You are here: Home> Turkey>TR-REACH>CAS 101-68-8> CAS 101-68-8 | Data Package > 1000 t/a (Affiliates of MDI-MDA Consortium members and III)
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: MDI: determination of physicochemical properties | Author: Fisk P.R. and Langer E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: MDI: determination of physicochemical properties | Author: Fisk P.R. and Langer E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Identity of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Identity of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of Melting point and Thermal Stability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of Melting point and Thermal Stability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of Melting point and Thermal Stability of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of Melting point and Thermal Stability of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor Pressure of Diphenylmethane Diisocyanate (MDI) Formulations | Author: Chakrabarti A. | Year: 1989 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor Pressure of Diphenylmethane Diisocyanate (MDI) Formulations | Author: Chakrabarti A. | Year: 1989 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diamino-monourea of 4,4'-MDI (CAS: 172944-17-1) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diamino-monourea of 4,4'-MDI (CAS: 172944-17-1) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diisocyanato-monourea of 4,4'-MDI (CAS 93805-48-2) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diisocyanato-monourea of 4,4'-MDI (CAS 93805-48-2) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the Water Solubility of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the Water Solubility of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the Water Solubility of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the Water Solubility of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Water solubility | Waiver | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J., Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J., Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y. et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26447-40-5 | EC 247-714-0 | Methylenediphenyl diisocyanate) |
- |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Octanol-Water Partition Coefficient (log Pow) of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Octanol-Water Partition Coefficient (log Pow) of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Octanol-Water Partition Coefficient (log Pow) of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Octanol-Water Partition Coefficient (log Pow) of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Partition coefficient | Waiver | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Robust Study Summary -- Title: Studies on the effect of the solvents DMSO and EGDE on the mutagenicity of four types of diisocyanates in the Salmonella/microsome test | Author: Herbold Hass, Seel Walber | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Waiver | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Surface tension | Waiver | - |
| Phys-Chem | Explosive properties | Waiver | - |
| Phys-Chem | Oxidising properties | Waiver | - |
| Phys-Chem | Stability: Dissociation constant | Waiver | - |
| Phys-Chem | Viscosity | Waiver | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Pouvoir irritant et allergisant de deux isocyanates toluène diisocyanate (TDI), diphénylméthane diisocyanate (MDI) | Author: Duprat P. Gradiski D. & Marignac B. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Waiver | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Pouvoir irritant et allergisant de deux isocyanates toluène diisocyanate (TDI), diphénylméthane diisocyanate (MDI) | Author: Duprat P. Gradiski D. & Marignac B. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI. | Author: Woolrich P.F. | Year: 1982 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Eye irritation | Waiver | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Identification of chemical respiratory allergens: dose-response relationships in the mouse IgE test. | Author: Hilton J. et al. | Year: 1995 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Characterization of murine immune responses to allergenic diisocyanates. | Author: Dearman R.J., Spence L.M., & Kimber I. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Chemical substances and contact allergy-244 substances ranked according to allergenic potency | Author: Schlede E. et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI MDI p-TMXDI IPDI m-TMXDI HMDI and m-TMI (modified Buehler method) | Author: Davis R.A., Auletta C.S. and Friedman M.A. | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI MDI p-TMXDI IPDI m-TMXDI HMDI and m-TMI (modified Buehler method) | Author: Davis R.A., Auletta C.S. and Friedman M.A. | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Waiver | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate (MDI-monomer): evaluation of respiratory sensitization in guinea pigs following brief high-level inhalation induction exposure and challenge with ramped MDI-concentrations | Author: Pauluhn J. | Year: 1995 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Respiratory sensitisation | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate (MDI-monomer): evaluation of respiratory sensitization in guinea pigs following brief high-level inhalation induction exposure and challenge with ramped MDI-concentrations | Author: Pauluhn J. | Year: 1995 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Inconsistencies between cytokine profiles antibody responses and respiratory hyperresponsiveness following dermal exposure to isocyanates. | Author: Selgrade M.K. et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Assessment of respiratory|hypersensitivity in guinea pigs sensitized to diphenylmethane-4,4'-diisocyanate (MDI) and challenged with MDI acetylcholine or MDI-albumin conjugate | Author: Pauluhn J. & Mohr U. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: MDI (Desmodur® 44M): evaluation of respiratory sensitisation in guinea pigs following intradermal induction and MDI-challenge | Author: Pauluhn J. | Year: 1994 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Respiratory sensitisation | Right to refer to study -- Title: MDI (Desmodur® 44M): evaluation of respiratory sensitisation in guinea pigs following intradermal induction and MDI-challenge | Author: Pauluhn J. | Year: 1994 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Animal model for MDI | Author: Rattray N.J. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Respiratory sensitisation | Right to refer to study -- Title: Animal model for MDI | Author: Rattray N.J. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Induction of respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate (MDI) in guinea pigs. Influence of route of exposure | Author: Rattray N.J. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: A two-centre study for the evaluation and validation of an animal model for the evaluation of the assessment of the potential of small molecular weight|chemicals to cause respiratory allergy | Author: Blaikie L. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulphoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the salmonella/microsome test | Author: Herbold B. et al. | Year: 1998 | Guideline: B.13/14 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Untersuchungen zur Stabilität aromatischer Diisocyanate in Dimethylsulfoxid (DMSO): Toluylendiisocyanat (TDI) und Diphenylmethandiisocyanat (MDI) im Ames-Test | Author: Gahlmann R. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulfoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the Salmonella/microsome test | Author: Herbold B. et al. | Year: 1998 | Guideline: B.13/14 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chemical behaviour of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test | Author: Seel K. et al. | Year: 1999 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Testing the mutagenic potential of HE 1002 in the mouse lymphoma mutation | Author: Mcgregor D.B., Harris W.J. & Ross C.A. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Testing the mutagenic potential of HE 1002 in the mouse lymphoma mutation | Author: Mcgregor D.B., Harris W.J. & Ross C.A. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Investigation of the Induction of DNA Double-Strand Breaks by Methylenediphenyl-4,4'-diisocyanate in Cultured Human Lung Epithelial Cells | Author: Vock E.H. et al | Year: 1998 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Waiver | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Waiver | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Induction of micronuclei following exposure to methylene di-phenyl diisocyanate: potential genotoxic metabolites | Author: Zhong B.Z. & Siegel P.D. | Year: 2000 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: In vivo comet assay in rat bronchoalveolar lavage (BAL) cells | Author: Sutter A. | Year: 2016 | Guideline: 489 | Klimisch score: 4 - Not assignable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: In vivo comet assay in rat bronchoalveolar lavage (BAL) cells | Author: Sutter A. | Year: 2016 | Guideline: 489 | Klimisch score: 4 - Not assignable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Micronuclei hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4'-methylenediphenyl diisocyanate (MDI) | Author: Lindberg H.K. et al. | Year: 2011 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Micronucleus test: hexamethylenetetramine and 4,4'-diphenylmethane-diisocyanate | Author: JETOC | Year: 1982 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evaluation of the genetic toxicity of methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) in humans | Author: Zeiger E. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Evaluation of the genetic toxicity of methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) in humans | Author: Zeiger E. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: The genetic toxicity of diisocyanates in humans and laboratory animals | Author: Zeiger E. & Woolhiser M. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. and Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. and Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Bone marrow micronucleus assay in Brown-Norway rats exposed to diphenyl-methane-4,4'-diisocyanate | Author: Pauluhn J. et al. | Year: 2001 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Investigation of adduct formation of 4,4'-methylenediphenyldiisocyanate (MDI) or 4,4'-methylenedianiline (MDA) with DNA or chromatin protein in dermally-exposed rats | Author: Vock E.H. & Lutz W.K. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Investigation of adduct formation of 4,4'-methylenediphenyldiisocyanate (MDI) or 4,4'-methylenedianiline (MDA) with DNA or chromatin protein in dermally-exposed rats | Author: Vock E.H. & Lutz W.K. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Distribution and DNA adduct formation of radiolabeled methylenediphenyl-4,4'-diisocyanate (MDI) in the rat after topical treatment | Author: Vock E.H. & Lutz W.K. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. and Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. and Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: 32P-Postlabeling of a DNA adduct derived from 4,4'-methylenedianiline in the olfactory epithelium of rats exposed by inhalation to 4,4'-methylenediphenyl diisocyanate | Author: Vock E.H. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Desmodur VP PU 1806: acute oral toxicity study in male and female Wistar rats | Author: Bomhard E. | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 26447-40-5 | EC 247-714-0 | Methylenediphenyl diisocyanate) |
- |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Desmodur VP PU 1806: acute oral toxicity study in male and female Wistar rats | Author: Bomhard E. | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 26447-40-5 | EC 247-714-0 | Methylenediphenyl diisocyanate) |
- |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Methylene bisphenyl isocyanate | Author: ACGIH | Year: 1980 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Organic Isocyanates | Author: Chadwick D.H. & Cleveland T.H. | Year: 1981 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2015 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2015 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2021 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2021 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2029 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2029 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: PAPI; MDI Pure Distilled : acute inhalation toxicity (LC50) in the male albino rat | Author: Wazeter F.X., Buller R.H. & Jacobs R.T. | Year: 1965 | Guideline: 403 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: no. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: PAPI; MDI Pure Distilled : acute inhalation toxicity (LC50) in the male albino rat | Author: Wazeter F.X., Buller R.H. & Jacobs R.T. | Year: 1965 | Guideline: 403 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: no. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: PAPI; MDI; TDI: acute inhalation exposure in male albino rats | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: no. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: PAPI; MDI; TDI: acute inhalation exposure in male albino rats | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: no. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Arbeitsmedizinische Aspekte der Verarbeitung von Lacksystemen im Spritzverfahren | Author: Bunge W., Ehrlicher H. & Kimmerle G. | Year: 1976 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: no. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Dose and Time Responses of Non-genotoxic Endpoints After Acute Inhalation Exposure to 4,4'-Methylene Diphenyl Diisocyanate (4,4'-MDI) | Author: Hotchkiss | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Dose and Time Responses of Non-genotoxic Endpoints After Acute Inhalation Exposure to 4,4'-Methylene Diphenyl Diisocyanate (4,4'-MDI) | Author: Hotchkiss | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI) - Acute inhalation toxicity in rats | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI) - Acute inhalation toxicity in rats | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Pulmonary and sensory irritation of diphenylmethane-4,4'- and dicyclohexylmethane-4,4'-diisocyanate | Author: Weyel D.A. & Schaffer R.B. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: CEFIC areosols | Author: CEFIC | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: ISOPA on MDI areosols in tox tests | Author: ISOPA | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Monomeric MDI: lethality to rats following one hour inhalation of an inhalable aerosol | Author: Pauluhn J. | Year: 2003 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Monomeric MDI: lethality to rats following one hour inhalation of an inhalable aerosol | Author: Pauluhn J. | Year: 2003 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Acute inhalation studies with irritant aerosols: technical issues and relevance for risk assessment | Author: Pauluhn J. | Year: 2004 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds. | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds. | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
- |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
- |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toxicological investigation of Mondur PF. | Author: Birch M.D. | Year: 1977 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
- |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toxicological investigation of Mondur PF. | Author: Birch M.D. | Year: 1977 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
- |
| Toxicological | Acute toxicity: other routes | Robust Study Summary -- Title: Micronucleus test : hexamethylenetetramine and 4 4'-diphenylmethane-diisocyanate | Author: JETOC | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: MDI: biotransformation in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: MDI: biotransformation in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Absorption distribution metabolism and excretion of an inhalation dose of (14C) 4,4'-methylenediphenyl diisocyanate in the male rat | Author: Gledhill A.et al. | Year: 2005 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: MDI: excretion and tissue distribution in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: MDI: excretion and tissue distribution in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Determination of a new biomarker in subjects exposed to 4,4'-methylenediphenyl diisocyanate. | Author: Sabbioni G., Dongari N. and Kumar A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: New isocyanate-specific albumin adducts of 4,4'-methylenediphenyl diisocyanate (MDI) in rats | Author: Kumar A., Dongari N. and Sabbioni G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Glutathione reactivity assay with MDI substances | Author: Wisnewski A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Glutathione reactivity assay with MDI substances | Author: Wisnewski A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Development, validation, and characterization of an analytical method for the quantification of hydrolysable urinary metabolites and plasma protein adducts of 2,4- and 2,6-toluene diisocyanate, 1,5-naphthalene diisocyanate, and 4,4'-methylenediphenyl diisocyanate | Author: Sennbro C.J. et al | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: An ultra performance liquid chromatography isotope dilution tandem mass spectrometry method for the quantification of 4,4'-MDI Human Serum Albumin Peptide Adducts | Author: Luna L. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: An ultra performance liquid chromatography isotope dilution tandem mass spectrometry method for the quantification of 4,4'-MDI Human Serum Albumin Peptide Adducts | Author: Luna L. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Identification and characterisation of adducts between serum albumin and 4,4' methylenediphenyl diisocyanate (MDI) in human plasma. | Author: Johanneson G. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate | Author: Wisnewski A.V., Liu J. and Redlich C.A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 3: Untersuchungen des transplazentaren Übergangs von MDA nach Ganzkörperexposition eines monomeren 4,4'-Methylendiphenyl-Diisocyanat (MDI) Aerosols | Author: Bartsch W. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Hemoglobin adducts and urine metabolites of 4,4'-methylenedianiline after 4,4'-methylenediphenyl diisocyanate exposure of rats | Author: Sepai O. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biochemical and histoautoradiographic characterization of the distribution of radioactivity following exposure to 14C-MDI aerosol | Author: Kennedy A.L. & Brown W.E. | Year: 1998 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Biochemical and histoautoradiographic characterization of the distribution of radioactivity following exposure to 14C-MDI aerosol | Author: Kennedy A.L. & Brown W.E. | Year: 1998 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Isocyanate-specific hemoglobin adduct in rats exposed to 4,4'-methylenediphenyl diisocyanate | Author: Sabbioni G. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetics of MDI after inhalation exposure of rats to labelled MDI (incl. pilot study) | Author: Centre d'Etudes Nucleaires de Saclay | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Pharmacokinetics of MDI after inhalation exposure of rats to labelled MDI (incl. pilot study) | Author: Centre d'Etudes Nucleaires de Saclay | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A study of the diffusion rate of MDI in rats contaminated via the respiratory system. Preliminary study | Author: CEA Saclay | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: A study of the diffusion rate of MDI in rats contaminated via the respiratory system. Preliminary study | Author: CEA Saclay | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Evaluation of in vitro reactivity between glutathione and selected MDI-based substances under physiologically-relevant conditions | Author: Zhang F. et al. | Year: 2021 | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Evaluation of in vitro reactivity between glutathione and selected MDI-based substances under physiologically-relevant conditions | Author: Zhang F. et al. | Year: 2021 | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: MDI: Identification of isocyanate specific urinary metabolites of MDI | Author: Bartels M.J. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: MDI: Identification of isocyanate specific urinary metabolites of MDI | Author: Bartels M.J. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: No information | Author: Mormann W. & Frank P. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: No information | Author: Mormann W. & Frank P. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Stability of N-acetyl-L-cysteine conjugates of p-tolylisocyanate TDI and MDI under physiological and biomonitoring hydrolysis conditions | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Stability of N-acetyl-L-cysteine conjugates of p-tolylisocyanate TDI and MDI under physiological and biomonitoring hydrolysis conditions | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Interactions of diisocyanates with N-acetyl-L-cysteine | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Interactions of diisocyanates with N-acetyl-L-cysteine | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Interactions of aromatic isocyanates with N-acetyl-L-cyteine(sic) under physiological conditions: formation of conjugates ureas and amines | Author: Mormann W. Vaquero R.L. & Seel K. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Reactions of n-acetylcysteine adducts of aromatic (di)isocyanates with functional groups of organic molecules: transcarbamoylation reactions in aqueous buffer and in an organic solvent | Author: Mormann W. et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Analysis of biomarkers in rats and dogs exposed to polymeric methylenediphenyl diisocyanate (pMDI) and its glutathione adduct | Author: Pauluhn J. et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Evaluation of the pattern of biomarkers of exposure in blood and urine following intratracheal instillation of MDI-GSH-conjugate | Author: Leng G. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Evaluation of the pattern of biomarkers of exposure in blood and urine following intratracheal instillation of MDI-GSH-conjugate | Author: Leng G. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: 32P-Postlabeling of a DNA adduct derived from 4,4'-methylenedianiline in the olfactory epithelium of rats exposed by inhalation to 4,4'-methylenediphenyl diisocyanate | Author: Vock E.H. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: 14C-Methylenbisphenylisocyanate (14C-MDI): study of the absorption after single dermal and intradermal administration in rats | Author: Leibold E., Hoffmann H.D. and Hildebrand B. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: 14C-Methylenbisphenylisocyanate (14C-MDI): study of the absorption after single dermal and intradermal administration in rats | Author: Leibold E., Hoffmann H.D. and Hildebrand B. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: In vitro absorption from various doses of MDI through guinea pig rat and human skin | Author: Clowes H.M. | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: In vitro absorption from various doses of MDI through guinea pig rat and human skin | Author: Clowes H.M. | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Dermal uptake and excretion of 14C-toulene diisocyanate (TDI) adn 14C-methylene dipheny diisocyanate (MDI) in male rats. CLinical and histopathology following dermal exposure of male rats to TDI | Author: Hoffmann H.D. et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Investigation of adduct formation of 4,4'-methylenediphenyldiisocyanate (MDI) or 4,4'-methylenedianiline (MDA) with DNA or chromatin protein in dermally-exposed rats | Author: Vock E.H. & Lutz W.K. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: Investigation of adduct formation of 4,4'-methylenediphenyldiisocyanate (MDI) or 4,4'-methylenedianiline (MDA) with DNA or chromatin protein in dermally-exposed rats | Author: Vock E.H. & Lutz W.K. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Distribution and DNA adduct formation of radiolabeled methylenediphenyl-4,4'-diisocyanate (MDI) in the rat after topical treatment | Author: Vock E.H. & Lutz W.K. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: 32P-Postlabeling analysis of DNA adducts formed in vitro and in rat skin by methylenediphenyl-4,4'-diisocyanate (MDI) | Author: Vock E.H. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays | Author: Feron V.J. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Interrelating the acute and chronic mode of action of inhaled methylenediphenyl diisocyanate (MDI) in rats assisted by computational toxicology | Author: Pauluhn J. | Year: 2011 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Inhalation exposure of rats to 4,4' methylenediphenyl-diisocyanate (MDI) | Author: U. Heinrich et al. | Year: 1991 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Embryotoxicity study of monomeric 4,4'-methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats | Author: Buschmann J. et al. | Year: 1996 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratogenicity study of monomeric 4,4'-methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats | Author: Buschmann J. | Year: 1994 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Waiver | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicity of MDI: evaluation with respect to cancer | Author: III Biochemistry Task Force | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Carcinogenicity | Right to refer to study -- Title: Toxicity of MDI: evaluation with respect to cancer | Author: III Biochemistry Task Force | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Carcinogenicity | Robust Study Summary -- Title: MECHANISMS FOR THE DEVELOPMENT OF RAT LUNG TUMORS FOLLOWING INHALATION EXPOSURES TO MDI | Author: Poole A., Chappelle A.H., Collins M.A. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Review of literature relevant to the development of rat lung tumors following inhalation exposures to methylenediphenyldiisocyanate and applicability to worker populations | Author: Poole A. and Collins M.A. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays | Author: Feron V.J. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Health Hazard Evaluation Report:: Distinctive Designs International Inc. Russellville Alabama USA | Author: Jennison E., Ugolini C. & Piacitelli C. (NIOSH) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: No information | Author: Distinctive Designs International Inc. Russellville Alabama. (NOISH) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Can reactive airways dysfunction syndrome (RADS) transform into occupational asthma due to "sensitisation" to isocyanates? | Author: Leroyer C., Perfetti L., Cartier A., & Malo J.C. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: No information | Author: European Chemical Bureau | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Health hazard and evaluation technical assistance report: Jim Walter Resources (JWR) Mining Division Brookwood Alabama USA | Author: Lyman M. & Berardinelli S. (NIOSH) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Reduction in Diisocyanate and Non-Diisocyanate Sensitizer-Induced Occupational Asthma in Ontario | Author: Buyantseva L.V. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Epidemiological data | Robust Study Summary -- Title: INDUSTRY ASSESSMENT OF WORKPLACE EXPOSURE AND DATA PERTAINING TO CARCINOGENICITY OF METHYLENEDIPHENYL DIISOCYANATE (MDI) | Author: ISOPA | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Epidemiological data | Robust Study Summary -- Title: Work-related asthma in France: recent trends for the period 2001-2009 | Author: Paris C. et al | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Epidemiological data | Robust Study Summary -- Title: Mortality and cancer morbidity of production workers in the UK flexible polyurethane foam industry: updated findings 1958-98 | Author: Sorahan T. and Nichols L. | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Toxicological | Epidemiological data | Robust Study Summary -- Title: Cytogenetic monitoring and cancer incidence in persons occupationally exposed during MDI and TDI production. | Author: Gundy S. and Farkas G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Epidemiological data | Right to refer to study -- Title: Cytogenetic monitoring and cancer incidence in persons occupationally exposed during MDI and TDI production. | Author: Gundy S. and Farkas G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Epidemiological data | Robust Study Summary -- Title: A 17-year epidemiological study on changes in lung function in toluene diisocyanate foam workers | Author: Clark R.L. et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Toxicological | Epidemiological data | Robust Study Summary -- Title: An overview of the epidemiology on MDI and TDI | Author: Collins M. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Epidemiological data | Right to refer to study -- Title: An overview of the epidemiology on MDI and TDI | Author: Collins M. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: The low prevalence of occupational asthma and antibody-dependent sensitization to diphenylmethane diisocyanate in a plant engineered for minimal exposure to diisocyanates | Author: Bernstein D.I. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Current diagnostic methods for diisocyanate induced occupational asthma | Author: Bernstein D.I. & Jolly A. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Diisocyanate asthma: clinical aspects and immunopathogenesis | Author: Redlich C.A. & Karol M.H. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates | Author: Baur X. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Evaluation of antibody binding to diisocyanate protein conjugates in a general population | Author: Bernstein D.I. et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Poor correlation between stated and found concentrations of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in petrolatum patch-test preparations | Author: Frick M. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Review of diisocyanate related occupational asthma in Europe | Author: Poole A. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Sensitisation data (humans) | Right to refer to study -- Title: Review of diisocyanate related occupational asthma in Europe | Author: Poole A. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Issues in diisocyanate antibody testing | Author: Ott M.G. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Frequency and trends of occupational asthma due to toluene diisocyanate: a critical review | Author: Diller W.F. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Assessment of the relationship between isocyanate exposure levels and occupational asthma | Author: Tarlo S.M. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Analytical determination of specific 4,4' methylene diphenyl diisocyanate hemoglobin adducts in human blood; | Author: Gries W. and Leng G. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Spezifische IgE- IgG- und IgG4-Antikörper bei isozyanatbedingtem Asthma bronchiale im Vergleich mit Kontrollpersonen und Arbeitnehmern unterschiedlicher Berufsgruppen mit Isozyanatexposition | Author: Saak A., Lenaerts-Langanke H. & Stresemann E. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Biomonitoring of workers exposed to 4,4'- methylenedianiline or 4,4'- methylenediphenylmethane diisocyanate | Author: Schütze D. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diamino-monourea of 4,4'-MDA) |
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| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diamino-monourea of 4,4'-MDA) |
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| Eco-Tox | Long-term toxicity to fish | Waiver | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Eco-Tox | Long-term toxicity to aquatic invertebrates | Waiver | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Waiver | - |
| Eco-Tox | Sediment toxicity | Waiver | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Robust Study Summary -- Title: Determination of the LC50 (14 days) of TDI TDA MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Right to refer to study -- Title: Determination of the LC50 (14 days) of TDI TDA MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Eco-Tox | Toxicity to terrestrial arthropods | Waiver | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Eco-Tox | Toxicity to terrestrial plants | Right to refer to study -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Eco-Tox | Toxicity to terrestrial plants | Waiver | - |
| Eco-Tox | Toxicity to soil microorganisms | Waiver | - |
| Eco-Tox | Toxicity to birds | Waiver | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Atmospheric reaction of isocyanates | Author: Bailey R. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: Atmospheric reaction of isocyanates | Author: Bailey R. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Estimation of gas-phase hydroxyl radical rate constants for organic chemicals | Author: Atkinson R. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Prediction of atmospheric half-lives for MDI, TDI, MDA and TDA using the AOPWIN™ model | Author: Pemberton D. and Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: Prediction of atmospheric half-lives for MDI, TDI, MDA and TDA using the AOPWIN™ model | Author: Pemberton D. and Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Summary of predicted overall second-order rate constants and half-lives (hours) for reaction with photochemically-generated hydroxyl radical (US EPA (2012); AOPWIN v1.92a | Author: West R. J. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: Summary of predicted overall second-order rate constants and half-lives (hours) for reaction with photochemically-generated hydroxyl radical (US EPA (2012); AOPWIN v1.92a | Author: West R. J. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Water Extractability of 4,4'-MDI | Author: Neuland M. | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Water Extractability of 4,4'-MDI | Author: Neuland M. | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neluand M. | Year: 2021 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neluand M. | Year: 2021 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Evaluation of Ready Biodegradability of Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Evaluation of Ready Biodegradability of Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Evaluation of Ready Biodegradability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Evaluation of Ready Biodegradability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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| Environmental | Biodegradation in water and sediment: simulation tests | Waiver | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Rate of Degradation of 4,4'-MDI in Soil | Author: Holzaht-Grimme D. | Year: 2017 | Guideline: 307 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in soil | Right to refer to study -- Title: Rate of Degradation of 4,4'-MDI in Soil | Author: Holzaht-Grimme D. | Year: 2017 | Guideline: 307 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in soil | Waiver | - |
| Environmental | Bioaccumulation: aquatic/sediment | Waiver | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Determination of an in vitro intrinsic clearance rate for the diamino-monourea of MDA with fish primary hepatocytes (OECD 319A). | Author: Ebersbach I. and Windisch H. | Year: 2019 | Guideline: 319A | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Determination of an in vitro intrinsic clearance rate for the diamino-monourea of MDA with fish primary hepatocytes (OECD 319A). | Author: Ebersbach I. and Windisch H. | Year: 2019 | Guideline: 319A | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Bioconcentration of 4,4'-MDI in Cyprinus carpio: Test Number 50043 | Author: CERI | Year: 2002 | Guideline: 305E | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Bioconcentration of 4,4'-MDI in Cyprinus carpio: Test Number 50043 | Author: CERI | Year: 2002 | Guideline: 305E | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Estimated bioconcentration factor (BCF) values for MDI and TDI | Author: Tury B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Estimated bioconcentration factor (BCF) values for MDI and TDI | Author: Tury B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: QSAR prediction of log Koc for 4,4'-MDI | Author: West B. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: QSAR prediction of log Koc for 4,4'-MDI | Author: West B. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Waiver | - |
| Toxicological | Toxic effects on livestock and pets | Robust Study Summary -- Title: Domestic animals and isocyanate products | Author: Collins M.A. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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| Toxicological | Toxic effects on livestock and pets | Right to refer to study -- Title: Domestic animals and isocyanate products | Author: Collins M.A. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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