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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition (Internet Version 2010) | Author: Lide D.R. ed. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Reregistration Eligibility Decision for Formaldehyde and Paraformaldehyde | Author: EPA | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Formaldehyde | Author: GESTIS - Substance database | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: NIOSH Pocket Guide to Chemical Hazards & Other Databases CD-ROM. | Author: NIOSH | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 14th Edition | Author: Lewis R. J. Sr. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Formaldehyde Health And Safety Guide | Author: World Health Organization | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Knovel Solvents: A Properties Database - A comprehensive collection of property information for over 1600 different solvents. | Author: Wypych G. ed. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: The Merck Index an encyclopedia of chemicals drugs and biologicals | Author: O'Neil M.J. (ed) | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Formaldehyd | Author: Römpp Chemie Lexikon | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Formaldehyde | Author: The Finnish Environment Institute (SYKE) | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Formaldehyde | Author: Reuss G. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Handbook of Environmental Data on Organic Chemicals 4th Edition | Author: Verschueren K. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Fest-FIüssig-Phasenverhalten und Viskosität von acht wässerigen Formaldehyd-Handelsprodukten | Author: BASF | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Fest-FIüssig-Phasenverhalten und Viskosität von acht wässerigen Formaldehyd-Handelsprodukten | Author: BASF | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Technische Entwicklung - Erstarrungstemperatur von Lutropur FEG 20 | Author: BASF | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition (Internet Version 2010) | Author: Lide D.R. ed. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Formaldehyde | Author: Chemsafe | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Reregistration Eligibility Decision for Formaldehyde and Paraformaldehyde) | Author: EPA | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Kirk-Othmer Encyclopedia of Chemical Technology - Aldehydes | Author: Kirk-Othmer | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Formaldehyde | Author: Reaxys | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Unknown | Author: Harries | Year: 1901 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The vapour-pressure curve of formaldehyde and some related data | Author: Spence R. Wild W. | Year: 1935 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Formaldehyde | Author: Reuss G. et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Yaws' Thermophysical Properties of Chemicals and Hydrocarbons | Author: Yaws C.L. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Yaws' handbook of physical properties for hydrocarbons and chemicals physical properties for more than 41 000 organic and inorganic chemical compounds. Coverage for C1 to C100 organics and Ac to Zr inorganics. | Author: Yaws C.L. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | pH | Robust Study Summary -- Title: The Merck Index an encyclopedia of chemicals drugs and biologicals | Author: O'Neil M.J. (ed) | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Formaldehyde | Author: GESTIS - Substance database | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 14th Edition | Author: Lewis R. J. Sr. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Merck Index an encyclopedia of chemicals drugs and biologicals | Author: O'Neil M.J. (ed.). | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Merck Index an encyclopedia of chemicals drugs and biologicals | Author: O'Neil M.J. (ed.) | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Unknown | Author: Maslov Yu.P. Maslov P.G. | Year: 1966 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Formaldehyd | Author: Römpp Chemie Lexikon | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Fest-FIüssig-Phasenverhalten und Viskosität von acht wässerigen Formaldehyd-Handelsprodukten | Author: BASF | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Fest-FIüssig-Phasenverhalten und Viskosität von acht wässerigen Formaldehyd-Handelsprodukten | Author: BASF | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Reregistration Eligibility Decision for Formaldehyde and Paraformaldehyde | Author: EPA | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Merck Index an encyclopedia of chemicals drugs and biologicals | Author: O'Neil M.J. (ed) | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Zur Kenntniss des Formaldehyds | Author: Kekulé A. | Year: 1892 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Formaldehyde | Author: Reuss G. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Prüfbericht | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Prüfbericht | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Stoffwerte wässrige Formaldehyd-Lösung 40 % | Author: BASF | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Stoffwerte wässrige Formaldehyd-Lösung 40 % | Author: BASF | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampf-Flüssiggleichgewicht im System Formaldehyd Wasser | Author: BASF | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampf-Flüssiggleichgewicht im System Formaldehyd Wasser | Author: BASF | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: The Vapour Pressures of Pure Substances. Second Revised Edition | Author: Boublik T., Fried V.. Hala E. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: FORMALDEHYDE (50-00-0) | Author: Boublik T., Fried V.. Hala E. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: The vapour pressure of pure substances - Selected values of the temperature dependence of the vapour pressures of some pure substances in the normal and low pressure region | Author: Boublik T., Fried V.. Hala E. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Unknown | Author: Mali Ghosh | Year: 1925 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: The vapour-pressure curve of formaldehyde and some related data | Author: Spence R. Wild W. | Year: 1935 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Data Compilation Tables of Properties of Pure Compounds. | Author: Daubert T. E. Danner R. P. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: Henry's law constants of some environmentally important aldehydes. | Author: Betterton EA Hoffman MR | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: A critical review of Henry's law constants for environmental applications. | Author: Staudinger J Roberts PV | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: A critical compilation of Henry's law constant temperature dependence for organic compounds in dilute aqueous solutions. | Author: Staudinger J Roberts PV | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: Apparent partition coefficients of 15 carbonyl compounds between air and seawater and between air and freshwater; implications for air-sea exchange. | Author: Zhou X Mopper K | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 14th Edition | Author: Lewis R. J. Sr. Lewis R. J. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Formaldehyde Release rate coefficients from selected consumer products. | Author: Pickrell J.A. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Formaldehyde Release rate coefficients from selected consumer products. | Author: Pickrell J.A. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Formaldehyde Release rate coefficients from selected consumer products. | Author: Pickrell J.A. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Exploring QSAR - Hydrophobic Electronic and Steric Constants. | Author: Hansch C. Leo A. D. Hoekman. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Octanol-Water Partition Coefficients of Simple Organic Compounds | Author: Sangster J. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: IARC carcinogens reported in cigarette mainstream smoke and their calculated log P values | Author: Smith C.J. et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: The Relative Toxicity of Compounds in Mainstream Cigarette Smoke Condensate | Author: Smith C. J. Hansch C. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Handbook of Environmental Data on Organic Chemicals 4th Edition | Author: Verschueren K. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Yaws' Handbook of Properties for Environmental and Green Engineering | Author: Yaws C.L. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: EPI Suite calculation for CAS No. 50-00-0 | Author: BASF | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: EPI Suite calculation for CAS No. 50-00-0 | Author: BASF | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Estimation Programs Interface Suite for Microsoft Windows v4.10 | Author: US-EPA | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Stability: thermal, sunlight, metals | Robust Study Summary -- Title: Dynamische Differenzkalorimetrie (DSC) | Author: BASF AG | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Stability: thermal, sunlight, metals | Right to refer to study -- Title: Dynamische Differenzkalorimetrie (DSC) | Author: BASF AG | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Ionisation Constants of Organic Acids | Author: Serjeant E.P. Dempsey B.; | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: FORMALDEHYDE (50-00-0) | Author: Serjeant E.P. Dempsey B. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Formaldehyde | Author: Reaxys | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: The acidity of formaldehyde and the endpoint in the formol titration | Author: Levy M | Year: 1933 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Über die saure Natur wäẞriger Formaldehyd-Lösungen | Author: Wadano M. | Year: 1934 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Fest-FIüssig-Phasenverhaiten und Viskosität von acht wässerigen Formaldehyd-Handelsprodukten | Author: BASF | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Fest-FIüssig-Phasenverhaiten und Viskosität von acht wässerigen Formaldehyd-Handelsprodukten | Author: BASF | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: DIPPR® PROJECT 801 Evaluated Standard Thermophysical Property Values | Author: Design Institute for Physical Properties Sponsored by AIChE | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Kirk-Othmer Encyclopedia of Chemical Technology - Aldehydes | Author: Kirk-Othmer | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Formaldehyde | Author: Reuss G. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Solubility in organic solvents/fat solubility | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 14th Edition | Author: Lewis R. J. Sr., Lewis R. J. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Solubility in organic solvents/fat solubility | Robust Study Summary -- Title: Unknown | Author: Sapgir S. | Year: 1929 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Solubility in organic solvents/fat solubility | Robust Study Summary -- Title: Some Properties of Anhydrous Formaldehyde | Author: Walker J.F. | Year: 1933 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Solubility in organic solvents/fat solubility | Robust Study Summary -- Title: Formaldehyde | Author: Reuss G. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Formaldehyde | Author: Chemsafe | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Knovel Solvents: A Properties Database - A comprehensive collection of property information for over 1600 different solvents. | Author: Wypych G. ed. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Fire Protection Guide on Hazardous Materials 5th ed. | Author: National Fire Protection Association | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Formaldehyde | Author: Chemical Risk Information Platform (CHRIP) | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Fire Protection Guide to Hazardous Materials. 13 ed. | Author: National Fire Protection Association | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 14th Edition | Author: Lewis R. J. Sr., Lewis R. J. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 14th Edition | Author: Lewis R. J. Sr., Lewis R. J. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: The Merck Index an encyclopedia of chemicals drugs and biologicals | Author: O'Neil M.J. (ed.) | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Prüfbericht | Author: BASF | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Prüfbericht | Author: BASF | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Prüfbericht - Kopie | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Prüfbericht - Kopie | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: No information | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: No information | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Prüfbericht | Author: BASF SE | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Prüfbericht | Author: BASF SE | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Formaldehyde third edition | Author: Walker J.F. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Additional physico-chemical information | Robust Study Summary -- Title: Formaldehyde | Author: GESTIS - Substance database | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Prüfbericht | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Prüfbericht | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition (Internet Version 2010) | Author: Lide D.R. ed. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Knovel Solvents: A Properties Database - A comprehensive collection of property information for over 1600 different solvents. | Author: Wypych G. ed. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Formaldehyd | Author: Römpp Chemie Lexikon | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Formaldehyde | Author: Reuss G. et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: unknown | Author: Legrand J. et al. | Year: 1959 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Unknown | Author: Vanpée M. | Year: 1955 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Formaldehyde - SIDS Initial Assessment Report For SIAM 14 | Author: OECD SIDS | Year: 2002 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Report on the study of the primary skin irritation of formalin | Author: BASF | Year: 1974 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Report on the study of the primary skin irritation of formalin | Author: BASF | Year: 1974 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Raw data of the study on the primary skin irritation of formalin | Author: BASF | Year: 1973 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Raw data of the study on the primary skin irritation of formalin | Author: BASF | Year: 1973 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Transient Receptor Potential Vanilloid 1 - a Polymodal Nociceptive Receptor - Plays a Crucial Role in Formaldehyde-Induced Skin Inflammation in Mice | Author: Usuda H et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Characterization of Skin Inflammation Induced by Repeated Exposure of Toluene Xylene and Formaldehyde in Mice | Author: Saito A et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Differential effects of topically applied formalin and aromatic compounds on neurogenic-mediated microvascular leakage in rat skin | Author: Futamura M et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nocireceptive neurons by formaldehyde | Author: Tian LJ et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Odor irritation and perception of health risk | Author: Dalton P | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Local effects in the respiratory tract: relevance of subjectively measured irritation for setting occupational exposure limits. | Author: Arts JHE, de Heer C, Woutersen R | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: A simple method for screening assessment of skin and eye irritation | Author: Sekizawa J et al. | Year: 1994 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Ocular Injury by Transient Formaldehyde Exposure in a Rabbit Eye Model | Author: Lai LJ et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: A simple method for screening assessment of skin and eye irritation | Author: Sekizawa J et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Chemical burns of the rabbit cornea | Author: Carpenter CP & Smith HF | Year: 1946 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Formaldehyde solution. Study on sensitizing properties in Pirbright White guinea pigs according to MAGNUSSON and KLIGMAN | Author: Hoechst AG | Year: 1983 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Formaldehyde solution. Study on sensitizing properties in Pirbright White guinea pigs according to MAGNUSSON and KLIGMAN | Author: Hoechst AG | Year: 1983 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Experimental assessment of the sensitizing properties of formaldehyde | Author: Hilton J et al. | Year: 1996 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: The murine local lymph node assay: results of an inter-laboratory trial | Author: Kimber I et al. | Year: 1991 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Formaldehyde. Study on the skin sensitizing effects in the guinea pig | Author: Bayer AG | Year: 1987 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Formaldehyde. Study on the skin sensitizing effects in the guinea pig | Author: Bayer AG | Year: 1987 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Formaldehyde. Study on the skin sensitizing effects in the guinea pig | Author: Bayer AG | Year: 1985 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Formaldehyde. Study on the skin sensitizing effects in the guinea pig | Author: Bayer AG | Year: 1985 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Usefulness and limitations of various guinea-pig test methods in detecting human skin sensitizers - validation of guinea-pig tests for skin hypersensitivity | Author: Marzulli F Maguire HC | Year: 1982 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Interlaboratory validation of 1 % pluronic L92 surfactant as a suitable aqueous vehicle for testing pesticide formulations using the murine local lymph node assay | Author: Boverhof DR et al. | Year: 2008 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Effect of prolonged and repeated exposure to formaldehyde donors wih doses below the EC3 value on draining Lymph node responses | Author: DeJong WH et al. | Year: 2007 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Human potency predictions for aldehydes using the local lymph node assay | Author: Basketter DA et al. | Year: 2001 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Comparison of cytokine secretion profiles provoked|in mice by glutaraldehyde and formaldehyde | Author: Dearman RJ et al. | Year: 1999 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Estimation of relative skin sensitizing potency using the local lymph node assay: a comparison of formaldehyde with glutaraldehyde | Author: Hilton J et al. | Year: 1998 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Local lymph node activation and IgE responses in brown Norway and Wistar rats after dermal application of sensitizing and non-sensitizing chemicals | Author: Arts JH et al. | Year: 1997 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Experimental assessment of the sensitizing properties of formaldehyde | Author: Hilton J et al. | Year: 1996 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: The murine local lymph node assay: results of an inter-laboratory trial | Author: Kimber I et al. | Year: 1991 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Usefulness and limitations of various guinea-pig test methods in detecting human skin sensitizers - validation of guinea-pig tests for skin hypersensitivity | Author: Marzulli F Maguire HC | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Induction of formaldehyde sensitivity in guinea pigs | Author: Lee HK, Alarie Y, Karol MH | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Zur Frage eines Astma auslösenden bzw. verschlechternden Potenzials von Formaldehyd in der Innenraumluft bei Kindern | Author: Umweltbundesamt Deutschland | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Acute airway effects of airborne formaldehyde in sensitized and non-sensitized mice housed in a dry or humid environment | Author: Larsen ST et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Adjuvant effects of gaseous formaldehyde on the hyper-responsiveness and inflammation in a mouse asthma model immunized by ovalbumin | Author: Liu D et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Role of Transient Receptor Potential Ion Channels and Evoked Levels of Neuropeptides in a Formaldehyde-lnduced Model of Asthma in Balb/c Mice | Author: Wu Y et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: The respiratory local lymph node assay as a tool to study respiratory sensitizers | Author: Arts JH et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Allergen-induced cytokine phenotypes in mice: role of CD4+ and CD8+ T cell populations | Author: Dearman RJ et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Expression of cytokine mRNAs in mice cutaneously exposed to formaldehyde | Author: Xu B et al. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Comparison of cytokine secretion profiles provoked|in mice by glutaraldehyde and formaldehyde | Author: Dearman RJ et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Local lymph node activation and IgE responses in brown Norway and Wistar rats after dermal application of sensitizing and non-sensitizing chemicals | Author: Arts JH et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Experimental assessment of the sensitizing properties of formaldehyde | Author: Hilton J et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Induction of formaldehyde sensitivity in guinea pigs | Author: Lee HK, Alarie Y, Karol MH | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA repair pathway | Author: Rosado I.V. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: CeIls Deficient in the FANC/BRCA Pathway Are Hypersensitive to Plasma Levels of Formaldehyde | Author: Ridpath J.R. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Significance of formaldehyde-induced DNA-protein crosslinks for mutagenicity | Author: Merk O Speit G | Year: 1998 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104 | Author: Marnett LJ et al. | Year: 1985 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Development of a standard protocol for in vitro cytogenetic testing with Chinese hamster ovary cells: Comparison of results for 22 compounds in two laboratories | Author: Galloway SM et al. | Year: 1985 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Specific identification of formaldehyde-mediated mutagenicity using the mouse lymphoma L5178Y+/- assay supplemented with formaldehyde dehydrogenase | Author: Blackburn G et al. | Year: 1991 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella mutagenicity test results for 250 chemicals. | Author: Haworth S et al. | Year: 1983 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity of formaldehyde in Chinese hamster lung fibroblasts: synergy with ionizing radiation and N-nitroso-N-methylurea | Author: Grafström RC, Hsu I-H, Harris C | Year: 1993 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde-induced and spontaneous alterations in human HPRT DNA sequence and mRNA expression | Author: Liber HL et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Molecular analysis of formaldehyde-induced mutations in human lymphoblasts and and E. coli | Author: Crosby RM et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Significance of formaldehyde-induced DNA-protein crosslinks for mutagenicity | Author: Merk O Speit G | Year: 1998 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde-induced cytotoxic genotoxic and mutagenic response in human lymphocytes and Salmonella typhimurium | Author: Schmid E, Göggelmann W, Bauchinger M | Year: 1986 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde: in vitro human lymphocyte clastogenicity testing | Author: Boots Company | Year: 1986 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Formaldehyde: in vitro human lymphocyte clastogenicity testing | Author: Boots Company | Year: 1986 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Genotoxic effects induced by formaldehyde in human blood and implications for the interpretation of biomonitoring studies | Author: Schmid O Speit G | Year: 2007 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Genotoxic effects induced by formaldehyde in human blood and implications for the interpretation of biomonitoring studies | Author: Schmid O Speit G | Year: 2007 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Benzo(a)pyrene- and formaldehyde-induced DNA damage and repair in rat tracheal epithelial cells | Author: Cosma GN & Marchok A | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Significance of formaldehyde-induced DNA-protein crosslinks for mutagenicity | Author: Merk O Speit G | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Genotoxic effects induced by formaldehyde in human blood and implications for the interpretation of biomonitoring studies | Author: Schmid O Speit G | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Genotoxic Effects of Formaldehyde in the Human Lung Cell Line A549 and in Primary Human Nasal Epithelial Cells | Author: Speit G et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Exposure of human nasal epithelial cells to formaldehyde does not lead to DNA damage in lymphocytes after co-cultivation | Author: Neuss S, Moepps B, Speit G | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Wood Dust and Formaldehyde | Author: IARC | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Characterization of the genotoxic potential of formaldehyde In V79 cells | Author: Speit G et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Characterization of the genotoxic potential of formaldehyde In V79 cells | Author: Speit G et al. | Year: 2007 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Analysis of Leukemia-Specific Aneuploidies in Cultured Myeloid Progenitor Cells in the Absence and Presence of Formaldehyde Exposure | Author: Kuehner S. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde induces toxic effects and regulates the expression of damage response genes in BM-MSCs | Author: She Y. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Further characterization of the genotoxicity of formaldehyde in vitro by the sister chromatid exchange test and co-cultivation experiments | Author: Neuss S Speit G | Year: 2008 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Quantitave Analysis of Histone Modifications: Formaldehyde Is a Source of Pathological N6-Formyllysine That Is Refractory to Histone Deacetylases | Author: Edrissi et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Evaluation of mutagenic effects of formaldehyde in vitro: detection of crosslinks and mutataions in mouse lymphoma cells | Author: Speit G Merk O | Year: 2002 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Protective effect of curcumin against formaldehyde-induced genotoxicity in A549 Cell Lines | Author: Zhang B-Y. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Characterization of the genotoxic potential of formaldehyde In V79 cells | Author: Speit G et al. | Year: 2007 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Does formaldehyde induce aneuploidy? | Author: Speit G. et al. | Year: 2011 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells | Author: Kuehner S. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In vitro effects of aldehydes present in tobacco smoke on gene expression 3 in human lung alveolar epithelial cells | Author: Cheah et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro | Author: Neuss S. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde-induced histone H3 phosphorylation via JNK and the expression of proto-oncogenes | Author: Yoshida I.; Ibuki Y. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Ames test formaldehyde | Author: BASF AG | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Ames test formaldehyde | Author: BASF AG | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde induces micronuclei in mouse erythropoietic cells and suppresses the expansion of human erythroid progenitor cells | Author: Ji Z. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell lines | Author: Ren X. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Comparison of the Ames II and traditional Ames test responses with respect to mutagenicity strain specifities need for metabolism and correlation with rodent carcinogenicity | Author: Kamber M et al. | Year: 2009 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formation of S-[1-(N-2-Deoxyguanosinyl)methyl]glutathione between Glutathione and DNA induced formaldehyde | Author: Lu K et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Formaldehyde-induced mutagenesis in Saccharomyces cerevisiae: Molecular properties and the roles of repair and bypass systems | Author: Grogan D.; Jinks-Robertson S. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Epigenetic Changes Induced by Air Toxics: Formaldehyde Exposure Alters miRNA Expression Profiles in Human Lung Cells | Author: Rager et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Structural characterization of formaldehyde-induced cross-links between amino acids and deoxynucleosides and their oligomers | Author: Lu K et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Low-Dose Formaldehyde Delays DNA Damage Recognition and DNA Excision Repair in Human Cells | Author: Luch A. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Investigations on potential co-mutagenic effects of formaldehyde | Author: Speit G. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Re-evaluation of a reported increased micronucleus frequency in lymphocytes of workers occupationally exposed to formaldehyde | Author: Speit G et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evaluation of inhaled low-dose formaldehyde-induced DNA adducts and DNA-protein cross-links by liquid chromatography-tandem mass spectrometry | Author: Leng J et al. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Dosimetry of N6-Formyllysine Adducts Following [13C2H2]-Formaldehyde Exposures in Rats | Author: Edrissi B. et al. | Year: 2013 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Molecular Dosimetry of N2-Hydroxymethyl-dG DNA Adducts in Rats Exposed to Formaldehyde | Author: Lu K. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Letter to the editor: Further Considerations for the implausibility of Leukemia Induction by Formaldehyde | Author: Lu K. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Analysis of micronuclei histopathological changes and cell proliferation in nasal epithelium cells of rats after exposure to formaldehyde by inhalation | Author: Speit G. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis Epidemiology and Risk Assessment | Author: Swenberg J.A. et al | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Formaldehyde: Integrating Dosimetry Cytotoxicity and Genomics to Understand Dose-Dependent Transitions for an Endogenous Compound | Author: Andersen M.E. et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Formation Accumulation and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage | Author: Yu R et al. | Year: 2015 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Do chromosome changes in blood cells implicate formaldehyde as a leukemogen? | Author: Albertini RJ Kaden DA | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Inhalation of formaldehyde does not induce systemic genotoxic effects in rats | Author: Speit G et al. | Year: 2009 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Cytogenetic analysis of lymphocytes from rats following formaldehyde inhalation | Author: Kligerman AD, Phelps M, Erexsen G | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1 2A and 2B): The summary report of the 6th collaborative study by CSGMT/JEMS MMS. Collaborative Study of the Micronucleus Group Test. | Author: Morita T et al. | Year: 1997 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Formadehyde - Cell proliferation and micronucleus formation in nasal epithelial cells after vapor inhalation 5-day exposure of male rats | Author: BASF AG | Year: 2001 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Formadehyde - Cell proliferation and micronucleus formation in nasal epithelial cells after vapor inhalation 5-day exposure of male rats | Author: BASF AG | Year: 2001 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Micronuclei and nuclear anomalies induced in the gastro-intestinal epithelium of rats treated with formaldehyde | Author: Migliore L et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Cytogenetic analysis of pulmonary lavage and bone marrow cells of rats after repeated formaldehyde inhalation | Author: Dallas CE, Scott M, Ward J | Year: 1992 | Guideline: 475 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Formaldehyde - SIDS Initial Assessment Report For SIAM 14 | Author: OECD SIDS | Year: 2002 | Guideline: 475 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Inhalation of formaldehyde does not induce systemic genotoxic effects in rats | Author: Speit G et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Testing of formaldehyde in the mammalian spot test by inhalation | Author: Jensen NJ Cohr KH | Year: 1982 | Guideline: 484 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Testing of formaldehyde in the mammalian spot test by inhalation (abstract no. 73) | Author: Jensen HJ Cohr KH | Year: 1983 | Guideline: 484 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Covalent binding of inhaled formaldehyde to DNA in the nasal mucosa of Fischer 344 rats: analysis of formaldehyde and DNA by high-performance liquid chromatography and provisional pharmacokinetic interpretation | Author: Casanova M, Deyo D, Heck H | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: DNA-Protein Cross-links and Cell Replication at Specific Sites in the Nose of F344 Rats Exposed Subchronically to Formaldehyde | Author: Casanova M et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of Rhesus monkeys: Pharmacokinetics rat-to-monkey interspecies scaling and extrapolation to man | Author: Casanova M et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia | Author: Lu K et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Inhaled Formaldehyde Induces DNA-Protein Crosslinks and Oxidative Stress in Bone Marrow and Other Distant Organs of Exposed Mice | Author: Ye X. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Formaldehyde induces bone marrow toxicity in mice by inhibiting peroxiredoxin 2 expression | Author: Yu G. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: DNA-protein crosslinks induced by formaldehyde and its repair process | Author: Zhao W. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Inhalation of formaldehyde does not induce genotoxic effects in broncho-alveolar lavage (BAL) cells of rats | Author: Neuss S et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evaluation of the mutagenicity of formaldehyde in mammalian cytogenetic assays in vivo and vitro | Author: Natarajan AT et al. | Year: 1983 | Guideline: 475 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Early changes to oxidative stress levels following exposure to formaldehyde in ICR mice | Author: Matsuoka T. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutations in Formaldehyde-induced Nasal Squamous Ccli Carcinomas in Rats | Author: Recio L. et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Attenuation of subchronic formaldehyde inhalation toxicity with oral administration of glutamate glycine and methionine | Author: Katsnelson B.A. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Formaldehyde exposure alters miRNA expression profiles in the olfactory bulb | Author: Li et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Formaldehyde-Associated Changes in microRNAs: Tissue and Temporal Specificity in the Rat Nose White Blood Cells and Bone Marrow | Author: Rager et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde | Author: Meng F et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: ACB_PCR Masurement of p53 Codon 271 CGT to CAT mutation in the nasal mucosa of rats exposed to formaldehyde | Author: Meng F et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Assessment of the carcinogenicity of formaldehyde. | Author: BfR | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Formaldehyde - SIDS Initial Assessment Report For SIAM 14 | Author: OECD SIDS | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Formaldehyde | Author: Greim H | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Wood Dust and Formaldehyde | Author: IARC | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposure | Author: Moeller B.C. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Letter to the editor: Further Considerations for the implausibility of Leukemia Induction by Formaldehyde | Author: Lu K. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Formaldehyde 2-Butoxyethanol and 1-tert-Butoxypropan-2-ol | Author: IARC | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Formaldehyde and Epigenetic Alterations: MicroRNA Changes in the Nasal Epithelium of Nonhuman Primates | Author: Rager et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evaluation of Genotoxic Effects of Formaldehyde in Adult Albino Rats and Its Implication In Case of Human Exposure | Author: Gomaa MS, Elmesallamy GE, Sameer MM | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicity of formaldehyde in experimental animals - concentrations of the chemical in the elution from dishes of formaldehyde resin in some vegetables | Author: Tsuchiya K et al. | Year: 1975 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: The single dose toxicity of some glycols and derivatives | Author: Smyth HF, Seaton J, Fischer L | Year: 1941 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Formaldehyde; Acute inhalation toxicity study in Wistar rats, 4-hour vapor exposure (whole body) | Author: BASF | Year: 2015 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Formaldehyde; Acute inhalation toxicity study in Wistar rats, 4-hour vapor exposure (whole body) | Author: BASF | Year: 2015 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Effects of acute exposure to formaldehyde on surface morphology of nasal epithelia in rats | Author: Bhalla DK et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Distribution progression and recovery of acute formaldehyde-induced inhibition of nasal mucociliary function in F-344 rats | Author: Morgan KT, Gross EA, Patterson DL | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Effect of single or repeated formaldehyde exposure on minute volume of B6C3F1 mice and F-344 rats | Author: Chang JCF, Steinhagen WH, Barrow CS | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Report on the inhalation hazard test in rats with 2.5 % formaldehyde solution in water | Author: BASF | Year: 1981 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Report on the inhalation hazard test in rats with 2.5 % formaldehyde solution in water | Author: BASF | Year: 1981 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Report on the inhalation hazard test in rats with 1% formaldehyde solution in water | Author: BASF | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Report on the inhalation hazard test in rats with 1% formaldehyde solution in water | Author: BASF | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Report on the inhalation hazard test in rats with 5% formaldehyde solution in water | Author: BASF | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Report on the inhalation hazard test in rats with 5% formaldehyde solution in water | Author: BASF | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Formaldehyde - SIDS Initial Assessment Report For SIAM 14 | Author: OECD SIDS | Year: 2002 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: [General toxic and allergic action of formaldehyde] [Article in Russian] | Author: Nagornyj PA, Sudakova ZhA, Shchablenko SM | Year: 1979 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Formaldehyde - SIDS Initial Assessment Report For SIAM 14 | Author: OECD SIDS | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: [General toxic and allergic action of formaldehyde] [Article in Russian] | Author: Nagornyj PA, Sudakova ZhA, Shchablenko SM | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: A toxicological investigation of lower aliphatic aldehydes | Author: Skog E | Year: 1950 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The determination of exogenous formaldehyde in blood of rats during and after inhalation exposure | Author: Kleinnijenhuis A.J. et al. | Year: 2013 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A novel bottom-up approach to bounding low-dose human cancer risks from chemical exposures | Author: Starr T.B. Swenberg J.A. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde: Integrating Dosimetry Cytotoxicity and Genomics to Understand Dose-Dependent Transitions for an Endogenous Compound | Author: Andersen M.E. et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Breath gas aldehydes as biomarkers of lung cancer | Author: Fuchs P. et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Experimental setup and analytical methods for the non-invasive determination of volatile organic compounds formaldehyde and NOx in exhaled human breath | Author: Riess U. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The fate of formaldehyde in rats after single exposure by inhalation. | Author: TNO Triskelion | Year: 2012 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: The fate of formaldehyde in rats after single exposure by inhalation. | Author: TNO Triskelion | Year: 2012 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Effects of Endogenous Formaldehyde in Nasal Tissues on Inhaled Formaldehyde Dosimetry Predictions in the Rat Monkey and Human Nasal Passages | Author: Schroeter J.D. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A lung dosimetry model of vapor uptake and tissue disposition | Author: Asgharian B. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Investigations of potential susceptibility toward formaldehyde-induced genotoxicity | Author: Zeller J. et al | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Genetic polymorphisms in the formaldehyde dehydrogenase gene and their biological significance | Author: Just W. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The fractions of respiratory tract cells at risk in formaldehyde carcinogenesis | Author: Miller F.J. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Is individual nasal sensitivity related to cellular metabolism of formaldehyde and susceptibility towards formaldehyde-induced genotoxicity? | Author: Zeller J. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Dosimetry of nasal uptake of water-soluble and reactive gases: a first study of interhuman variability | Author: Garcia GJM et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Sensitivity Analysis of Biologically Motivated Model for Formaldehyde-Induced Respiratory Cancer in Humans | Author: Crump K.S. et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Uncertainties in Biologically-Based Modeling of Formaldehyde-Induced Respiratory Cancer Risk: Identification of Key Issues | Author: Subramaniam R.P. et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Uncertainties in the CIIT model for formaldehyde-induced carcinogenicity in the rat: a limited sensitivity analysis-I. | Author: Subramaniam R.P. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Dosimetry Modeling of Inhaled Formaldehyde: Comparisons of Local FIux Predictions in the Rat Monkey and Human Nasal Passages | Author: J. S. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: CICAD No. 40 Formaldehyde | Author: WHO | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A mathematical model for the absorption and metabolism of formaldehyde vapour by humans | Author: Franks SJ | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Human Respiratory Tract Cancer Risks of Inhaled Formaldehyde: Dose-Response Predictions Derived From Biologically-Motivated Computational Modeling of a Combined Rodent and Human Dataset | Author: Conolly R.B. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Functional polymorphism in the alcohol dehydrogenase 3 (ADH3) promotor | Author: Hedberg J.J. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Dosimetry modeling of inhaled formaldehyde: the human respiratory tract | Author: Overton JH, Kimbell JS, Millert FJ | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Expression of alcohol dehydrogenase 3 in tissue and cultured cells from human oral mucosa | Author: Hedberg JJ et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase | Author: Sanghani PC et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Xenobiotic-metabolizing enzymes in the canine respiratory tract | Author: Maier KL et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Expression of formaldehyde dehydrogenase and S-formylglutathione hydrolase activities in different rat tissues | Author: Uotila L Koivusalo M | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Reactions of hydrated formaldehyde in nasal mucus | Author: Priha E et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Expression of formaldehyde dehydrogenyse and S-formylglutathione hydrolase activities in different rat tissues | Author: Uotila L Koivusalo M | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Nasal dosimetry of formaldehyde: modelling site specificity and the effects of preexposure | Author: Heck H Casanova M | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: DNA-Protein Cross-links and Cell Replication at Specific Sites in the Nose of F344 Rats Exposed Subchronically to Formaldehyde | Author: Casanova M et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biochemical and histopathological changes in nasal epithelium of rats after 3-day intermittent exposure to formaldehyde and ozone alone or in combination | Author: Cassee FR Feron VJ | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Site-directed mutagenesis and enzyme properties of mammalian alcohol dehydrogenases correlated with their tissue distribution. | Author: Höög JO, Estonius M, Danielsson O. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Mammalian alcohol dehydrogenase - functional and structural implications | Author: Höög JO et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde-oral toxicity assessment | Author: Cascieri TC Clary JJ | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Monomorphism of formaldehyde dehydrogenase in different populations | Author: Benkmann HG et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of Rhesus monkeys: Pharmacokinetics rat-to-monkey interspecies scaling and extrapolation to man | Author: Casanova M et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Histochemical localization of formaldehyde dehydrogenase in the rat | Author: Keller DA et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde in drinking water: comparative hazard evaluation and an approach to regulation | Author: Owen BA et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde Toxicity - DNA-protein cross-linking studies in rats and nonhuman primates | Author: Heck HA et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Effects of formaldehyde gas on the respiratory tract of rhesus monkeys | Author: Monticello TM et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Glutathione-dependent oxidoreductases: formaldehyde dehydrogenase | Author: Uotila L Koivusalo M | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde concentrations in the blood of Rhesus monkeys after inhalation exposure | Author: Casanova M et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Isotope effects and their implications for the covalent binding of inhaled [3H]- and [14C]Formaldehyde in the rat nasal mucosa | Author: Heck H, Casanova M | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Multiple forms of formaldehyde dehydrogenase from human red blood cells | Author: Uotila L, Koivusalo M | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Inhibition of the low-km mitochondrial aldehyde dehydrogenase by diethyl maleate and phorone in vivo and in vitro | Author: Dicker E, Cederbaum AI | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde (CH2O) concentrations in the blood of humans and Fischer-344 rats exposed to CH2O under controlled conditions | Author: Heck HA et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Oxidation of formaldehyde and acetaldehyde by NAD+-dependent dehydrogenases in rat nasal mucosal homogenates | Author: Casanova-Schmitz M, David R, Heck H | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Further studies on the metabolic incorporation and covalent binding of inhaled 3H- and 14C-formaldehyde in Fischer-344 rats: effect of glutathione | Author: Casanova M Heck H | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehyde - SIDS Initial Assessment Report For SIAM 14 | Author: OECD SIDS | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Nasal cavity deposition histopathology and cell proliferation after single or repeated formaldehyde exposures in B6C3F1 mice and F-344 rats | Author: Chang JCF et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Study on absorption and elimination of the test substance Basfin in male rats after single application in comparison to absorption and elimination of its synthesis components formaldehyde and urea | Author: BASF AG | Year: 1983 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Study on absorption and elimination of the test substance Basfin in male rats after single application in comparison to absorption and elimination of its synthesis components formaldehyde and urea | Author: BASF AG | Year: 1983 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Distribution of [14C]formaldehyde in rats after inhalation exposure | Author: Heck H, Chin TY, Casanova-Schmitz M | Year: 1983 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Electrophoretic Investigation of Formaldehyde Dehydrogenase from Human Tissues | Author: Castle S, Board P | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Determination of Formaldehyde in biological tissues by gas chromatography/mass spectrometry | Author: Heck H, White El, Casanova-Schmitz M | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Lack of a role for formaldehyde in methanol poisoning in the monkey | Author: McMartin KE et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Kinetik und Wege des Methanolumsatzes (Kinetics and Pathways of Methanol Metabolsm) | Author: Rietbrock N | Year: 1969 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Formaldehydoxydation bei der Ratte | Author: Rietbrock N | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Alcohol dehydrogenase in human tissues: localization of transcripts coding for five classes of the enzyme | Author: Estonius M, Svensson S, Höög JO | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Disposition of 14C-formaldehyde after topical exposure to rats guinea pigs and monkeys | Author: Jeffcoat AR et al. | Year: 1983 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: The in vitro permeability of human skin to benzene ethylene glycol formaldehyde and n-Hexane | Author: Loden M | Year: 1986 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Percutaneous absorption of formaldehyde in rats | Author: Bartnik FG, Gloxhuber C, Zimmermann V | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Two-years drinking-water study of formaldehyde in rats | Author: Til HP et al. | Year: 1989 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Chronic (2-year) oral toxicity and carcinogenicity study with formaldehyde in rats, including interim kills after 12 and 18 months, final report | Author: CIVO Institutes, TNO | Year: 1988 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Chronic (2-year) oral toxicity and carcinogenicity study with formaldehyde in rats, including interim kills after 12 and 18 months, final report | Author: CIVO Institutes, TNO | Year: 1988 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Subacute immunotoxicity study of formaldehyde in male rats | Author: Vargova M et al. | Year: 1993 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Formaldehyde - SIDS Initial Assessment Report For SIAM 14 | Author: OECD SIDS | Year: 2002 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Chronic toxicity study on formaldehyde administered orally to rats | Author: Tobe M, Naito K, Kurokawa Y | Year: 1989 | Guideline: 452 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Evaluation of the oral toxicity of acetaldehyde and formaldehyde in a 4-week drinking water study in rats | Author: Til HP et al. | Year: 1988 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Effects of formaldehyde in the rat and dog following oral exposure | Author: Johannsen FR, Levinskas GL, Tegeris AS | Year: 1986 | Guideline: 408 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Effects of formaldehyde in the rat and dog following oral exposure | Author: Johannsen FR, Levinskas GL, Tegeris AS | Year: 1986 | Guideline: 409 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Sperm count morphology and fluorescent body frequency in autopsy service workers exposed to formaldehyde | Author: Ward JB et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Lowest adverse effects concentrations (LOAECs) for formaldehyde exposure | Author: Gelbke HP, Gröters S, Morfeld P | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Inhalation of formaldehyde does not induce systemic genotoxic effects in rats | Author: Speit G et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat | Author: Andersen ME et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Formaldehyde. | Author: WHO | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subacute (4-week) inhalation toxicity study of formaldehyde in male rats: 8-hour intermittent versus 8-hour continuous exposure. | Author: Wilmer JW et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Results of a 28-month chronic inhalation toxicity study of formaldehyde in male Fisher-344 rats | Author: Kamata E et al. | Year: 1997 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells | Author: Monticello TM et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Regional increases in rat nasal epithelial cell proliferation following acute and subchronic inhalation of formaldehyde | Author: Monticello TM, Miller F, Morgan K | Year: 1991 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronic (13 week) inhalation toxicity study of formaldehyde in rats | Author: Woutersen RA et al. | Year: 1987 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronic (13 week) inhalation toxicity study with formaldehyde in rats | Author: civo Institutes TNO | Year: 1984 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronic (13 week) inhalation toxicity study of formaldehyde in rats: 8-hour intermittent versus 8-hour continuous exposures | Author: Wilmer JW et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronic (13 week) inhalation toxicity study of formaldehyde in rats: 8-hour intermittent versus 8-hour continuous exposures | Author: Directorate-General of Labour Ministry of Social Affairs and Employment Netherlands | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicity of formaldehyde vapour in B6C3F1 mice exposed for 13 weeks | Author: Maronpot RR et al. | Year: 1986 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Ultrastructiiral evaluation of acute nasal toxicity in the rat respiratory epithelium in response to formaldehyde gas | Author: Monteiro-Riviere NA and Popp JA | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Localization and quantitation of cell proliferation following exposure to nasal irritants | Author: Swenberg JA, Gross EA, Randall HW | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 26-week inhalation toxicity study with formaldehyde in the monkey rat and hamster | Author: Rusch GM et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Mechanism of formaldehyde toxicity | Author: Swenberg JA et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: The effect of formaldehyde exposure on cytotoxicity and cell proliferation | Author: Swenberg JA et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure | Author: Kerns WD et al. | Year: 1983 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Responses of the nasal mucociliary apparatus of F-344 rats to formaldehyde gas | Author: Morgan KT, Patterson DL, Gross EA | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: A teratology study of inhaled formaldehyde in the rats | Author: Martin WJ | Year: 1990 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Reproduction study with formaldehyde and hexamethylenetetramine in Beagle dogs | Author: Hurni H & Ohder H | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: The effect of maternally inhaled formaldehyde on embryonal and foetal development in rats | Author: Saillenfait AM, Bonnet P, de Ceaurriz J | Year: 1989 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Influence of formaldehyde and Sonacide® (potentiated acid glutaraldehyde) on embryo and fetal development in mice | Author: Marks TA, Worthy W, Staples R | Year: 1980 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Evaluation of a testicular sperm head counting technique using rats exposed to dimethoxyethyl phthalate (DMEP) glycerol α-monochlorohydrin (GMCH) epichlorohydrin (ECH) formaldehyde (FA) or methyl methanesulphonate (MMS). | Author: Cassidy S.L., Dix K.M., Jenkins T. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: NTP Research Report on Absence of Formaldehyde-Induced Neoplasia in Trp53 Haploinsufficient Mice Exposed by Inhalation | Author: Morgan DL et al. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Two-years drinking-water study of formaldehyde in rats | Author: Til HP et al. | Year: 1989 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: CHRONIC (2-YEAR) ORAL TOXICITY AND CARCINOGENICITY STUDY WITH FORMALDEHYDE IN RATS INCLUDING INTERIM KILLS AFTER 12 AND 18 MONTHS, final report | Author: Celanese Corporation | Year: 1988 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: CHRONIC (2-YEAR) ORAL TOXICITY AND CARCINOGENICITY STUDY WITH FORMALDEHYDE IN RATS, INCLUDING INTERIM KILLS AFTER 12 AND 18 MONTHS, final report | Author: Celanese Corporation | Year: 1988 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Using mechanistic information to support evidence integration and synthesis: a case study with inhaled formaldehyde and leukemia | Author: Gentry R et al. | Year: 2020 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: occupational exposure to formaldehyde and risk of lung cancer: A systematic review and meta-analysis | Author: Kwak K, Paek D, Park JT | Year: 2020 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Commentary on New Formaldehyde Studies in Trp53 Haploinsufficient Mice: Further Support for Nonlinear Risks From Inhaled Formaldehyde | Author: Thompson CM | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Mortality From Solid Tumors Among Workers in Formaldehyde Industries: An Update of the NCI Cohort | Author: Beane Freeman et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Cancer effects of formaldehyde: a proposal for an indoor air guideline value | Author: Nielsen GD Wolkoff P | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Hyperplasia of the lymphoepithelium of NALT in rats but not in mice upon 28-day exposure to 15 ppm formaldehyde vapor | Author: Kuper CF et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Guidance for the classification of carcinogens under the Globally Harmonised System of classification and labelling of chemicals (GHS) | Author: McGregor D et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Formaldehyde and glutaraldehyde and nasal cytotoxicity: case-study within the context of the IPCS framework for analysing the relevance of a cancer mode of action for humans | Author: McGregor D et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Results of a 28-month chronic inhalation toxicity study of formaldehyde in male Fisher-344 rats | Author: Kamata E et al. | Year: 1997 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells | Author: Monticello TM et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Formaldehyde: an experimental multipotential carcinogen | Author: Soffritti M et al. | Year: 1989 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats. | Author: Soffritti M et al. | Year: 2002 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Assessment of the carcinogenicity of formaldehyde. | Author: BfR | Year: 2006 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Formaldehyde - SIDS Initial Assessment Report For SIAM 14 | Author: OECD SIDS | Year: 2002 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Letter to the editor | Author: Feron V, Til HP, Woutersen RA | Year: 1990 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Formaldehyde 2-Butoxyethanol and 1-tert-Butoxypropan-2-ol | Author: IARC | Year: 2006 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Mycoplasma pulmonis and lymphoma in bioassays in rats | Author: SCHOEB TR et al. | Year: 2009 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Confidence in rodent carcinogenesis bioassays | Author: Ward JM & Alden CL | Year: 2009 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Nasal tumours in rats after severe injury to the nasal mucosa and prolonged exposure to 10 ppm formaldehyde | Author: Woutersen RA et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Nasal tumours in rats after short-term exposure to a cytotoxic concentration of formaldehyde | Author: Feron VJ et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Effects of ethanol potassium metabisulfite formaldehyde and hydrogen peroxide on gastric carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine. | Author: Takahashi M et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Carcinogenicity of formaldehyde and hydrogen chloride in the rat | Author: Sellakumar AR et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Gaseous formaldehyde and hydrogen chloride induction of nasal cancer in the rat | Author: Albert RE et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Skin initiation/promotion study with formaldehyde in CD1 mice | Author: Krivanek ND, Chromey NC, McAlack WJ | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Formaldehyde and tumours in hamster respiratory tract | Author: Dalbey WE | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Chemical agents and related occupations | Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: The perception of odor is not a surrogate marker for chemical exposure: a review of factors infl uencing human odor perception | Author: Greenberg M.I., Curtis J.A., Vearrier D. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Exposure Study to Examine Chemosensory Effects of Formaldehyde in Hypersensitive and Hyposensitive Humans | Author: Mueller J., Triebig G., Bruckner T. Reviewed by Heinz-Peter Gelbke Sc.D MD. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Exposure study to examine chemosensory effects of formaldehyde on hyposensitive and hypersensitive males | Author: Mueller J.U. Bruckner T. Triebig G. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: A Bisensory Method for Odor and Irritation Detection of Formaldehyde and Pyridine | Author: Berglund B., Höglund A., Esfandabad H.S. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Formaldehyde and chemosensory irritation in humans: a controlled human exposure study | Author: Lang I Bruckner T Triebig G | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Controlled human studies with formaldehyde | Author: Andersen I, Molhave L | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Formaldehyde dose-response in healthy nonsmokers | Author: Kulle TJ et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Acute odor and irritation response in healthy nonsmokers with formaldehyde exposure. | Author: Kulle TJ | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Inhaled formaldehyde exposure: effect on bronchial response to mite allergen in sensitized asthma patients | Author: Casset A et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Low exposure to inhaled formaldehyde: Effect on allergen bronchial response In asthmatics sensitized to mite | Author: Casset A et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Effect of Formaldehyde on Asthmatic Response to Inhaled Allergen Challenge | Author: Ezratty V et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Toxicity of ingested formalin and its management. | Author: Pandey CK et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Irritation and odor from fromaldehyde:chamber studies | Author: Cain WS See LC Tosun T | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: A recommended occupational exposure limit for formaldehyde based on irritation. | Author: Paustenbach D et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Local effects in the respiratory tract: relevance of subjectively measured irritation for setting occupational exposure limits. | Author: Arts JHE, de Heer C, Woutersen R | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Inhaled formaldehyde: evaluation of sensory irritation in relation to carcinogenicity | Author: Arts JHE, Rennen MAJ. de Heer C | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Formaldehyde. | Author: WHO | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Formaldehyde | Author: Greim H | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Assessment of the carcinogenicity of formaldehyde. | Author: BfR | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Formaldehyde-induced corrosive gastric cicatrisation: case report. | Author: Kochhar R et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Formaldehyde - SIDS Initial Assessment Report For SIAM 14 | Author: OECD SIDS | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Lymphocyte subsets and sister-chromatid exchanges in the students exposed to formaldehyde Vapor | Author: Ying H et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Formaldehyde. | Author: WHO | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Changes in subjective symptoms and allergy state among medical students exposed to low-level formaldehyde 6 months after completion of a gross anatomy dissection course | Author: Mori et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Respiratory Morbidity Induced by Occupational Inhalation Exposure to Formaldehyde | Author: Neghab et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: The lnfluence of Environmental Exposure to Formaldehyde in Nasal Mucosa of Medical Students during Cadaver Dissection | Author: Hisamitsu et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Ocular symptoms tear film stability nasal patency and biomarkers in nasal lavage in indoor painters in relation to emissions from water-based paint | Author: Wieslander and Norbäck | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Irritating Effects of Formaldehyde (HCHO) on Men | Author: Weber-Tschopp A, Fischer T, Grandjean E | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Upper Airway Cancer Myeloid Leukemia and Other Cancers in a Cohort of British Chemical Workers Exposed to Formaldehyde | Author: Coggon D. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Mortality From Solid Tumors Among Workers in Formaldehyde Industries: An Update of the NCI Cohort | Author: Beane Freeman L.E. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Cohort Mortality Study of Garment Industry Workers Exposed to Formaldehyde: Update and Internal Comparisons | Author: Meyers A.R. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Occupational exposure to wood dust and formaldehyde and risk of nasal nasopharyngeal and lung cancer among Finnish men | Author: Siew S.S. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Occupational exposure to formaldehyde hematotoxicity and leukemia-specific chromosome changes in cultured myeloid progenitor cells | Author: Zhang L et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Detection of cytogenetic effects in peripheral lymphocytes of students exposed to formaldehyde with cytokinesis-blocked micronucleus assay | Author: He JL, Jin LF, Jin HY | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Pharyngeal cancer mortality among chemical plant workers exposed to formaldehyde | Author: Marsh GM et al. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Extended follow-up of a cohort of British chemical workers exposed to formaldehyde | Author: Coggon D et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Mortality among a cohort of garment workers exposed to formaldehyde | Author: Pinkerton LE, Hein M, Stayner L | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Quantification of epithelial cell micronuclei by fluorescence in situ hybridization (FISH) in mortuary science students exposed to formaldehyde | Author: Titenko-Holland N et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries | Author: Hauptmann M et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Mortality from solid cancers among workers in the formaldehyde industries | Author: Hauptmann M et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries: The National Cancer Institute Cohort | Author: Beane Freeman et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Supplementary data 2009b | Author: Beane Freeman LE. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde exposure and leukemia: A new meta-analysis and potential mechanisms | Author: Zhang L et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Assessment of local genotoxic effects of formaldehyde in humans measured by the micronucleus test with exfoliated buccal cells. | Author: Speit G et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Epidemiological studies of formaldehyde exposure and risk of leukemia and nasopharyngeal cancer: A meta-analysis | Author: Bachand AM et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde and cancer risk: a quantitative review of cohort studies through 2006 | Author: Bosetti O et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: A review and meta-analysis of formaldehyde exposure and leukemia | Author: Collins JJ, Lineker GA | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Mortality From Lymphohematopoietic Malignancies and Brain Cancer Among Embalmers Exposed to Formaldehyde | Author: Hauptmann M et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Micronucleated cells in nasal mucosa of formaldehyde-exposed workers | Author: Ballarian C et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Occupational exposure to formaldehyde and wood dust and nasopharyngeal carcinoma | Author: Vaughan TL et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde and cancers of the pharynx sinus and nasal cavity: II. Residential exposures | Author: Vaughan TL et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde and cancers of the pharynx sinus and nasal cavity: I. Occupational exposures | Author: Vaughan TL et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Re: "Mortality from Solid Cancers among Workers in Formaldehyde Industries" | Author: Tarone RE, McLaughlin JK | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Sinonasal cancer occupation and tobacco smoking in European women and men | Author: T Mannetje A et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde and the risk of squamous cell carcinoma of the sinonasal cavities | Author: Olsen JH, Asnaes S | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Nasopharyngeal cancer sinonasal cancer and occupations related to formaldehyde: a case-control study | Author: Roush GC et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Mortality among chemical workers in a factory where formaldehyde was used | Author: Marsh GM et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Pharyngeal cancer mortality among chemical plant workers exposed to formaldehyde | Author: Marsh GM et al. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Mis-specified and non-robust mortality risk models for nasopharyngeal cancer in the National Cancer Institute formaldehyde worker cohort study | Author: Marsh GM, Youk AO, Morfeld P | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Work in the metal industry and nasopharyngeal cancer mortality among formaldehyde-exposed workers | Author: Marsh GM et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Incomplete follow-up in the National Cancer Institute's formaldehyde worker study and the impact on subsequent reanalyses and causal evaluations | Author: Marsh GM et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Sinonasal cancer and occupational exposures: a pooled analysis of 12 case-control studies | Author: Luce D et al. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde and cancer morbidity among male employees in Denmark | Author: Johnni Hansen and Jorgen H. Olsen | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Cancer risks due to occupational exposure to formaldehyde: results of a multi-site case-control study in Montreal | Author: Gérin M et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: An Updated Meta-Analysis of Formaldehyde Exposure and Upper Respiratory Tract Cancers | Author: James J. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Occupational Exposure to Wood Formaldehyde and Solvents and Risk of Nasopharyngeal Carcinoma | Author: Hildesheim A et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Mortality of U.S. Embalmers and Funeral Directors | Author: Richard B. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Non-viral risk factors for nasopharyngeal carcinoma in the philippines: Results from a case-control study | Author: Sheila West et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Summary of IARC Monographs on formaldehyde 2-butoxyethanol and 1-tert-butoxy-2-propanol | Author: Cogliano VC et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde and leukaemia: an improbable causal relationship | Author: Cole P, Axten C | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Letters to the editor. The authors reply. | Author: Hauptmann M et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Reevaluation of mortality risks from nasopharyngeal cancer in the formaldehyde cohort study of the National Cancer Institute | Author: Marsh GM, Youk AO | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: The enigmatic epidemiology of nasopharyngeal carcinoma | Author: Chang ET, and Adami HO | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Carcinogenic potential of formaldehyde in occupational settings: a critical assessment and possible impact on occupational exposure levels. | Author: Duhayon S et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Occupational Exposure and Laryngeal and Hypopharyngeal Cancer Risk in Central and Eastern Europe | Author: Shangina O et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Reevaluation of mortality risks from leukemia in the formaldehyde cohort study of the National Cancer Institute. | Author: Marsh GM, Youk AO | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde and leukemia: epidemiology potential mechanisms and implications for risk assessment | Author: Zhang L et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Occupational exposures and salivary gland cancer mortality among African American and white workers in the United States | Author: Wilson RT Moore LE Dosemeci M | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde as a potential human leukemogen: An assessment of biological plausibility | Author: Golden R Pyatt D Shields PG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries (multiple letters) | Author: Casanova M et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: The implausibility of leukemia induction by formaldehyde: a critical review of the biological evidence on distant-site toxicity | Author: Heck H & Casanova M | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: A review of adverse pregnancy outcomes and formaldehyde exposure in human and animal studies | Author: Collins JJ et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde | Author: OECD | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Is inhalation exposure to formaldehyde a biologically plausible cause of lymphohematopoietic malignancies | Author: Pyatt D Natelson E Golden R | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Berufliche Formaldehydexposition und Nasopharynxkarzinom (Project number: F 2177; Formaldehyde Exposure and Nasopharyngeal Carcinoma); | Author: BAUA (Bundesanstalt für Arbeitsschutz und Arbeitsmedizin) | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Assessment of genotoxic effects and changes in gene expression in humans exposed to formaldehyde by inhalation under controlled conditions | Author: Zeller J. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Reproductive and developmental toxicity of formaldehyde: A systematic review | Author: Duong A. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma | Author: Wu H. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: A review of human carcinogens- Part F: chemical agents and related occupations | Author: Baan R et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Genomic damages in peripheral blood lymphocytes and association with polymorphisms of three glutathione S-transferases in workers exposed to formaldehyde | Author: Jiang S. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde | Author: Costa S et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Genotoxic risk assessment of pathology and anatomy laboratory workers exposed to formaldehyde by use of personal air sampling and analysis of DNA damage in peripheral lymphocytes. | Author: Orsiere T et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Sister chromatid exchange in pathology staff occupationally exposed to formaldehyde | Author: Shaham J, Gurvich R, Kaufman Z | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: DNA-protein crosslinks and p53 protein expression in relation to occupational exposure to formaldehyde. | Author: Shaham J et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Local genotoxic effects of formaldehyde in humans measured by the micronucleus test with exfoliated epithelial cells. | Author: Speit G, Schmid O | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Inhalation of formaldehyde does not induce systemic genotoxic effects in rats | Author: Speit G et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde Exposure and Asthma in Children: A Systematic Review | Author: McGwin G. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Effects of Formaldehyde on Lymphocyte Subsets and Cytokines in the Peripheral Blood of Exposed Workers | Author: Jia X. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde Exposure and Mortality Risks From Acute Myeloid Leukemia and Other Lymphohematopoietic Malignancies in the US National Cancer Institute Cohort Study of Workers in Formaldehyde Industries | Author: Checkoway H. et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Cytogenetic and Immunological Effects Associated with Occupational Formaldehyde Exposure | Author: Costa S. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Assessment of the effect of occupational exposure to formaldehyde on the risk of lung cancer in two Canadian population-based case-control studies. | Author: Mahboubi A. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: The Influence of Genetic Polymorphisms in XRCC3 and ADH5 GENES on the Frequency of Genotoxicity Biomarkers in Workers Exposed to Formaldehyde | Author: Ladeira C. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde and leukemia: missing evidence! | Author: Morfeld P | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Critical review and synthesis of the epidemiologic evidence on formaldehyde exposure and risk of leukemia and other lymphohematopoietic malignancies | Author: Checkoway H. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Lung cancer and occupational exposures other than cotton dust and endotoxin among women textile workers in Shanghai China | Author: Checkoway H. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Occupational Exposures and Cancer of the Larynx - Systematic Review and Meta-analysis | Author: Paget-Bailly S. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde and lymphohematopoietic cancers: A review of two recent studies | Author: Cole PP. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Occupational Exposure to Formaldehyde and Alterations in Lymphocyte Subsets | Author: Hosgood H.D. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Assessment of ALS mortality in a cohort of formaldehyde-exposed garment workers | Author: Pinkerton et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production | Author: Viegas et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Genotoxic Effects of Exposure to Formaldehyde in Two Different Occupational Settings | Author: Viegas S. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Exposure and Genotoxicity Assessment Methodologies - The Case of Formaldehyde Occupational Exposure | Author: Viegas S. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde exposure and leukemia: Critical review and reevaluation of the results from a study that is the focus for evidence of biological plausibility | Author: Gentry P.R. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Use of nasal cells in micronucleus assays and other genotoxicity studies | Author: Knasmueller S. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Micronucleus frequencies in Iymphocytes and buccal cells in formaldehyde exposed workers | Author: Costa S. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Hematological and toxicological evaluation of formaldehyde as a potential cause of human leukemia | Author: Goldstein BD et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Mortality from lymphohematopoietic neoplasms and other causes in a cohort of laminated plastic workers exposed to formaldehyde | Author: Pira E. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Is exposure to formaldehyde in air causally associated with leukemia? - A hypothesis-based weight-of-evidence analysis | Author: Rhomberg L.R. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Genotoxicity biomarkers in occupational exposure to formaldehyde - The case of histopathology laboratories | Author: Ladeira C. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde and Leukemia: An Updated Meta-Analysis and Evaluation of Bias | Author: Schwilk E. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Combined analysis of chromosomal aberrations and glutathione S-transferase M1 and T1 polymorphisms in pathologists occupationally exposed to formaldehyde. | Author: Santovito A. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Chromosome-wide aneuploidy study of cultured circulating myeloid progenitor cells from workers occupationally exposed to formaldehyde. | Author: Lan Q. et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Chromosome aberrations and sister-chromatid exchange frequencies in pathology staff occupationally exposed to formaldehyde. | Author: Thomson E.J. Shackleton S. Harrinton J.M. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Micronuclei in nasal mucosa oral mucosa and lymphocytes in students exposed to formaldehyde vapor in anatomy class. | Author: Ying C.J. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Chromosomal damage among medical staff occupationally exposed to volatile anesthetics antineoplastic drugs and formaldehyde | Author: Musak L. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: DNA-Protein Crosslinks and Sister Chromatid Exchanges as Biomarkers of Exposure to Formaldehyde | Author: Shaham J et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: DNA--protein crosslinks a biomarker of exposure to formaldehyde--in vitro and in vivo studies | Author: Shaham J et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Formaldehyde-induced chromosomal aberrations and apoptosis in peripheral blood lymphocytes of personnel working in pathology departments | Author: Jakab M.G. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde | Author: Costa S et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Exposure to formaldehyde in health care: an evaluation of the white blood count differential | Author: Sancini A. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Flow cytometric determination of neutrophil respiratory burst activity in workers exposed to formaldehyde | Author: Lyapina M. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Cytogenetic effects in lymphocytes of formaldehyde workers of a paper factory. | Author: Bauchinger M. Schmid E. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Sister-chromatid exchanges in lymphocytes of anatomy students exposed to formaldehyde-embalming solution | Author: Yager J.W. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Sperm count morphology and fluorescent body frequency in autopsy service workers exposed to formaldehyde | Author: Ward JB et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: A combination of micronucleus assay and fluorescence in situ hybridization analysis to evaluate the genotoxicity of formaldehyde. | Author: Bouraoui S. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Immunologic Biomarkers Associated with an Acute Exposure to Exothermic Byproducts of a Ureaformaldehyde Spill | Author: Madison R.E., Broughton A., Thrasher J.D. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Occupational exposure to formaldehyde and genetic damage in the peripheral blood lymphocytes of plywood workers. | Author: Lin D. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Occupational exposure to formaldehyde: genotoxic risk evaluation by comet assay and micronucleus test usingperipheral lymphocytes | Author: Costa S et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Evidence for Formaldehyde Antibodies and Altered Cellular Immunity in Subjects Exposed to Formaldehyde in Mobile Homes | Author: Thrasher J.D. et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Assessment of immunotoxicity and genotoxicity in workers exposed to low concentrations of formaldehyde | Author: Aydin S. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Cytogenetic analysis of nasal mucosa cells and lymphocytes from high-level long-term formaldehyde exposed workers and low-level short-term exposed waiters | Author: Ye X. et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: White Blood Cell Count as an Indicator of Formaldehyde Exposure | Author: Kuo H. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Cytogenetic effects of formaldehyde exposure in students of mortuary science. | Author: Suruda A. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Clinical evaluation of workers handling melamine formaldehyde resin. | Author: Srivastava A.K. et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Monitoring of formic acid in urine of humans exposed to low levels of formaldehyde | Author: Gottschling L.M., Beaulieu H.J., Melvin W.W. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Genotoxic damage in pathology anatomy laboratory workers exposedl to formaldehyde | Author: Costa S et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Cytokinesis Blocked Micronucleus Assay of Peripheral Lymphocytes Revealing the Genotoxic Effect of Formaldehyde Exposure | Author: Souza AD, Devi R | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Chromosomal damage in peripheral blood lymphocytes from nurses occupationally exposed to chemicals | Author: Santovito A, Cervella P, Delpero M | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Occupational exposure to formaldehyde and biological monitoring of research institute workers | Author: Pala M et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: DNA--protein crosslinks a biomarker of exposure to formaldehyde--in vitro and in vivo studies | Author: Shaham J et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Recent trend in risk assessment of formaldehyde exposures from indoor air | Author: Nielsen D.G., Larsen S.T., Wolkoff P. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: The burden of disease related to indoor air in the Nethedands: do different methods lead to different results? | Author: Schram-Bijkerk D. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Identifying an indoor air exposure limit for formaldehyde considering both irritation and cancer hazards | Author: Golden R. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Influence of indoor factors in dwellings on the development of childhood asthma | Author: Heinrich J. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Non-cancer effects of formaldehyde and relevance for setting an indoor air guideline | Author: Wolkoff P., Nielsen G.D. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Poor air quality in classrooms related to asthma and rhinitis in primary schoolchildren of the French 6 Cities Study | Author: Annesi-Maesano I et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Regional variation in prevalence and etiology of allergic contact dermatitis | Author: Thompson TR, Belsito DV | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Anaphylaxis due to formaldehyde released from root-canal disinfectant. | Author: Kunisada M et al. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: The prevalence of IgE sensitization to formaldehyde in asthmatic children | Author: Doi S et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Patch testing with 2.0% (0.60 mg/cm2) formaldehyde instead of 1.0% (0.30 mg/cm2 ) detects significantly more contact allergy | Author: Ponten A. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Frequency of positive patch test reactions to preservatives: The Australian experience | Author: Chow et al | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Occupational Contact Allergens: Are They Also Associated With Occupational Asthma? | Author: Arrandale V.H. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Formaldehyde exposure and patterns of concomitant contact allergy to formaldehyde and formaldehyde-releasers | Author: Lundov M.D. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Occupational Dermatitis in Health Care Workers Evaluated for Suspected Allergic Contact Dermatitis | Author: Kadivar and Belsito | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Patch-test results of the North American contact dermatitis group 2005-2006 | Author: Zug KA. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Respiratory Health among Korean Pupils in Relation to Home School and Outdoor Environment | Author: Kim et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Multicentre patch testing with a resol resin based on phenol and formaldehyde | Author: Isaksson M. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Formaldehyde [MAK Value Documentation 2010] | Author: Deutsche Forschungsgemeinschaft | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Toxicological profile of formaldehyde. | Author: ATSDR | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Patch test reactivity to DMDM hydantoin - Relationship to formaldehyde allergy | Author: Anton C. De Groot et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Formaldehyde-releasers: relationships to formaldehyde contact allergy. Contact allergy to formaldehyde and inventory of formaldehyde-releasers | Author: de Groot AC et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Threshold for occluded formaldehyde patch test in formaldehyde-sensitive patients | Author: Flyvholm MA et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Formaldehyde concentration in diagnostic patch testing: comparison of 1% with 2%. | Author: Trattner A Johansen JD Menné T | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde | Author: Thompson CM, Subramaniam RP, Grafström RC | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Mechanistic considerations for formaldehyde-induced bronchoconstriction involving s-nitrosoglutathione reductase | Author: Thompson CM, Grafström RC | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: The use of graded concentrations in studying skin sensitizers: experimental contact sensitization in man | Author: Marzulli FN, Maibach HI | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Threshold responses in formaldehyde-sensitive subjects | Author: Jordan WP, Sherman WT, King SE | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Effect of prolonged exposure to low concentrations of formaldehyde on the corticotropin releasing hormone neurons in the hypothalamus and adrenocorticotropic hormone cells in the pituitary gland in female mice | Author: Sari DK et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Hypothalamo-pituitary-adrenal gland axis in mice inhaling toluene prior to low-level long-term exposure to formaldehyde | Author: Sari DK et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Exposure to repeated low-level formaldehyde in rats increased basal corticosterone levels and enhances the corticosterone response to subsequent formaldehyde | Author: Sorg BA et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Effects of formaldehyde exposure on granule cell number and volume of dentate gyrus: A histopathological and stereological study. | Author: Aslan H et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: A study on the effects of inhalative formaldehyde exposure on water labyrinth test performance in rats | Author: Malek FA, Möritz KU, Fanghänel J | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: A study on specific behavioural effects of formaldehyde in the rat | Author: Malek FA, Möritz KU, Fanghänel J | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Formaldehyde and phenol exposure during an anatomy dissection course: a possible source of IgE-mediated sensitization? | Author: F. Wantke et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Toxicological profile of formaldehyde. | Author: ATSDR | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Immunotoxicity | Robust Study Summary -- Title: Effects of formaldehyde gas exposure in a murine allergic contact hypersensitivity model | Author: Fujii K et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Immunotoxicity | Robust Study Summary -- Title: Irritant and adjuvant effects of gaseous formaldehyde on the ovalbumin-induced hyperresponsiveness and inflammation in a rat model | Author: Qiao Y et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Immunotoxicity | Robust Study Summary -- Title: Effects of formaldehyde inhalation on humoral immunity and protective effect of Nigella sativa oil: An experimental study | Author: Sapmaz H.I. et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Formaldehyde in China: Production consumption exposure levels and health effects | Author: Tang X. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: White Blood Cell Count as an Indicator of Formaldehyde Exposure | Author: Kuo H et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas) volume V. | Author: Geiger DL Brooke LT Call DJ | Year: 1990 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: The toxicity of nine therapeutic and herbicidal compounds to striped bass. | Author: Wellborn T | Year: 1969 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Formalin: Its Toxicity to Nontarget Aquatic Organisms Persistence and Counteraction. | Author: Bills TD Marking LL Chandler JH | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Use of Formalin for selective control of tadpoles in the presence of fishes | Author: Helms D. R. | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity of 22 Therapeutic Compounds to Six Fishes | Author: Willford W.A. | Year: 1966 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ergebnisse der Untersuchung von 200 chemischen Verbindungen auf akute Fischtoxizität mit dem Goldorfentest. | Author: Juhnke I, Lüdemann D | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicology Handbook: Mammalian and aquaticdata. Book 1 Toxicology data | Author: Schneider B.A. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Vergleich der Empfindlichkeit von Brachydanio rerio und Leuciscus idus bei der Untersuchung der Fischtoxizität von chemischen Verbindungen und Abwässern. | Author: Wellens H | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: The Chemical Control of Some Diseases and Parasites of Channel Catfish | Author: Clemens H.P. and K.E. Sneed | Year: 1958 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Lethal Doses of Several Commercial Chemicals for Fingerling Channel Catfish | Author: Clemens H.P. and K.E. Sneed | Year: 1959 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Efficacy and Toxicity of Formalin Solutions Containing Paraformaldehyde for Fish and Egg Treatments | Author: Howe G.E: et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Polychlorinated Biphenyl (Arochlor 1254)Residues in Rainbow Trout: Effects on Sensitivity to Nine Fishery Chemicals | Author: Bills T.D. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity of Ten Commonly Used Chemicals to American Eels | Author: Hinton M.J. and Eversole A.G. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity of Ten Chemicals Commonly Used in Aquaculture to the Black Eel Stage of the American Eel | Author: Hinton M.J. and Eversole A.G. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity and Tolerance Studies with Yellow-Phase Eels: Five Chemicals | Author: Hinton M.J. and Eversole A.G. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Sensitivity of Juvenile Striped Bass to Chemicals used in Aquaculture | Author: Bills T. D. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity of formalin to bullseye puffer fish (Sphoeroides annulatus Jenyns 1843) and its effectiveness to control ectoparasites | Author: Fajer-Ávila EJ et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Trimmed SpearmanKarber method for estimating median lethal concentrations in toxicity bioassays. | Author: Hamilton MA, Russo RC, Thurston RV | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute toxic and genotoxic effects of formalin in Danio rerio (zebrafish) | Author: Resendes A.S., dos Santos D.S., França F.M. et al | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Histopathological evaluation of formalin toxicity in Arapaima gigas (Arapaimidae) the giant fish from Amazon | Author: Andrade-Porto Sanny M. et al. | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Toxicity of Four Chemotherapeutic Agents to Rabbitfish Siganus rivulatus | Author: Nasser N et al. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Comparative assessment of toxicity of phenol formaldehyde and industrial wastewater to aquatic organisms | Author: Tisler T, Zagorc-Koncan J | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Rapid toxicity screening tests for aquatic biota. 1. Methodology and experiments with Daphnia magna | Author: Janssen CR, Persoone G | Year: 1993 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ergebnisse der Schadwirkung wassergefährdender Stoffe gegen Daphnia magna in einem weiterentwickelten standardisierten Testverfahren. | Author: Bringmann G, Kuehn R | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Toxicity of Laundry Detergent Components to a Freshwater Cladoceran and Their Contribution to Detergent Toxicity | Author: Warne M.St.J, Schifko A.D. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Befunde der Schadwirkung wassergefährdender Stoffe gegen Daphnia magna | Author: Bringmann G., Kuehn R. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute toxicity of formaldehyde to the pearl oyster Pinctada fucata martensii | Author: Takayanagi K et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Formalin: Its Toxicity to Nontarget Aquatic Organisms Persistence and Counteraction. | Author: Bills TD, Marking LL, Chandler JH | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Comparative studies on algal toxicity testing using fluorometric microplate and Erlenmeyer flask growth-inhibition assays | Author: Eisentraeger A et al. | Year: 2003 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Individual and Combined Toxicity of Nitriles and Aldehydes to Raphidocelis subcapitata | Author: Chen CY, Chen SL, Christensen ER | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: An algal toxicity data base of organic toxicants derived by a closed system technique. | Author: Tsai K.P., Chen C.Y | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Toxicity assessment of pesticides to Pseudokirchneriella subcapitata under air-tight test environment. | Author: Yeh H.J., Chen C.Y. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Toxicity assessment of polycyclic aromatic hydrocarbons using an air-tight algal toxicity test. | Author: Chen C.Y., Yan Y.K., Yang C.F. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Estimating low-toxic-effect concentrations in closed-system algal toxicity tests | Author: Chen Wang Yang | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Evaluation of the OECD activated sludge respiration test | Author: Klecka GM, Landi LP, Bodner KM | Year: 1985 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Comparative assessment of toxicity of phenol formaldehyde and industrial wastewater to aquatic organisms | Author: Tisler T, Zagorc-Koncan J | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: The biodegradability and inhibitory treshold concentration of some disinfectants | Author: Gerike P., Gode P. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Formaldehyde toxicity altered by calcium and organic matter | Author: Meinelt T et al. | Year: 2005 | Guideline: 212 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Formaldehyde residues in formalin-treated olive flounder (Paralichthys olivaceus) black rockfish (Sebastes schlegeli) and seawater | Author: Jung SH et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Residues of formaldehyde undetected in fish exposed to formalin | Author: Sills JB Allen JL | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: PSL assessment report Formaldehyde | Author: Envrionment Canada | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: CICAD No. 40 Formaldehyde | Author: WHO | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Absence of formaldehyde residues in penaeid shrimp exposed to formalin | Author: Hose JE, Lighter DN | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to soil macro-organisms except anthropods | Robust Study Summary -- Title: Relative toxicities of chemicals to the earthworm eisenia foetida. | Author: Roberts BL, Dorough HW | Year: 1984 | Guideline: 207 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Effects of exposure to|various injurious gases on germination of lily pollen | Author: Masaru N, Syozo F, Saburo K | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to other above-ground organisms | Robust Study Summary -- Title: Formaldehyde exposure affects growth and metabolism of common bean. | Author: Mutters RG, Madore M, Bytnerowicz A | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to other above-ground organisms | Robust Study Summary -- Title: Effect of formaldehyde and urea contaminated feed exposure into the liver of young and adult pigeons (Columba livia) | Author: Hasan I et al. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Reactive scavenging of pollutants by rain: a modeling approach | Author: Kumar | Year: 1986 | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: DOC Die-Away Test Ready Biodegradability of Formaldehyde (30 - 55 % W/W aqueous solution) by activated sludge | Author: Fraunhofer IME | Year: 2011 | Guideline: 301A | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: DOC Die-Away Test Ready Biodegradability of Formaldehyde (30 - 55 % W/W aqueous solution) by activated sludge | Author: Fraunhofer IME | Year: 2011 | Guideline: 301A | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: The biodegradability and inhibitory threshold concentration of some disinfectants. | Author: Gerike P Gode P | Year: 1990 | Guideline: 301D | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: The Official Bulletin of Economy Trade and Industry | Author: National Institute of Technology and Evaluation Japan | Year: 1989 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. R-A to CAS 30525-89-4 / EC 608-494-5 / 30525-89-4 |
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| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Formaldehyde biodegradation in the presence of methanol under denitrifying conditions. | Author: Eiroa M et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Data assessment 15 Jan 2008 | Author: BASF SE | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: Data assessment 15 Jan 2008 | Author: BASF SE | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: EPIwin calculation formaldehyde | Author: BASF | Year: 2022 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: EPIwin calculation formaldehyde | Author: BASF | Year: 2022 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Estimation Programs Interface Suite for Microsoft Windows v4.10 | Author: US-EPA | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: Simultaneous nitrification and formaldehyde biodegradation in an activated sludge unit. | Author: Eiroa M Kennes C Veiga MC | Year: 2005 | Guideline: 303A | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Mackay Level I calculation | Author: BASF SE | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Mackay Level I calculation | Author: BASF SE | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Primary Quantum yields of Photodecomposition of Acetone in Air under Tropospheric Conditions. | Author: Gardner EP, Wijayaratne RD, Calvert JG | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Wavelength Dependence of the Quantum Efficiencies of the Primary Processes in Formaldehyde Photolysis. | Author: Horowitz A, Calvert JG | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Evaluated Kinetic Photochemical and Heterogeneous Data for Atmospheric Chemistry: Supplement V IUPAC Subcommittee on Gas Kinetic Data Evaluation for Atmospheric Chemistry. | Author: Atkinson R et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: The role of clouds in tropospheric photochemistry | Author: Lelieveld J | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Gas-phase Tropospheric Chemistry of Organic Compounds | Author: Atkinson R | Year: 1994 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Evaluated Kinetic Photochemical and Heterogeneous Data for Atmospheric Chemistry: Supplement V IUPAC Subcommittee on Gas Kinetic Data Evaluation for Atmospheric Chemistry. | Author: Atkinson R et al. | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Estimation of phototransformation in air using AOPWIN v1.91 | Author: EPIWIN | Year: 2006 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Environmental | Additional information on environmental fate and behaviour | Robust Study Summary -- Title: An Ecological Risk Assessment of Formaldehyde | Author: Chénier Robert | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Additional information on environmental fate and behaviour | Robust Study Summary -- Title: Formaldehyde. Environmental Health Criteria 89. | Author: WHO (World Health Organization) | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Additional information on environmental fate and behaviour | Robust Study Summary -- Title: Formation of carbonyl compounds from UVinduced photodegradation of humic substances in natural waters: Fate of riverine carbon in the sea | Author: Kieber RJ, Zhou X, and Mopper K. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Additional information on environmental fate and behaviour | Robust Study Summary -- Title: Monitoring Firefighter Exposure to Air Toxins at Prescribed Burns of Forest and Range Biomass. | Author: Reinhardt TE | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Additional information on environmental fate and behaviour | Robust Study Summary -- Title: Handbook of Environmental Fate and Exposure Data for Organic Chemicals vol 1. Large Production and Priority Pollutants | Author: Howard PH. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Mode of degradation in actual use | Robust Study Summary -- Title: Mechanism of formaldehyde biodegradation by Pseudomonas putida. | Author: Adroer N et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |