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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: The Merck Index - An Encyclopedia of Chemicals Drugs and Biologicals | Author: Budavari S (ed.). | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics. 81st Edition. | Author: Lide DR (ed.). | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Chemical Hazard Response Information System. Hazard assessment handbook. Washington DC: U.S. Department of Transportation U.S. Coast Guard. Commandant Instruction M.16465.12A. | Author: No author provided | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Material Safety Data Sheet version 9.00 | Author: Millennium Inorganic Chemicals | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Material Safety Data Sheet version 9.00 | Author: Millennium Inorganic Chemicals | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The Merck Index - An Encyclopedia of Chemicals Drugs and Biologicals | Author: Budavari S (ed.). | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Merck Index - An Encyclopedia of Chemicals Drugs and Biologicals | Author: Budavari S (ed.). | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Merck Index - An Encyclopedia of Chemicals Drugs and Biologicals | Author: Budavari S (ed.). | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: IUCLID 2000 physico-chemical data set 2.4 | Author: Kronos International | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: IUCLID 2000 physico-chemical data set 2.4 | Author: Kronos International | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Kronos International Leverkusen | Year: 1951 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: No information | Author: Kronos International Leverkusen | Year: 1951 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor Pressure of Pure substances | Author: Stull D R | Year: 1947 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dangerous Properties of Industrial Materials | Author: Sax N I | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Material Safety Data Sheet version 9.00 for Titanium Tetrachloride | Author: Millennium Inorganic Chemicals | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Material Safety Data Sheet version 9.00 for Titanium Tetrachloride | Author: Millennium Inorganic Chemicals | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Philip F & Foster C T | Year: 1959 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Schaefea H & Zeppernick F | Year: 1953 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Weed H C | Year: 1958 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: The Merck Index | Author: O'Neil M J | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Titanium dioxide pigment - determination of water solubility and effect of pH on water solubility | Author: Harvey SE | Year: 2004 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Behaviour of titanium tetrachloride and oxychloride in water and consequences for assessing fate and effects in man and the environment | Author: Fisk PR et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Behaviour of titanium tetrachloride and oxychloride in water and consequences for assessing fate and effects in man and the environment | Author: Fisk PR et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: 24h screening transformation/dissolution test of Chloride reactor discharge at a 100 mg/L loading in a standard aqueous medium at pH 6, 7 and 8 | Author: Brouwers T | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Solubility behavior of titanium(IV) oxide in alkaline media at elevated temperatures | Author: Ziemniak SE; Jones ME and Combs KES | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Behaviour of titanium tetrachloride and oxychloride in water and consequences for assessing fate and effects in man and the environment | Author: Fisk PR et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Behaviour of titanium tetrachloride and oxychloride in water and consequences for assessing fate and effects in man and the environment | Author: Fisk PR et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Oxidising properties | Robust Study Summary -- Title: Behaviour of titanium tetrachloride and oxychloride in water and consequences for assessing fate and effects in man and the environment | Author: Fisk PR et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Oxidising properties | Right to refer to study -- Title: Behaviour of titanium tetrachloride and oxychloride in water and consequences for assessing fate and effects in man and the environment | Author: Fisk PR et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Oxidising properties | Robust Study Summary -- Title: Advanced Inorganic Chemistry | Author: Cotton FA; Wilkinson G | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toxicity of Titanium Tetrachloride | Author: Foulger JH; Zapp JA | Year: 1949 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Toxicity of Titanium Tetrachloride | Author: Foulger JH; Zapp JA | Year: 1949 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: The Toxicity of Titanium Tetrachloride | Author: Lawson JJ | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity of metal salts in combination with 9-amino-acridine in S typhimurium | Author: Ogawa HI et al. | Year: 1987 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Combined mutagenicity of cobalt (II) salt and heteroaromatic compounds in Salmonella typhimurium | Author: Ogawa HI et al. | Year: 1986 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Screening of Environmental Chemical Mutagens by the Rec-Assay System with Bacillus Subtilis | Author: Kada T; Hirano K and Shirasu Y | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Rec Assay and Mutagenicity Studies on Metal Compounds | Author: Kanematsu N; Hara M and Kada T | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Toxicological profile for titanium tetrachloride | Author: Research Triangle Institute | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Acute Inhalation Studies with Titanium Tetrachloride | Author: Kelly DP | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Acute Inhalation Studies with Titanium Tetrachloride | Author: Kelly DP | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Titanium tetrachloride (TiC14) - Assessment of Toxikokinetic Behaviour | Author: Frère F | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Titanium tetrachloride (TiC14) - Assessment of Toxikokinetic Behaviour | Author: Frère F | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: H-27201 and H-27203: Repeated-dose oral toxicity 28-day gavage study in rats | Author: Mayer T.W.; et al. | Year: 2006 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: H-27201 and H-27203: Repeated-dose oral toxicity 28-day gavage study in rats | Author: Mayer T.W.; et al. | Year: 2006 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: H-29865: Subchronic toxicity 90-day gavage study in rats | Author: Carpenter C. | Year: 2011 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: H-29865: Subchronic toxicity 90-day gavage study in rats | Author: Carpenter C. | Year: 2011 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles | Author: Warheit DB; Brown SC and Donner EM | Year: 2015 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Four-week inhalation study with titanium tetrachloride (TiCl4) | Author: Kelly DP | Year: 1979 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Four-week inhalation study with titanium tetrachloride (TiCl4) | Author: Kelly DP | Year: 1979 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Prenatal developmental toxicity study after repeated oral administration in Wistar rats with TiO2 pg-3 | Author: Takawale P. | Year: 2014 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Characterization of Pigment Grade and Ultra Fine Titanium Dioxide Particles | Author: Brown S.C. | Year: 2014 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Characterization of Pigment Grade and Ultra Fine Titanium Dioxide Particles | Author: Brown S.C. | Year: 2014 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Pigment grade titanium dioxide (TiO2 pg-1): Developmental toxicity study in rats | Author: Munley S.M. | Year: 2014 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Pigment grade titanium dioxide (TiO2 pg-1): Developmental toxicity study in rats | Author: Munley S.M. | Year: 2014 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Prenatal developmental toxicity study after repeated oral administration in Wistar rats with TiO2 uf-2 | Author: Holalagoudar S.R. | Year: 2014 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Ultrafine titanium dioxide (TiO2 uf-1): Developmental toxicity study in rats | Author: Munley S.M. | Year: 2014 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Ultrafine titanium dioxide (TiO2 uf-1): Developmental toxicity study in rats | Author: Munley S.M. | Year: 2014 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Ultrafine Titanium dioxide (TiO2 uf-3): Developmental toxicity study in rats | Author: Munley S. M. | Year: 2014 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Ultrafine Titanium dioxide (TiO2 uf-3): Developmental toxicity study in rats | Author: Munley S. M. | Year: 2014 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Prenatal developmental toxicity study after repeated oral administration in Wistar rats with TiO2 pg-2 | Author: Holalagoudar S.R. | Year: 2014 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Static acute 96-hour LC50 of H19277 to Fathead Minnows (Pimephales promelas) | Author: Hutton DG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Static acute 96-hour LC50 of H19277 to Fathead Minnows (Pimephales promelas) | Author: Hutton DG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit DB et al. | Year: 2007 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Chloride Reactor Discharge: A Study on the Respiration Inhibition of Activated Sludge | Author: Egeler P Goth M | Year: 2009 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Eco-Tox | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): Gill injury oxidative stress and other physiological effects | Author: Federici G; Shaw BJ and Handy RD | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 13463-67-7 | EC 236-675-5) |
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| Environmental | Hydrolysis | Robust Study Summary -- Title: Behaviour of titanium tetrachloride and oxychloride in water and consequences for assessing fate and effects in man and the environment | Author: Fisk PR et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Behaviour of titanium tetrachloride and oxychloride in water and consequences for assessing fate and effects in man and the environment | Author: Fisk PR et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Method for production of mono-dispersed and crystalline TiO2 ultrafine powders for aqueous TiOCl2 solution using homogeneous precipitation | Author: Kim S-J et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Preparation of crystalline TiO2 ultrafine powders from aqueous TiCl4 solution by precipitation method | Author: Kim et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Partitioning and mobility of trace metals in the Blesbokspruit: Impact assessment of dewatering of mine waters in the East Rand, South Africa. | Author: Roychoudhury AN; Starke MF | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. Read-Across (CAS 7440-32-6 | EC 231-142-3) |
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| Environmental | Adsorption/desorption | Robust Study Summary -- Title: A compendium of Geochemistry: From Solar Nebula to the Human Brain | Author: Li Y-H | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. Read-Across (CAS 7440-32-6 | EC 231-142-3) |
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| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Solid-water partitioning of elements in Czech freshwaters | Author: Veselý J et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. Read-Across (CAS 7440-32-6 | EC 231-142-3) |
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| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Soil Chemistry | Author: Bohn HL; McNeal BL and O'Connor GA (Eds) | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 16887-00-6 | EC 690-375-2) |
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