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CAS 101-68-8 | Data Package > 1000 t/a

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Includes:

Study name Short Description Data Owner
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: MDI: determination of physicochemical properties | Author: Fisk PR and Langer EJ | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Appearance/physical state/colour Right to refer to study -- Title: MDI: determination of physicochemical properties | Author: Fisk PR and Langer EJ | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Melting point/freezing point Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Boiling point Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Density Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Density Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution Waiver -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: A.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Right to refer to study -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: A.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: A.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Right to refer to study -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: A.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diamino-monourea of 4,4'-MDI (CAS: 172944-17-1) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diamino-monourea of 4,4'-MDI (CAS: 172944-17-1) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diisocyanato-monourea of 4,4'-MDI (CAS 93805-48-2) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diisocyanato-monourea of 4,4'-MDI (CAS 93805-48-2) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Water solubility Waiver -
Phys-Chem | Water solubility Robust Study Summary -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West RJ; Pemberton D & Tury B | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Water solubility Right to refer to study -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West RJ; Pemberton D & Tury B | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Water solubility Robust Study Summary -- Title: No information | Author: Yakabe | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: N. -
Phys-Chem | Water solubility Right to refer to study -- Title: No information | Author: Yakabe | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: N. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Determination of the Water Solubility of Diamino-monourea of 4,4'-MDA | Author: Michael Neuland | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Water solubility Right to refer to study -- Title: Determination of the Water Solubility of Diamino-monourea of 4,4'-MDA | Author: Michael Neuland | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Determination of the Water Solubility of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Water solubility Right to refer to study -- Title: Determination of the Water Solubility of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Partition coefficient Right to refer to study -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Partition coefficient Waiver -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Octanol-Water Partition Coefficient (log Pow) of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Partition coefficient Right to refer to study -- Title: Octanol-Water Partition Coefficient (log Pow) of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Octanol-Water Partition Coefficient (log Pow) of Diamino-monourea of 4,4'-MDA | Author: Michael Neuland | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Partition coefficient Right to refer to study -- Title: Octanol-Water Partition Coefficient (log Pow) of Diamino-monourea of 4,4'-MDA | Author: Michael Neuland | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Flammability Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flammability Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flammability Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flammability Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flammability Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flammability Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Explosive properties Waiver -
Phys-Chem | Oxidising properties Waiver -
Phys-Chem | Stability: Dissociation constant Waiver -
Phys-Chem | Viscosity Waiver -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Pouvoir irritant et allergisant de deux isocyanates toluène diisocyanate (TDI) diphénylméthane diisocyanate (MDI) | Author: Duprat P; Gradiski D & Marignac B | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. -
Toxicological | Skin irritation / corrosion Waiver -
Toxicological | Eye irritation Robust Study Summary -- Title: Pouvoir irritant et allergisant de deux isocyanates toluène diisocyanate (TDI) diphénylméthane diisocyanate (MDI) | Author: Duprat P; Gradiski D & Marignac B | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Eye irritation Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Eye irritation Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Identification of chemical respiratory allergens: dose-response relationships in the mouse IgE test. | Author: Hilton J et al. | Year: 1995 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Characterization of murine immune responses to allergenic diisocyanates. | Author: Dearman RJ; Spence LM & Kimber I | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Chemical substances and contact allergy-244 substances ranked according to allergenic potency | Author: Schlede E. W. et al | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI MDI p-TMXDI IPDI m-TMXDI HMDI and m-TMI (modified Buehler method) | Author: Davis RA; Auletta CS and Friedman MA | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Skin sensitisation Right to refer to study -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI MDI p-TMXDI IPDI m-TMXDI HMDI and m-TMI (modified Buehler method) | Author: Davis RA; Auletta CS and Friedman MA | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulphoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the salmonella/microsome test | Author: Herbold B et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | other mutagenicity information Robust Study Summary -- Title: Untersuchungen zur Stabilität aromatischer Diisocyanate in Dimethylsulfoxid (DMSO): Toluylendiisocyanat (TDI) und Diphenylmethandiisocyanat (MDI) im Ames-Test | Author: Gahlmann R et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulfoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the Salmonella/microsome test | Author: Herbold B et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Chemical behaviour of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test | Author: Seel K et al. | Year: 1999 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Waiver -
Toxicological | in vitro gene mutation study in mammalian cells Waiver -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Micronuclei hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4'-methylenediphenyl diisocyanate (MDI) | Author: Lindberg HK et al. | Year: 2011 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Micronucleus test: hexamethylenetetramine and 4,4'-diphenylmethane-diisocyanate | Author: JETOC | Year: 1982 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: In vivo comet assay in rat bronchoalveolar lavage (BAL) cells | Author: Sutter A | Year: 2016 | Guideline: 489 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: In vivo comet assay in rat bronchoalveolar lavage (BAL) cells | Author: Sutter A | Year: 2016 | Guideline: 489 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Evaluation of the genetic toxicity of methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) in humans | Author: Zeiger E | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: Evaluation of the genetic toxicity of methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) in humans | Author: Zeiger E | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: The genetic toxicity of diisocyanates in humans and laboratory animals | Author: Zeiger E & Woolhiser M | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: The genetic toxicity of diisocyanates in humans and laboratory animals | Author: Zeiger E & Woolhiser M | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Bone marrow micronucleus assay in Brown-Norway rats exposed to diphenyl-methane-4,4'-diisocyanate | Author: Pauluhn J et al. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: Bone marrow micronucleus assay in Brown-Norway rats exposed to diphenyl-methane-4,4'-diisocyanate | Author: Pauluhn J et al. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Desmodur VP PU 1806: acute oral toxicity study in male and female Wistar rats | Author: Bomhard E | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y.
Read-Across (CAS 26447-40-5)
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Toxicological | Acute toxicity: oral Right to refer to study -- Title: Desmodur VP PU 1806: acute oral toxicity study in male and female Wistar rats | Author: Bomhard E | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y.
Read-Across (CAS 26447-40-5)
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Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat Up-And-Down Procedure with Suprasec 2015 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat Up-And-Down Procedure with Suprasec 2015 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat Up-And-Down Procedure with Suprasec 2021 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat Up-And-Down Procedure with Suprasec 2021 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat Up-And-Down Procedure with Suprasec 2029 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat Up-And-Down Procedure with Suprasec 2029 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat Up-And-Down Procedure with Suprasec 2449 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat Up-And-Down Procedure with Suprasec 2449 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat Up and Down Prodecure with Suprasec 2020 | Author: Mallory VT | Year: 2009 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat Up and Down Prodecure with Suprasec 2020 | Author: Mallory VT | Year: 2009 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI) - Acute inhalation toxicity in rats | Author: Pauluhn J | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI) - Acute inhalation toxicity in rats | Author: Pauluhn J | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Pulmonary and sensory irritation of diphenylmethane-4,4'- and dicyclohexylmethane-4,4'-diisocyanate | Author: Weyel DA & Schaffer RB | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: CEFIC areosols | Author: CEFIC | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: CEFIC areosols | Author: CEFIC | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: ISOPA on MDI areosols in tox tests | Author: ISOPA | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: ISOPA on MDI areosols in tox tests | Author: ISOPA | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Monomeric MDI: lethality to rats following one hour inhalation of an inhalable aerosol | Author: Pauluhn J | Year: 2003 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Monomeric MDI: lethality to rats following one hour inhalation of an inhalable aerosol | Author: Pauluhn J | Year: 2003 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Acute inhalation studies with irritant aerosols: technical issues and relevance for risk assessment | Author: Pauluhn | Year: 2004 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Dose and Time Responses of Non-genotoxic Endpoints After Acute Inhalation Exposure to 4,4'-Methylene Diphenyl Diisocyanate (4,4'-MDI) | Author: Hotchkiss | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Dose and Time Responses of Non-genotoxic Endpoints After Acute Inhalation Exposure to 4,4'-Methylene Diphenyl Diisocyanate (4,4'-MDI) | Author: Hotchkiss | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter FX; Buller RH & Geil RG | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N.
Read-Across (CAS 9016-87-9)
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Toxicological | Acute toxicity: dermal Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter FX; Buller RH & Geil RG | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N.
Read-Across (CAS 9016-87-9)
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Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Toxicological investigation of Mondur PF. | Author: Birch M. D. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Toxicological | Acute toxicity: dermal Right to refer to study -- Title: Toxicological investigation of Mondur PF. | Author: Birch M. D. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays | Author: Feron VJ et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann HG et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann HG et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl RW & Neeper-Bradley TL | Year: 1989 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Toxicity to reproduction Right to refer to study -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl RW & Neeper-Bradley TL | Year: 1989 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Embryotoxicity study of monomeric 4,4'-methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats | Author: Buschmann J et al. | Year: 1996 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Teratogenicity study of monomeric 4,4'-methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats | Author: Buschmann J | Year: 1994 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann HG et al. | Year: 1995 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Developmental toxicity/teratogenicity Waiver -
Toxicological | Carcinogenicity Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann HG et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Carcinogenicity Robust Study Summary -- Title: Toxicity of MDI: evaluation with respect to cancer | Author: III Biochemistry Task Force | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Carcinogenicity Right to refer to study -- Title: Toxicity of MDI: evaluation with respect to cancer | Author: III Biochemistry Task Force | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Carcinogenicity Robust Study Summary -- Title: MECHANISMS FOR THE DEVELOPMENT OF RAT LUNG TUMORS FOLLOWING INHALATION EXPOSURES TO MDI | Author: Poole A; Chappelle AH; Collins MA | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Carcinogenicity Robust Study Summary -- Title: Review of literature relevant to the development of rat lung tumors following inhalation exposures to methylenediphenyldiisocyanate and applicability to worker populations | Author: Poole A and Collins MA | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Carcinogenicity Robust Study Summary -- Title: Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays | Author: Feron VJ et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Fish Acute Toxicity Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Fish Acute Toxicity Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Fish Acute Toxicity Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Fish Acute Toxicity Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Long-term toxicity to fish Waiver -
Eco-Tox | Long-term toxicity to fish Waiver -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Alga Growth Inhibition Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Alga Growth Inhibition Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Alga Growth Inhibition Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Alga Growth Inhibition Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE 67056 Ludwigshafen Germany | Year: 2019 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to microorganisms Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE 67056 Ludwigshafen Germany | Year: 2019 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI) diphenylmethanediisocyanate (MDI) toluenediamine (TDA) diphenylmethanediamine (MDA | Author: Caspers N et al. | Year: 1986 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 9016-87-9)
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Eco-Tox | Long-term toxicity to aquatic invertebrates Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI) diphenylmethanediisocyanate (MDI) toluenediamine (TDA) diphenylmethanediamine (MDA | Author: Caspers N et al. | Year: 1986 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 9016-87-9)
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Eco-Tox | Long-term toxicity to aquatic invertebrates Waiver -
Eco-Tox | Toxicity to terrestrial arthropods Waiver -
Eco-Tox | Toxicity to terrestrial plants Robust Study Summary -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N; Roza P and Henzen L | Year: 1992 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to terrestrial plants Right to refer to study -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N; Roza P and Henzen L | Year: 1992 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to terrestrial plants Waiver -
Environmental | Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: Bioconcentration of 4,4'-MDI in Cyprinus carpio: Test Number 50043 | Author: CERI | Year: 2002 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Environmental | Bioaccumulation: aquatic/sediment Waiver -
Eco-Tox | Toxicity to soil macro-organisms except anthropods Robust Study Summary -- Title: Determination of the LC50 (14 days) of TDI TDA MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N; Roza P and Henzen L | Year: 1992 | Guideline: 207 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y.
Read-Across (CAS 9016-87-9)
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Eco-Tox | Toxicity to soil macro-organisms except anthropods Right to refer to study -- Title: Determination of the LC50 (14 days) of TDI TDA MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N; Roza P and Henzen L | Year: 1992 | Guideline: 207 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y.
Read-Across (CAS 9016-87-9)
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Environmental | Hydrolysis Robust Study Summary -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Hydrolysis Right to refer to study -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Hydrolysis Robust Study Summary -- Title: Water Extractability of 4,4'-MDI | Author: Neuland M | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Environmental | Hydrolysis Right to refer to study -- Title: Water Extractability of 4,4'-MDI | Author: Neuland M | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE, 67056 Ludwigshafen, Germany | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE, 67056 Ludwigshafen, Germany | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Biodegradation in water and sediment: simulation tests Waiver -
Environmental | Adsorption/desorption Robust Study Summary -- Title: QSAR prediction of log Koc for 4,4'-MDI | Author: West B | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Adsorption/desorption Right to refer to study -- Title: QSAR prediction of log Koc for 4,4'-MDI | Author: West B | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Adsorption/desorption Waiver -
Toxicological | Direct observations: clinical cases, poisoning incidents and other Robust Study Summary -- Title: Health hazard and evaluation technical assistance report: Jim Walter Resources (JWR) Mining Division Brookwood Alabama USA | Author: Lyman M & Berardinelli S (NIOSH) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Toxicological | Direct observations: clinical cases, poisoning incidents and other Robust Study Summary -- Title: Health Hazard Evaluation Report: Distinctive Designs International Inc. Russellville Alabama USA | Author: Jennison E, Ugolini C & Piacitelli C (NIOSH) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Current diagnostic methods for diisocyanate induced occupational asthma | Author: Bernstein DI & Jolly A | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Issues in diisocyanate antibody testing | Author: Ott MG et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Diisocyanate asthma: clinical aspects and immunopathogenesis | Author: Redlich CA & Karol MH | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates | Author: Baur X | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Poor correlation between stated and found concentrations of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in petrolatum patch-test preparations | Author: Frick M et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Epidemiological data Robust Study Summary -- Title: Cytogenetic monitoring and cancer incidence in persons occupationally exposed during MDI and TDI production. | Author: Gundy S. and Farkas G | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Phototransformation in air Robust Study Summary -- Title: Summary of predicted overall second-order rate constants and half-lives (hours) for reaction with photochemically-generated hydroxyl radical (US EPA (2012); AOPWIN v1.92a | Author: West R. J. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Phototransformation in air Right to refer to study -- Title: Summary of predicted overall second-order rate constants and half-lives (hours) for reaction with photochemically-generated hydroxyl radical (US EPA (2012); AOPWIN v1.92a | Author: West R. J. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -