You are here: Home> Taiwan>TW-REACH>CAS 5873-54-1> CAS 5873-54-1 | Data Package 100 - 1000 t/a (Affiliates of MDI-MDA Consortium members and III)
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Diphenylmethane-2,4'-diisocyanate (2,4'-MDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Diphenylmethane-2,4'-diisocyanate (2,4'-MDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Diphenylmethane-2,4'-diisocyanate (2,4'-MDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Diphenylmethane-2,4'-diisocyanate (2,4'-MDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Determination of the boiling point of Lupranat MCI according to OECD 103 resp. EU A.2 | Author: Paulus J. | Year: 2008 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Determination of the boiling point of Lupranat MCI according to OECD 103 resp. EU A.2 | Author: Paulus J. | Year: 2008 | Guideline: 103 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Physico-chemical Properties Testing on a Sample of 2,4'-MDI (EC Number: 227-534-9) Final Report | Author: Baker Daniel | Year: 2019 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Physico-chemical Properties Testing on a Sample of 2,4'-MDI (EC Number: 227-534-9) Final Report | Author: Baker Daniel | Year: 2019 | Guideline: 109 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Diphenylmethane-2,4'-diisocyanate (2,4'-MDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.4 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Diphenylmethane-2,4'-diisocyanate (2,4'-MDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.4 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26447-40-5 | EC 247-714-0) |
- |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26447-40-5 | EC 247-714-0) |
- |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor pressure of MDi MI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26447-40-5 | EC 247-714-0) |
- |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor pressure of MDi MI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26447-40-5 | EC 247-714-0) |
- |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Yakabe | Year: 1997 | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: No information | Author: Yakabe | Year: 1997 | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Physico-chemical Properties Testing on a Sample of 2,4'-MDI (EC Number: 227-534-9) Final Report | Author: Baker Daniel | Year: 2019 | Guideline: 114 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Physico-chemical Properties Testing on a Sample of 2,4'-MDI (EC Number: 227-534-9) Final Report | Author: Baker Daniel | Year: 2019 | Guideline: 114 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of 2,4-MDI | Author: Shajad Younis | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of 2,4-MDI | Author: Shajad Younis | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Pyrophoric Properties | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of 2,4-MDI | Author: Shajad Younis | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Pyrophoric Properties | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of 2,4-MDI | Author: Shajad Younis | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of 2,4-MDI | Author: Shajad Younis | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of 2,4-MDI | Author: Shajad Younis | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Physico-chemical Properties Testing on a Sample of 2,4'-MDI (EC Number: 227-534-9) Final Report | Author: Baker Daniel | Year: 2019 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Physico-chemical Properties Testing on a Sample of 2,4'-MDI (EC Number: 227-534-9) Final Report | Author: Baker Daniel | Year: 2019 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4'-MDI) |
- |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4'-MDI) |
- |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: MDI 2,2: Acute skin irritation/corrosion on rabbits | Author: Gmelin C. | Year: 2010 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: MDI 2,2: Acute skin irritation/corrosion on rabbits | Author: Gmelin C. | Year: 2010 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: A Comparative Primary Dermal Irritation Study in Rabbits | Author: Mallory V.T. | Year: 2010 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: A Comparative Primary Dermal Irritation Study in Rabbits | Author: Mallory V.T. | Year: 2010 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary Dermal Irritation Study in Rabbits with Suprasec 2029 | Author: Mallory V.T. | Year: 2010 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary Dermal Irritation Study in Rabbits with Suprasec 2029 | Author: Mallory V.T. | Year: 2010 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute Dermal Irritation/Corrosion Test (patch test) of MDI PIR in rabbits | Author: Leuschner J. | Year: 2012 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Acute Dermal Irritation/Corrosion Test (patch test) of MDI PIR in rabbits | Author: Leuschner J. | Year: 2012 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toxicological investigation of Mondur PF | Author: Birch M.D. | Year: 1977 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Toxicological investigation of Mondur PF | Author: Birch M.D. | Year: 1977 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary Dermal Irritation Study in Rabbits with SUPRASEC®2444, SUPRASEC®2449-PPF1-10, and SUPRASEC® 2449-PPF1-15 | Author: Vasquez R.E. | Year: 2011 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary Dermal Irritation Study in Rabbits with SUPRASEC®2444, SUPRASEC®2449-PPF1-10, and SUPRASEC® 2449-PPF1-15 | Author: Vasquez R.E. | Year: 2011 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary Dermal Irritation Study in Rabbits with Suprasec 2021 | Author: Mallory V.T. | Year: 2010 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary Dermal Irritation Study in Rabbits with Suprasec 2021 | Author: Mallory V.T. | Year: 2010 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary Dermal Irritation Study in Rabbits with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary Dermal Irritation Study in Rabbits with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Desmodur VP PU 1806: study for skin and eye irritation/corrosion in rabbits | Author: Märtins T. | Year: 1991 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Desmodur VP PU 1806: study for skin and eye irritation/corrosion in rabbits | Author: Märtins T. | Year: 1991 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G. | Year: 1981 | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G. | Year: 1981 | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toxicological investigation of Mondur PF | Author: Birch M.D. | Year: 1977 | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Toxicological investigation of Mondur PF | Author: Birch M.D. | Year: 1977 | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Acute eye irritation/corrosion test of MDI PIR in rabbits | Author: Leuschner J. | Year: 2012 | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Acute eye irritation/corrosion test of MDI PIR in rabbits | Author: Leuschner J. | Year: 2012 | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit. | Author: Wazeter F. X. et al. | Year: 1964 | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Desmodur VP PU 1806: study for skin and eye irritation/corrosion in rabbits | Author: Märtins T. | Year: 1991 | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Desmodur VP PU 1806: study for skin and eye irritation/corrosion in rabbits | Author: Märtins T. | Year: 1991 | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: MDI 2,2: Acute eye irritation on rabbits | Author: Gmelin C. | Year: 2010 | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: MDI 2,2: Acute eye irritation on rabbits | Author: Gmelin C. | Year: 2010 | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Adequacy: weight of evidence. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI, MDI, p-TMXDI, IPDI, m-TMXDI, HMDI, and m-TMI (modified Buehler method) | Author: Davis R.A. Auletta C.S. and Friedman M.A. | Year: 1984 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI, MDI, p-TMXDI, IPDI, m-TMXDI, HMDI, and m-TMI (modified Buehler method) | Author: Davis R.A. Auletta C.S. and Friedman M.A. | Year: 1984 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella/Microsome test: 2,4'-MDI. First addendum to the final report | Author: Herbold B. | Year: 1996 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Salmonella/Microsome test: 2,4'-MDI. First addendum to the final report | Author: Herbold B. | Year: 1996 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: 2,4'-MDI (in EGDE) Salmonella/Microsome Test | Author: Herbold B. | Year: 1996 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: 2,4'-MDI (in EGDE) Salmonella/Microsome Test | Author: Herbold B. | Year: 1996 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chemical behaviour of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test | Author: Seel K. et al. | Year: 1999 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Waiver | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Bone marrow micronucleus assay in Brown-Norway rats exposed to diphenyl-methane-4,4'-diisocyanate | Author: Pauluhn J. et al. | Year: 2001 | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Bone marrow micronucleus assay in Brown-Norway rats exposed to diphenyl-methane-4,4'-diisocyanate | Author: Pauluhn J. et al. | Year: 2001 | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. & Gollapudi B. | Year: 2001 | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. & Gollapudi B. | Year: 2001 | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Desmodur VP PU 1806: acute oral toxicity study in male and female Wistar rats | Author: Bomhard E. | Year: 1990 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Desmodur VP PU 1806: acute oral toxicity study in male and female Wistar rats | Author: Bomhard E. | Year: 1990 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2015 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2015 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2021 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2021 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2029 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2029 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: PAPI; MDI; TDI: acute inhalation exposure in male albino rats | Author: Wazeter F.X. Buller R.H. & Geil R.G. | Year: 1964 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: PAPI; MDI; TDI: acute inhalation exposure in male albino rats | Author: Wazeter F.X. Buller R.H. & Geil R.G. | Year: 1964 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Diphenylmethane 2,4'-Diisocyanate (2,4'-MDI) Acute Inhalation Toxicity in Rats (Exposure 1X4 hours following by a postexposure period of 2 weeks | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Diphenylmethane 2,4'-Diisocyanate (2,4'-MDI) Acute Inhalation Toxicity in Rats (Exposure 1X4 hours following by a postexposure period of 2 weeks | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: CEFIC areosols | Author: CEFIC | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: ISOPA on MDI areosols in tox tests | Author: ISOPA | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit. | Author: Wazeter F.X. Buller R.H. & Geil R.G. | Year: 1964 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toxicological investigation of Mondur PF. | Author: Birch M. D. | Year: 1977 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toxicological investigation of Mondur PF. | Author: Birch M. D. | Year: 1977 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Absorption distribution metabolism and excretion of an inhalation dose of (14C) 4,4'-methylenediphenyl diisocyanate in the male rat | Author: Gledhill A. et al. | Year: 2005 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: MDI: excretion and tissue distribution in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: MDI: excretion and tissue distribution in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Glutathione reactivity assay with MDI substances | Author: Wisnewski A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Glutathione reactivity assay with MDI substances | Author: Wisnewski A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic toxicity/carcinogenicity inhalation study of polymeric methylenediphenyl diisocyanate aerosol in rats. 3 vols | Author: Reuzel P.G.J. et al. | Year: 1990 | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic inhalation toxicity and carcinogenicity study of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats | Author: Reuzel P.G.J. et al. | Year: 1994 | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays | Author: Feron V.J. et al. | Year: 2001 | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Prenatal toxicity if inhaled polymeric methylenediphenyl diisocyanate (MDI) aerosols in pregnant Wistar rats. | Author: Gamer A. et al. | Year: 2000 | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Prenatal toxicity of polymeric MDI in rats. Aerosol inhalation. 3 vols | Author: Gamer A.O. | Year: 1994 | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Prenatal toxicity of polymeric MDI in rats. Aerosol inhalation. 3 vols | Author: Gamer A.O. | Year: 1994 | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratogenicity study of monomeric 4,4'-methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats | Author: Buschmann J. | Year: 1994 | Adequacy: weight of evidence. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Embryotoxicity study of monomeric 4,4'-methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats | Author: Buschmann J. et al. | Year: 1996 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with Desmodur PF re-written 2010 | Author: CURRENTA | Year: 2010 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with Desmodur PF re-written 2010 | Author: CURRENTA | Year: 2010 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI/DPG | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI/DPG | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI/13-BD/TPG/PG | Author: Neuhahn A | Year: 2016 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI/13-BD/TPG/PG | Author: Neuhahn A | Year: 2016 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI/DPG/HMWP (Monomer depleted) | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI/DPG/HMWP (Monomer depleted) | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with MDI PIR | Author: Neuhahn A. | Year: 2012 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with MDI PIR | Author: Neuhahn A. | Year: 2012 | Adequacy: weight of evidence. | - |
| Eco-Tox | Long-term toxicity to fish | Waiver | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 2,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 2,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 2,4'-MDI with humic acid | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 2,4'-MDI with humic acid | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A | Year: 2021 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A | Year: 2021 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A | Year: 2021 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A | Year: 2021 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI/DPG/HMWP (Monomer depleted) | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI/DPG/HMWP (Monomer depleted) | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with MDI mixed isomers/13-BD/TPG/PG | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with MDI mixed isomers/13-BD/TPG/PG | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with MDI PIR | Author: Neuhahn A. | Year: 2012 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with MDI PIR | Author: Neuhahn A. | Year: 2012 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI/13-BD/TPG/PG | Author: Neuhahn A. | Year: 2016 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI/13-BD/TPG/PG | Author: Neuhahn A. | Year: 2016 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI/DPG/HMWP | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI/DPG/HMWP | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with MDI Polyisocyanurate | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with MDI Polyisocyanurate | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with MDI PIR | Author: Neuhahn | Year: 2012 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with MDI PIR | Author: Neuhahn | Year: 2012 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI/13-BD/TPG/PG | Author: Neuhahn A. | Year: 2016 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI/13-BD/TPG/PG | Author: Neuhahn A. | Year: 2016 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI/DPG | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI/DPG | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Effect of pMDI on the growth of the green alga Scenedesmus subspicatus | Author: Blom A.J.M. & Oldersma H. | Year: 1994 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Effect of pMDI on the growth of the green alga Scenedesmus subspicatus | Author: Blom A.J.M. & Oldersma H. | Year: 1994 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Report: 4,4'-MDI/DPG - Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Report: 4,4'-MDI/DPG - Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Activated Sludge Respiration Inhibition Test with MDI PIR | Author: CURRENTA | Year: 2012 | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Activated Sludge Respiration Inhibition Test with MDI PIR | Author: CURRENTA | Year: 2012 | Adequacy: weight of evidence. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neluand M. | Year: 2021 | Adequacy: weight of evidence. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neluand M. | Year: 2021 | Adequacy: weight of evidence. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of Polymeric MDI under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Adequacy: weight of evidence. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of Polymeric MDI under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Adequacy: weight of evidence. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of 4,4'-MDI/DPG/HMWP under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Adequacy: weight of evidence. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of 4,4'-MDI/DPG/HMWP under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation of MDI PIR | Author: Richter Chr. | Year: 2012 | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Biodegradation of MDI PIR | Author: Richter Chr. | Year: 2012 | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Report: 4,4'-MDI/DPG Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Report: 4,4'-MDI/DPG Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: QSAR prediction of log Koc for 4,4'-MDI | Author: West B. | Year: 2021 | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: QSAR prediction of log Koc for 4,4'-MDI | Author: West B. | Year: 2021 | Adequacy: key study. | - |