You are here: Home> Taiwan>TW-REACH>CAS 101-68-8> CAS 101-68-8 | Data Package 1 - 10 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Robust Study Summary -- Title: Studies on the effect of the solvents DMSO and EGDE on the mutagenicity of four types of diisocyanates in the Salmonella/microsome test | Author: Herbold Hass; Seel Walber | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Right to refer to study -- Title: Studies on the effect of the solvents DMSO and EGDE on the mutagenicity of four types of diisocyanates in the Salmonella/microsome test | Author: Herbold Hass; Seel Walber | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: MDI: determination of physicochemical properties | Author: Fisk PR and Langer EJ | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: MDI: determination of physicochemical properties | Author: Fisk PR and Langer EJ | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Identity of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Identity of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of Melting point and Thermal Stability of Diisocyanato-monourea of 4,4'-MDI | Author: Michael Neuland | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of Melting point and Thermal Stability of Diisocyanato-monourea of 4,4'-MDI | Author: Michael Neuland | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of Melting point and Thermal Stability of Diamino-monourea of 4,4'-MDA | Author: Michael Neuland | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of Melting point and Thermal Stability of Diamino-monourea of 4,4'-MDA | Author: Michael Neuland | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Phys-Chem | Boiling point | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor Pressure of Diphenylmethane Diisocyanate (MDI) Formulations | Author: Chakrabarti A | Year: 1989 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor Pressure of Diphenylmethane Diisocyanate (MDI) Formulations | Author: Chakrabarti A | Year: 1989 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diamino-monourea of 4,4'-MDI (CAS: 172944-17-1) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Phys-Chem | Vapour pressure | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diamino-monourea of 4,4'-MDI (CAS: 172944-17-1) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diisocyanato-monourea of 4,4'-MDI (CAS 93805-48-2) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Phys-Chem | Vapour pressure | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diisocyanato-monourea of 4,4'-MDI (CAS 93805-48-2) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Phys-Chem | Water solubility | Robust Study Summary -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West RJ; Pemberton D & Tury B | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West RJ; Pemberton D & Tury B | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the Water Solubility of Diamino-monourea of 4,4'-MDA | Author: Michael Neuland | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the Water Solubility of Diamino-monourea of 4,4'-MDA | Author: Michael Neuland | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the Water Solubility of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the Water Solubility of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Yakabe | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: No information | Author: Yakabe | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Octanol-Water Partition Coefficient (log Pow) of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Octanol-Water Partition Coefficient (log Pow) of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Octanol-Water Partition Coefficient (log Pow) of Diamino-monourea of 4,4'-MDA | Author: Michael Neuland | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Octanol-Water Partition Coefficient (log Pow) of Diamino-monourea of 4,4'-MDA | Author: Michael Neuland | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: EU Method A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: EU Method A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulphoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the salmonella/microsome test | Author: Herbold B et al. | Year: 1998 | Guideline: EU Method B.13/14 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulfoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the Salmonella/microsome test | Author: Herbold B et al. | Year: 1998 | Guideline: EU Method B.13/14 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI) - Acute inhalation toxicity in rats | Author: Pauluhn J | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI) - Acute inhalation toxicity in rats | Author: Pauluhn J | Year: 2008 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Pouvoir irritant et allergisant de deux isocyanates toluène diisocyanate (TDI), diphénylméthane diisocyanate (MDI) | Author: Duprat P; Gradiski D & Marignac B | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Identification of chemical respiratory allergens: dose-response relationships in the mouse IgE test. | Author: Hilton J et al. | Year: 1995 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Characterization of murine immune responses to allergenic diisocyanates. | Author: Dearman RJ; Spence LM & Kimber I | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Chemical substances and contact allergy-244 substances ranked according to allergenic potency | Author: Schlede E et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chemical behaviour of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test | Author: Seel K et al. | Year: 1999 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI MDI, p-TMXDI, IPDI, m-TMXDI, HMDI and m-TMI (modified Buehler method) | Author: Davis RA, Auletta CS and Friedman MA | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI MDI, p-TMXDI, IPDI, m-TMXDI, HMDI and m-TMI (modified Buehler method) | Author: Davis RA, Auletta CS and Friedman MA | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Untersuchungen zur Stabilität aromatischer Diisocyanate in Dimethylsulfoxid (DMSO): Toluylendiisocyanat (TDI) und Diphenylmethandiisocyanat (MDI) im Ames-Test | Author: Gahlmann R et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Monomeric MDI: lethality to rats following one hour inhalation of an inhalable aerosol | Author: Pauluhn J | Year: 2003 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Monomeric MDI: lethality to rats following one hour inhalation of an inhalable aerosol | Author: Pauluhn J | Year: 2003 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Acute inhalation studies with irritant aerosols: technical issues and relevance for risk assessment | Author: Pauluhn | Year: 2004 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Dose and Time Responses of Non-genotoxic Endpoints After Acute Inhalation Exposure to 4,4'-Methylene Diphenyl Diisocyanate (4,4'-MDI) | Author: Hotchkiss | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Dose and Time Responses of Non-genotoxic Endpoints After Acute Inhalation Exposure to 4,4'-Methylene Diphenyl Diisocyanate (4,4'-MDI) | Author: Hotchkiss | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Pulmonary and sensory irritation of diphenylmethane-4,4'- and dicyclohexylmethane-4,4'-diisocyanate | Author: Weyel DA & Schaffer RB | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: ISOPA on MDI areosols in tox tests | Author: ISOPA | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: ISOPA on MDI areosols in tox tests | Author: ISOPA | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Evaluation of Ready Biodegradability of Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Evaluation of Ready Biodegradability of Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDI) |
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| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Evaluation of Ready Biodegradability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Evaluation of Ready Biodegradability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | Diisocyanato-monourea of 4,4'-MDI) |
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