You are here: Home> Turkey>TR-REACH>CAS 872-50-4> CAS 872-50-4 | Data Package 10 - 100 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Analytical Report - Characterization of "N-Methylpyrrolidon" for toxicological studies | Author: BASF AG | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Analytical Report - Characterization of "N-Methylpyrrolidon" for toxicological studies | Author: BASF AG | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary. 12th ed. | Author: Lewis R.J. Sr (Ed.) | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Ullmann's Encyclopedia of Industrial Chemistry | Author: Elvers B et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: 2-Pyrrolidone | Author: Albrecht Ludwig Harreus | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: (Solid + liquid) phase equilibria of binary mixtures containing N-methyl-2-pyrrolidinone and long-chain n-alkanols at atmospheric pressure | Author: Domanska U and Lachwa J | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Schmelzpunkt von 1-Methylpyrrolidon- 2 | Author: BASF AG | Year: 1984 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Schmelzpunkt von 1-Methylpyrrolidon- 2 | Author: BASF AG | Year: 1984 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruck 1-METHYL-2-PYRROLIDON | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruck 1-METHYL-2-PYRROLIDON | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruck und Verdampfungsenthalpie von 1-Methylpyrrolidon-2 | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruck und Verdampfungsenthalpie von 1-Methylpyrrolidon-2 | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruck N-Methylpyrrolidon | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruck N-Methylpyrrolidon | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Ullmann's Encyclopedia of Industrial Chemistry | Author: Elvers B et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: 2-Pyrrolidone | Author: Albrecht Ludwig Harreus | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Physical Properties of Aqueous N-Methyl Pyrrolidone at Different Temperatures | Author: Maloka IE and Ibrahim SY | Year: 2004 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Merck Index - An Encyclopedia of Chemicals Drugs and Biologicals | Author: Budavari S. (ed.) | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruck von 1-Methylpyrrolidon-2 | Author: BASF AG | Year: 1985 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruck von 1-Methylpyrrolidon-2 | Author: BASF AG | Year: 1985 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruck N-Methylpyrrolidon | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruck N-Methylpyrrolidon | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruck und Verdampfungsenthalpie von 1-Methylpyrrolidon-2 | Author: BASF AG | Year: 1985 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruck und Verdampfungsenthalpie von 1-Methylpyrrolidon-2 | Author: BASF AG | Year: 1985 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruck 1-METHYL-2-PYRROLIDON | Author: BASF AG | Year: 1989 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruck 1-METHYL-2-PYRROLIDON | Author: BASF AG | Year: 1989 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Partition coefficient | Author: Sasaki et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Bestimmung des Verteilungskoeffizienten Pow von N-Methylpyrrolidon in 1-Octanol/Wasser bei Raumtemperatur (25 °C) | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Bestimmung des Verteilungskoeffizienten Pow von N-Methylpyrrolidon in 1-Octanol/Wasser bei Raumtemperatur (25 °C) | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Techniques of Chemistry. Volume 2: Organic Solvents. 4th edition | Author: Riddick JA, Bunger WB, and Sakano TK | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: GESTIS database query | Author: IFA Institute for Occupational Safety and Health of the German Social Accident Insurance | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Encyclopedia of Chemical Technology. 4th ed. | Author: Kirk-Othmer | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Ullmann's Encyclopedia of Industrial Chemistry | Author: Elvers B et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: 2-Pyrrolidone | Author: Albrecht Ludwig Harreus | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Techniques of Chemistry. Volume 2: Organic Solvents. 4th edition | Author: Riddick JA, Bunger WB, and Sakano TK | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Ullmann's Encyclopedia of Industrial Chemistry | Author: Elvers B et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: 2-Pyrrolidone | Author: Albrecht Ludwig Harreus | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 616-45-5 | EC 210-483-1 | 2-Pyrrolidone ) |
- |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: GESTIS database query | Author: IFA Institute for Occupational Safety and Health of the German Social Accident Insurance | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation and Bioaccumulation Data of Existing Chemicals | Author: MITI | Year: 1992 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: N-methyl-2-pyrrolidone-degrading bacteria from activated sludge | Author: Krížek K. et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: A Correlation Study of Biodegradability Determinations with Various Chemicals in Various Tests | Author: Gerike P and Fischer WK | Year: 1979 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Methodenkombination zur sukzessiven Prüfung und Bewertung der biologischen Abbaubarkeit synthetischer Substanzen z.B. organischer Komplexbildner über allgemein gültige Summenparameter (BSB, CO2, COD, TOC). | Author: Fischer WK, Gerike P and Schmid R | Year: 1974 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: EPI Suite v4.11: Calculation for CAS 872-50-4 | Author: BASF SE | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: EPI Suite v4.11: Calculation for CAS 872-50-4 | Author: BASF SE | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Estimation Programs Interface Suite for Microsoft Windows v4.11 | Author: US EPA | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Untitled study report - short-term toxicity to fish | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Untitled study report - short-term toxicity to fish | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Bestimmung der akuten Wirkung von N-Methylpyrrolidon-2 (NMP) gegenüber dem Wasserfloh Daphnia magna Straus. | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Bestimmung der akuten Wirkung von N-Methylpyrrolidon-2 (NMP) gegenüber dem Wasserfloh Daphnia magna Straus. | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Untitled study report - toxicity to aquatic algae and cyanobacteria | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Untitled study report - toxicity to aquatic algae and cyanobacteria | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Statistical evaluation ToxRatPro (v2.08) | Author: BASF SE | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Statistical evaluation ToxRatPro (v2.08) | Author: BASF SE | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Kurzzeitatmungstest | Author: BASF AG | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Kurzzeitatmungstest | Author: BASF AG | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: The Effect of N-Methylpyrrolidone (NMP) on the Action of Activated Sludge | Author: Gomolka B. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Oral, dermal and inhalation pharmacokinetics and disposition of [2-14C] NMP in the rat | Author: Haskell Laboratory for Toxicology and Industrial Medicine USA | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Oral, dermal and inhalation pharmacokinetics and disposition of [2-14C] NMP in the rat | Author: Haskell Laboratory for Toxicology and Industrial Medicine USA | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Concentrations of N-methyl-2-pyrrolidone (NMP) and its metabolites in plasma and urine following oral administration to rats | Author: Carnerup A., Saillenfait A. M., and Joensson B.O.G. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Contribution of CYP2E1 to N-methyl-2-pyrrolidone metabolism (Animal studies) | Author: Ligocka D, Lison D, and Haufroid V | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Richtwerte für 1-Methyl-2-pyrrolidon in der Innenraumluft | Author: Umweltbundesamt | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Quantitative Risk Analysis for N-Methyl-Pyrrolidone using Physiologically Based Pharmacokinetic and Benchmark Dose Modeling | Author: Poet TS et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Using physiologically based pharmacokinetic modeling and benchmark dose methods to derive an occupational exposure limit for N-methylpyrrolidone | Author: Poet TS et al. | Year: 2015 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Toxicokinetics and metabolism of N-[14C]methyl-2-pyrrolidone in male Sprague-Dawley rats. A saturable NMP elimination process. | Author: Payan JP et al. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Disposition and metabolism of double-labeled [3H and 14C] N-Methyl-2-Pyrrolidone in the rat | Author: Wells DA Digenis GA | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Isolation and identification of the major urinary metabolite of N-Methylpyrrolidone in the rat | Author: Wells DA, Hawi AA, and Digenis GA | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: The In Vivo Percutaneous Absorption of [14C]-N-Methylpyrrolidone in the rat | Author: Inveresk Research Tranent Scotland UK | Year: 2003 | Guideline: 427 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: The In Vivo Percutaneous Absorption of [14C]-N-Methylpyrrolidone in the rat | Author: Inveresk Research Tranent Scotland UK | Year: 2003 | Guideline: 427 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Permeability of commercial solvents through living human skin | Author: Ursin C et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: N-methylpyrrolidone: In vitro dermal penetration through human skin | Author: SafePharm Laboratories Limited | Year: 2004 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: N-methylpyrrolidone: In vitro dermal penetration through human skin | Author: SafePharm Laboratories Limited | Year: 2004 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Toxicokinetics and metabolism of N-[14C]methyl-2-pyrrolidone in male Sprague-Dawley rats: in vivo and in vitro percutaneous absorption | Author: Payan JP et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Percutaneous Absorption of co-administered N-methyl-2-[14C]pyrrolidinone and 2-[14C]pyrrolidinone in the rat | Author: Midgley I et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: [14C]-N-methylpyrrolidone: Topical application: Dermal absorption study in the rat | Author: Huntingdon Life Science Ltd Eye Suffolk UK | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: [14C]-N-methylpyrrolidone: Topical application: Dermal absorption study in the rat | Author: Huntingdon Life Science Ltd Eye Suffolk UK | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: [14C]-N-Methylpyrrolidone - in vitro dermal penetration study using human and rat skin | Author: Huntingdon Life Sci. Cambridgeshire UK | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: [14C]-N-Methylpyrrolidone - in vitro dermal penetration study using human and rat skin | Author: Huntingdon Life Sci. Cambridgeshire UK | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: The acute oral toxicity and primary ocular and dermal irritation of selected N-alkyl-2-pyrrolidones | Author: Ansell JM & Fowler JA | Year: 1988 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Evaluation in rats of acute inhalation toxicity (LC50) of N-methylpyrrolidone as an aerosol liquid. Four-hour exposure | Author: BASF AG | Year: 1988 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Evaluation in rats of acute inhalation toxicity (LC50) of N-methylpyrrolidone as an aerosol liquid. Four-hour exposure | Author: BASF AG | Year: 1988 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Dermal toxicity of dimethyl acetylene dicarboxylate N-methyl pyrrolidone triethylene glycol dimethyl ether dioxane and tetralin in the rat | Author: Clark B et al. | Year: 1984 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: The acute oral toxicity and primary ocular and dermal irritation of selected N-alkyl-2-pyrrolidones | Author: Ansell JM, & Fowler JA | Year: 1988 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: 1-methyl-2-pyrrolidone SIDS Initial Assessment Report For SIAM 24 | Author: OECD HPV Chemicals Programme | Year: 2007 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute toxicity and skin irritation of pyrrolidone derivates as transdermal penetration enhancer | Author: Sasaki H et al. | Year: 1990 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: The acute oral toxicity and primary ocular and dermal irritation of selected N-alkyl-2-pyrrolidones | Author: Ansell JM, & Fowler JA | Year: 1988 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: N-Ethyl-2-pyrrolidon - Murine Local Lymph Node Assay (LLNA). | Author: BASF AG | Year: 2005 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 2687-91-4 | EC 220-250-6 | N-Ethyl-2-pyrrolidon) |
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| Toxicological | Skin sensitisation | Right to refer to study -- Title: N-Ethyl-2-pyrrolidon - Murine Local Lymph Node Assay (LLNA). | Author: BASF AG | Year: 2005 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 2687-91-4 | EC 220-250-6 | N-Ethyl-2-pyrrolidon) |
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| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Amendment No. 1 to the report. | Author: BASF AG | Year: 2006 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 2687-91-4 | EC 220-250-6 | N-Ethyl-2-pyrrolidon) |
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| Toxicological | Skin sensitisation | Right to refer to study -- Title: Amendment No. 1 to the report. | Author: BASF AG | Year: 2006 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 2687-91-4 | EC 220-250-6 | N-Ethyl-2-pyrrolidon) |
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| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Repeated dose toxicity study with N-methylpyrrolidone in B6C3F1 mice. Administration in the diet for 4 weeks (Range-finding study) | Author: BASF AG Department of Toxicology | Year: 1994 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Repeated dose toxicity study with N-methylpyrrolidone in B6C3F1 mice. Administration in the diet for 4 weeks (Range-finding study) | Author: BASF AG Department of Toxicology | Year: 1994 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Subchronic oral toxicity: 28-day feeding study in rats with N-methylpyrrolidone (NMP) | Author: Haskell laboratories | Year: 1994 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Subchronic oral toxicity: 28-day feeding study in rats with N-methylpyrrolidone (NMP) | Author: Haskell laboratories | Year: 1994 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella mutagenicity test: II. Results from the testing of 270 chemicals | Author: Mortelmans K. et al. | Year: 1986 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chemical Effects in Biological Systems (CEBS): N-Methyl-2-pyrrolidone | Author: National Institute of Environmental Health Sciences | Year: 2015 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Ames test for N-methylpyrrolidone | Author: BASF AG Department of Toxicology | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Ames test for N-methylpyrrolidone | Author: BASF AG Department of Toxicology | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Assessment of reproductive toxicity and gonadotoxic potential of N-methyl-2-pyrrolidone in male rats | Author: Sitarek K, Stetkiewicz J | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |