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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Flash point | Robust Study Summary -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - I | Author: DCC | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - I | Author: DCC | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella Typhimurium and Escherichia Coli Reverse Mutation Assay with Tetramethyldisiloxane | Author: Dow Corning Corporation | Year: 2009 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Salmonella Typhimurium and Escherichia Coli Reverse Mutation Assay with Tetramethyldisiloxane | Author: Dow Corning Corporation | Year: 2009 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: DETERMINATION OF THE VAPOUR PRESSURE OF 1,1,3,3-TETRAMETHYLDISILOXANE USING THE STATIC METHOD | Author: Baltussen E | Year: 2012 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: DETERMINATION OF THE VAPOUR PRESSURE OF 1,1,3,3-TETRAMETHYLDISILOXANE USING THE STATIC METHOD | Author: Baltussen E | Year: 2012 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Assessment of acute oral toxicity with TMHD in the rat (acute toxic class method) | Author: NOTOX B.V. | Year: 2007 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Assessment of acute oral toxicity with TMHD in the rat (acute toxic class method) | Author: NOTOX B.V. | Year: 2007 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Acute eye irritation study of Siloxan HSi2 by instillation into the conjunctival sac of rabbits | Author: Laboratory of Pharmacology and Toxicology | Year: 2002 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Acute eye irritation study of Siloxan HSi2 by instillation into the conjunctival sac of rabbits | Author: Laboratory of Pharmacology and Toxicology | Year: 2002 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute Skin Irritation Test (Patch Test) of Siloxan HSI2 in Rabbits | Author: Laboratory of Pharmacology and Toxicology | Year: 2002 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Acute Skin Irritation Test (Patch Test) of Siloxan HSI2 in Rabbits | Author: Laboratory of Pharmacology and Toxicology | Year: 2002 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: 1,1,3,3-Tetramethyldisiloxane (CAS RN 3277-26-7): Study for Effects on Embryo-Fetal Development in the Sprague Dawley Rat by Oral Gavage Administration | Author: Covance Laboratories Ltd. | Year: 2020 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: 1,1,3,3-Tetramethyldisiloxane (CAS RN 3277-26-7): Study for Effects on Embryo-Fetal Development in the Sprague Dawley Rat by Oral Gavage Administration | Author: Covance Laboratories Ltd. | Year: 2020 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Examination of SILOXAN HSI2 in an acute immobilisation test in Daphnia magna | Author: LPT | Year: 2003 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Examination of SILOXAN HSI2 in an acute immobilisation test in Daphnia magna | Author: LPT | Year: 2003 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Evaluation of the Ability of 1,1,3,3-tetramethyldisiloxane (CAS RN 3277-26-7) to Induce Chromosome Aberrations in Cultured Peripheral Human Lymphocytes | Author: Charles River Laboratories | Year: 2022 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Evaluation of the Ability of 1,1,3,3-tetramethyldisiloxane (CAS RN 3277-26-7) to Induce Chromosome Aberrations in Cultured Peripheral Human Lymphocytes | Author: Charles River Laboratories | Year: 2022 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Comparison of Hydrolysis Rates of 1,1,3,3-Tetramethyldisiloxane and Hexamethyldisiloxane in pH 7 Imidazole Buffer containing 10% Acetonitrile | Author: Dow Corning Corporation | Year: 2012 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Comparison of Hydrolysis Rates of 1,1,3,3-Tetramethyldisiloxane and Hexamethyldisiloxane in pH 7 Imidazole Buffer containing 10% Acetonitrile | Author: Dow Corning Corporation | Year: 2012 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |