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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Final Report - Desmodur N3300 | Author: Prüm M. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Final Report - Desmodur N3300 | Author: Prüm M. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | Covestro |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of the melting point of Desmodur N 3300 according to OECD 102 resp. EU A.1 | Author: LAUS GmbH | Year: 2010 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of the melting point of Desmodur N 3300 according to OECD 102 resp. EU A.1 | Author: LAUS GmbH | Year: 2010 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | Vencorex | BASF | Labcorp | Covestro |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Determination of the boiling point of Desmodur N 3300 according to OECD 103 resp. EU A.2 | Author: LAUS GmbH | Year: 2010 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Determination of the boiling point of Desmodur N 3300 according to OECD 103 resp. EU A.2 | Author: LAUS GmbH | Year: 2010 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | Vencorex | BASF | Labcorp | Covestro |
| Phys-Chem | Density | Robust Study Summary -- Title: Untersuchungsbericht Physikalische Daten von N3300 roh | Author: Keldenich/Krasemann | Year: 2009 | Guideline: A.3 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Phys-Chem | Density | Right to refer to study -- Title: Untersuchungsbericht Physikalische Daten von N3300 roh | Author: Keldenich/Krasemann | Year: 2009 | Guideline: A.3 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | Covestro |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Determination of the Vapour Pressure of Desmodur N 3300 according to OECD 104 resp. EU A.4 | Author: LAUS GmbH | Year: 2010 | Guideline: A.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Determination of the Vapour Pressure of Desmodur N 3300 according to OECD 104 resp. EU A.4 | Author: LAUS GmbH | Year: 2010 | Guideline: A.4 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | Vencorex | BASF | Labcorp | Covestro |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow estimation of 1,3,5-Triazine -2,4,6(1H,3H,5H)-trione 1,3,5-tris(6-isocyanatohexyl)- (CAS No. 3779-63-3) | Author: Allmendinger H. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow estimation of 1,3,5-Triazine -2,4,6(1H,3H,5H)-trione 1,3,5-tris(6-isocyanatohexyl)- (CAS No. 3779-63-3) | Author: Allmendinger H. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | Covestro |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Prüfbericht (nach DIN EN 45001) der Proben N75M Z 4470 N 3300 Desmodur | Author: Heitkamp / Krasemann | Year: 1997 | Guideline: DIN EN 45001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Phys-Chem | Flash point | Right to refer to study -- Title: Prüfbericht (nach DIN EN 45001) der Proben N75M Z 4470 N 3300 Desmodur | Author: Heitkamp / Krasemann | Year: 1997 | Guideline: DIN EN 45001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | Covestro |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Duranate TPA100 (Lot. 30157): Acute oral toxicity in the rat - Acute Toxic Class Method | Author: Pooles A | Year: 2004 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Duranate TPA100 (Lot. 30157): Acute oral toxicity in the rat - Acute Toxic Class Method | Author: Pooles A | Year: 2004 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | Asahi Kasei |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Duranate TKA100 (Lot. 30318): Reverse Mutation Assay "Ames Test" using Salmonella Typhimurium and Escherichia coli | Author: Thompson P W | Year: 2004 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | HDI Trimer Consortium |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Duranate TKA100 (Lot. 30318): Reverse Mutation Assay "Ames Test" using Salmonella Typhimurium and Escherichia coli | Author: Thompson P W | Year: 2004 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | Asahi Kasei |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In vitro chromosome aberration assay in V79 cells with HDI Trimer | Author: Schulz M Landsiedel R | Year: 2007 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | HDI Trimer Consortium |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: In vitro chromosome aberration assay in V79 cells with HDI Trimer | Author: Schulz M Landsiedel R | Year: 2007 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | Covestro | BASF | Vencorex | Evonik |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In vitro gene mutation test in CHO cells with HDI Trimer | Author: Schulz M & Mellert W | Year: 2006 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | HDI Trimer Consortium |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: In vitro gene mutation test in CHO cells with HDI Trimer | Author: Schulz M & Mellert W | Year: 2006 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | Covestro | BASF | Vencorex | Evonik |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Amendment No. 1 to the Report In vitro gene mutation test in CHO cells with HDI Trimer | Author: Schulz M & Landsiedel R | Year: 2007 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Amendment No. 1 to the Report In vitro gene mutation test in CHO cells with HDI Trimer | Author: Schulz M & Landsiedel R | Year: 2007 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | Covestro | BASF | Vencorex | Evonik |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Tolonate HDT: Micronucleus Test in Bone Marrow of CD-1 mice | Author: Holmstrom M & McGregor D B | Year: 1986 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | HDI Trimer Consortium |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Tolonate HDT: Micronucleus Test in Bone Marrow of CD-1 mice | Author: Holmstrom M & McGregor D B | Year: 1986 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | Vencorex France |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Desmodur N 3300 Untersuchungen zur akuten inhalativen Toxizität | Author: Pauluhn J | Year: 1984 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Desmodur N 3300 Untersuchungen zur akuten inhalativen Toxizität | Author: Pauluhn J | Year: 1984 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | Covestro |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Duranate TKA100 (Lot. 30318): Acute dermal toxicity (Limit Test) in the rat | Author: Pooles A | Year: 2004 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Duranate TKA100 (Lot. 30318): Acute dermal toxicity (Limit Test) in the rat | Author: Pooles A | Year: 2004 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | Asahi Kasei |
| Toxicological | Eye irritation | Robust Study Summary -- Title: 1,6-Diisocyanatohexan homopolymer Eye Irritation to the rabbit | Author: Parcell B I | Year: 1996 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | HDI Trimer Consortium |
| Toxicological | Eye irritation | Right to refer to study -- Title: 1,6-Diisocyanatohexan homopolymer Eye Irritation to the rabbit | Author: Parcell B I | Year: 1996 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | Covestro |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: 1,6-Diisocyanatohexan homopolymer Skin Irritation to the rabbit | Author: Parcell B I | Year: 1996 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | HDI Trimer Consortium |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: 1,6-Diisocyanatohexan homopolymer Skin Irritation to the rabbit | Author: Parcell B I | Year: 1996 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | Covestro |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Duranate TKA100 (Lot. 30318): Local Lymph Node Assay in the mouse | Author: Pooles A | Year: 2004 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | HDI Trimer Consortium |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Duranate TKA100 (Lot. 30318): Local Lymph Node Assay in the mouse | Author: Pooles A | Year: 2004 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | Asahi Kasei |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A combined reproduction neonatal development and neurotoxicity study with 1,6-hexamethylene diisocyanate (HDI) in the rat | Author: Astroff AB et al | Year: 2000 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using 1,6-hexamethylene diisocyanate (HDI) in the Sprague-Dawley rat. | Author: Astroff AB | Year: 1999 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | HDI Trimer Consortium |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using 1,6-hexamethylene diisocyanate (HDI) in the Sprague-Dawley rat. | Author: Astroff AB | Year: 1999 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | Covestro | Vencorex (Sponsor: CMA) |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Investigation of the ecological properties of Desmodur N 3300 | Author: Caspers N. | Year: 2000 | Guideline: C.1 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Investigation of the ecological properties of Desmodur N 3300 | Author: Caspers N. | Year: 2000 | Guideline: C.1 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | Covestro |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Desmodur N 3600 - Akute Daphnientoxizität | Author: Caspers N. | Year: 2001 | Guideline: C.2 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Desmodur N 3600 - Akute Daphnientoxizität | Author: Caspers N. | Year: 2001 | Guideline: C.2 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | Covestro |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Prüfbericht 53 A/88 | Author: Caspers N. | Year: 1989 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Prüfbericht 53 A/88 | Author: Caspers N. | Year: 1989 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | Covestro |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis of HDI Trimer | Author: Feldhues E. | Year: 2007 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis of HDI Trimer | Author: Feldhues E. | Year: 2007 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | Covestro | BASF | Vencorex | Evonik |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Desmodur N 3600 - Biodegradation | Author: Müller G. | Year: 2001 | Guideline: 301D | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | HDI Trimer Consortium |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Desmodur N 3600 - Biodegradation | Author: Müller G. | Year: 2001 | Guideline: 301D | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | Covestro |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Desmodur N 3300 Untersuchungen zur Subakuten Inhalationstoxizität an der Ratte (Aerosol-Exposition 15x6 Stunden) | Author: Pauluhn J | Year: 1985 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | HDI Trimer Consortium |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Desmodur N 3300 Untersuchungen zur Subakuten Inhalationstoxizität an der Ratte (Aerosol-Exposition 15x6 Stunden) | Author: Pauluhn J | Year: 1985 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | Covestro |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Histopathological re-evaluation of studies on subacute/subchronic inhalation toxicity in rats | Author: Pauluhn J & Mohr U | Year: 2001 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | HDI Trimer Consortium |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Histopathological re-evaluation of studies on subacute/subchronic inhalation toxicity in rats | Author: Pauluhn J & Mohr U | Year: 2001 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | Covestro |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Desmodur N 3300 Untersuchungen zur subchronischen Inhalationstoxizität an der Ratte nach OECD-Richtlinie No.: 413 - Band 2-4 | Author: Pauluhn J | Year: 1987 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | HDI Trimer Consortium |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Desmodur N 3300 Untersuchungen zur subchronischen Inhalationstoxizität an der Ratte nach OECD-Richtlinie No.: 413 - Band 2-4 | Author: Pauluhn J | Year: 1987 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | Covestro |