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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: HSDB HEXAMETHYLENE DIAMINE | Author: NLM - U.S. National Library of Medicine | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Physical state of Hexamethylenediamine | Author: Renck P., Lambert L. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Physical state of Hexamethylenediamine | Author: Renck P., Lambert L. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Hexamethylene diamine - Documentation technique | Author: Rhone-Poulenc | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Hexamethylene diamine - Documentation technique | Author: Rhone-Poulenc | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Surface tension on Hexamethylene Diamine CAS 124-09-4 | Author: Ferron Nadège | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Surface tension on Hexamethylene Diamine CAS 124-09-4 | Author: Ferron Nadège | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Determination of the relative density and hydrosolubility of Hexamethylenediamine (HMD) | Author: Canet X. Courtois C. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Determination of the relative density and hydrosolubility of Hexamethylenediamine (HMD) | Author: Canet X. Courtois C. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics - 90th edition | Author: CRC Press | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Determination of the flash point, explosion properties and the auto-ignition temperature of hexamethylene diamine | Author: Martine VIBERT | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Determination of the flash point, explosion properties and the auto-ignition temperature of hexamethylene diamine | Author: Martine VIBERT | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Mise à jour des propriétes physiques (fusion, vaporisation) de l'hexamethylene diamine (HMD) | Author: Tanguy D., Certon A. | Year: 1989 | Guideline: A.1 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Mise à jour des propriétes physiques (fusion, vaporisation) de l'hexamethylene diamine (HMD) | Author: Tanguy D., Certon A. | Year: 1989 | Guideline: A.1 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: No information | Author: No author provided | Year: 2008 | Guideline: A.1 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Enthalpies and entropies of fusion of ten alkane-α ω-diamines H2N-(CH2)n-NH2 where 3 ≤ n ≤ 12 | Author: Dall'Acqua L. et al. | Year: 2002 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: HSDB HEXAMETHYLENE DIAMINE | Author: NLM - U.S. National Library of Medicine | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics - 90th edition | Author: CRC Press | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics - 90th edition | Author: CRC Press | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: No information | Author: No author provided | Year: 2008 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: HSDB HEXAMETHYLENE DIAMINE | Author: NLM - U.S. National Library of Medicine | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: No information | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: No information | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: No information | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: No information | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Mise à jour des propriétés physiques (fusion vaporisation) de l'hexamethylene diamine (HMD) | Author: Tanguy D., Certon A | Year: 1989 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Mise à jour des propriétés physiques (fusion vaporisation) de l'hexamethylene diamine (HMD) | Author: Tanguy D., Certon A | Year: 1989 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Determination of the relative density and hydrosolubility of Hexamethylenediamine (HMD) | Author: Canet X., Courtois C. | Year: 2010 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Determination of the relative density and hydrosolubility of Hexamethylenediamine (HMD) | Author: Canet X., Courtois C. | Year: 2010 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Hexamethylenediamine - HMD | Author: U.S. Coast Guard department of Transportation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: HSDB HEXAMETHYLENE DIAMINE | Author: NLM - U.S. National Library of Medicine | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruck von 1,6-Diaminohexan | Author: BASF AG | Year: 1989 | Guideline: A.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruck von 1,6-Diaminohexan | Author: BASF AG | Year: 1989 | Guideline: A.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: BASF AG | Year: 1982 | Guideline: A.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: No information | Author: BASF AG | Year: 1982 | Guideline: A.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: BASF AG | Year: 1982 | Guideline: A.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: No information | Author: BASF AG | Year: 1982 | Guideline: A.