You are here: Home> Taiwan>TW-REACH>CAS 9016-87-9> CAS 9016-87-9 | Data Package 1 - 10 t/a (Affiliates of MDI-MDA Consortium members and III)
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: GESTIS Substance Database Polymeric diphenylmethane diisocyanate CAS: 9016-87-9 | Author: Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) | Year: 2020 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Monographs on the Evaluation of the Carcinogenic Risk of Chemicals | Author: IARC | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Polymeric diphenylmethane 4,4'-diisocyanate (PMDI): determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Polymeric diphenylmethane 4,4'-diisocyanate (PMDI): determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Monographs on the Evaluation of the Carcinogenic Risk of Chemicals | Author: IARC | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Waiver | - |
| Phys-Chem | Density | Robust Study Summary -- Title: GESTIS Substance Database Polymeric diphenylmethane diisocyanate CAS: 9016-87-9 | Author: Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) | Year: 2020 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Monographs on the Evaluation of the Carcinogenic Risk of Chemicals | Author: IARC | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor pressure of PMDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor pressure of PMDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y. et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y. et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Guideline: Calculation | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Guideline: Calculation | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Monographs on the Evaluation of the Carcinogenic Risk of Chemicals | Author: IARC | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: GESTIS Substance Database Polymeric diphenylmethane diisocyanate CAS: 9016-87-9 | Author: Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) | Year: 2020 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Polymeric diphenylmethane 4,4'-diisocyanate (PMDI): determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Polymeric diphenylmethane 4,4'-diisocyanate (PMDI): determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Waiver | - |
| Phys-Chem | Explosive properties | Waiver | - |
| Phys-Chem | Oxidising properties | Waiver | - |
| Phys-Chem | pH | Waiver | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit. | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit. | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI, MDI, p-TMXDI, IPDI, m-TMXDI, HMDI and m-TMI (modified Buehler method) | Author: Davis R.A., Auletta C.S. and Friedman M.A. | Year: 1984 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI, MDI, p-TMXDI, IPDI, m-TMXDI, HMDI, and m-TMI (modified Buehler method) | Author: Davis R.A., Auletta C.S. and Friedman M.A. | Year: 1984 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulphoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the salmonella/microsome test | Author: Herbold B., Haas P., Seel K. and Walber U. | Year: 1998 | Guideline: B13/14 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Desmodur 44 V 20 L: acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks) | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Desmodur 44 V 20 L: acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks) | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Acute inhalation toxicity study of polymeric MDI in rats | Author: Appelman L.M. & De Jong A.W.J. | Year: 1982 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Acute inhalation toxicity study of polymeric MDI in rats | Author: Appelman L.M. & De Jong A.W.J. | Year: 1982 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Deposition of aerosol components on the hair of rats exposed to polymeric MDI aerosols. Addendum : analytical methods for the determination of aerosol components in hair of test animals | Author: Appelman L.M. & De Jong A.W.J. | Year: 1982 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Deposition of aerosol components on the hair of rats exposed to polymeric MDI aerosols. Addendum : analytical methods for the determination of aerosol components in hair of test animals | Author: Appelman L.M. & De Jong A.W.J. | Year: 1982 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A. | Year: 2021 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A. | Year: 2021 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Effect of pMDI on the growth of the green alga Scenedesmus subspicatus | Author: Blom A.J.M. and Oldersma H. | Year: 1994 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Effect of pMDI on the growth of the green alga Scenedesmus subspicatus | Author: Blom A.J.M. and Oldersma H. | Year: 1994 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 302C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 302C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |