You are here: Home> South Korea>K-REACH>EC 701-124-4> EC 701-124-4 | Data Package 10 - 100 t/a (Read-Across to CAS 103837-35-0)
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Identity | Author: Currenta GmbH & Co. OHG | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Identity | Author: Currenta GmbH & Co. OHG | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor Pressure of Diphenylmethane Diisocyanate (MDI) Formulations | Author: Chakrabarti A | Year: 1989 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor Pressure of Diphenylmethane Diisocyanate (MDI) Formulations | Author: Chakrabarti A | Year: 1989 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Phys-Chem | Water solubility | Robust Study Summary -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the Water Solubility of Desmodur PF | Author: Neuland | Year: 2014 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the Water Solubility of Desmodur PF | Author: Neuland | Year: 2014 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Yakabe | Year: 1997 | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: No information | Author: Yakabe | Year: 1997 | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: QSAR Estimations for MDI-TPG | Author: Currenta GmbH & Co. OHG | Year: 2010 | Guideline: 107/117/122/123 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Estimations for MDI-TPG | Author: Currenta GmbH & Co. OHG | Year: 2010 | Guideline: 107/117/122/123 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y et al. | Year: 2000 | Guideline: 107/117/122/123 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.14 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Explosive properties | Right to refer to study -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.14 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Oxidising properties | Robust Study Summary -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.21 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Oxidising properties | Right to refer to study -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.21 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Phys/Chem. Testing on Desmodur PF | Author: Chilworth | Year: 2013 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toxicological investigation of Mondur PF | Author: Birch MD | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Toxicological investigation of Mondur PF | Author: Birch MD | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toxicological investigation of Mondur PF | Author: Birch MD | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Toxicological investigation of Mondur PF | Author: Birch MD | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI, MD,I p-TMXDI, IPDI, m-TMXDI, HMDI and m-TMI (modified Buehler method) | Author: Davis RA, Auletta CS, and Friedman MA | Year: 1984 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI, MD,I p-TMXDI, IPDI, m-TMXDI, HMDI and m-TMI (modified Buehler method) | Author: Davis RA, Auletta CS, and Friedman MA | Year: 1984 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2449 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2449 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2020 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2020 | Author: Mallory VT | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulfoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the Salmonella/microsome test | Author: Herbold B et al. | Year: 1998 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: 4,4'-MDI/DPG/HMWP SALMONELLA TYPHIMURIUM / ESCHERICHIA COLI REVERSE MUTATION ASSAY | Author: C. Rülker | Year: 2021 | Adequacy: weight of evidence. Read-Across (EC 701-041-3 | 4,4'-MDI/DPG/HMWP) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: 4,4'-MDI/DPG/HMWP SALMONELLA TYPHIMURIUM / ESCHERICHIA COLI REVERSE MUTATION ASSAY | Author: C. Rülker | Year: 2021 | Adequacy: weight of evidence. Read-Across (EC 701-041-3 | 4,4'-MDI/DPG/HMWP) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial Reverse Mutation Assay | Author: Valentine O. et al. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial Reverse Mutation Assay | Author: Valentine O. et al. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial Reverse Mutation As | Author: Valentine O. et al. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial Reverse Mutation As | Author: Valentine O. et al. | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial reverse mutation assay | Author: Wagner VO and VanDyke MR | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial reverse mutation assay | Author: Wagner VO and VanDyke MR | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial Reverse Mutation Assay | Author: Wagner VO and VanDyke MR | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial Reverse Mutation Assay | Author: Wagner VO and VanDyke MR | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: MDI PIR Samonella/Microsome Test Plate incorporation and preincubation method | Author: Jarzombek M. | Year: 2013 | Adequacy: weight of evidence. Read-Across (CAS 109331-54-6 | EC 500-297-1 | MDI Mixed Isomers/PIR) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: MDI PIR Samonella/Microsome Test Plate incorporation and preincubation method | Author: Jarzombek M. | Year: 2013 | Adequacy: weight of evidence. Read-Across (CAS 109331-54-6 | EC 500-297-1 | MDI Mixed Isomers/PIR) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial Reverse Mutation Assay | Author: Wagner VO and VanDyke MR | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial Reverse Mutation Assay | Author: Wagner VO and VanDyke MR | Year: 2009 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: MDI 22: Salmonella/Microsome Test (Plate incorporation and preincubation method) | Author: Nern M | Year: 2011 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: MDI 22: Salmonella/Microsome Test (Plate incorporation and preincubation method) | Author: Nern M | Year: 2011 | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: 2,4'-MDI (in EGDE) Salmonella/Microsome Test | Author: Herbold B. | Year: 1996 | Adequacy: weight of evidence. Read-Across (CAS 5873-54-1 | EC 227-534-9 | 2,4’-MDI) |
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| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: 2,4'-MDI (in EGDE) Salmonella/Microsome Test | Author: Herbold B. | Year: 1996 | Adequacy: weight of evidence. Read-Across (CAS 5873-54-1 | EC 227-534-9 | 2,4’-MDI) |
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| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Bone marrow micronucleus assay in Brown-Norway rats exposed to diphenyl-methane-4,4'-diisocyanate | Author: Pauluhn J et al. | Year: 2001 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J & Gollapudi B | Year: 2001 | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J & Gollapudi B | Year: 2001 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicological investigation of Mondur PF | Author: Birch MD | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Toxicological investigation of Mondur PF | Author: Birch MD | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: OECD Guideline 403 acute inhalation toxicity study for the no-longer-polymer (NLP) reaction product of 4,4'-MDI and diproplylene glycol (4,4'-MDI/DPG; EC 701-041-3). | Author: Hotchkiss J. A. and Weidemoyer L. J. | Year: 2020 | Guideline: 403 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: OECD Guideline 403 acute inhalation toxicity study for the no-longer-polymer (NLP) reaction product of 4,4'-MDI and diproplylene glycol (4,4'-MDI/DPG; EC 701-041-3). | Author: Hotchkiss J. A. and Weidemoyer L. J. | Year: 2020 | Guideline: 403 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Acute inhalation toxicity of an MDI pre-polymer in rats according to OECD Test Guideline 403. | Author: Kopf J. | Year: 2016 | Guideline: 403 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Acute inhalation toxicity of an MDI pre-polymer in rats according to OECD Test Guideline 403. | Author: Kopf J. | Year: 2016 | Guideline: 403 | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Interrelating the acute and chronic mode of action of inhaled methylenediphenyl diisocyanate (MDI) in rats assisted by computational toxicology. | Author: Pauluhn J. | Year: 2011 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Toxicological investigation of Mondur PF | Author: Birch MD | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Toxicological investigation of Mondur PF | Author: Birch MD | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toxicological investigation of Mondur PF | Author: Birch MD | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toxicological investigation of Mondur PF | Author: Birch MD | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic inhalation toxicity and carcinogenicity study of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats | Author: Reuzel PGJ et al. | Year: 1994 | Guideline: 453 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | EC N/A | Polymeric MDI) |
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| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Prenatal toxicity of polymeric MDI in rats. Aerosol inhalation. 3 vols | Author: Gamer AO | Year: 1994 | Guideline: 414 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | EC N/A | Polymeric MDI) |
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| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Prenatal toxicity of polymeric MDI in rats. Aerosol inhalation. 3 vols | Author: Gamer AO | Year: 1994 | Guideline: 414 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | EC N/A | Polymeric MDI) |
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| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Guideline: 203 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Guideline: 203 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with Desmodur PF re-written 2010 | Author: CURRENTA | Year: 2010 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with Desmodur PF re-written 2010 | Author: CURRENTA | Year: 2010 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA | Author: Caspers N et al. | Year: 1986 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA | Author: Caspers N et al. | Year: 1986 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI/DPG | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (EC 701-040-8 | 4,4'-MDI/DPG ) |
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| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI/DPG | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (EC 701-040-8 | 4,4'-MDI/DPG ) |
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| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI/DPG/HMWP (Monomer depleted) | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (EC 701-041-3 | 4,4'-MDI/DPG/HMWP) |
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| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI/DPG/HMWP (Monomer depleted) | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (EC 701-041-3 | 4,4'-MDI/DPG/HMWP) |
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| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Adequacy: weight of evidence. Read-Across (EC 701-040-8 | 4,4'-MDI/DPG ) |
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| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Adequacy: weight of evidence. Read-Across (EC 701-040-8 | 4,4'-MDI/DPG ) |
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| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with MDI PIR | Author: Neuhahn | Year: 2012 | Adequacy: weight of evidence. Read-Across (CAS 109331-54-6 | EC 500-297-1 | MDI Mixed Isomers/PIR) |
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| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with MDI PIR | Author: Neuhahn | Year: 2012 | Adequacy: weight of evidence. Read-Across (CAS 109331-54-6 | EC 500-297-1 | MDI Mixed Isomers/PIR) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A | Year: 2021 | Adequacy: weight of evidence. Read-Across (CAS 25686-28-6 | EC 500-040-3 | 4,4’-MDI homopolymer) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A | Year: 2021 | Adequacy: weight of evidence. Read-Across (CAS 25686-28-6 | EC 500-040-3 | 4,4’-MDI homopolymer) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A | Year: 2021 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | EC N/A | Polymeric MDI) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A | Year: 2021 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | EC N/A | Polymeric MDI) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI/DPG/HMWP (Monomer depleted) | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (EC 701-041-3 | 4,4'-MDI/DPG/HMWP) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI/DPG/HMWP (Monomer depleted) | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (EC 701-041-3 | 4,4'-MDI/DPG/HMWP) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M | Year: 2016 | Adequacy: weight of evidence. Read-Across (EC 701-040-8 | 4,4'-MDI/DPG ) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M | Year: 2016 | Adequacy: weight of evidence. Read-Across (EC 701-040-8 | 4,4'-MDI/DPG ) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with MDI PIR | Author: Neuhahn | Year: 2012 | Adequacy: weight of evidence. Read-Across (CAS 109331-54-6 | EC 500-297-1 | MDI Mixed Isomers/PIR) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with MDI PIR | Author: Neuhahn | Year: 2012 | Adequacy: weight of evidence. Read-Across (CAS 109331-54-6 | EC 500-297-1 | MDI Mixed Isomers/PIR) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | EC N/A | Polymeric MDI) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | EC N/A | Polymeric MDI) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI/DPG/HMWP | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (EC 701-041-3 | 4,4'-MDI/DPG/HMWP) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI/DPG/HMWP | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (EC 701-041-3 | 4,4'-MDI/DPG/HMWP) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with MDI Polyisocyanurate | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with MDI Polyisocyanurate | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (CAS 25686-28-6 | EC 500-040-3 | 4,4’-MDI homopolymer) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (CAS 25686-28-6 | EC 500-040-3 | 4,4’-MDI homopolymer) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Adequacy: weight of evidence. Read-Across (EC 701-040-8 | 4,4'-MDI/DPG ) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Adequacy: weight of evidence. Read-Across (EC 701-040-8 | 4,4'-MDI/DPG ) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with MDI PIR | Author: Neuhahn | Year: 2012 | Adequacy: weight of evidence. Read-Across (CAS 109331-54-6 | EC 500-297-1 | MDI Mixed Isomers/PIR) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with MDI PIR | Author: Neuhahn | Year: 2012 | Adequacy: weight of evidence. Read-Across (CAS 109331-54-6 | EC 500-297-1 | MDI Mixed Isomers/PIR) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI/DPG | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (EC 701-040-8 | 4,4'-MDI/DPG ) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI/DPG | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. Read-Across (EC 701-040-8 | 4,4'-MDI/DPG ) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Effect of pMDI on the growth of the green alga Scenedesmus subspicatus | Author: Blom AJM & Oldersma H | Year: 1994 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | EC N/A | Polymeric MDI) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Effect of pMDI on the growth of the green alga Scenedesmus subspicatus | Author: Blom AJM & Oldersma H | Year: 1994 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | EC N/A | Polymeric MDI) |
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| Environmental | Hydrolysis | Robust Study Summary -- Title: Water Extractability of (4,4'-) MDI/TPG | Author: Neuland M | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Water Extractability of (4,4'-) MDI/TPG | Author: Neuland M | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Water Extractability of (4,4'-) MDI/TPG | Author: Neuland M | Year: 2016 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Water Extractability of (4,4'-) MDI/TPG | Author: Neuland M | Year: 2016 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neuland M | Year: 2021 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neuland M | Year: 2021 | Adequacy: weight of evidence. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4’-MDI) |
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| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of Polymeric MDI under homogenous reaction conditions | Author: Neuland M | Year: 2021 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | EC N/A | Polymeric MDI) |
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| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of Polymeric MDI under homogenous reaction conditions | Author: Neuland M | Year: 2021 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | EC N/A | Polymeric MDI) |
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| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of 4,4'-MDI/DPG/HMWP under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Adequacy: weight of evidence. Read-Across (EC 701-041-3 | 4,4'-MDI/DPG/HMWP) |
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| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of 4,4'-MDI/DPG/HMWP under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Adequacy: weight of evidence. Read-Across (EC 701-041-3 | 4,4'-MDI/DPG/HMWP) |
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| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation of MDI PIR | Author: Richter Chr. | Year: 2012 | Adequacy: weight of evidence. Read-Across (CAS 109331-54-6 | EC 500-297-1 | MDI Mixed Isomers/PIR) |
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| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Biodegradation of MDI PIR | Author: Richter Chr. | Year: 2012 | Adequacy: weight of evidence. Read-Across (CAS 109331-54-6 | EC 500-297-1 | MDI Mixed Isomers/PIR) |
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| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Report: 4,4'-MDI/DPG Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE 67056 Ludwigshafen Germany | Year: 2019 | Adequacy: weight of evidence. Read-Across (EC 701-040-8 | 4,4'-MDI/DPG ) |
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| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Report: 4,4'-MDI/DPG Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE 67056 Ludwigshafen Germany | Year: 2019 | Adequacy: weight of evidence. Read-Across (EC 701-040-8 | 4,4'-MDI/DPG ) |
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