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: HSDB HEXAMETHYLENE DIAMINE | Author: NLM - U.S. National Library of Medicine | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: PhysProp | Author: Syracuse Reasearch Corporation | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Surface tension on Hexamethylene Diamine CAS 124-09-4 | Author: Ferron Nadège | Year: 2010 | Guideline: 115 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Surface tension | Right to refer to study -- Title: Surface tension on Hexamethylene Diamine CAS 124-09-4 | Author: Ferron Nadège | Year: 2010 | Guideline: 115 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Hexamethylenediamine - HMD | Author: U.S. Coast Guard department of Transportation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: HSDB HEXAMETHYLENE DIAMINE | Author: NLM - U.S. National Library of Medicine | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the relative density and hydrosolubility of Hexamethylenediamine (HMD) | Author: Canet X., Courtois C. | Year: 2010 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the relative density and hydrosolubility of Hexamethylenediamine (HMD) | Author: Canet X., Courtois C. | Year: 2010 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Atom/Fragment contribution method for estimating octanol-water partition coefficients | Author: Meylan W.M. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: HSDB HEXAMETHYLENE DIAMINE | Author: NLM - U.S. National Library of Medicine | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: PhysProp | Author: Syracuse Reasearch Corporation | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: HSDB HEXAMETHYLENE DIAMINE | Author: NLM - U.S. National Library of Medicine | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: PhysProp | Author: Syracuse Reasearch Corporation | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: Determination of the flash point, explosion properties and the auto-ignition temperature of hexamethylene diamine | Author: Martine VIBERT | Year: 2007 | Guideline: A.14 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Explosive properties | Right to refer to study -- Title: Determination of the flash point, explosion properties and the auto-ignition temperature of hexamethylene diamine | Author: Martine VIBERT | Year: 2007 | Guideline: A.14 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: Calcul des critères de dispense d'essais pour la réglementation transport (ONU) et pour REACH concernant l'hexaméthylène diamine (HMD) | Author: Martine VIBERT | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Explosive properties | Right to refer to study -- Title: Calcul des critères de dispense d'essais pour la réglementation transport (ONU) et pour REACH concernant l'hexaméthylène diamine (HMD) | Author: Martine VIBERT | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: HSDB HEXAMETHYLENE DIAMINE | Author: NLM - U.S. National Library of Medicine | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Flammability of solids on Hexamethylene Diamine CAS 124-09-4 (draft report) | Author: DEMANGEL Benjamin | Year: 2010 | Guideline: A.10-13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Flammability of solids on Hexamethylene Diamine CAS 124-09-4 (draft report) | Author: DEMANGEL Benjamin | Year: 2010 | Guideline: A.10-13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Oxidising properties | Robust Study Summary -- Title: Calcul des critères de dispense d'essais pour la réglementation transport (ONU) et pour REACH concernant l'hexaméthylène diamine (HMD) | Author: Martine VIBERT | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Oxidising properties | Right to refer to study -- Title: Calcul des critères de dispense d'essais pour la réglementation transport (ONU) et pour REACH concernant l'hexaméthylène diamine (HMD) | Author: Martine VIBERT | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Hexamethylenediamine - HMD | Author: U.S. Coast Guard department of Transportation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: HSDB HEXAMETHYLENE DIAMINE | Author: NLM - U.S. National Library of Medicine | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Determination of the flash point, explosion properties and the auto-ignition temperature of hexamethylene diamine | Author: Martine VIBERT | Year: 2007 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Determination of the flash point, explosion properties and the auto-ignition temperature of hexamethylene diamine | Author: Martine VIBERT | Year: 2007 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Additional physico-chemical information | Robust Study Summary -- Title: Calcul des critères de dispense d'essais pour la réglementation transport (ONU) et pour REACH concernant l'hexaméthylène diamine (HMD) | Author: Martine VIBERT | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Additional physico-chemical information | Right to refer to study -- Title: Calcul des critères de dispense d'essais pour la réglementation transport (ONU) et pour REACH concernant l'hexaméthylène diamine (HMD) | Author: Martine VIBERT | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Determination of the flash point explosion properties and the auto-ignition temperature of hexamethylene diamine | Author: Martine VIBERT | Year: 2007 | Guideline: A.15-16 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Determination of the flash point explosion properties and the auto-ignition temperature of hexamethylene diamine | Author: Martine VIBERT | Year: 2007 | Guideline: A.15-16 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: H-22685 Corrositex® in vitro test | Author: Ladics G.S. | Year: 1998 | Guideline: 435 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: H-22685 Corrositex® in vitro test | Author: Ladics G.S. | Year: 1998 | Guideline: 435 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Produit n°7273 R.P. Toxicité aigue chez le rat par voies orale et percutanée ainsi que la tolérance locale oculaire et cutanée chez le lapin | Author: Marzin D. | Year: 1978 | Guideline: B.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Produit n°7273 R.P. Toxicité aigue chez le rat par voies orale et percutanée ainsi que la tolérance locale oculaire et cutanée chez le lapin | Author: Marzin D. | Year: 1978 | Guideline: B.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Produit n°7273 R.P. Toxicité aigue par voies orale et percutanée chez le rat Tolérance locale chez le lapin | Author: Marzin R. | Year: 1978 | Guideline: B.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Produit n°7273 R.P. Toxicité aigue par voies orale et percutanée chez le rat Tolérance locale chez le lapin | Author: Marzin R. | Year: 1978 | Guideline: B.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Activity of T1623 in the in vitro mammalian cell transformation assay in the absence of exogenous metabolic activation | Author: Schechtman L. M. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Activity of T1623 in the in vitro mammalian cell transformation assay in the absence of exogenous metabolic activation | Author: Schechtman L. M. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Activity of T1623 in the in vitro mammalian cell transformation assay in the presence of exogenous metabolic activation | Author: Schechtman L. M. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Activity of T1623 in the in vitro mammalian cell transformation assay in the presence of exogenous metabolic activation | Author: Schechtman L. M. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Evaluation of 81/229 Hexamethylene diamine in the primary rat hepatocyte unscheduled DNA synthesis assay | Author: Myhr B. C. | Year: 1981 | Guideline: 482 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | other mutagenicity information | Right to refer to study -- Title: Evaluation of 81/229 Hexamethylene diamine in the primary rat hepatocyte unscheduled DNA synthesis assay | Author: Myhr B. C. | Year: 1981 | Guideline: 482 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: NTP Technical Report on Toxicity Studies of 1,6-Hexanediamine Dihydrochloride administered by drinking water and inhalation to F344/N rats and B6C3F1 Mice | Author: Hébert C. D. | Year: 1993 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. | Author: Galloway S. et al. | Year: 1987 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: CHO/HGPRT Mammalian Cell Forward Gene Mutation assay | Author: Godek E.G. | Year: 1985 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: CHO/HGPRT Mammalian Cell Forward Gene Mutation assay | Author: Godek E.G. | Year: 1985 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial Reverse Mutation Test (non-audited draft) | Author: Sire G. | Year: 2015 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial Reverse Mutation Test (non-audited draft) | Author: Sire G. | Year: 2015 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: NTP Technical Report on Toxicity Studies of 1,6-Hexanediamine Dihydrochloride administered by drinking water and inhalation to F344/N rats and B6C3F1 Mice | Author: Hébert C. D. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. | Author: Galloway S. et al. | Year: 1987 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: NTP Technical Report on Toxicity Studies of 1,6-Hexanediamine Dihydrochloride administered by drinking water and inhalation to F344/N rats and B6C3F1 Mice | Author: Hébert C. D. | Year: 1993 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 6055-52-3 | EC 227-977-8 | Hexamethylenediammonium dichloride) |
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| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: In vivo Bone Marrow Chromosome Study in Rats | Author: Farrow M.G. | Year: 1984 | Guideline: 475 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: In vivo Bone Marrow Chromosome Study in Rats | Author: Farrow M.G. | Year: 1984 | Guideline: 475 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Produit n°7273 R.P. Toxicité aigue par voies orale et percutanée chez le rat Tolérance locale chez le lapin. | Author: Marzin D. | Year: 1978 | Guideline: B.1 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Produit n°7273 R.P. Toxicité aigue par voies orale et percutanée chez le rat Tolérance locale chez le lapin. | Author: Marzin D. | Year: 1978 | Guideline: B.1 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicological Investigation of CP54121 | Author: Anonymous | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Toxicological Investigation of CP54121 | Author: Anonymous | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicological Profile of Orally Administered 1,6-Hexane Diamine in the Rat | Author: Johannsen F.R., Levinskas G.J. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: The Effects of Fasting on the Acute Oral Toxicity of Nine Chemicals in the Rat | Author: Dashiell O.L., Kennedy G.L. Jr. | Year: 1984 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Produit n° 7273 R.P. Toxicité aiguë par voies orale et percutanée chez le rat Tolérance locale chez le lapin. | Author: Marzin D. | Year: 1978 | Guideline: B.3 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Produit n° 7273 R.P. Toxicité aiguë par voies orale et percutanée chez le rat Tolérance locale chez le lapin. | Author: Marzin D. | Year: 1978 | Guideline: B.3 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A cyclic imine intermediate in the in vitro metabolic conversion of 1,6-Diaminohexane to 6-aminohexanoic acid and caprolactam | Author: Subramanyam B. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biological monitoring of isocyanates and related amines | Author: Brorson T. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: NTP Technical Report on Toxicity Studies of 1,6-Hexanediamine Dihydrochloride administered by drinking water and inhalation to F344/N rats and B6C3F1 Mice | Author: Hébert C. D. | Year: 1993 | Guideline: 408 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. Read-Across (CAS 6055-52-3 | EC 227-977-8 | Hexamethylenediammonium dichloride) |
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| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: NTP Technical Report on Toxicity Studies of 1,6-Hexanediamine Dihydrochloride administered by drinking water and inhalation to F344/N rats and B6C3F1 Mice | Author: Hébert C. D. | Year: 1993 | Guideline: 408 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. Read-Across (CAS 6055-52-3 | EC 227-977-8 | Hexamethylenediammonium dichloride) |
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| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: A 7-DAY TOXICITY STUDY BY THE ORAL ROUTE (GAVAGE) IN RABBITS | Author: N. Quesnot | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: A 7-DAY TOXICITY STUDY BY THE ORAL ROUTE (GAVAGE) IN RABBITS | Author: N. Quesnot | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: NTP Technical Report on Toxicity Studies of 1,6-Hexanediamine Dihydrochloride administered by drinking water and inhalation to F344/N rats and B6C3F1 Mice | Author: Hébert C. D. | Year: 1993 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. Read-Across (CAS 6055-52-3 | EC 227-977-8 | Hexamethylenediammonium dichloride) |
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| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Inhalation Toxicity of 1,6-Hexanediamine Dihydrochloride in F344/N Rats and B6C3F1 Mice | Author: Hébert C.D. et al. | Year: 1993 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. Read-Across (CAS 6055-52-3 | EC 227-977-8 | Hexamethylenediammonium dichloride) |
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| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: NTP Technical Report on Toxicity Studies of 1,6-Hexanediamine Dihydrochloride administered by drinking water and inhalation to F344/N rats and B6C3F1 Mice | Author: Hébert C. D. | Year: 1993 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 6055-52-3 | EC 227-977-8 | Hexamethylenediammonium dichloride) |
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| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Inhalation Toxicity of 1,6-Hexanediamine Dihydrochloride in F344/N Rats and B6C3F1 Mice | Author: Hébert C.D. et al. | Year: 1993 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 6055-52-3 | EC 227-977-8 | Hexamethylenediammonium dichloride) |
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| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 13 week inhalation toxicity study of Hexamethylene diamine in the rat | Author: Ben-Dyke R. | Year: 1981 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 13 week inhalation toxicity study of Hexamethylene diamine in the rat | Author: Ben-Dyke R. | Year: 1981 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronic inhalation toxicity of hexamethylenediamine in rats. | Author: F.R. Johannsen et al. | Year: 1987 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Subchronic inhalation toxicity of hexamethylenediamine in rats. | Author: F.R. Johannsen et al. | Year: 1987 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A Teratology Study in Rats | Author: Preache M. | Year: 1979 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: A Teratology Study in Rats | Author: Preache M. | Year: 1979 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Toxicological Profile of Orally Administered 1,6-Hexane Diamine in the Rat | Author: Johannsen F.R., Levinskas G.J. | Year: 1987 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A preliminary study for establishing the appropriate dose range for a teratology study | Author: Preache M. | Year: 1979 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: A preliminary study for establishing the appropriate dose range for a teratology study | Author: Preache M. | Year: 1979 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Prenatal developmental toxicity study by oral route (gavage) in rabbits | Author: François Spézia | Year: 2017 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Prenatal developmental toxicity study by oral route (gavage) in rabbits | Author: François Spézia | Year: 2017 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: NTP Technical Report on Toxicity Studies of 1,6-Hexanediamine Dihydrochloride administered by drinking water and inhalation to F344/N rats and B6C3F1 Mice | Author: Hébert C. D. | Year: 1993 | Guideline: 415 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. Read-Across (CAS 6055-52-3 | EC 227-977-8 | Hexamethylenediammonium dichloride) |
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| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Inhalation Toxicity of 1,6-Hexanediamine Dihydrochloride in F344/N Rats and B6C3F1 Mice | Author: Hébert C.D. et al. | Year: 1993 | Guideline: 415 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. Read-Across (CAS 6055-52-3 | EC 227-977-8 | Hexamethylenediammonium dichloride) |
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| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: NTP Technical Report on Toxicity Studies of 1,6-Hexanediamine Dihydrochloride administered by drinking water and inhalation to F344/N rats and B6C3F1 Mice | Author: Hébert C. D. | Year: 1993 | Guideline: 415 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. Read-Across (CAS 6055-52-3 | EC 227-977-8 | Hexamethylenediammonium dichloride) |
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| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Inhalation Toxicity of 1,6-Hexanediamine Dihydrochloride in F344/N Rats and B6C3F1 Mice | Author: Hébert C.D. et al. | Year: 1993 | Guideline: 415 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. Read-Across (CAS 6055-52-3 | EC 227-977-8 | Hexamethylenediammonium dichloride) |
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| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Two Generation Reproduction Study in Rats | Author: Schardein J.L. | Year: 1985 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Two Generation Reproduction Study in Rats | Author: Schardein J.L. | Year: 1985 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A two-generation reproduction study in rats receiving diets containing Hexamethylenediamine | Author: Short R.D. et al. | Year: 1991 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Static acute 96-h LC50 of 1,6-Hexanediamine to the fathead minnow Pimephales promelas | Author: Stahl R., Hall C. | Year: 1985 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Static acute 96-h LC50 of 1,6-Hexanediamine to the fathead minnow Pimephales promelas | Author: Stahl R., Hall C. | Year: 1985 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Report of the study of the acute toxicity | Author: Munk | Year: 1992 | Guideline: C.1 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Report of the study of the acute toxicity | Author: Munk | Year: 1992 | Guideline: C.1 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Static acute 48-hour EC50 of 1,6-Hexanediamine to Daphnia magna | Author: Stahl J.R. et al. | Year: 1985 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Static acute 48-hour EC50 of 1,6-Hexanediamine to Daphnia magna | Author: Stahl J.R. et al. | Year: 1985 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute toxicity of hexamethylenediamine to Daphnia magna | Author: Ziegenfuss P.S., Adams W.J. | Year: 1984 | Guideline: U.S. EPA 660/3-75-009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Acute toxicity of hexamethylenediamine to Daphnia magna | Author: Ziegenfuss P.S., Adams W.J. | Year: 1984 | Guideline: U.S. EPA 660/3-75-009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Toxicity of Hexamethylenediamine to Pseudokirchneriella subcapitata in an Algal Growth Inhibition Test | Author: Katrin Hoffmann, Thomas Deierling | Year: 2010 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Toxicity of Hexamethylenediamine to Pseudokirchneriella subcapitata in an Algal Growth Inhibition Test | Author: Katrin Hoffmann, Thomas Deierling | Year: 2010 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Hexamethylenediamine: A Study on the Respiration Inhibition of Activated Sludge | Author: Egeler P., Weil M. | Year: 2015 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Hexamethylenediamine: A Study on the Respiration Inhibition of Activated Sludge | Author: Egeler P., Weil M. | Year: 2015 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Bakterienwachstumshemmtest | Author: DB Siebel-Sauer | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Bakterienwachstumshemmtest | Author: DB Siebel-Sauer | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to soil microorganisms | Robust Study Summary -- Title: Hexamethylenediamine: Effects on Soil Microorganisms - Nitrogen Transformation Test | Author: Förster B. | Year: 2017 | Guideline: 216 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil microorganisms | Right to refer to study -- Title: Hexamethylenediamine: Effects on Soil Microorganisms - Nitrogen Transformation Test | Author: Förster B. | Year: 2017 | Guideline: 216 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Robust Study Summary -- Title: Hexamethylenediamine: Reproduction toxicity to the earthworm Eisenia fetida in artificial soil | Author: Adam Scheffczyk | Year: 2017 | Guideline: 222 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Right to refer to study -- Title: Hexamethylenediamine: Reproduction toxicity to the earthworm Eisenia fetida in artificial soil | Author: Adam Scheffczyk | Year: 2017 | Guideline: 222 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: BIODEGRADABILITY OF HEXAMETHYLENEDIAMINE (CAS 124-09-4) IN THE CLOSED BOTTLE TEST METHOD | Author: Ginkel C.G. | Year: 2009 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: BIODEGRADABILITY OF HEXAMETHYLENEDIAMINE (CAS 124-09-4) IN THE CLOSED BOTTLE TEST METHOD | Author: Ginkel C.G. | Year: 2009 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Adsorption/Desorption of BHT amine on Four Soils and One Sediment | Author: Wehrhan A. | Year: 2013 | Guideline: 106 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 68815-47-4 | EC 907-605-7 | Reaction mass of 7-azatridecane-1,13-diamine and hexamethynlenediamine (BHT)) |
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| Environmental | Adsorption/desorption | Right to refer to study -- Title: Adsorption/Desorption of BHT amine on Four Soils and One Sediment | Author: Wehrhan A. | Year: 2013 | Guideline: 106 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 68815-47-4 | EC 907-605-7 | Reaction mass of 7-azatridecane-1,13-diamine and hexamethynlenediamine (BHT)) |
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