You are here: Home> Europe>UK-REACH>CAS 57-55-6> CAS 57-55-6 | Data Package > 1000 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Monopropylene glycol:determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Monopropylene glycol:determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: Sax NI | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Physical properties of propylene glycol. | Author: Jones WS Tamplin WS | Year: 1952 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: Puck TT Wise H | Year: 1945 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Physical properties of propylene glycol. | Author: Jones WS and Tamplin WS | Year: 1952 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: No information | Author: Puck TT Wise H | Year: 1945 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: No information | Author: Weast RC Astle MJ | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Weast RC Astle MJ | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Physical properties of propylene glycol. | Author: Jones WS; Tamplin WS | Year: 1952 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Puck TT; Wise H | Year: 1945 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Physical properties of propylene glycol | Author: Jones WS; Tamplin WS | Year: 1952 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Puck TT Wise H | Year: 1945 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: No information | Author: Verschueren K | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Weast RC Astle MJ | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Surface tension | Right to refer to study -- Title: Monopropylene glycol: determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Monopropylene glycol: determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Monopropylene glycol: determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Propanediols | Author: Sullivan CJ | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Monopropylene glycol: determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Monopropylene glycol: determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Densities Dynamic Viscosities Speeds of Sound and Relative Permittivities for Water + Alkanediols (Propane-l2- and -13-diol and Butane-l2- -13- -14- and -23-Diol) at Different Temperatures | Author: George J Sastry NV | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Densities Excess Molar Volumes Viscosities Speeds of Sound Excess Isentropic Compressibilities and Relative Permittivities for Alkyl (Methyl Ethyl Butyl and Isoamyl) Acetates + Glycols at Different Temperatures | Author: Sastry NV Patel MC | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: AOPWIN™ Version 1.92 | Author: US Environmental Protection Agency | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Computer estimation of the atmospheric gas-phase reaction rate of organic compounds with hydroxyl radicals and ozone | Author: Meylan WM and Howard PH | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: A structure-activity relationship for the estimation of rate constants for the gas-phase reactions of OH radicals with organic compounds | Author: Atkinson R | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Estimation of gas-phase hydroxyl radical rate constants for organic chemicals | Author: Atkinson R | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Estimating atmospheric degradation processes by SARs | Author: Müller M and Klein W | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: No information | Author: Anbar M and Neta P | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Phototransformation in water | Robust Study Summary -- Title: Washington National Bureau of Standards p51 NSRD -NBS -46 (NTIS COM-73-50623) | Author: Dorfman LM and Adam GE | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Summary report for glycol biodegradability testing program | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Summary report for glycol biodegradability testing program | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradability relationships among propylene glycol substances in the organization for economic cooperation and development ready- and seawater biodegradability tests | Author: West RJ et al. | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradability relationships among propylene glycol substances in the organization for economic cooperation and development ready- and seawater biodegradability tests (seawater) | Author: West RJ et al. | Year: 2007 | Guideline: 306 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Evaluation of ready biodegradability of propylene glycol using the OECD method 301F: manometric respirometry test. | Author: The Dow Chemical Company | Year: 1999 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Evaluation of ready biodegradability of propylene glycol using the OECD method 301F: manometric respirometry test. | Author: The Dow Chemical Company | Year: 1999 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Anaerobic biodegradation of propylene glycol in soil | Author: The Dow Chemical Company | Year: 1986 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Biodegradation in soil | Right to refer to study -- Title: Anaerobic biodegradation of propylene glycol in soil | Author: The Dow Chemical Company | Year: 1986 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Handbook of Chemical Property Estimation Methods McGraw -Hill New York. | Author: Lyman WJ | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Technical Guidance Document on Risk Assessment | Author: ECB | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: No information | Author: The European Union System for the Evaluation of Substances. TSA Group Delft bv. The Netherlands | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Other distribution data | Robust Study Summary -- Title: SIDS Initial Assessment Report for propylene glycol | Author: OECD | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Static acute toxicity of propylene glycol to the rainbow trout Oncorhynchus mykiss | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Static acute toxicity of propylene glycol to the rainbow trout Oncorhynchus mykiss | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Evaluation of the acute toxicity of industrial grade propylene glycol to representative freshwater organisms | Author: The Dow Chemical Company | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Evaluation of the acute toxicity of industrial grade propylene glycol to representative freshwater organisms | Author: The Dow Chemical Company | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Static acute toxicity of propylene glycol to the fathead minnow Pimephales promelas | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Static acute toxicity of propylene glycol to the fathead minnow Pimephales promelas | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Evaluation of the toxicity of industrial grade propylene glycol to representative aquatic organisms | Author: The Dow Chemical Company | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Evaluation of the toxicity of industrial grade propylene glycol to representative aquatic organisms | Author: The Dow Chemical Company | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: ECOSAR v1.00 | Author: U.S. Environmental Protection Agency | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Evaluation of the toxicity of industrial grade propylene glycol to representative aquatic organisms | Author: The Dow Chemical Company | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Evaluation of the toxicity of industrial grade propylene glycol to representative aquatic organisms | Author: The Dow Chemical Company | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Static acute toxicity of propylene glycol to the mysid Mysidopsis bahia. | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Static acute toxicity of propylene glycol to the mysid Mysidopsis bahia. | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Static Acute Toxicity of Propylene Glycol to the Daphnid Daphnia magna | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Static Acute Toxicity of Propylene Glycol to the Daphnid Daphnia magna | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Comparative toxicity of formulated glycol deicers and pure ethylene and propylene glycol to Ceriodaphnia dubia and Pimephales promelas | Author: Pillard DA | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Comparative toxicity of formulated glycol deicers and pure ethylene and propylene glycol to Ceriodaphnia dubia and Pimephales promelas. | Author: Pillard DA | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Static Acute Toxicity of Propylene Glycol to the Freshwater Alga Selenastrum capricornutum | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Static Acute Toxicity of Propylene Glycol to the Freshwater Alga Selenastrum capricornutum | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Static acute toxicity of propylene glycol to the marine alga Skeletonema costatum | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Static acute toxicity of propylene glycol to the marine alga Skeletonema costatum | Author: ARCO Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: The effect of propylene glycol on the growth of the bacterium Pseudomona putida | Author: The Dow Chemical Company | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: The effect of propylene glycol on the growth of the bacterium Pseudomona putida | Author: The Dow Chemical Company | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Propylene Glycol | Author: National Toxicology Program | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism of Tripropylene Glycol in Rats | Author: Dow Chemical Company | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Metabolism of Tripropylene Glycol in Rats | Author: Dow Chemical Company | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Dermal penetration of propylene glycols: measured absorption across human abdominal skin in vitro and comparison with a QSAR model | Author: Fasano WJ ten Berge WF Banton MI Heneweer M Moore NP | Year: 2011 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: The toxicology of some glycols and derivatives | Author: Laug EP Calvery HO Morris HJ Woodard G | Year: 1939 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Effect of the inhalation of a surface tension-reducing substance (propylene glycol) on the ultrastructure of the epithelium of the respiratory passages in rabbits | Author: Konradova V Vavrova V Janota J | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Acute dermal toxicity in albino rabbits | Author: MB Research Laboratories Inc. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Acute dermal toxicity in albino rabbits | Author: MB Research Laboratories Inc. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Prufung der akuten Hauttreizwirkung von 12-Propulenglykol. | Author: Hüls | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Prufung der akuten Hauttreizwirkung von 1,2-Propulenglykol. | Author: Hüls | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: OECD Eye irritation tests on propylene glycol and Solketal | Author: Jacobs GA | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Comparative study of methods chosen by the Association Française de Normalisation (AFNOR) for evaluating sensitizing potential in the albino guinea-pig | Author: Guillot JP Gonnet JF Clément C Faccini JM | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Guinea pig maximization test open epicutaneous test and chamber test in induction of delayed contact hypersensitivity | Author: Kero M Hannuksela M | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Comparative study of methods chosen by the Association Française de Normalisation (AFNOR) for evaluating sensitizing potential in the albino guinea-pig | Author: Guillot JP Gonnet JF Clément C Faccini JM | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Strategies for identifying false positive responses in predictive skin sensitization tests | Author: Basketter DA Gerberick GF Kimber I | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Results of a toxicology study in cats fed diets containing propylene glycol for up to three months. | Author: Toxicology Research Laboratory | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Results of a toxicology study in cats fed diets containing propylene glycol for up to three months. | Author: Toxicology Research Laboratory | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Long-term toxicity of propylene glycol in rats. | Author: Gaunt IF Carpanini FMB Grasso P Lansdown ABG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Results of feeding propylene glycol in the diet of dogs for two years. | Author: Weil CS Woodside MD Smyth HF Carpenter CP | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: The general properties actions and toxicity of propylene glycol | Author: Seidenfeld MA Hanzlik PJ | Year: 1932 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronic nose-only inhalation study of propylene glycol in Sprague-Dawley rats | Author: Suber RL et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: dermal | Robust Study Summary -- Title: Lack of toxicity and carcinogenicity of some commonly used cutaneous agents | Author: Stenbäck F Schubik P | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenic evaluation of compound FDA 71-56. Propylene glycol. | Author: Litton Bionetics Inc. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Primary mutagenicity screening of food additives currently used in Japan | Author: Ishidate M et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity of ethylene oxide and propylene oxide and of the glycols and halohydrins formed from them during the fumigation of foodstuffs. | Author: Pfeiffer EH Dunkelberg H | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Propylene glycol. Metaphase chromosome analysis of human lymphocytes cultured in vitro | Author: Huntingdon Research Centre Ltd | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Propylene glycol. Metaphase chromosome analysis of human lymphocytes cultured in vitro | Author: Huntingdon Research Centre Ltd | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenic Evaluation of Compound FDA 71-56 Propylene Glycol. (Dominant lethal Assary) | Author: Litton Bionetics Inc. L | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals. | Author: Hayashi M. Kishi M Sofuni T and Ishidate M | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenic Evaluation of Compound FDA 71-56 Propylene Glycol. | Author: Litton Bionetics Inc. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: NTP Technical Report on the toxicology and carcinogenesis studies of dipropylene glycol (CAS No. 25265-71-8) in F344/N rats and B6C3F1 mice (drinking water studies) | Author: National Toxicology Program | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: The general properties actions and toxicity of propylene glycol. | Author: Seidenfeld MA Hanzlik PJ | Year: 1932 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: NTP Technical Report on the toxicology and carcinogenesis studies of dipropylene glycol (CAS No. 25265-71-8) in F344/N rats and B6C3F1 mice (drinking water studies) | Author: National Toxicology Program | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Long-term toxicity of propylene glycol in rats. | Author: Gaunt IF Carpanini FMB Grasso P Lansdown ABG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Lack of toxicity and carcinogenicity of some commonly used cutaneous agents. | Author: Stenbäck F Shubik P | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Tests for the chronic toxicity of propylene glycol and triethylene glycol on monkeys and rats by vapor inhalation and oral administration (monkeys) | Author: Robertson OH et al. | Year: 1947 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Results of feeding propylene glycol in the diet of dogs for two years. | Author: Weil CS Woodside MD Smyth HF Carpenter CP | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Observations on the chronic toxicities of propylene glycol ethylene glycol diethylene glycol ethylene glycol mono-ethyl -ether and diethylene glycol mono-ethyl-ether | Author: Morris HJ Nelson AA Calvery HO | Year: 1941 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Tests for the chronic toxicity of propylene glycol and triethylene glycol on monkeys and rats by vapor inhalation and oral administration (rats) | Author: Robertson OH Loosli CG Puck TT Wise H Lemon HM Lester Jr. W | Year: 1947 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Propylene glycol | Author: National Toxicology Program | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Results and evaluations of 48 continuous breeding reproduction studies conducted in mice | Author: Morrissey RE et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Propylene glycol: reproduction and fertility assessment in CD-1 mice when administered in drinking water | Author: National Toxicology Program | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratological evaluation of FDA-71-56 (propylene glycol) in mice rats hamsters and rabbits | Author: Food and Drug Administration | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of ethylene glycol. | Author: NTP | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Further evaluation of an in vivo teratology screen | Author: Kavlock RJ Short RD Chernoff N | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Propylene glycol: developmental toxicity gavage study III in CD-1 mice | Author: Bushy Run Research Center | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Propylene glycol: developmental toxicity gavage study III in CD-1 mice | Author: Bushy Run Research Center | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Skin-sensitizing and irritant properties of propylene glycol | Author: Lessmann H Schnuch A Geier J Uter W | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Positive patch-test reactiosn to propylene glycol: a retrospective cross-sectional analysis from the North American Contact Dermatitis Group 1996 to 2006 | Author: Warshaw EM et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Repeated Insult Patch Test Protocol No. 1.01. Propylene glycol (semi) | Author: Consumer Product Testing Co. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Right to refer to study -- Title: Repeated Insult Patch Test Protocol No. 1.01. Propylene glycol (semi) | Author: Consumer Product Testing Co. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Repeated Insult Patch Test protocol # 1.01. Propylene glycol (796047C) occluded. | Author: Consumer Product Testing Co. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Sensitisation data (humans) | Right to refer to study -- Title: Repeated Insult Patch Test protocol # 1.01. Propylene glycol (796047C) occluded. | Author: Consumer Product Testing Co. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: 14 Day Cumulative Irritation Test. Protocol # 1.04. | Author: Consumer Product Testing Co. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Exposure-related observations in humans: other data | Right to refer to study -- Title: 14 Day Cumulative Irritation Test. Protocol # 1.04. | Author: Consumer Product Testing Co. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Evaluation of primary irritation potential in humans (single 24-hour application) | Author: Hill Top Research Inc. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Exposure-related observations in humans: other data | Right to refer to study -- Title: Evaluation of primary irritation potential in humans (single 24-hour application) | Author: Hill Top Research Inc. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: The measurement of fluid deposition in humans following mist tent therapy | Author: Bau SK Aspin N Wood DR Levison H. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Exclusive 48 hour patch test | Author: Consumer Product Testing Co. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Exposure-related observations in humans: other data | Right to refer to study -- Title: Exclusive 48 hour patch test | Author: Consumer Product Testing Co. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Additional toxicological information | Robust Study Summary -- Title: NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Propylene Glycol | Author: National Toxicology Program | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Additional toxicological information | Robust Study Summary -- Title: 1,2-dihydroxypropanol | Author: Sponsor country: USA | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |