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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (89th Ed) | Author: Lide DR | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: The Condensed Chemical Dictionary (10th Ed) | Author: Hawley G | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals Drugs and Biologicals (14th Edition) | Author: O'Neil MJ | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Directory of Solvents Blackie Academic & Professional | Author: B.P. Whim and P.G. Johnson | Year: 1996 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals Drugs and Biologicals (14th Edition) | Author: O'Neil MJ | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals Drugs and Biologicals (14th Edition) | Author: O'Neil MJ | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Directory of Solvents Blackie Academic & Professional | Author: B.P. Whim and P.G. Johnson | Year: 1996 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: The Condensed Chemical Dictionary (10th Ed) | Author: Hawley G | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Henry's law constant | Robust Study Summary -- Title: Henry's constant Law calculation | Author: Guidance on information requirements and chemical safety assessment (IR & CSA) Chapter 16 "Environmental exposure estimate" | Year: 2010 | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the Water Solubility of 4-methylpentan-2-one | Author: Mollandin G | Year: 2010 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the Water Solubility of 4-methylpentan-2-one | Author: Mollandin G | Year: 2010 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Methyl Isobutyl Ketone: Determination of the n-Octanol/Water Partition Coefficient Using a Reverse-Phase HPLC Method (1983) | Author: Eadsforth CV | Year: 1983 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Methyl Isobutyl Ketone: Determination of the n-Octanol/Water Partition Coefficient Using a Reverse-Phase HPLC Method (1983) | Author: Eadsforth CV | Year: 1983 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Lange's Handbook of Chemistry (15th Ed) | Author: Dean JA | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Directory of Solvents Blackie Academic & Professional | Author: B.P. Whim and P.G. Johnson | Year: 1996 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals Drugs and Biologicals (14th Edition) | Author: O'Neil MJ | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: The Condensed Chemical Dictionary (10th Ed) | Author: Hawley G | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Directory of Solvents Blackie Academic & Professional | Author: B.P. Whim and P.G. Johnson | Year: 1996 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: METHYL ISO BUTYL KETONE : SKIN IRRITATION IN THE RABBIT | Author: Gardner JR | Year: 1996 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: METHYL ISO BUTYL KETONE : SKIN IRRITATION IN THE RABBIT | Author: Gardner JR | Year: 1996 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toxicity and Irritation Assay Results of Some Food, Drug or Cosmetic Product Chemicals | Author: UCC | Klimisch score: 4 - Not assignable. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Toxicity and Irritation Assay Results of Some Food, Drug or Cosmetic Product Chemicals | Author: UCC | Klimisch score: 4 - Not assignable. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: METHYL ISO BUTYL KETONE : EYE IRRITATION IN THE RABBIT | Author: Gardner JR | Year: 1996 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: METHYL ISO BUTYL KETONE : EYE IRRITATION IN THE RABBIT | Author: Gardner JR | Year: 1996 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Methyl isobutyl ketone EEC study, BCO-P assay no. 30 | Author: Giroux J | Year: 1992 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Methyl isobutyl ketone EEC study, BCO-P assay no. 30 | Author: Giroux J | Year: 1992 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Interlaboratory assessment of the bovine corneal opacity and permeability (BCOP) assay | Author: Gautheron P. et al. | Year: 1994 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Technical report no. 48. Eye irritation : reference chemical data bank | Author: ECETOC | Year: 1992 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Eye irritation: Reference chemicals data bank | Author: Bagley D.M. et al. | Year: 1992 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Prüfung auf hautsensibilisierende Wirkung am Meerschweinchen von Methylisobutylketon | Author: Mürmann P | Year: 1989 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Prüfung auf hautsensibilisierende Wirkung am Meerschweinchen von Methylisobutylketon | Author: Mürmann P | Year: 1989 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Toxicity Studies with chemical solvents: short-term in vitro tests for genotoxic activity with methyl isobutyl ketone | Author: Thorpe E | Year: 1982 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Toxicity Studies with chemical solvents: short-term in vitro tests for genotoxic activity with methyl isobutyl ketone | Author: Thorpe E | Year: 1982 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: The genetic toxicology of some hydrocarbon and oxygenated solvents | Author: Brooks TM, Meyer AL, and Hutson DH | Year: 1988 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity studies on ketone solvents: methyl ethyl ketone, methyl isobutyl ketone and isophorone | Author: O'Donoghue J.L. et al. | Year: 1988 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity studies on ketone solvents: methyl ethyl ketone, methyl isobutyl ketone and isophorone | Author: O'Donoghue J.L. et al. | Year: 1988 | Guideline: 482 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Toxicity Studies with chemical solvents: short-term in vitro tests for genotoxic activity with methyl isobutyl ketone | Author: Thorpe E | Year: 1982 | Guideline: 480 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Toxicity Studies with chemical solvents: short-term in vitro tests for genotoxic activity with methyl isobutyl ketone | Author: Thorpe E | Year: 1982 | Guideline: 480 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: The genetic toxicology of some hydrocarbon and oxygenated solvents | Author: Brooks TM, Meyer AL, and Hutson DH | Year: 1988 | Guideline: 480 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity studies on ketone solvents: methyl ethyl ketone, methyl isobutyl ketone and isophorone | Author: O'Donoghue J.L. et al. | Year: 1988 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Toxicity Studies with chemical solvents: short-term in vitro tests for genotoxic activity with methyl isobutyl ketone | Author: Thorpe E | Year: 1982 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Toxicity Studies with chemical solvents: short-term in vitro tests for genotoxic activity with methyl isobutyl ketone | Author: Thorpe E | Year: 1982 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: The genetic toxicology of some hydrocarbon and oxygenated solvents | Author: Brooks T.M., Meyer A.L. and Hutson D.H. | Year: 1988 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenicity studies on ketone solvents: methyl ethyl ketone, methyl isobutyl ketone and isophorone | Author: O'Donoghue J.L. et al. | Year: 1988 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: RANGE-FINDING TOXICITY DATA: LIST IV | Author: Smyth H.F., Carpenter C.P. and Weil C.S. | Year: 1951 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Toxicity and Irritation Assay Results of Some Food, Drug or Cosmetic Product Chemicals | Author: UCC | Year: 1976 | Klimisch score: 4 - Not assignable. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: Toxicity and Irritation Assay Results of Some Food, Drug or Cosmetic Product Chemicals | Author: UCC | Year: 1976 | Klimisch score: 4 - Not assignable. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: RANGE-FINDING TOXICITY DATA: LIST IV | Author: Smyth H.F., Carpenter C.P. and Weil C.S. | Year: 1951 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Acute response of guinea pigs to inhalation of methyl isobutyl ketone | Author: Specht H | Year: 1938 | Klimisch score: 4 - Not assignable. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Acute response of guinea pigs to the inhalation of ketone vapors | Author: Specht H. et al. | Year: 1940 | Klimisch score: 4 - Not assignable. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: METHYL ISO BUTYL KETONE : ACUTE DERMAL TOXICITY IN THE RAT | Author: Gardner JR | Year: 1996 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: METHYL ISO BUTYL KETONE : ACUTE DERMAL TOXICITY IN THE RAT | Author: Gardner JR | Year: 1996 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toxicity and Irritation Assay Results of Some Food, Drug or Cosmetic Product Chemicals | Author: UCC | Year: 1976 | Klimisch score: 4 - Not assignable. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toxicity and Irritation Assay Results of Some Food, Drug or Cosmetic Product Chemicals | Author: UCC | Year: 1976 | Klimisch score: 4 - Not assignable. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Tissue concentrations of methyl isobutyl ketone methyl nbutyl ketone and their metabolites after oral and inhalation exposure | Author: Duguay AB and Plaa GL | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Plasma concentrations in methyl isobutyl ketone-potentiated experimental cholestasis after inhalation or oral administration | Author: Duguay AB and Plaa GL | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Characterization of the Metabolites of Methyl n-Butyl Ketone Methyl iso-Butyl Ketone and Methyl Ethyl Ketone in Guinea Pig and their Clearance | Author: DiVincenzo GD, Kaplan CJ, and Dedinas J | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolic fate of methyl n-butyl ketone methyl isobutyl ketone and their metabolites in mice | Author: Granvil CP, Aharkawi M, and Plaa GL | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (4-hydroxy-4 methyl-2-pentanone (HMP); 4-methyl-2-pentanol (4-MPOL MIBC); methyl isobutyl ketone (MIBK)) |
- |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Mechanism of Transport and Distribution of Organic Solvents in Blood | Author: Lam C. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Comparative metabolism of methyl isobutyl carbinol and methyl isobutyl ketone in male rats | Author: Gingell R. et al. | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The metabolism of methyl isobutyl ketone and its biological monitoring: Part 1. Qualitative and quantitative studies of methyl isobutyl ketone exhaled from the lungs and excreted in the urine and the metabolites in the urine of rats injected with MIBK | Author: Hirota N | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The Transplacental Migration and Accumulation in Blood of Volatile Organic constituents | Author: Dowty BJ, Laseter JL and Storer J | Year: 1976 | Klimisch score: 2 - Reliable with restrictions. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Dermal Absorption Potential of Industrial Chemicals: Criteria for Skin Notation | Author: Fiserova-Bergerova V, Pierce JT, and Droz PO | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Percutaneous uptake and kinetics of methyl isobutyl ketone (MIBK) in the guinea pig | Author: Hjelm E.W. et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: TOXICOLOGICAL REVIEW OF METHYL ISOBUTYL KETONE (CAS No. 108-10-1). In Support of Summary Information on the Integrated Risk Information System (IRIS) | Author: EPA (U.S. Environmental Protection Agency) | Year: 2003 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: 14-week inhalation toxicity study of methyl isobutyl ketone | Author: Phillips R.D. et al. | Year: 1987 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: 14-week inhalation toxicity study of methyl isobutyl ketone | Author: Phillips R.D. et al. | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Effect of 90-day continuous exposure to methylisobutylketone on dogs monkeys and rats | Author: Mac Ewen JD, Vernot EH and Haun CC | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Continuous exposure of animals to methyl isobutyl ketone | Author: Vernot EH, MacEwen JD, and Harris ES | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Pathological lesions caused by methylisobutylketone | Author: MacKenzie WF | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: 14-week inhalation toxicity study of methyl isobutyl ketone | Author: Phillips RD et al. | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: 14-week inhalation toxicity study of methyl isobutyl ketone | Author: Phillips RD et al. | Year: 1987 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: TOXICOLOGY AND CARCINOGENESIS STUDIES OF METHYL ISOBUTYL KETONE (CAS NO. 108-10-1) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) | Author: NTP | Year: 2007 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure | Author: Stout MD et al. | Year: 2008 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: TOXICOLOGY AND CARCINOGENESIS STUDIES OF METHYL ISOBUTYL KETONE (CAS NO. 108-10-1) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) | Author: NTP | Year: 2007 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure | Author: Stout MD et al. | Year: 2008 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity evaluation of inhaled methyl isobutyl ketone in Fischer 344 rats and CD-1 mice | Author: Tyl RW et al. | Year: 1987 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity evaluation of inhaled methyl isobutyl ketone in Fischer 344 rats and CD-1 mice | Author: Tyl RW et al. | Year: 1987 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Inhalation two-generation reproductive toxicity study of methyl isobutyl ketone in rats | Author: Nemec MD et al. | Year: 2004 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: TOXICOLOGY AND CARCINOGENESIS STUDIES OF METHYL ISOBUTYL KETONE (CAS NO. 108-10-1) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) | Author: NTP | Year: 2007 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure | Author: Stout MD et al. | Year: 2008 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: TOXICOLOGY AND CARCINOGENESIS STUDIES OF METHYL ISOBUTYL KETONE (CAS NO. 108-10-1) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) | Author: NTP | Year: 2007 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure | Author: Stout MD et al. | Year: 2008 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Neurobehavioral effects from acute exposures to methyl isobutyl ketone and methyl ethyl ketone | Author: Dick RB et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Methyl isobutyl ketone and methyl ethyl ketone in urine as biological markers of occupational exposure to these solvents at low levels | Author: Kawai T, et al. | Year: 2003. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Exposure to methyl isobutyl ketone: toxicokinetics and occurrence of irritative and CNS symptoms in man | Author: Hjelm EW et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Human experimental MIBK exposure: effects on heart rate performance and symptoms | Author: Iregren A, Tesarz M, and Wigaeus-Hjelm E | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: The metabolism of methyl isobutyl ketone and its biological monitoring: Part 2. Qualitative and quantitative study of 4-methy-2pentanol excreted in the urine of workers exposed to methyl isobutyl ketone | Author: Hirota N | Year: 1991. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Occupational exposure to methyl isobutyl ketone causes lasting impairment in workin memory | Author: Grober E and Schaumburg HH | Year: 2000. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: The effect of repeated methyl iso-butyl ketone vapor exposure on schedule-controlled operant behavior in rats | Author: David RM et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: A thirteen-week inhalation schedule-controlled operant behavior study of methyl iso-butyl ketone in the rat | Author: Bernard L et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Aspiration Toxicity of Ketones | Author: Panson RD and Winek CL | Year: 1980 | Klimisch score: 2 - Reliable with restrictions. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: The aspiration hazard and toxicity of a series of ketones | Author: Exxon Chemical Company | Year: 1982. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: The aspiration hazard and toxicity of a series of ketones | Author: Exxon Chemical Company | Year: 1982. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Potentiation of chloroform-induced hepatoxicity by methyl isobutyl ketone and two metabolites | Author: Vézina M, et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Methyl isobutyl ketone exposure-related increases in specific measures of α2μ-globulin (α2μ) nephropathy in male rats along with in vitro evidence of reversible protein binding. | Author: Borghoff SJ et al. | Year: 2015 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Sensory irritation casused by various industrial airborne chemicals | Author: De Ceaurriz J. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Methyl isobutyl ketone (MIBK) induction of α2μ-globulin nephropathy in male but not female rats | Author: Borhoff SJ et al. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Quantitative ealuation of sensory irritating and neurobehavioural properties of aliphatic ketones in mice | Author: De Ceaurriz J. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Characterization of the Mode of Action (MoA) for MIBK-induced hepatocellular carcinoma in B6C3F1 mice | Author: Hughes B et al. | Year: 2015 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Methyl isobutyl ketone-induced hepatocellular carcinogenesis in B6C3F1 mice: A constitutive androstane receptor (CAR)-mediated mode of action | Author: Hughes. B. et al. | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Methyl isobutyl ketone - effects on gene expression enzyme activities and cell proliferation in cultured male C57BL/6 mouse primary cryopreserved hepatocytes | Author: Dowers K | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: Methyl isobutyl ketone - effects on gene expression enzyme activities and cell proliferation in cultured male C57BL/6 mouse primary cryopreserved hepatocytes | Author: Dowers K | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Methyl Isobutyl Ketone - Effects on Gene Expression Enzyme Activities and Cell Proliferation in Cultured Male Human Primary Cryopreserved Hepatocytes | Author: Dowers K | Year: 2022 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: Methyl Isobutyl Ketone - Effects on Gene Expression Enzyme Activities and Cell Proliferation in Cultured Male Human Primary Cryopreserved Hepatocytes | Author: Dowers K | Year: 2022 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Acute inhalation (LC50) and human sensory irritation studies on cyclopentanone isophorone dihydroisophorone cyclohexanone and methyl isobutyl ketone. Submitted by Exxon Chemicals America. | Author: Esso Research and Engineering Company | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Further studies on sensory response to certain industrial solvent vapors | Author: Silverman L Schulte HF First MW | Year: 1946 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Sensory Response to Certain Industrial Solvent Vapor | Author: Nelson KW et al. | Year: 1943 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Human sensory irritation thresholds in five ketones: final report | Author: Alarie Y and Polise FA | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Right to refer to study -- Title: Human sensory irritation thresholds in five ketones: final report | Author: Alarie Y and Polise FA | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Evaluation of Odor and Sensory Irritation Thresholds for Methyl Isobutyl Ketone in Humans | Author: Dalton PH, Dilks DD, and Banton MI | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute Toxicity of 4-methylpentan-2-one to Zebrafish (Danio rerio) in a 96-hour Static Limit-Test in Closed Vessel Design | Author: Kuhl R & Deierling T | Year: 2010 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Acute Toxicity of 4-methylpentan-2-one to Zebrafish (Danio rerio) in a 96-hour Static Limit-Test in Closed Vessel Design | Author: Kuhl R & Deierling T | Year: 2010 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ergebnisse der Untersuchung von 200 chemischen Verbindungen auf aktue Fischtoxizität mit den Goldenorfentest | Author: Juhnke I, Lüdemann D | Year: 1978 | Klimisch score: 3 - Not reliable. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Determination of Acute toxicity to Fish of Shell Chemials | Author: Bridié AL, Winter M, Wolff CJM | Year: 1973 | Klimisch score: 3 - Not reliable. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Determination of Acute toxicity to Fish of Shell Chemials | Author: Bridié AL, Winter M, Wolff CJM | Year: 1973 | Klimisch score: 3 - Not reliable. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute Toxicity of 4-methylpentan-2-one to Daphnia magna in a Static 48-hour Immobilisation Limit-Test in Closed Vessel Design | Author: Kuhl R & Wydra V | Year: 2009 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Acute Toxicity of 4-methylpentan-2-one to Daphnia magna in a Static 48-hour Immobilisation Limit-Test in Closed Vessel Design | Author: Kuhl R & Wydra V | Year: 2009 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Befunde der Schadwirkung wassergefährdender Stoffe gegen Daphnia magna | Author: Bringmann G and Kühn R | Year: 1977 | Klimisch score: 3 - Not reliable. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ergebnisse der Schadwirkung wassergefährdender Stoffe gegen Daphnia magna in einem weiterentwickel standardisierten Testverfahren | Author: Bringmann G and Kühn R | Year: 1981 | Klimisch score: 3 - Not reliable. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Bestimmung der biologischen Schadwirkung wassergefährdender Stoffe gegen Protozoen. I. Bakterienfressende Flagellaten (Modellorganismus: Entosiphon sulcatum Stein) | Author: Bringmann G. | Year: 1978 | Guideline: 209 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Bestimmung der biologischen Schadwirkung wassergefährdender Stoffe gegen Protozoen. II. Bakterienfressende Ciliaten | Author: Bringmann G. and Kühn R. | Year: 1980 | Guideline: 209 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Bestimmung der biologischen Schadwirkung wassergefährdender Stoffe gegen Protozoen. III. Saprozoische Flagellaten | Author: Bringmann G., Kühn R. and Winter A. | Year: 1980 | Guideline: 209 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Bakterien (Pseudomonas putida) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann G and Kühn R | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Schadstoffeinwirkungen von Umweltchemikalien im Daphnien-Reproduktionstest als Grundlage zur Bewertung der Umweltgefährlichkeit in aquatischen Systemen | Author: Kühn R., Pattard M. and Pernak K. | Year: 1988 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Blaualgen (Microcystis aeruginosa) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann G and Kühn R | Year: 1978 | Klimisch score: 3 - Not reliable. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Bakterien (Pseudomonas putida) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann G and Kühn R | Year: 1977 | Klimisch score: 3 - Not reliable. | - |
| Eco-Tox | Toxicity to aquatic plants other than algae | Robust Study Summary -- Title: Toxicity of 4-methylpentan-2-one to the Aquatic Plant Lemna gibba in a Semi-Static Growth Inhibition Limit-Test in Closed Vessel Design | Author: Kuhl R and Deierling T | Year: 2010 | Guideline: 221 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic plants other than algae | Right to refer to study -- Title: Toxicity of 4-methylpentan-2-one to the Aquatic Plant Lemna gibba in a Semi-Static Growth Inhibition Limit-Test in Closed Vessel Design | Author: Kuhl R and Deierling T | Year: 2010 | Guideline: 221 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Ready Biodegradability of Methylisobutylcetone in a Manometric Respirometry Test | Author: Feil N | Year: 2009 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Ready Biodegradability of Methylisobutylcetone in a Manometric Respirometry Test | Author: Feil N | Year: 2009 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation and Bioaccumulation Data of Existing Chemicals Based on the CSCL Japan | Author: Chemicals Inspection & Testing Institute Japan | Year: 1992 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: BOD and COD of Some Petrochemicals | Author: Bridié AL, Wolff CJM, Winter M | Year: 1979 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Non hydrophobic equation | Author: Guidance on information requirements and chemical safety assessment (IR & CSA) Chapter 16 "Environmental exposure estimate" | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Rilievi clinici ed ematochimici in operai esposti all'azione di un chetone superiore (MIBK) ripetuti a distanza di 5 anni | Author: Armeli G, Linari F, and Martorano G | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Rilievi clinici ed ematochimici in operai esposti all'azione di un chetone superiore: metil-iosbutil-chetone | Author: Linari F, Perelli G, and Varese D | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |