You are here: Home> Turkey>TR-REACH>CAS 101-68-8> CAS 101-68-8 | Data Package 1 - 10 t/a (Affiliates of MDI-MDA Consortium members and III)
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: MDI: determination of physicochemical properties | Author: Fisk P.R. and Langer E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: MDI: determination of physicochemical properties | Author: Fisk P.R. and Langer E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Identity of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Identity of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of Melting point and Thermal Stability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of Melting point and Thermal Stability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of Melting point and Thermal Stability of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of Melting point and Thermal Stability of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor Pressure of Diphenylmethane Diisocyanate (MDI) Formulations | Author: Chakrabarti A. | Year: 1989 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor Pressure of Diphenylmethane Diisocyanate (MDI) Formulations | Author: Chakrabarti A. | Year: 1989 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diamino-monourea of 4,4'-MDI (CAS: 172944-17-1) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diamino-monourea of 4,4'-MDI (CAS: 172944-17-1) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diisocyanato-monourea of 4,4'-MDI (CAS 93805-48-2) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diisocyanato-monourea of 4,4'-MDI (CAS 93805-48-2) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the Water Solubility of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the Water Solubility of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the Water Solubility of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the Water Solubility of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Water solubility | Waiver | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J., Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J., Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y. et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26447-40-5 | EC 247-714-0 | Methylenediphenyl diisocyanate) |
- |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Octanol-Water Partition Coefficient (log Pow) of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Octanol-Water Partition Coefficient (log Pow) of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Octanol-Water Partition Coefficient (log Pow) of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Octanol-Water Partition Coefficient (log Pow) of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Phys-Chem | Partition coefficient | Waiver | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Waiver | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Surface tension | Waiver | - |
| Phys-Chem | Explosive properties | Waiver | - |
| Phys-Chem | Oxidising properties | Waiver | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Pouvoir irritant et allergisant de deux isocyanates toluène diisocyanate (TDI), diphénylméthane diisocyanate (MDI) | Author: Duprat P. Gradiski D. & Marignac B. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Waiver | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Pouvoir irritant et allergisant de deux isocyanates toluène diisocyanate (TDI), diphénylméthane diisocyanate (MDI) | Author: Duprat P. Gradiski D. & Marignac B. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI. | Author: Woolrich P.F. | Year: 1982 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Eye irritation | Waiver | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Identification of chemical respiratory allergens: dose-response relationships in the mouse IgE test. | Author: Hilton J. et al. | Year: 1995 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Characterization of murine immune responses to allergenic diisocyanates. | Author: Dearman R.J., Spence L.M., & Kimber I. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Chemical substances and contact allergy-244 substances ranked according to allergenic potency | Author: Schlede E. et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI MDI p-TMXDI IPDI m-TMXDI HMDI and m-TMI (modified Buehler method) | Author: Davis R.A., Auletta C.S. and Friedman M.A. | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI MDI p-TMXDI IPDI m-TMXDI HMDI and m-TMI (modified Buehler method) | Author: Davis R.A., Auletta C.S. and Friedman M.A. | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Waiver | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulphoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the salmonella/microsome test | Author: Herbold B. et al. | Year: 1998 | Guideline: B.13/14 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Untersuchungen zur Stabilität aromatischer Diisocyanate in Dimethylsulfoxid (DMSO): Toluylendiisocyanat (TDI) und Diphenylmethandiisocyanat (MDI) im Ames-Test | Author: Gahlmann R. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulfoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the Salmonella/microsome test | Author: Herbold B. et al. | Year: 1998 | Guideline: B.13/14 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chemical behaviour of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test | Author: Seel K. et al. | Year: 1999 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Desmodur VP PU 1806: acute oral toxicity study in male and female Wistar rats | Author: Bomhard E. | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 26447-40-5 | EC 247-714-0 | Methylenediphenyl diisocyanate) |
- |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Desmodur VP PU 1806: acute oral toxicity study in male and female Wistar rats | Author: Bomhard E. | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 26447-40-5 | EC 247-714-0 | Methylenediphenyl diisocyanate) |
- |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Methylene bisphenyl isocyanate | Author: ACGIH | Year: 1980 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Organic Isocyanates | Author: Chadwick D.H. & Cleveland T.H. | Year: 1981 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2015 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2015 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2021 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2021 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2029 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2029 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Evaluation of Ready Biodegradability of Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Evaluation of Ready Biodegradability of Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
- |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Evaluation of Ready Biodegradability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Evaluation of Ready Biodegradability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
- |