No information | Author: IPCS | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: GESTIS - Substance database of 'Berufsgenossenschaftlichen Instituts für Arbeitsschutz' (BGIA) 09 Jan 2010 | Author: BGIA | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Karteibogen | Author: BASF AG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Karteibogen | Author: BASF AG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Calculation of pKa value (dissociation constant) for γ-Butyrolactone using SPARC Online v4.5 | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Right to refer to study -- Title: Calculation of pKa value (dissociation constant) for γ-Butyrolactone using SPARC Online v4.5 | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Acetylene-Derived Chemicals | Author: Hort EV Taylor P | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Solvents | Author: Stoye D. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: No information | Author: Harris | Year: 1958 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Additional physico-chemical information | Robust Study Summary -- Title: GESTIS - Substance database of 'Berufsgenossenschaftlichen Instituts für Arbeitsschutz' (BGIA) 09 Jan 2010 | Author: BGIA | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Additional physico-chemical information | Robust Study Summary -- Title: No information | Author: IPCS | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Additional physico-chemical information | Robust Study Summary -- Title: Karteibogen | Author: BASF AG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Additional physico-chemical information | Right to refer to study -- Title: Karteibogen | Author: BASF AG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Molecular Structure and Photochemical Reactivity. VI. Photochemistry of γ-Butyrolactone in the liquid phase | Author: Simonaitis R and Pitts JN jr | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: γ-Butyrolactone CAS No. 96-48-0 Beilstein Registry No. 105248. Beilstein Database. Copyright 1988-2006 Beilstein Institut zur Foerderung der Chemischen Wissenschaften licensed to Beilstein GmbH and MDL Information Systems GmbH. | Author: Blerbach A et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Estimation of Atmospheric Oxidation Rate Constant for γ-Butyrolactone using EPA AOPWIN v1.92 | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: Estimation of Atmospheric Oxidation Rate Constant for γ-Butyrolactone using EPA AOPWIN v1.92 | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: The Chemical Interconversion of GHB and GBL: Forensic Issues and Implications | Author: Ciolino L.A. et al. | Year: 2001 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Phototransformation in soil | Robust Study Summary -- Title: The Photodecomposition of γ-Butyrolactone in the Vapor Phase | Author: Simonaitis R and Pitts JN jr | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Test protocol of BOD study | Author: BASF AG | Year: 1977 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Test protocol of BOD study | Author: BASF AG | Year: 1977 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Test protocol Zahn-Wellens-study 'Standversuch' | Author: BASF AG | Year: 1977 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Test protocol Zahn-Wellens-study 'Standversuch' | Author: BASF AG | Year: 1977 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation and Bioaccumulation of Existing Chemical Substances under the Chemical Substances Control Law. | Author: METI | Year: 2007 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Estimation of Bioaccumulation Potential (Aquatic / Sediment) for 1,4-Butanediol (CASRN: 110-63-4) using USEPA BCFBAFWIN v3.0 (October 2008) | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Estimation of Bioaccumulation Potential (Aquatic / Sediment) for 1,4-Butanediol (CASRN: 110-63-4) using USEPA BCFBAFWIN v3.0 (October 2008) | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Estimation of Log KOC using EPA KOCWIN v2.00 for γ-Butyrolactone CAS# 96-48-0 | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: Estimation of Log KOC using EPA KOCWIN v2.00 for γ-Butyrolactone CAS# 96-48-0 | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: γ-Butyrolactone (CASRN: 96-48-0): Estimation of Henry's Law Constant Using US EPA HENRYWIN v3.20 (October 2008) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Distribution modelling | Right to refer to study -- Title: γ-Butyrolactone (CASRN: 96-48-0): Estimation of Henry's Law Constant Using US EPA HENRYWIN v3.20 (October 2008) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: Wide Distribution of Interspecific Stimulatory Events on Antibiotic Production and Sporulation Among Streptomyces species. | Author: Ueda K et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: Contribution of coffee aroma constituents to the mutagenicity of coffee | Author: Aeschbacher HU et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: γ-Butyrolactone CAS No. 96-48-0 Beilstein Registry No. 105248. Beilstein Database. Copyright 1988-2006 Beilstein Institut zur Foerderung der Chemischen Wissenschaften licensed to Beilstein GmbH and MDL Information Systems GmbH. | Author: McKenzie LM et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: Volatile Components of Chickpea Cicer arietinum L.) Seed. | Author: Rembold H et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: γ-Butyrolactone CAS No. 96-48-0 Beilstein Registry No. 105248. Beilstein Database. Copyright 1988-2006 Beilstein Institut zur Foerderung der Chemischen Wissenschaften licensed to Beilstein GmbH and MDL Information Systems GmbH. | Author: Pimenta AS et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Report on the study of acute toxicity of butyrolactone on Leuciscus idus | Author: BASF AG | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Report on the study of acute toxicity of butyrolactone on Leuciscus idus | Author: BASF AG | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Test report on fish (golden orfe) toxicity study | Author: BASF AG | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Test report on fish (golden orfe) toxicity study | Author: BASF AG | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Report on the acute effect of butyrolactone to the waterflea Daphnia magna Straus | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Report on the acute effect of butyrolactone to the waterflea Daphnia magna Straus | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Test protocol Algae study with γ-butyrolactone. | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Test protocol Algae study with γ-butyrolactone. | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Statistical evaluation with ToxRatPro (v2.09) of BASF algae study | Author: ECT Oekotoxikologie GmbH | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Statistical evaluation with ToxRatPro (v2.09) of BASF algae study | Author: ECT Oekotoxikologie GmbH | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Test protocol Algae study with γ-butyrolactone. | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Test protocol Algae study with γ-butyrolactone. | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Statistical evaluation with ToxRatPro (v2.09) of BASF algae study report No. 2/00w9/88 (test date: 03 June 1988) | Author: ECT Oekotoxikologie GmbH | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Statistical evaluation with ToxRatPro (v2.09) of BASF algae study report No. 2/00w9/88 (test date: 03 June 1988) | Author: ECT Oekotoxikologie GmbH | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Structure-Toxicity Relationships for Selected Lactones to Tetrahymena pyriformis | Author: Schultz TW and Deweese AD | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Test report on the growth inhibition test according to Bringmann-Kuehn | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Test report on the growth inhibition test according to Bringmann-Kuehn | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to other above-ground organisms | Robust Study Summary -- Title: The Acute Oral Toxicity Repellency and Hazard Potential of 998 Chemicals to One or More Species of Wild and Domestic Birds | Author: Schafer E.W. et. al | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Toxicology and Carcinogenesis Studies of γ-Butyrolactone (CAS No. 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) | Author: NTP | Year: 1992 | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Preliminary Report on the Metabolism of γ-Butyrolactone and γ-Hydroxybutyric Acid | Author: Roth R. H. et. al. | Year: 1965 | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: γ-Butyrolactone and γ-Hydroxybutyric Acid - I. Distribution and Metabolism | Author: Roth R.H. et. al | Year: 1966 | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Improved pharmacological activity via pro-drug modification: comparative pharmacokinetics of sodium γ-hydroxybutyrate and γ-butyrolactone | Author: Lettieri J.T. et. al. | Year: 1978 | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Absorption of sodium γ-hydroxybutyrate and its Prodrug γ-butyrolactone: Relationship between in vitro transport and in Vivo absorption | Author: Arena C. et. al. | Year: 1980 | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Percutaneous butyrolactone absorption in rats | Author: Fung H.L. et. al | Year: 1979 | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: NTP Study Summary Report on the Metabolism Disposition and Toxicity of 1,4-Butanediol. | Author: NTP | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Permeability of Commercial Solvents Through Living Human Skin | Author: Ursin C. et. al. | Year: 1995 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Industrial hygiene orientating investigation. | Author: BASF AG | Year: 1960 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Industrial hygiene orientating investigation. | Author: BASF AG | Year: 1960 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Industrial hygiene orientating investigation | Author: BASF AG | Year: 1960 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Industrial hygiene orientating investigation | Author: BASF AG | Year: 1960 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Industrial hygiene orientating investigation | Author: BASF AG | Year: 1960 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Industrial hygiene orientating investigation | Author: BASF AG | Year: 1960 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Report γ-Butyrolactone Comparative HET-CAM Test Alternative method to study the potential of serious damage to the eyes/mucous membranes in incubated hen eggs. | Author: BASF AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Report γ-Butyrolactone Comparative HET-CAM Test Alternative method to study the potential of serious damage to the eyes/mucous membranes in incubated hen eggs. | Author: BASF AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Evaluation of a Modified HET-CAM Assay as a Screening Test for Eye Irritancy | Author: Gilleron L. et. al | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Interlaboratory Assessment of the Bovine Corneal Opacity and Permeability (BCOP) Assay | Author: Gautheron P. et. al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Report: Gamma-Butyrolactone - Acute eye irritation in rabbits | Author: BASF AG | Year: 2005 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Report: Gamma-Butyrolactone - Acute eye irritation in rabbits | Author: BASF AG | Year: 2005 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) Technical Report No. 48 (2) Eye Irritation: Reference Chemicals Data Bank (Second Edition) | Author: ECETOC | Year: 1998 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Industrial hygiene orientating investigation | Author: BASF AG | Year: 1960 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Industrial hygiene orientating investigation | Author: BASF AG | Year: 1960 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: γ-Butyrolactone Murine Local Lymph Node Assay (LLNA) | Author: BASF SE | Year: 2010 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: γ-Butyrolactone Murine Local Lymph Node Assay (LLNA) | Author: BASF SE | Year: 2010 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: NTP Technical Report on the Toxicology and Carcinogenesis Studies of Gamma-Butyrolactone (Cas No. 96-48-0) In F344/N Rats and B6C3Fl Mice (Gavage Studies) | Author: NTP | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Toxicology and Carcinogenesis Studies of γ-Butyrolactone (CAS No. 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) | Author: NTP | Year: 1992 | Klimisch score: Reliable review by government agency experts | Adequacy: weight of evidence. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Chromosome Aberration and Sister Chromatid Exchange Tests in Chinese Hamster Ovary Cells In Vitro: II. Results with 20 Chemicals | Author: Loveday K.S. et al. | Year: 1989 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella mutagenicity test results for 250 chemicals | Author: Haworth S. et al. | Year: 1983 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Japan Chemical Industry Ecology - Toxicology and Information Center Japan; Mutagenicity test data of existing chemical substances based on the toxicity investigation of the industrial safety and health law Supplement 2 | Author: Japan MHLW | Year: 2000 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Toxicology and Carcinogenesis Studies of γ-Butyrolactone (CAS No. 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) | Author: NTP | Year: 1992 | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Toxicology and Carcinogenesis Studies of γ-Butyrolactone (CAS No. 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) | Author: NTP | Year: 1992 | Guideline: 477 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Chemical Mutagenesis Testing in Drosophila. X. Results of 70 Coded Chemicals Tested for the National Toxicology Program | Author: Foureman P et. al. | Year: 1994 | Guideline: 477 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Performance of 181 chemicals in a Drosophila assay predominantly monitoring interchromosomal mitotic recombination | Author: Vogel E.W. and Nivard M.J.M. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicology and Carcinogenesis Studies of γ-Butyrolactone (CAS No. 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - rat | Author: NTP | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicology and Carcinogenesis Studies of γ-Butyrolactone (CAS No. 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - mice | Author: NTP | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A comparison of γ-butyrolactone and pimozide on serum gonadotropins and ovulation in the rat | Author: Beattie C.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Combined Repeat Dose and Reproductive / Developmental Toxicity Screening Test of 1,4-Butanediol in Rats | Author: MHW | Year: 1999 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratogenicity Test of γ-Butyrolactone in the Sprague-Dawley Rat | Author: Kronevi T. et. al. | Year: 1988 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Combined Repeat Dose and Reproductive / Developmental Toxicity Screening Test of 1,4-Butanediol in Rats | Author: MHW | Year: 1999 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity evaluation of 1,4-Butanediol administered by gavage to Swiss mice on gestation days 6 through 15. | Author: NTP | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |